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The map label for this gene is pyrC [H]

Identifier: 170078674

GI number: 170078674

Start: 2152541

End: 2153806

Strand: Reverse

Name: pyrC [H]

Synonym: SYNPCC7002_A2070

Alternate gene names: 170078674

Gene position: 2153806-2152541 (Counterclockwise)

Preceding gene: 170078677

Following gene: 170078672

Centisome position: 71.6

GC content: 52.13

Gene sequence:

>1266_bases
ATGGATAACGTTGTTTTACGGCAGGTGCGGGTTCTGGATCCCGTGGCCAACTTGGATCATCGCCAAGATGTCTGGTTTAA
GGATGGTCAGCTCCAGGCGATCACCCCCCAATTGTCAGATCTCCCCACCGCAGTAGAATCCATCGAAGCCGCAGATCTAA
TCCTGGCGCCCGGTTTAGTGGATCTTTATAGCCACAGTAGCGAACCTGGGTACGAATCCCGCGAAACGTTGAAACAACTC
GCCCAAGGTGCCCTCGCTGGAGGGTTTACCCAAGTGGGGATTTTGCCGAATACCCAGCCTCCCCTTGATAATCTTGGCCA
ACTGCAAAGCTTTCAACAACTCATCCAGCAAATACCCGGCCCCAAACCAAATTTTTTACCCTGGGCTGCCCTGACGAAAA
AATGCCAAGGGGAAAGCCTCACGGAATTAGGAGAACTCGCGGCCGCAAATATTGCCGGATTTAGCGACAGCCAAGCGTTA
AACAATTGGCTCCTGCTGCGGCGTACCCTCGAATATTTATGCCCCCATCACCGACCCATCGCCCTCTACCCGCAAAATTT
AGCCCTCCATAACGGGGGAACGGCCCGCTACGGCAAGGCGAGTTTAGCCTATGGCCTCGTGGAGGAATTAGTCTCAGTAG
AAACCACGGCGATCGCTTCGATCTGTGAACTGGTGGCCGAACTGAAAACCCCTGTCCATCTCATGCGCATCTCCACCGCC
CGGGGGGTGGAATTGATTGCGGAAGCCAAACAACGGGGATTGCCAATTACTGCCAGTGTTTCTTGGATGCATCTGCTCTG
GAATACGAAGGCCCTCAGTACCTATGACCCGAATCTCCGCCTAGATCCGCCCCTTGGTAATCCCGAAGATCAACAAGCAT
TAATCGAGGGCGTGAAAACTGGGGTCATTGAGGCGATCGCCATTGACCACCAACCCTATCTCTACGAAGAAAAAACCGTC
AGCTTTGCCGAAGCCCCTTCCGGCGTGATTGGTTTAGAAATTGCCCTGCCAATCCTCTGGCAAAATTTTGTTGTTTCCCA
AGAATGGCAACCCCTCCAACTTTGGCAAGCCCTCAGTACCAATCCCCAGAAATGCTTAGGTCAGGCAATAAAGTCGATTG
CCCCCGAAAATTGCCAACCCCTAATCCTTTTTGACCCCAGCAAAACCTGGCAGGTTAACCACGAAAATCTCCACTGTCCC
CAGACCAATACCCCTTGGTGGCAAAAAACGCTCACGGGCAAAGTGATCAATACATTTTTAGGTTAA

Upstream 100 bases:

>100_bases
GTTGTTGAATTTCACAAAGTCCAGGGGGATTTGGGGCAGAAACAGTAGAATGGGGGACGGATTTTCATGGAAGGGGAATA
TTTCGGTGGTAAGCGCGGCA

Downstream 100 bases:

>100_bases
AACCCGCCATCAAAAAAGGGTTGACCCAGATCAACCCCTGTCATGTTTATTCAAGTTAAAAAGAAATCAAGCTTTAGTAC
TTGTAGCTTTCCGTTTTGAA

Product: dihydroorotase

Products: N-carbamoyl-L-aspartate

Alternate protein names: Aspartate carbamoyltransferase 42 kDa non-catalytic chain [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MDNVVLRQVRVLDPVANLDHRQDVWFKDGQLQAITPQLSDLPTAVESIEAADLILAPGLVDLYSHSSEPGYESRETLKQL
AQGALAGGFTQVGILPNTQPPLDNLGQLQSFQQLIQQIPGPKPNFLPWAALTKKCQGESLTELGELAAANIAGFSDSQAL
NNWLLLRRTLEYLCPHHRPIALYPQNLALHNGGTARYGKASLAYGLVEELVSVETTAIASICELVAELKTPVHLMRISTA
RGVELIAEAKQRGLPITASVSWMHLLWNTKALSTYDPNLRLDPPLGNPEDQQALIEGVKTGVIEAIAIDHQPYLYEEKTV
SFAEAPSGVIGLEIALPILWQNFVVSQEWQPLQLWQALSTNPQKCLGQAIKSIAPENCQPLILFDPSKTWQVNHENLHCP
QTNTPWWQKTLTGKVINTFLG

Sequences:

>Translated_421_residues
MDNVVLRQVRVLDPVANLDHRQDVWFKDGQLQAITPQLSDLPTAVESIEAADLILAPGLVDLYSHSSEPGYESRETLKQL
AQGALAGGFTQVGILPNTQPPLDNLGQLQSFQQLIQQIPGPKPNFLPWAALTKKCQGESLTELGELAAANIAGFSDSQAL
NNWLLLRRTLEYLCPHHRPIALYPQNLALHNGGTARYGKASLAYGLVEELVSVETTAIASICELVAELKTPVHLMRISTA
RGVELIAEAKQRGLPITASVSWMHLLWNTKALSTYDPNLRLDPPLGNPEDQQALIEGVKTGVIEAIAIDHQPYLYEEKTV
SFAEAPSGVIGLEIALPILWQNFVVSQEWQPLQLWQALSTNPQKCLGQAIKSIAPENCQPLILFDPSKTWQVNHENLHCP
QTNTPWWQKTLTGKVINTFLG
>Mature_421_residues
MDNVVLRQVRVLDPVANLDHRQDVWFKDGQLQAITPQLSDLPTAVESIEAADLILAPGLVDLYSHSSEPGYESRETLKQL
AQGALAGGFTQVGILPNTQPPLDNLGQLQSFQQLIQQIPGPKPNFLPWAALTKKCQGESLTELGELAAANIAGFSDSQAL
NNWLLLRRTLEYLCPHHRPIALYPQNLALHNGGTARYGKASLAYGLVEELVSVETTAIASICELVAELKTPVHLMRISTA
RGVELIAEAKQRGLPITASVSWMHLLWNTKALSTYDPNLRLDPPLGNPEDQQALIEGVKTGVIEAIAIDHQPYLYEEKTV
SFAEAPSGVIGLEIALPILWQNFVVSQEWQPLQLWQALSTNPQKCLGQAIKSIAPENCQPLILFDPSKTWQVNHENLHCP
QTNTPWWQKTLTGKVINTFLG

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=333, Percent_Identity=27.6276276276276, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786722, Length=415, Percent_Identity=21.9277108433735, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87082175, Length=424, Percent_Identity=22.1698113207547, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193204318, Length=386, Percent_Identity=25.3886010362694, Blast_Score=98, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6322218, Length=390, Percent_Identity=22.8205128205128, Blast_Score=83, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004722 [H]

Pfam domain/function: NA

EC number: 3.5.2.3

Molecular weight: Translated: 46373; Mature: 46373

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNVVLRQVRVLDPVANLDHRQDVWFKDGQLQAITPQLSDLPTAVESIEAADLILAPGLV
CCCHHHHHHHHHHHHHCCCCCCCCEEECCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHH
DLYSHSSEPGYESRETLKQLAQGALAGGFTQVGILPNTQPPLDNLGQLQSFQQLIQQIPG
HHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCC
PKPNFLPWAALTKKCQGESLTELGELAAANIAGFSDSQALNNWLLLRRTLEYLCPHHRPI
CCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCE
ALYPQNLALHNGGTARYGKASLAYGLVEELVSVETTAIASICELVAELKTPVHLMRISTA
EECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCH
RGVELIAEAKQRGLPITASVSWMHLLWNTKALSTYDPNLRLDPPLGNPEDQQALIEGVKT
HHHHHHHHHHHCCCCEEECHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHH
GVIEAIAIDHQPYLYEEKTVSFAEAPSGVIGLEIALPILWQNFVVSQEWQPLQLWQALST
HHEEEEEECCCCCEECCCCCHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
NPQKCLGQAIKSIAPENCQPLILFDPSKTWQVNHENLHCPQTNTPWWQKTLTGKVINTFL
CHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCEECCCCCCCHHHHHHHHHHHHHHC
G
C
>Mature Secondary Structure
MDNVVLRQVRVLDPVANLDHRQDVWFKDGQLQAITPQLSDLPTAVESIEAADLILAPGLV
CCCHHHHHHHHHHHHHCCCCCCCCEEECCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHH
DLYSHSSEPGYESRETLKQLAQGALAGGFTQVGILPNTQPPLDNLGQLQSFQQLIQQIPG
HHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCC
PKPNFLPWAALTKKCQGESLTELGELAAANIAGFSDSQALNNWLLLRRTLEYLCPHHRPI
CCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCE
ALYPQNLALHNGGTARYGKASLAYGLVEELVSVETTAIASICELVAELKTPVHLMRISTA
EECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCH
RGVELIAEAKQRGLPITASVSWMHLLWNTKALSTYDPNLRLDPPLGNPEDQQALIEGVKT
HHHHHHHHHHHCCCCEEECHHHHHHHHCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHH
GVIEAIAIDHQPYLYEEKTVSFAEAPSGVIGLEIALPILWQNFVVSQEWQPLQLWQALST
HHEEEEEECCCCCEECCCCCHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
NPQKCLGQAIKSIAPENCQPLILFDPSKTWQVNHENLHCPQTNTPWWQKTLTGKVINTFL
CHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCEECCCCCCCHHHHHHHHHHHHHHC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-dihydroorotate; H2O

Specific reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]