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The map label for this gene is fimB [H]

Identifier: 170684056

GI number: 170684056

Start: 2565160

End: 2565789

Strand: Reverse

Name: fimB [H]

Synonym: EcSMS35_2512

Alternate gene names: 170684056

Gene position: 2565789-2565160 (Counterclockwise)

Preceding gene: 170681753

Following gene: 170680105

Centisome position: 50.62

GC content: 35.24

Gene sequence:

>630_bases
ATGCAAAACAGAAAATTTTTAACGCATCATGAAATTAATTTACTACTTCAATCTGTAAGACAAAAGAGTTGCTCTTCACG
CGATGTTTGCATGATTTTATTGGCTTATTTTCATGGTCTGCGTGTTAGTGAGCTCTTATCTCTGCAGTTGTCGGATTTAG
AACTAACTACAGAAAAAATATATATTCAACGGATAAAAAATGGATTCAGTACAGTCCATCCACTTCAAAAGGAAGAGGTG
ATTGCAATAACAAACTGGCTGAATGAAAGGAATTCATTAAATGTTAAACATTTCAATGATAACCCGTGGTTATTTGTTTC
CCGAACAGGAAAACCATTATCGAGACAACGATTTTATAACATAGTTTCTGCTGCGGGTAAAAATGCAGGTTTAAATATTA
AAGTTCATCCACATATGTTACGCCATGCATGTGGTTATTCACTAGCAGATAATGGTGTGGATACCCGTCTTATTCAGGAC
TATCTCGGGCATCGTAATATCAGGCATACGGTAATTTATACTGCTTCTAATTCAATGAGATTTGAAAAAATGTGGGGGAG
AGGTGACGCAAAAAAGCAACATTTTGACCCAAAATGTAAACCCAATCTTTGTTTAGAAATTCTCGTATAG

Upstream 100 bases:

>100_bases
AATCTATAATCATACAGCAACTATATGAATTATATTATTGACTAAATGTAATTCTTTCATCATAGTTGACATGGTTATTT
TATATAAATAGAGGTGATTT

Downstream 100 bases:

>100_bases
AAAAACATTTTTTTCTATAAAAAACATTAAATTTACTGATTTAGATCAATGTGTGACGTCAATCTACACATAAAGAGGTA
GGTTTGTCTTCTTTTTAATC

Product: type 1 fimbriae regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MQNRKFLTHHEINLLLQSVRQKSCSSRDVCMILLAYFHGLRVSELLSLQLSDLELTTEKIYIQRIKNGFSTVHPLQKEEV
IAITNWLNERNSLNVKHFNDNPWLFVSRTGKPLSRQRFYNIVSAAGKNAGLNIKVHPHMLRHACGYSLADNGVDTRLIQD
YLGHRNIRHTVIYTASNSMRFEKMWGRGDAKKQHFDPKCKPNLCLEILV

Sequences:

>Translated_209_residues
MQNRKFLTHHEINLLLQSVRQKSCSSRDVCMILLAYFHGLRVSELLSLQLSDLELTTEKIYIQRIKNGFSTVHPLQKEEV
IAITNWLNERNSLNVKHFNDNPWLFVSRTGKPLSRQRFYNIVSAAGKNAGLNIKVHPHMLRHACGYSLADNGVDTRLIQD
YLGHRNIRHTVIYTASNSMRFEKMWGRGDAKKQHFDPKCKPNLCLEILV
>Mature_209_residues
MQNRKFLTHHEINLLLQSVRQKSCSSRDVCMILLAYFHGLRVSELLSLQLSDLELTTEKIYIQRIKNGFSTVHPLQKEEV
IAITNWLNERNSLNVKHFNDNPWLFVSRTGKPLSRQRFYNIVSAAGKNAGLNIKVHPHMLRHACGYSLADNGVDTRLIQD
YLGHRNIRHTVIYTASNSMRFEKMWGRGDAKKQHFDPKCKPNLCLEILV

Specific function: FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimB switches f

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1790767, Length=193, Percent_Identity=52.3316062176166, Blast_Score=219, Evalue=7e-59,
Organism=Escherichia coli, GI1790768, Length=187, Percent_Identity=54.0106951871658, Blast_Score=209, Evalue=1e-55,
Organism=Escherichia coli, GI1790244, Length=164, Percent_Identity=31.0975609756098, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789261, Length=191, Percent_Identity=29.8429319371728, Blast_Score=75, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 24224; Mature: 24224

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNRKFLTHHEINLLLQSVRQKSCSSRDVCMILLAYFHGLRVSELLSLQLSDLELTTEKI
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHH
YIQRIKNGFSTVHPLQKEEVIAITNWLNERNSLNVKHFNDNPWLFVSRTGKPLSRQRFYN
HHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHH
IVSAAGKNAGLNIKVHPHMLRHACGYSLADNGVDTRLIQDYLGHRNIRHTVIYTASNSMR
HHHHCCCCCCCEEEECHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCEE
FEKMWGRGDAKKQHFDPKCKPNLCLEILV
HHHHHCCCCCCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MQNRKFLTHHEINLLLQSVRQKSCSSRDVCMILLAYFHGLRVSELLSLQLSDLELTTEKI
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHH
YIQRIKNGFSTVHPLQKEEVIAITNWLNERNSLNVKHFNDNPWLFVSRTGKPLSRQRFYN
HHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHH
IVSAAGKNAGLNIKVHPHMLRHACGYSLADNGVDTRLIQDYLGHRNIRHTVIYTASNSMR
HHHHCCCCCCCEEEECHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCEE
FEKMWGRGDAKKQHFDPKCKPNLCLEILV
HHHHHCCCCCCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]