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The map label for this gene is dsdC [H]

Identifier: 170681753

GI number: 170681753

Start: 2567502

End: 2568449

Strand: Reverse

Name: dsdC [H]

Synonym: EcSMS35_2514

Alternate gene names: 170681753

Gene position: 2568449-2567502 (Counterclockwise)

Preceding gene: 170682814

Following gene: 170684056

Centisome position: 50.68

GC content: 47.26

Gene sequence:

>948_bases
ATGGAACCCCTTCGTGAAATAAGAAATCGACTGCTTAACGGCTGGCAACTATCAAAACTGCATACTTTTGAAGTGGCTGC
CAGGCATCAGTCCTTCGCCCTTGCGGCAGAGGAATTGTCGCTGAGCCCCAGTGCGGTAAGTCACCGTATCAATCAGCTGG
AAGAAGAATTAGGTATTCAGTTGTTTGTTCGTTCCCATCGCAAAGTGGAATTAACGCACGAGGGGAAACGCGTTTATTGG
GCGCTAAAATCGTCGCTGGATACCCTGAACCAGGAAATTCTTGATATCAAAAATCAGGAATTATCGGGAACGTTAACGCT
GTATTCCCGGCCCTCTATCGCCCAATGCTGGTTGGTGCCCGCATTAGGTGACTTTACACGCCGATATCCGTCTATTTCGC
TCACCGTGCTCACTGGTAATGACAATGTCAATTTGCAACGTGCCGGAATCGATTTGGCGATCTACTTTGATGATGCGCCG
TCAGCGCAATTGGCTCATCACTTTCTGATGGATGAAGAAATCTTGCCTGTATGTAGCCCGGAATACGCTCAAAGACATGC
TTTAACCAACCAGGTAATTAACCTGCGCCACTGTACGTTGCTCCATGACAGACAGGCATGGAGCAACGACTCCGGTACGG
ATGAATGGCATAGTTGGGCGCAACATTATGCGGTTAATTTGCCGACATCTTCTGGGATTGGCTTTGATCGTTCTGATTTA
GCTGTTATCGCTGCGATGAATCATATTGGGGTAGCGATGGGAAGAAAACGCCTGGTACAAAAAAGGCTTGCCAGTGGTGA
GCTCGTCGCGCCGTTTGGCGATATGACGGTGAAATGCCATCAGCATTATTACATCACCACATTACCGGGCAGGCAGTGGC
CAAAAATTGAGGCATTTATTACTTGGTTAAGAGAACAGGTAAGTCAATATGAATGTTATACCTTATAA

Upstream 100 bases:

>100_bases
CTAAAAATGAAGGTGAATTGAGATATGGTTCACTTTAGCTCACCTTACAGCTGAAATTTTGCCGCTATTTTTTTACACTT
AAGAGAAAAATGAGGTGATT

Downstream 100 bases:

>100_bases
TACATTAAATCATCTGGTTCCTAAATAACCTTATTATGCACTGTAAGTGTATGTTGGCTTTATAAATTGCAATTTTTATA
TGGGAATTGTTTTGTCAATA

Product: DNA-binding transcriptional regulator DsdC

Products: NA

Alternate protein names: D-serine deaminase activator [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQLFVRSHRKVELTHEGKRVYW
ALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVPALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAP
SAQLAHHFLMDEEILPVCSPEYAQRHALTNQVINLRHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRSDL
AVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFITWLREQVSQYECYTL

Sequences:

>Translated_315_residues
MEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQLFVRSHRKVELTHEGKRVYW
ALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVPALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAP
SAQLAHHFLMDEEILPVCSPEYAQRHALTNQVINLRHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRSDL
AVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFITWLREQVSQYECYTL
>Mature_315_residues
MEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQLFVRSHRKVELTHEGKRVYW
ALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVPALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAP
SAQLAHHFLMDEEILPVCSPEYAQRHALTNQVINLRHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRSDL
AVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFITWLREQVSQYECYTL

Specific function: Regulates the expression of the dsd operon for D-serine deaminase (dsdA) [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788706, Length=307, Percent_Identity=98.371335504886, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI1786448, Length=302, Percent_Identity=33.4437086092715, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1789173, Length=288, Percent_Identity=31.25, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786401, Length=296, Percent_Identity=25.6756756756757, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787128, Length=300, Percent_Identity=27, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87081978, Length=193, Percent_Identity=31.0880829015544, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI145693105, Length=168, Percent_Identity=27.3809523809524, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI145693193, Length=176, Percent_Identity=30.6818181818182, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789440, Length=269, Percent_Identity=26.3940520446097, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788748, Length=169, Percent_Identity=28.4023668639053, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787589, Length=248, Percent_Identity=28.2258064516129, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790208, Length=143, Percent_Identity=32.1678321678322, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI157672245, Length=172, Percent_Identity=33.1395348837209, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87082132, Length=284, Percent_Identity=25.3521126760563, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787806, Length=176, Percent_Identity=28.4090909090909, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789639, Length=141, Percent_Identity=29.0780141843972, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011781
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35923; Mature: 35923

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQ
CCHHHHHHHHHCCCEEECCEEHHHHHHHHHHHHEEHHHHCCCHHHHHHHHHHHHHHHCEE
LFVRSHRKVELTHEGKRVYWALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVP
EEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHEEEEH
ALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAPSAQLAHHFLMDEEILPVCSP
HHHHHHHHCCCEEEEEEECCCCCEEEECCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCH
EYAQRHALTNQVINLRHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRSDL
HHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHEEEECCCCCCCCCCCCCC
AVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFI
EEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECEEEEEECCCCCCCHHHHHH
TWLREQVSQYECYTL
HHHHHHHHHCCCCCC
>Mature Secondary Structure
MEPLREIRNRLLNGWQLSKLHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQ
CCHHHHHHHHHCCCEEECCEEHHHHHHHHHHHHEEHHHHCCCHHHHHHHHHHHHHHHCEE
LFVRSHRKVELTHEGKRVYWALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVP
EEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHEEEEH
ALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAPSAQLAHHFLMDEEILPVCSP
HHHHHHHHCCCEEEEEEECCCCCEEEECCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCH
EYAQRHALTNQVINLRHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRSDL
HHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHEEEECCCCCCCCCCCCCC
AVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFI
EEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECEEEEEECCCCCCCHHHHHH
TWLREQVSQYECYTL
HHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592420; 9205837; 9278503 [H]