Click here to switch to the map view.

The map label for this gene is dcuR [H]

Identifier: 170681636

GI number: 170681636

Start: 1137015

End: 1137740

Strand: Reverse

Name: dcuR [H]

Synonym: EcSMS35_1119

Alternate gene names: 170681636

Gene position: 1137740-1137015 (Counterclockwise)

Preceding gene: 170683932

Following gene: 170683987

Centisome position: 22.45

GC content: 34.3

Gene sequence:

>726_bases
ATGAACAATGTATTAATTGTTGATGACGATATATTAGTAGCTGATGTGATTCGTCGCATTGTAGAACAAACCCCGGCATT
TAAATGCTGTGGCATAGCGTTATCACTTGGTCAGGCGAAAGAAATTATATCTGTAAATAAAAAACTGGCTGACTTGATTT
TGCTTGATCTTTATATCAATAAAGATAACGGACTTGATTTACTCCCTTTTCTTCATAGCATTCATTGCAAAAGTGATGTT
ATTGTAATTTCTGCTGCTGATGACTCTGCGACAATTAAAGATTCATTACATTATGGTGTTTCTGATTATCTGATAAAGCC
ATTTCATATCTCACGTTTGGTTGATTCGCTTACACGATGGAAACATAAAAAGACTCTTCTTGAGAGTCAGAAGATATTCA
ATCAATCAGAACTGGATTTATTAACTCACAAAATAATTCCGAACACAGAAAAAATAAGACATTTACCCAAAGGACTGTCA
ACAGATACATTGCGAATTATTTGTAGGTGGATTGATGAGCATCAACATAAAAAATTCACACTCAATGAACTGGCCAGTGG
TATTAAGATATCCAGAATCTCATGCAGAAAATATATCATCTGGCTGGTAAGTTGCCATATATTGGCATTTGATTTTTCCT
GTGGTGTCACTGGTCGCCCTGCTTATCGTTACTGGATAAGACATCAATATTACCCATATATTAAAAAATATAGTGAAAAA
CCGTAA

Upstream 100 bases:

>100_bases
TTAATTAAATTCCATAAGTAACAATAGGGTTGATTTTTAAATCACTATATAGAATATTTATATAGATTTAGGTATTACGT
TGGCAAGCTAGGTTGGAAAA

Downstream 100 bases:

>100_bases
GCCTTTTAATCATTTATCTACCATAATTATGACATCTACTTAATCACAATAAACTCATCGTGCGATAATTTCTGGAGAGT
GTGTTCCGGATATTAAGAGG

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MNNVLIVDDDILVADVIRRIVEQTPAFKCCGIALSLGQAKEIISVNKKLADLILLDLYINKDNGLDLLPFLHSIHCKSDV
IVISAADDSATIKDSLHYGVSDYLIKPFHISRLVDSLTRWKHKKTLLESQKIFNQSELDLLTHKIIPNTEKIRHLPKGLS
TDTLRIICRWIDEHQHKKFTLNELASGIKISRISCRKYIIWLVSCHILAFDFSCGVTGRPAYRYWIRHQYYPYIKKYSEK
P

Sequences:

>Translated_241_residues
MNNVLIVDDDILVADVIRRIVEQTPAFKCCGIALSLGQAKEIISVNKKLADLILLDLYINKDNGLDLLPFLHSIHCKSDV
IVISAADDSATIKDSLHYGVSDYLIKPFHISRLVDSLTRWKHKKTLLESQKIFNQSELDLLTHKIIPNTEKIRHLPKGLS
TDTLRIICRWIDEHQHKKFTLNELASGIKISRISCRKYIIWLVSCHILAFDFSCGVTGRPAYRYWIRHQYYPYIKKYSEK
P
>Mature_241_residues
MNNVLIVDDDILVADVIRRIVEQTPAFKCCGIALSLGQAKEIISVNKKLADLILLDLYINKDNGLDLLPFLHSIHCKSDV
IVISAADDSATIKDSLHYGVSDYLIKPFHISRLVDSLTRWKHKKTLLESQKIFNQSELDLLTHKIIPNTEKIRHLPKGLS
TDTLRIICRWIDEHQHKKFTLNELASGIKISRISCRKYIIWLVSCHILAFDFSCGVTGRPAYRYWIRHQYYPYIKKYSEK
P

Specific function: Member of the two-component regulatory system dcuR/dcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-di

COG id: COG4565

COG function: function code KT; Response regulator of citrate/malate metabolism

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790566, Length=239, Percent_Identity=56.9037656903766, Blast_Score=284, Evalue=3e-78,
Organism=Escherichia coli, GI1786838, Length=220, Percent_Identity=32.2727272727273, Blast_Score=107, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR012287
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 27814; Mature: 27814

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNVLIVDDDILVADVIRRIVEQTPAFKCCGIALSLGQAKEIISVNKKLADLILLDLYIN
CCCEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEC
KDNGLDLLPFLHSIHCKSDVIVISAADDSATIKDSLHYGVSDYLIKPFHISRLVDSLTRW
CCCCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCHHHHHCCHHHHHHHHHHHHHH
KHKKTLLESQKIFNQSELDLLTHKIIPNTEKIRHLPKGLSTDTLRIICRWIDEHQHKKFT
HHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEE
LNELASGIKISRISCRKYIIWLVSCHILAFDFSCGVTGRPAYRYWIRHQYYPYIKKYSEK
HHHHHCCCEEEHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHCCCHHHHHCCCC
P
C
>Mature Secondary Structure
MNNVLIVDDDILVADVIRRIVEQTPAFKCCGIALSLGQAKEIISVNKKLADLILLDLYIN
CCCEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEC
KDNGLDLLPFLHSIHCKSDVIVISAADDSATIKDSLHYGVSDYLIKPFHISRLVDSLTRW
CCCCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCHHHHHCCHHHHHHHHHHHHHH
KHKKTLLESQKIFNQSELDLLTHKIIPNTEKIRHLPKGLSTDTLRIICRWIDEHQHKKFT
HHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEE
LNELASGIKISRISCRKYIIWLVSCHILAFDFSCGVTGRPAYRYWIRHQYYPYIKKYSEK
HHHHHCCCEEEHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHCCCHHHHHCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]