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The map label for this gene is cofH [H]

Identifier: 170078525

GI number: 170078525

Start: 2003029

End: 2004186

Strand: Direct

Name: cofH [H]

Synonym: SYNPCC7002_A1920

Alternate gene names: 170078525

Gene position: 2003029-2004186 (Clockwise)

Preceding gene: 170078524

Following gene: 170078526

Centisome position: 66.59

GC content: 53.97

Gene sequence:

>1158_bases
ATGAAGTTACTGCAGGTACTAGATGCGGCGATCGCCGGTGTTGATCTCACGGTTGAGGCCGGAGTATTCCTCCTTTCCCA
AACGGAGCCGGAGGCCATCGAAAGTATCCGCATGGCGGCTGATACCCTCAGACAATCGCTTTGTGGGGAAACCGTTACCT
ATGTGGTGAACCGCAATCTAAACTTCACCAATATTTGTGAGCAGCACTGTCACTTTTGTGCCTTTCGACGGGATGCGGGA
GACCCAGATTCCTTTTGGCTCGATCAAGCACAACTCCAGGAAAAAGCGGCGGCGGCCTGGGCGGAGGGGGCAACGGAACT
GTGCATCCAGGGGGGGTTAAATCCCCAGGCAAAACGTAATGGACGATCGCTCGACTACTACCTCGATCTGGTTGCTGCTT
TGAAGGATGCTTTTCCCGGTTTGCATCTCCACGCCTTTTCTCCCCAGGAAATTGAATTTATTGCCCGCGAGGATCAGCTG
TCCTTCCGAGATGTAATCATTGCCCTCAAGGACGCTGGTGTTGGTTCCCTACCGGGTACGGCGGCAGAAGTCCTCGACGA
TCAGATTCGTCGTCAAATTTGCCCCGAAAAGTTAAAGGCGGCAACGTGGCTAGAAATTGTCAGCACAGCCCATCACCTGG
GACTACCGACCACCAGCACAATGCTCTGTGGCCACATCGAAACACCATTGCATCAGGTACAGCATTTAGACCAGATCCGG
CAACTGCAACAACAGGCGATCGCCGAGGGGAAACCCGCTAAAATCACTGAATTTATTCTCTTACCCTTTGTCGGCCAACT
AGCCCCCCAGGTACTCCGCAAAAAAGTGGGCCGGGATCAACCGGATCTACGAAAAACCCTGTTATTAACGGCAGTGGCGC
GTCTCTTTCTTGGAAAATGGATCATCAATCACCAGCCGAGCTGGGTCAAACTGGGCTTAGGGGGGGCCACCACTGCCCTC
CGTTGGGGTTGCAATGATTTGGGCGGCACCCTCATGGAAGAGCACATTACAACCATGGCTGGGGCCCAAGGGGGAACCTG
TTTAACGGTCTCTCAATTACGAATGGCGATCGCCTCAGTGGATCGCCTTCCCGCAGAACGTACCACCCTCTATCAGGATC
GACATAGCCGTCGGGGGAGCTCAGCCGATATGATCTAA

Upstream 100 bases:

>100_bases
CCATTGCTGGTGTTGCGGCCCTTGAAGCCCATGGGTTTCGCTCAGGGGTCATTGCTGCTGTTACCGCGGCGAAGGCCCGT
TCTGTCGAGTTGGGCCAAGG

Downstream 100 bases:

>100_bases
TGGGAAAATAAGTAACGATAAAAATTTTTTAATTACAGTCCGCTAAAAGTCCAAGCTTTTTTGATCGATATTTTTTTAGG
AGAATCGCACAATGGATTTG

Product: FO synthase subunit 2

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2 [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKLLQVLDAAIAGVDLTVEAGVFLLSQTEPEAIESIRMAADTLRQSLCGETVTYVVNRNLNFTNICEQHCHFCAFRRDAG
DPDSFWLDQAQLQEKAAAAWAEGATELCIQGGLNPQAKRNGRSLDYYLDLVAALKDAFPGLHLHAFSPQEIEFIAREDQL
SFRDVIIALKDAGVGSLPGTAAEVLDDQIRRQICPEKLKAATWLEIVSTAHHLGLPTTSTMLCGHIETPLHQVQHLDQIR
QLQQQAIAEGKPAKITEFILLPFVGQLAPQVLRKKVGRDQPDLRKTLLLTAVARLFLGKWIINHQPSWVKLGLGGATTAL
RWGCNDLGGTLMEEHITTMAGAQGGTCLTVSQLRMAIASVDRLPAERTTLYQDRHSRRGSSADMI

Sequences:

>Translated_385_residues
MKLLQVLDAAIAGVDLTVEAGVFLLSQTEPEAIESIRMAADTLRQSLCGETVTYVVNRNLNFTNICEQHCHFCAFRRDAG
DPDSFWLDQAQLQEKAAAAWAEGATELCIQGGLNPQAKRNGRSLDYYLDLVAALKDAFPGLHLHAFSPQEIEFIAREDQL
SFRDVIIALKDAGVGSLPGTAAEVLDDQIRRQICPEKLKAATWLEIVSTAHHLGLPTTSTMLCGHIETPLHQVQHLDQIR
QLQQQAIAEGKPAKITEFILLPFVGQLAPQVLRKKVGRDQPDLRKTLLLTAVARLFLGKWIINHQPSWVKLGLGGATTAL
RWGCNDLGGTLMEEHITTMAGAQGGTCLTVSQLRMAIASVDRLPAERTTLYQDRHSRRGSSADMI
>Mature_385_residues
MKLLQVLDAAIAGVDLTVEAGVFLLSQTEPEAIESIRMAADTLRQSLCGETVTYVVNRNLNFTNICEQHCHFCAFRRDAG
DPDSFWLDQAQLQEKAAAAWAEGATELCIQGGLNPQAKRNGRSLDYYLDLVAALKDAFPGLHLHAFSPQEIEFIAREDQL
SFRDVIIALKDAGVGSLPGTAAEVLDDQIRRQICPEKLKAATWLEIVSTAHHLGLPTTSTMLCGHIETPLHQVQHLDQIR
QLQQQAIAEGKPAKITEFILLPFVGQLAPQVLRKKVGRDQPDLRKTLLLTAVARLFLGKWIINHQPSWVKLGLGGATTAL
RWGCNDLGGTLMEEHITTMAGAQGGTCLTVSQLRMAIASVDRLPAERTTLYQDRHSRRGSSADMI

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. CofH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR020050
- InterPro:   IPR005244
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 42312; Mature: 42312

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLQVLDAAIAGVDLTVEAGVFLLSQTEPEAIESIRMAADTLRQSLCGETVTYVVNRNL
CHHHHHHHHHHHCCCEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCC
NFTNICEQHCHFCAFRRDAGDPDSFWLDQAQLQEKAAAAWAEGATELCIQGGLNPQAKRN
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHCC
GRSLDYYLDLVAALKDAFPGLHLHAFSPQEIEFIAREDQLSFRDVIIALKDAGVGSLPGT
CCCHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCH
AAEVLDDQIRRQICPEKLKAATWLEIVSTAHHLGLPTTSTMLCGHIETPLHQVQHLDQIR
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHH
QLQQQAIAEGKPAKITEFILLPFVGQLAPQVLRKKVGRDQPDLRKTLLLTAVARLFLGKW
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IINHQPSWVKLGLGGATTALRWGCNDLGGTLMEEHITTMAGAQGGTCLTVSQLRMAIASV
HHCCCCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHH
DRLPAERTTLYQDRHSRRGSSADMI
HHCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKLLQVLDAAIAGVDLTVEAGVFLLSQTEPEAIESIRMAADTLRQSLCGETVTYVVNRNL
CHHHHHHHHHHHCCCEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCC
NFTNICEQHCHFCAFRRDAGDPDSFWLDQAQLQEKAAAAWAEGATELCIQGGLNPQAKRN
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHCC
GRSLDYYLDLVAALKDAFPGLHLHAFSPQEIEFIAREDQLSFRDVIIALKDAGVGSLPGT
CCCHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCH
AAEVLDDQIRRQICPEKLKAATWLEIVSTAHHLGLPTTSTMLCGHIETPLHQVQHLDQIR
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHH
QLQQQAIAEGKPAKITEFILLPFVGQLAPQVLRKKVGRDQPDLRKTLLLTAVARLFLGKW
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IINHQPSWVKLGLGGATTALRWGCNDLGGTLMEEHITTMAGAQGGTCLTVSQLRMAIASV
HHCCCCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHH
DRLPAERTTLYQDRHSRRGSSADMI
HHCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA