Click here to switch to the map view.

The map label for this gene is tpm [H]

Identifier: 170078961

GI number: 170078961

Start: 2448588

End: 2449187

Strand: Direct

Name: tpm [H]

Synonym: SYNPCC7002_A2366

Alternate gene names: 170078961

Gene position: 2448588-2449187 (Clockwise)

Preceding gene: 170078957

Following gene: 170078963

Centisome position: 81.4

GC content: 47.5

Gene sequence:

>600_bases
ATGGTAATGGTTCGGAAAAAAAATTTTTGGGAAGAAAAATATCAAACGGCTCAACATCGCTGGGATCTCGGCCAAGCAGC
GCCACCGCTCCAGGATTTTTTCGCAAAGACAGCACCATTACCCCAAGGGAAATGGGGGGTTTTGGGTTGTGGCCAGGGCC
ATGATGCTGTGTTTTTAGCAAAACAGGGGTTCTCAGTAACGGGGGTTGATTTTGCCCCAGCGGCGATCGCCGCCGCGAAA
GCATTAAGCCAAGATCATGGTGTTACTCTTACTTTACTCGAAGAAAATATTTTTGATCTCAAAAAAAGTCATAAAAGTCA
CTTTGATTATCTGTTCGAGCATACCTGTTTCTGTGCGATCGCCCCAGAGCAGCGTCCCGATTACGTTACCTTGGCGGCCA
CAATCCTTAAACCAGGGGCCAAACTCTACGGTATTTTCTACACCCACAACAAAACGGGAGGCCCGCCCTTTGGCACAACC
CCCCAGGAAGTAATTCAGTTGTTTTCCCCACAATTTAAGATTCTTGCCCTCGATCCGATTCAAAATTCTGTGTCGAGTCG
GCAAGGGGATGAACATTGGGGGATCTTGCAAAAGAAATAG

Upstream 100 bases:

>100_bases
AATCAATTTGAAAAGTTTGATAAGAAAGCCTCTGGAAATTAGTGTAATACTGATTAAATAAACTCATTAGTGCTTTGCAA
CTAAGCTTTAAGGTTGGGCA

Downstream 100 bases:

>100_bases
GCGATCGCTTTAATTTAATGCATCACCATCCCGCCATCTACATTAAACGTTTGACCTGTAATGTAAGCAGCAGCAGGATC
AGCGGCGAGGAAACGAATCA

Product: thiopurine S-methyltransferase (tpmt)

Products: NA

Alternate protein names: Thiopurine methyltransferase [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MVMVRKKNFWEEKYQTAQHRWDLGQAAPPLQDFFAKTAPLPQGKWGVLGCGQGHDAVFLAKQGFSVTGVDFAPAAIAAAK
ALSQDHGVTLTLLEENIFDLKKSHKSHFDYLFEHTCFCAIAPEQRPDYVTLAATILKPGAKLYGIFYTHNKTGGPPFGTT
PQEVIQLFSPQFKILALDPIQNSVSSRQGDEHWGILQKK

Sequences:

>Translated_199_residues
MVMVRKKNFWEEKYQTAQHRWDLGQAAPPLQDFFAKTAPLPQGKWGVLGCGQGHDAVFLAKQGFSVTGVDFAPAAIAAAK
ALSQDHGVTLTLLEENIFDLKKSHKSHFDYLFEHTCFCAIAPEQRPDYVTLAATILKPGAKLYGIFYTHNKTGGPPFGTT
PQEVIQLFSPQFKILALDPIQNSVSSRQGDEHWGILQKK
>Mature_199_residues
MVMVRKKNFWEEKYQTAQHRWDLGQAAPPLQDFFAKTAPLPQGKWGVLGCGQGHDAVFLAKQGFSVTGVDFAPAAIAAAK
ALSQDHGVTLTLLEENIFDLKKSHKSHFDYLFEHTCFCAIAPEQRPDYVTLAATILKPGAKLYGIFYTHNKTGGPPFGTT
PQEVIQLFSPQFKILALDPIQNSVSSRQGDEHWGILQKK

Specific function: Ubiquinone biosynthesis. [C]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822 [H]

Pfam domain/function: PF05724 TPMT [H]

EC number: =2.1.1.67 [H]

Molecular weight: Translated: 22099; Mature: 22099

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMVRKKNFWEEKYQTAQHRWDLGQAAPPLQDFFAKTAPLPQGKWGVLGCGQGHDAVFLA
CEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCEEEEE
KQGFSVTGVDFAPAAIAAAKALSQDHGVTLTLLEENIFDLKKSHKSHFDYLFEHTCFCAI
ECCCEEECCCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCEEEEE
APEQRPDYVTLAATILKPGAKLYGIFYTHNKTGGPPFGTTPQEVIQLFSPQFKILALDPI
CCCCCCCEEEEEHHHHCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHCCCEEEEEECCH
QNSVSSRQGDEHWGILQKK
HHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MVMVRKKNFWEEKYQTAQHRWDLGQAAPPLQDFFAKTAPLPQGKWGVLGCGQGHDAVFLA
CEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCEEECCCCCCEEEEE
KQGFSVTGVDFAPAAIAAAKALSQDHGVTLTLLEENIFDLKKSHKSHFDYLFEHTCFCAI
ECCCEEECCCCCHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCEEEEE
APEQRPDYVTLAATILKPGAKLYGIFYTHNKTGGPPFGTTPQEVIQLFSPQFKILALDPI
CCCCCCCEEEEEHHHHCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHCCCEEEEEECCH
QNSVSSRQGDEHWGILQKK
HHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA