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The map label for this gene is groEL [H]

Identifier: 170079053

GI number: 170079053

Start: 2555207

End: 2556832

Strand: Direct

Name: groEL [H]

Synonym: SYNPCC7002_A2458

Alternate gene names: 170079053

Gene position: 2555207-2556832 (Clockwise)

Preceding gene: 170079052

Following gene: 170079054

Centisome position: 84.95

GC content: 52.83

Gene sequence:

>1626_bases
ATGGCTAAATCTATTATTTACAACGAAGATGCTCGCCGCGCCCTCGAAAAAGGGATCGACCTCCTCGCTGAAGCTGTTGC
GGTAACCCTCGGCCCCAAAGGTCGGAACGTTGTGCTCGAAAAGAAATTTGGCGCACCCCAGATCGTGAATGACGGTGTGA
CCATTGCCAAGGAAATCGAGCTCGAAGACCACATCGAAAACACCGGTGTTTCTTTGATTCGCCAAGCGGCTTCTAAAACC
AATGATGTGGCCGGTGATGGAACCACCACAGCAACGGTTCTCGCCCATGCCATGGTCAAGGAAGGTCTCCGCAACGTCGC
GGCTGGTGCGAACCCCATCGCCCTCAAGCGTGGTATTGATAAAGCGACTGAATTCCTCGTTGGCCGCATCAAAGATCAAG
CTCGTCCGGTAGAAGATTCGACGGCGATTGCCCAAGTCGGTGCCATCTCTGCGGGTAACGACAAGGAAGTTGGTGACATG
ATCGCCAAAGCCATGGACAAAGTCGGTAAAGAAGGTGTGATCTCCCTCGAAGAAGGGAAATCCATGGAAACCGAACTCGA
AATCACCGAAGGGATGCGTTTCGACAAGGGTTACACTTCCCCCTACTTCGTCACCGACACCGAGCGCATGGAAGCGGTTC
TTGAAGATCCTTTCATCCTCATCACTGACAAGAAAATCACCCTGGTTCAAGACCTTGTACCGATTCTCGAACAGGTTGCT
CGCCAAGGTAAGCCCCTCGTAATTATCGCTGAAGATATCGAGAAAGAAGCCCTTGCTACCCTCGTGGTCAACCGTCTCCG
GGGTGTCCTCAACGTTGCTGCGGTTAAAGCGCCTGGTTTTGGCGATCGCCGCAAGCAGATGCTCGAAGATATTGCTGTAC
TCACCGGTGGCCAACTGATCACCGAAGATGCGGGTCTCAAGCTCGACAACACCAGCGTTGATATGCTCGGTAAAGCACGC
CGCATCACCATCACCAAGGACAACACCACCATTGTGGCCGATGGTAACGAGCAGGCAGTTAAGACCCGTTGTGAGCAGAT
CCGCCGTCAAATCGAAGAATCTGACTCTTCTTATGACAAAGAAAAACTCCAAGAGCGTCTCGCGAAACTCTCCGGTGGTG
TCGCTGTGATCAAAGTCGGTGCAGCAACCGAAACTGAGATGAAAGACCGTAAGCTTCGTCTCGAAGATGCGATCAACGCG
ACCAAAGCAGCCGTTGAAGAAGGGATTGTTCCCGGTGGTGGTACAACCCTGGCGCACCTCGCTCCCGAATTAGAAACTTG
GGCGAATGATAACCTCACTGCGGAGCAACTCACTGGTGCTTTGATCGTGGCCCGTGCCTTGACTGCCCCCCTGAAGCGCA
TTGCTGAAAACGCTGGCCAAAACGGTGCGGTAATCGCTGAGCGTGTGAAGGAAAAAGACTTCAATACTGGTTTTAACGCA
GCAACTAACGAATTCGTGGATATGCTCGCTGCTGGTATCGTTGACCCCGCTAAGGTAACCCGTTCTGCAACCCAGAATGC
GGCTTCTATCGCTGGCATGGTTCTCACCACTGAGTGCATCGTTGTTGACAAGCCTGAAAAAGATAAAGCTGGTGCGGCTC
CCGGTGCCGGTGACTTCGACTACTAA

Upstream 100 bases:

>100_bases
TCGCAACCGTTGCGTAATTATTTTTAGGTTTGACCTAAGCAATCGTTTCAGATTTTTCTATTTTTTCTCGTAAAACGCTC
AACCTAGAAATTCAATCATT

Downstream 100 bases:

>100_bases
GGCGGATCGATCGATGTAGGAGTTTACCATGGTGAACCCCTAGAGAAATCACTCTGTAAATAATTTCATCCACTAAAAAC
AATTAAAAGATCTCCTTAAT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MAKSIIYNEDARRALEKGIDLLAEAVAVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIELEDHIENTGVSLIRQAASKT
NDVAGDGTTTATVLAHAMVKEGLRNVAAGANPIALKRGIDKATEFLVGRIKDQARPVEDSTAIAQVGAISAGNDKEVGDM
IAKAMDKVGKEGVISLEEGKSMETELEITEGMRFDKGYTSPYFVTDTERMEAVLEDPFILITDKKITLVQDLVPILEQVA
RQGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKQMLEDIAVLTGGQLITEDAGLKLDNTSVDMLGKAR
RITITKDNTTIVADGNEQAVKTRCEQIRRQIEESDSSYDKEKLQERLAKLSGGVAVIKVGAATETEMKDRKLRLEDAINA
TKAAVEEGIVPGGGTTLAHLAPELETWANDNLTAEQLTGALIVARALTAPLKRIAENAGQNGAVIAERVKEKDFNTGFNA
ATNEFVDMLAAGIVDPAKVTRSATQNAASIAGMVLTTECIVVDKPEKDKAGAAPGAGDFDY

Sequences:

>Translated_541_residues
MAKSIIYNEDARRALEKGIDLLAEAVAVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIELEDHIENTGVSLIRQAASKT
NDVAGDGTTTATVLAHAMVKEGLRNVAAGANPIALKRGIDKATEFLVGRIKDQARPVEDSTAIAQVGAISAGNDKEVGDM
IAKAMDKVGKEGVISLEEGKSMETELEITEGMRFDKGYTSPYFVTDTERMEAVLEDPFILITDKKITLVQDLVPILEQVA
RQGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKQMLEDIAVLTGGQLITEDAGLKLDNTSVDMLGKAR
RITITKDNTTIVADGNEQAVKTRCEQIRRQIEESDSSYDKEKLQERLAKLSGGVAVIKVGAATETEMKDRKLRLEDAINA
TKAAVEEGIVPGGGTTLAHLAPELETWANDNLTAEQLTGALIVARALTAPLKRIAENAGQNGAVIAERVKEKDFNTGFNA
ATNEFVDMLAAGIVDPAKVTRSATQNAASIAGMVLTTECIVVDKPEKDKAGAAPGAGDFDY
>Mature_540_residues
AKSIIYNEDARRALEKGIDLLAEAVAVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIELEDHIENTGVSLIRQAASKTN
DVAGDGTTTATVLAHAMVKEGLRNVAAGANPIALKRGIDKATEFLVGRIKDQARPVEDSTAIAQVGAISAGNDKEVGDMI
AKAMDKVGKEGVISLEEGKSMETELEITEGMRFDKGYTSPYFVTDTERMEAVLEDPFILITDKKITLVQDLVPILEQVAR
QGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKQMLEDIAVLTGGQLITEDAGLKLDNTSVDMLGKARR
ITITKDNTTIVADGNEQAVKTRCEQIRRQIEESDSSYDKEKLQERLAKLSGGVAVIKVGAATETEMKDRKLRLEDAINAT
KAAVEEGIVPGGGTTLAHLAPELETWANDNLTAEQLTGALIVARALTAPLKRIAENAGQNGAVIAERVKEKDFNTGFNAA
TNEFVDMLAAGIVDPAKVTRSATQNAASIAGMVLTTECIVVDKPEKDKAGAAPGAGDFDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=45.2830188679245, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=45.2830188679245, Blast_Score=473, Evalue=1e-133,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=57.1698113207547, Blast_Score=600, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=45.5743879472693, Blast_Score=465, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=43.8679245283019, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=49.6197718631179, Blast_Score=505, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6322524, Length=376, Percent_Identity=23.1382978723404, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24641193, Length=529, Percent_Identity=47.069943289225, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24641191, Length=529, Percent_Identity=47.069943289225, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=45.4372623574144, Blast_Score=460, Evalue=1e-129,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=45.4372623574144, Blast_Score=460, Evalue=1e-129,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=45.4372623574144, Blast_Score=460, Evalue=1e-129,
Organism=Drosophila melanogaster, GI17864606, Length=539, Percent_Identity=38.961038961039, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24584129, Length=532, Percent_Identity=35.9022556390977, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI19921262, Length=532, Percent_Identity=35.9022556390977, Blast_Score=305, Evalue=5e-83,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57719; Mature: 57587

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSIIYNEDARRALEKGIDLLAEAVAVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIE
CCCCEEECHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVSLIRQAASKTNDVAGDGTTTATVLAHAMVKEGLRNVAAGANPIALKRGID
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCHH
KATEFLVGRIKDQARPVEDSTAIAQVGAISAGNDKEVGDMIAKAMDKVGKEGVISLEEGK
HHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCC
SMETELEITEGMRFDKGYTSPYFVTDTERMEAVLEDPFILITDKKITLVQDLVPILEQVA
CCCCEEEHHCCCEECCCCCCCEEEECHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHH
RQGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKQMLEDIAVLTGGQLI
HCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
TEDAGLKLDNTSVDMLGKARRITITKDNTTIVADGNEQAVKTRCEQIRRQIEESDSSYDK
ECCCCCEECCCCHHHCCCCEEEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCH
EKLQERLAKLSGGVAVIKVGAATETEMKDRKLRLEDAINATKAAVEEGIVPGGGTTLAHL
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
APELETWANDNLTAEQLTGALIVARALTAPLKRIAENAGQNGAVIAERVKEKDFNTGFNA
CHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCH
ATNEFVDMLAAGIVDPAKVTRSATQNAASIAGMVLTTECIVVDKPEKDKAGAAPGAGDFD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCC
Y
C
>Mature Secondary Structure 
AKSIIYNEDARRALEKGIDLLAEAVAVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIE
CCCEEECHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVSLIRQAASKTNDVAGDGTTTATVLAHAMVKEGLRNVAAGANPIALKRGID
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCHH
KATEFLVGRIKDQARPVEDSTAIAQVGAISAGNDKEVGDMIAKAMDKVGKEGVISLEEGK
HHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCC
SMETELEITEGMRFDKGYTSPYFVTDTERMEAVLEDPFILITDKKITLVQDLVPILEQVA
CCCCEEEHHCCCEECCCCCCCEEEECHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHH
RQGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKQMLEDIAVLTGGQLI
HCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
TEDAGLKLDNTSVDMLGKARRITITKDNTTIVADGNEQAVKTRCEQIRRQIEESDSSYDK
ECCCCCEECCCCHHHCCCCEEEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCH
EKLQERLAKLSGGVAVIKVGAATETEMKDRKLRLEDAINATKAAVEEGIVPGGGTTLAHL
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
APELETWANDNLTAEQLTGALIVARALTAPLKRIAENAGQNGAVIAERVKEKDFNTGFNA
CHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCH
ATNEFVDMLAAGIVDPAKVTRSATQNAASIAGMVLTTECIVVDKPEKDKAGAAPGAGDFD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8093614; 8905231; 9298645 [H]