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The map label for this gene is hisB [H]

Identifier: 170078589

GI number: 170078589

Start: 2068680

End: 2069291

Strand: Reverse

Name: hisB [H]

Synonym: SYNPCC7002_A1985

Alternate gene names: 170078589

Gene position: 2069291-2068680 (Counterclockwise)

Preceding gene: 170078593

Following gene: 170078588

Centisome position: 68.79

GC content: 53.92

Gene sequence:

>612_bases
ATGATGCCTGCTTCTTCTGAGTCCCCCCGGATTGCGACCGTTGCCCGGGTGACGGGTGAAACGAATGTGAAAGTAACGGT
CAATCTGGATGGAACTGGCAAGTGTGAGGTGAATACTGGGGTGCCATTCCTCGATCACATGCTGCATCAGCTTTGTTCCC
ATGGTCTATTGGATCTGCACATCCAGGCCCAAGGGGACTATGAGATTGACGACCACCACACCAACGAGGATGTGGGCATT
ACCCTGGGGATGGCGATCGCCAAAGCCATTGGTGAGCGCAAAGGGATTCAGCGGTTTGGTCATTTTGTCGCGCCCCTCGA
CGAGGCCTTAGTACAGGTCGCCTTAGATTTTTCTGGTCGGCCCCACCTCAGCTATGGTTTAGAAATCCCCACGGAACGGG
TCGGCACCTACGATACCCAACTGGTGCGGGAATTTTTTGTGGCGATCGTCAACCATGTCCAAATGACGATCCACGTGCGC
CAATTAGACGGTATTAATTCCCACCACATCATTGAAGCGACCTTTAAAGCCTTTGCCCGGGCGATGCGCATGGCCCTAGA
AATTGACCCCCGTCGGGCGGCAACGATCCCTAGTTCTAAAGGGGTTCTTTAG

Upstream 100 bases:

>100_bases
GTCCATGGTGTAGTCTGTCTCGTCTTCAGTATGGGTTTCCCTAAATGGTTTCAACCTTAAGCTAGAATAGCTTAGCGAAT
TTGAACCTAGCTATATTCTA

Downstream 100 bases:

>100_bases
GCTCTTTCTAAAATTTTTATTCCCAACATTTGCAAGCAGATTTTCACAGCTAAAGTGTATTGGGGCATTGCTTCGCTCCT
CCCCCCTTGCGGAAAGGTTA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MMPASSESPRIATVARVTGETNVKVTVNLDGTGKCEVNTGVPFLDHMLHQLCSHGLLDLHIQAQGDYEIDDHHTNEDVGI
TLGMAIAKAIGERKGIQRFGHFVAPLDEALVQVALDFSGRPHLSYGLEIPTERVGTYDTQLVREFFVAIVNHVQMTIHVR
QLDGINSHHIIEATFKAFARAMRMALEIDPRRAATIPSSKGVL

Sequences:

>Translated_203_residues
MMPASSESPRIATVARVTGETNVKVTVNLDGTGKCEVNTGVPFLDHMLHQLCSHGLLDLHIQAQGDYEIDDHHTNEDVGI
TLGMAIAKAIGERKGIQRFGHFVAPLDEALVQVALDFSGRPHLSYGLEIPTERVGTYDTQLVREFFVAIVNHVQMTIHVR
QLDGINSHHIIEATFKAFARAMRMALEIDPRRAATIPSSKGVL
>Mature_203_residues
MMPASSESPRIATVARVTGETNVKVTVNLDGTGKCEVNTGVPFLDHMLHQLCSHGLLDLHIQAQGDYEIDDHHTNEDVGI
TLGMAIAKAIGERKGIQRFGHFVAPLDEALVQVALDFSGRPHLSYGLEIPTERVGTYDTQLVREFFVAIVNHVQMTIHVR
QLDGINSHHIIEATFKAFARAMRMALEIDPRRAATIPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=46.9072164948454, Blast_Score=177, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6324776, Length=216, Percent_Identity=37.037037037037, Blast_Score=142, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 22313; Mature: 22313

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPASSESPRIATVARVTGETNVKVTVNLDGTGKCEVNTGVPFLDHMLHQLCSHGLLDLH
CCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHCCEEEEE
IQAQGDYEIDDHHTNEDVGITLGMAIAKAIGERKGIQRFGHFVAPLDEALVQVALDFSGR
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
PHLSYGLEIPTERVGTYDTQLVREFFVAIVNHVQMTIHVRQLDGINSHHIIEATFKAFAR
CCEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHH
AMRMALEIDPRRAATIPSSKGVL
HHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMPASSESPRIATVARVTGETNVKVTVNLDGTGKCEVNTGVPFLDHMLHQLCSHGLLDLH
CCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEECCCCCHHHHHHHHHHHCCEEEEE
IQAQGDYEIDDHHTNEDVGITLGMAIAKAIGERKGIQRFGHFVAPLDEALVQVALDFSGR
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
PHLSYGLEIPTERVGTYDTQLVREFFVAIVNHVQMTIHVRQLDGINSHHIIEATFKAFAR
CCEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHH
AMRMALEIDPRRAATIPSSKGVL
HHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8391534; 11759840 [H]