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The map label for this gene is proC [H]

Identifier: 170078524

GI number: 170078524

Start: 2002223

End: 2003032

Strand: Direct

Name: proC [H]

Synonym: SYNPCC7002_A1919

Alternate gene names: 170078524

Gene position: 2002223-2003032 (Clockwise)

Preceding gene: 170078523

Following gene: 170078525

Centisome position: 66.56

GC content: 56.67

Gene sequence:

>810_bases
ATGGCGGCAAAATTCGGCATGATTGGCGGCGGTGTCATGGGAGAGGCCCTCCTCGCACGGCTCCTCAAGGAACAAATTTA
CTTGCCAGCAGATGTGATTGTGAGTGAACCTGTGGCGGAACGGCGGGCTTATTTACAACAGGAATATCAAGTGGGTGTCA
CGGCCAGTAACCAGGAAGCGGCGATCGCCTCTGAAGTTTTAATGTTGGCAATCAAGCCACAAATTTTTAATCAAGTCAGC
ACCGAACTCCAAGGTCAACAGCTAGAAACGCCTCCCCTGGTGTTGTCAATCCTCGCTGGGGTTACCCTGGCTCAGTTACA
AGGCGGTTTTAGGGACTATCCAGTGGTGCGGGCAATGCCAAATACACCGGCGATTATTGGCCAAGGGATGACGGCGATCA
CCCCTGGGGATCGCGTTTCAGAAGCCCAGGTCGCCCTCGCAAAACGAATTTTTGGGGCTGTGGGTGAAGTGGTGGCAGTA
CCAGAGTCTCTGATGGATGCGGTGACTGGACTTTCTGGCTCTGGCCCGGCTTTTGTGGCCTTGATGGTAGAAGCCCTGGC
CGATGGCGGCGTTGCGGCAGGTTTGCCCCGGGCCACGGCCCAACAACTCGCCCTCCAAACGGTCAAGGGAACGGCGGAAT
TACTCCAAACCTCCGGCTTACATCCCGCTCAACTCAAAGACCGGGTGACCAGTCCAGGGGGCACTACCATTGCTGGTGTT
GCGGCCCTTGAAGCCCATGGGTTTCGCTCAGGGGTCATTGCTGCTGTTACCGCGGCGAAGGCCCGTTCTGTCGAGTTGGG
CCAAGGATGA

Upstream 100 bases:

>100_bases
ATAGATTTTCTGTCCCCTTTTTAGTGCGCTGCATTTGCCTTCTGGGAAAAAATCAGTCAAGATGAATGCGTCATTTCAGG
GATGAATGTGAAGAATTAAG

Downstream 100 bases:

>100_bases
AGTTACTGCAGGTACTAGATGCGGCGATCGCCGGTGTTGATCTCACGGTTGAGGCCGGAGTATTCCTCCTTTCCCAAACG
GAGCCGGAGGCCATCGAAAG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MAAKFGMIGGGVMGEALLARLLKEQIYLPADVIVSEPVAERRAYLQQEYQVGVTASNQEAAIASEVLMLAIKPQIFNQVS
TELQGQQLETPPLVLSILAGVTLAQLQGGFRDYPVVRAMPNTPAIIGQGMTAITPGDRVSEAQVALAKRIFGAVGEVVAV
PESLMDAVTGLSGSGPAFVALMVEALADGGVAAGLPRATAQQLALQTVKGTAELLQTSGLHPAQLKDRVTSPGGTTIAGV
AALEAHGFRSGVIAAVTAAKARSVELGQG

Sequences:

>Translated_269_residues
MAAKFGMIGGGVMGEALLARLLKEQIYLPADVIVSEPVAERRAYLQQEYQVGVTASNQEAAIASEVLMLAIKPQIFNQVS
TELQGQQLETPPLVLSILAGVTLAQLQGGFRDYPVVRAMPNTPAIIGQGMTAITPGDRVSEAQVALAKRIFGAVGEVVAV
PESLMDAVTGLSGSGPAFVALMVEALADGGVAAGLPRATAQQLALQTVKGTAELLQTSGLHPAQLKDRVTSPGGTTIAGV
AALEAHGFRSGVIAAVTAAKARSVELGQG
>Mature_268_residues
AAKFGMIGGGVMGEALLARLLKEQIYLPADVIVSEPVAERRAYLQQEYQVGVTASNQEAAIASEVLMLAIKPQIFNQVST
ELQGQQLETPPLVLSILAGVTLAQLQGGFRDYPVVRAMPNTPAIIGQGMTAITPGDRVSEAQVALAKRIFGAVGEVVAVP
ESLMDAVTGLSGSGPAFVALMVEALADGGVAAGLPRATAQQLALQTVKGTAELLQTSGLHPAQLKDRVTSPGGTTIAGVA
ALEAHGFRSGVIAAVTAAKARSVELGQG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=220, Percent_Identity=43.1818181818182, Blast_Score=157, Evalue=7e-39,
Organism=Homo sapiens, GI24797097, Length=220, Percent_Identity=43.1818181818182, Blast_Score=157, Evalue=8e-39,
Organism=Homo sapiens, GI21361454, Length=220, Percent_Identity=43.1818181818182, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=34.9624060150376, Blast_Score=148, Evalue=5e-36,
Organism=Escherichia coli, GI1786585, Length=269, Percent_Identity=40.5204460966543, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17569021, Length=268, Percent_Identity=38.0597014925373, Blast_Score=160, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17540664, Length=284, Percent_Identity=32.7464788732394, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320861, Length=291, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=38.4057971014493, Blast_Score=174, Evalue=5e-44,
Organism=Drosophila melanogaster, GI21358587, Length=266, Percent_Identity=38.3458646616541, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=42.8571428571429, Blast_Score=136, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27560; Mature: 27429

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKFGMIGGGVMGEALLARLLKEQIYLPADVIVSEPVAERRAYLQQEYQVGVTASNQEA
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHH
AIASEVLMLAIKPQIFNQVSTELQGQQLETPPLVLSILAGVTLAQLQGGFRDYPVVRAMP
HHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECC
NTPAIIGQGMTAITPGDRVSEAQVALAKRIFGAVGEVVAVPESLMDAVTGLSGSGPAFVA
CCCHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHH
LMVEALADGGVAAGLPRATAQQLALQTVKGTAELLQTSGLHPAQLKDRVTSPGGTTIAGV
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHH
AALEAHGFRSGVIAAVTAAKARSVELGQG
HHHHHCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AAKFGMIGGGVMGEALLARLLKEQIYLPADVIVSEPVAERRAYLQQEYQVGVTASNQEA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHH
AIASEVLMLAIKPQIFNQVSTELQGQQLETPPLVLSILAGVTLAQLQGGFRDYPVVRAMP
HHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECC
NTPAIIGQGMTAITPGDRVSEAQVALAKRIFGAVGEVVAVPESLMDAVTGLSGSGPAFVA
CCCHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHH
LMVEALADGGVAAGLPRATAQQLALQTVKGTAELLQTSGLHPAQLKDRVTSPGGTTIAGV
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHH
AALEAHGFRSGVIAAVTAAKARSVELGQG
HHHHHCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]