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The map label for this gene is mscL [H]

Identifier: 170079057

GI number: 170079057

Start: 2562688

End: 2563125

Strand: Direct

Name: mscL [H]

Synonym: SYNPCC7002_A2462

Alternate gene names: 170079057

Gene position: 2562688-2563125 (Clockwise)

Preceding gene: 170079054

Following gene: 170079060

Centisome position: 85.19

GC content: 46.58

Gene sequence:

>438_bases
ATGGCAAAAAAAAGTAGTTTTTGGAGTGATTTCCAAGCCTTCATCATGAGGGGGAATGTGATTGATTTGGCAGTGGCCGT
CGTGATCGGCGGGGCCTTTGGTCAAATTGTCAATTCTTTAGTTGCAGATATTATTACGCCCGCGATCTTACAACCCGCCT
TAAGTGCAGCTAATTTAGATGCCCTGGGTGAATTGTCTTTTAATGGCATTAAATACGGGCTTTTTTTGGCGGCTGTAATT
AACTTTTTGGTGATTGCATTTGCGATTTTCTTGGTTATTCGGGCCATCGAAAAAATGCAACGGCGATTTAACCGAGCGAA
AGCCATGGAAGAAATAGACGCGCCGCCCCCAGCCCCCGATCCGGCGGTTGTGGCCCAAGAAAACCTCACGGCGGCCATCG
AACGTCTGGCTAATTTAATGGAAAATCGTCAGCAATAG

Upstream 100 bases:

>100_bases
GAAAATTGATTTGCTGGATCGGGTCGCTTATCTTTATAGGGGCGATGACATTTTTATCTTTGTTTATCGTTTTTAATCCA
TCACTAAGGAATGAGCATTT

Downstream 100 bases:

>100_bases
AGCTGAATTCTCACAATACCTGACGGAAGGATTGCCTCCTTTGGTGGGGGCTTTTTTATGGGTGAGAAGAGGTGCCATCA
AAGCCGATGTGATCGGAGCT

Product: large conductance mechanosensitive channel protein

Products: non-specific ion/solute [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 145; Mature: 144

Protein sequence:

>145_residues
MAKKSSFWSDFQAFIMRGNVIDLAVAVVIGGAFGQIVNSLVADIITPAILQPALSAANLDALGELSFNGIKYGLFLAAVI
NFLVIAFAIFLVIRAIEKMQRRFNRAKAMEEIDAPPPAPDPAVVAQENLTAAIERLANLMENRQQ

Sequences:

>Translated_145_residues
MAKKSSFWSDFQAFIMRGNVIDLAVAVVIGGAFGQIVNSLVADIITPAILQPALSAANLDALGELSFNGIKYGLFLAAVI
NFLVIAFAIFLVIRAIEKMQRRFNRAKAMEEIDAPPPAPDPAVVAQENLTAAIERLANLMENRQQ
>Mature_144_residues
AKKSSFWSDFQAFIMRGNVIDLAVAVVIGGAFGQIVNSLVADIITPAILQPALSAANLDALGELSFNGIKYGLFLAAVIN
FLVIAFAIFLVIRAIEKMQRRFNRAKAMEEIDAPPPAPDPAVVAQENLTAAIERLANLMENRQQ

Specific function: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell [H]

COG id: COG1970

COG function: function code M; Large-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscL family [H]

Homologues:

Organism=Escherichia coli, GI1789686, Length=146, Percent_Identity=40.4109589041096, Blast_Score=89, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019823
- InterPro:   IPR001185 [H]

Pfam domain/function: PF01741 MscL [H]

EC number: NA

Molecular weight: Translated: 15701; Mature: 15569

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS01327 MSCL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKSSFWSDFQAFIMRGNVIDLAVAVVIGGAFGQIVNSLVADIITPAILQPALSAANLD
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
ALGELSFNGIKYGLFLAAVINFLVIAFAIFLVIRAIEKMQRRFNRAKAMEEIDAPPPAPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PAVVAQENLTAAIERLANLMENRQQ
CCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKKSSFWSDFQAFIMRGNVIDLAVAVVIGGAFGQIVNSLVADIITPAILQPALSAANLD
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
ALGELSFNGIKYGLFLAAVINFLVIAFAIFLVIRAIEKMQRRFNRAKAMEEIDAPPPAPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PAVVAQENLTAAIERLANLMENRQQ
CCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: non-specific ion/solute [Cytoplasm] [C]

Specific reaction: non-specific ion/solute [Cytoplasm] = non-specific ion/solute [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]