Click here to switch to the map view.

The map label for this gene is panB

Identifier: 170078435

GI number: 170078435

Start: 1916949

End: 1917737

Strand: Direct

Name: panB

Synonym: SYNPCC7002_A1829

Alternate gene names: 170078435

Gene position: 1916949-1917737 (Clockwise)

Preceding gene: 170078434

Following gene: 170078436

Centisome position: 63.73

GC content: 55.39

Gene sequence:

>789_bases
ATGCGGGTTACACCGAGAACACTACAAAACTATAAAAAAACGGCACGACCCATCGTGACCCTGACGGCCTGGGACTATGC
GATCGCCCGCTTAGTTGATCAAGCCGGGGTCGATGTCATCCTGGTGGGGGACTCCCTCGCGATGGTGGCCCTCGGCTATG
AAAATACGCTGCCTGTGACCCTAGAGGCGATGATTCACCATACCCAGGCCGTTTGTCGGGGGGTTAAAAATGCCCTCGTG
GTCAGTGATCTTCCTTTTTTAACCTACCAAGAAAGCCTCTCCCAGGCGATCCATACGGCGGGTCGAATTCTCAAGGAAAC
CACCGCCCAGGCGATCAAACTGGAAGGGGGACACCCAGCGATGGCCGAAACGGTGGAACGTCTCACTCGCTTAGGGGTAC
CGGTGATGGGTCATGTGGGTCTCACTCCCCAATCGGTGCATACCCTGGGTTATCGGCAACAGGGCAATACGGAACTAGAA
GCGACACGGGTGATCCAAGAGGCGATCGCCCTCGAACAGGCCGGGGCCTTTGCGGTGGTCTTAGAACATATTCCAGCGAC
CCTGGCACAGACGATTACCGAAAAACTGACAATTCCGACCATTGGCATCGGCGCGGGACGCCATTGTGATGGGCAAGTGC
TGGTAACGGCGGATCTTTTGGGCCTCAGTGAAAAAGCGCCCCCCTTTGCCAAACAATATTTAGACTTAGACAATCTGATT
ACCAACGCAGTCCAACGCTATAGCGATGATGTTCGTACGCAGCAGTTTCCGCCCCATCTGGGCTCCTAG

Upstream 100 bases:

>100_bases
ATTACCGGAAAAGTCCAACACCAGCGGTGGCAATTCAAGCCGCTTTGGGGTGTTGCTCACCACTGCCCGGTCAGCTTTAT
TGTGCCCTAGAGAACGATTG

Downstream 100 bases:

>100_bases
ATTTCTCGTATTAGGGGCAGGGGTACTGATGGGCATGGCCTCGGCCCCCGTCGAAGCTTGGTATCTCGCTTGGATCGCCT
TGATCCCCCTCTGGATCTAT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MRVTPRTLQNYKKTARPIVTLTAWDYAIARLVDQAGVDVILVGDSLAMVALGYENTLPVTLEAMIHHTQAVCRGVKNALV
VSDLPFLTYQESLSQAIHTAGRILKETTAQAIKLEGGHPAMAETVERLTRLGVPVMGHVGLTPQSVHTLGYRQQGNTELE
ATRVIQEAIALEQAGAFAVVLEHIPATLAQTITEKLTIPTIGIGAGRHCDGQVLVTADLLGLSEKAPPFAKQYLDLDNLI
TNAVQRYSDDVRTQQFPPHLGS

Sequences:

>Translated_262_residues
MRVTPRTLQNYKKTARPIVTLTAWDYAIARLVDQAGVDVILVGDSLAMVALGYENTLPVTLEAMIHHTQAVCRGVKNALV
VSDLPFLTYQESLSQAIHTAGRILKETTAQAIKLEGGHPAMAETVERLTRLGVPVMGHVGLTPQSVHTLGYRQQGNTELE
ATRVIQEAIALEQAGAFAVVLEHIPATLAQTITEKLTIPTIGIGAGRHCDGQVLVTADLLGLSEKAPPFAKQYLDLDNLI
TNAVQRYSDDVRTQQFPPHLGS
>Mature_262_residues
MRVTPRTLQNYKKTARPIVTLTAWDYAIARLVDQAGVDVILVGDSLAMVALGYENTLPVTLEAMIHHTQAVCRGVKNALV
VSDLPFLTYQESLSQAIHTAGRILKETTAQAIKLEGGHPAMAETVERLTRLGVPVMGHVGLTPQSVHTLGYRQQGNTELE
ATRVIQEAIALEQAGAFAVVLEHIPATLAQTITEKLTIPTIGIGAGRHCDGQVLVTADLLGLSEKAPPFAKQYLDLDNLI
TNAVQRYSDDVRTQQFPPHLGS

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family

Homologues:

Organism=Escherichia coli, GI1786326, Length=252, Percent_Identity=44.047619047619, Blast_Score=198, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6319653, Length=262, Percent_Identity=37.4045801526718, Blast_Score=192, Evalue=3e-50,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PANB_SYNP2 (B1XQ35)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001735073.1
- ProteinModelPortal:   B1XQ35
- SMR:   B1XQ35
- GeneID:   6057291
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A1829
- HOGENOM:   HBG299908
- OMA:   DMMIAHG
- GO:   GO:0005737
- HAMAP:   MF_00156
- InterPro:   IPR003700
- InterPro:   IPR015813
- Gene3D:   G3DSA:3.20.20.60
- PANTHER:   PTHR20881
- PIRSF:   PIRSF000388
- TIGRFAMs:   TIGR00222

Pfam domain/function: PF02548 Pantoate_transf; SSF51621 Pyrv/PenolPyrv_Kinase_cat

EC number: =2.1.2.11

Molecular weight: Translated: 28342; Mature: 28342

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: ACT_SITE 182-182 BINDING 83-83 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVTPRTLQNYKKTARPIVTLTAWDYAIARLVDQAGVDVILVGDSLAMVALGYENTLPVT
CCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCCCHH
LEAMIHHTQAVCRGVKNALVVSDLPFLTYQESLSQAIHTAGRILKETTAQAIKLEGGHPA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCH
MAETVERLTRLGVPVMGHVGLTPQSVHTLGYRQQGNTELEATRVIQEAIALEQAGAFAVV
HHHHHHHHHHCCCCCEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
LEHIPATLAQTITEKLTIPTIGIGAGRHCDGQVLVTADLLGLSEKAPPFAKQYLDLDNLI
HHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEEHHCCCCCCCHHHHHHHHHHHHH
TNAVQRYSDDVRTQQFPPHLGS
HHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRVTPRTLQNYKKTARPIVTLTAWDYAIARLVDQAGVDVILVGDSLAMVALGYENTLPVT
CCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCCCHH
LEAMIHHTQAVCRGVKNALVVSDLPFLTYQESLSQAIHTAGRILKETTAQAIKLEGGHPA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCH
MAETVERLTRLGVPVMGHVGLTPQSVHTLGYRQQGNTELEATRVIQEAIALEQAGAFAVV
HHHHHHHHHHCCCCCEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
LEHIPATLAQTITEKLTIPTIGIGAGRHCDGQVLVTADLLGLSEKAPPFAKQYLDLDNLI
HHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEEHHCCCCCCCHHHHHHHHHHHHH
TNAVQRYSDDVRTQQFPPHLGS
HHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA