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The map label for this gene is hemF [H]

Identifier: 170078434

GI number: 170078434

Start: 1915691

End: 1916725

Strand: Direct

Name: hemF [H]

Synonym: SYNPCC7002_A1828

Alternate gene names: 170078434

Gene position: 1915691-1916725 (Clockwise)

Preceding gene: 170078433

Following gene: 170078435

Centisome position: 63.69

GC content: 52.75

Gene sequence:

>1035_bases
ATGACAGCTTTGCAAACAGAATCCACCAATGCCAGTTCCGCTAAGCCTGTGCCCCCCAGTGATTCCAAAGAACGGGTGAG
CCAGTTTATGCAGCAAATCCAGGACAAAATTTGTCAGGGATTAGAGGTGGCCGACGGAAAAGGAAAATTTCAGGAAGATT
CTTGGCAGCGACAGGAGGGCGGCGGCGGTCGTTCTCGGGTAATGCGTGAGGGGAATGTCCTAGAACAGGGGGGCGTCAAT
TTCTCTGAGGTATGGGGTGATCAACTGCCGCCTTCGATTTTGAAACAGCGCCCTGAAGCCGCAGGCCACGGGTTCTATGC
CACGGGCACATCAATGGTGTTACATCCCCGCAATCCTTATATCCCAACGGTTCACCTCAACTATCGTTATTTTGAAGCTG
GCCCCGTCTGGTGGTTTGGCGGTGGTGCAGATTTGACGCCCTACTACCCTTTTGCTGAGGATGCGGCCCATTTCCACAAA
ACCTACCAAGCCGCCTGCGATCGCCACCACAAAGAGTATTACAACGTCTTTAAGCGCTGGTGTGATGAATATTTCTACCT
GAAGCACCGGGACGAAACCCGTGGGGTCGGTGGATTGTTCTTCGACTATCAAGATGGCACCGGGGAACTGTATAAAGGCC
CCCACCCCGATAAAGCTGCTGCTGCCTACAGTAAGGATTTAGGGGAACAGCCCCAGCGCAGTTGGGAAGATATTTTTGCG
TTTGTGCAAGACTGTGGTGGTTCCTTCCTTGATTCCTATGTGCCGATCATTGAACGGCGACGCAACACAGAATATGGCGA
TCGCGAACGGCAATTCCAACTTTACCGCCGGGGCCGCTACGTCGAATTTAACCTCGTCTATGACCGGGGAACTATTTTCG
GCTTGCAGACCAATGGCCGTACCGAATCGATTTTGATGTCTTTACCGCCCCTGGTGCGTTGGGAATATAGCTACAGTCCT
GAGCCTGGTACCCCAGAGGCAGAACTCTATGAACGGTTCCTCAAGCCCCAGGATTGGGCCAACTGGCAAGGTTAA

Upstream 100 bases:

>100_bases
AGTTTGACCTGTGTCGACCTAAAGAAGCCTTGCAACATCAGCCTTTGGGCCATCAGGTAAACCCTTTTAATAAATAGATA
AAACTTCTTCCCACGCAACC

Downstream 100 bases:

>100_bases
GAATCGGCCTCTTTTAAAGAGTCAAAACCGAAAGCGAAAATTGTAGTGATCACTGGGGCAAATCTGGGGGCGCGAACGCC
GAGATTTCCCCAGAATTTTG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MTALQTESTNASSAKPVPPSDSKERVSQFMQQIQDKICQGLEVADGKGKFQEDSWQRQEGGGGRSRVMREGNVLEQGGVN
FSEVWGDQLPPSILKQRPEAAGHGFYATGTSMVLHPRNPYIPTVHLNYRYFEAGPVWWFGGGADLTPYYPFAEDAAHFHK
TYQAACDRHHKEYYNVFKRWCDEYFYLKHRDETRGVGGLFFDYQDGTGELYKGPHPDKAAAAYSKDLGEQPQRSWEDIFA
FVQDCGGSFLDSYVPIIERRRNTEYGDRERQFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLVRWEYSYSP
EPGTPEAELYERFLKPQDWANWQG

Sequences:

>Translated_344_residues
MTALQTESTNASSAKPVPPSDSKERVSQFMQQIQDKICQGLEVADGKGKFQEDSWQRQEGGGGRSRVMREGNVLEQGGVN
FSEVWGDQLPPSILKQRPEAAGHGFYATGTSMVLHPRNPYIPTVHLNYRYFEAGPVWWFGGGADLTPYYPFAEDAAHFHK
TYQAACDRHHKEYYNVFKRWCDEYFYLKHRDETRGVGGLFFDYQDGTGELYKGPHPDKAAAAYSKDLGEQPQRSWEDIFA
FVQDCGGSFLDSYVPIIERRRNTEYGDRERQFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLVRWEYSYSP
EPGTPEAELYERFLKPQDWANWQG
>Mature_343_residues
TALQTESTNASSAKPVPPSDSKERVSQFMQQIQDKICQGLEVADGKGKFQEDSWQRQEGGGGRSRVMREGNVLEQGGVNF
SEVWGDQLPPSILKQRPEAAGHGFYATGTSMVLHPRNPYIPTVHLNYRYFEAGPVWWFGGGADLTPYYPFAEDAAHFHKT
YQAACDRHHKEYYNVFKRWCDEYFYLKHRDETRGVGGLFFDYQDGTGELYKGPHPDKAAAAYSKDLGEQPQRSWEDIFAF
VQDCGGSFLDSYVPIIERRRNTEYGDRERQFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLVRWEYSYSPE
PGTPEAELYERFLKPQDWANWQG

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=335, Percent_Identity=42.6865671641791, Blast_Score=277, Evalue=9e-75,
Organism=Escherichia coli, GI1788777, Length=321, Percent_Identity=55.1401869158878, Blast_Score=349, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6320249, Length=343, Percent_Identity=43.1486880466472, Blast_Score=275, Evalue=8e-75,
Organism=Drosophila melanogaster, GI17864388, Length=334, Percent_Identity=46.1077844311377, Blast_Score=303, Evalue=1e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 39650; Mature: 39519

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALQTESTNASSAKPVPPSDSKERVSQFMQQIQDKICQGLEVADGKGKFQEDSWQRQEG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHCC
GGGRSRVMREGNVLEQGGVNFSEVWGDQLPPSILKQRPEAAGHGFYATGTSMVLHPRNPY
CCHHHHHHHCCCCHHHCCCCHHHHHCCCCCHHHHHCCCCCCCCCEEECCCEEEEECCCCC
IPTVHLNYRYFEAGPVWWFGGGADLTPYYPFAEDAAHFHKTYQAACDRHHKEYYNVFKRW
CCEEEEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CDEYFYLKHRDETRGVGGLFFDYQDGTGELYKGPHPDKAAAAYSKDLGEQPQRSWEDIFA
HHHHHEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
FVQDCGGSFLDSYVPIIERRRNTEYGDRERQFQLYRRGRYVEFNLVYDRGTIFGLQTNGR
HHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEEEEECCEEEEEECCCC
TESILMSLPPLVRWEYSYSPEPGTPEAELYERFLKPQDWANWQG
CHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TALQTESTNASSAKPVPPSDSKERVSQFMQQIQDKICQGLEVADGKGKFQEDSWQRQEG
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHCC
GGGRSRVMREGNVLEQGGVNFSEVWGDQLPPSILKQRPEAAGHGFYATGTSMVLHPRNPY
CCHHHHHHHCCCCHHHCCCCHHHHHCCCCCHHHHHCCCCCCCCCEEECCCEEEEECCCCC
IPTVHLNYRYFEAGPVWWFGGGADLTPYYPFAEDAAHFHKTYQAACDRHHKEYYNVFKRW
CCEEEEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CDEYFYLKHRDETRGVGGLFFDYQDGTGELYKGPHPDKAAAAYSKDLGEQPQRSWEDIFA
HHHHHEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
FVQDCGGSFLDSYVPIIERRRNTEYGDRERQFQLYRRGRYVEFNLVYDRGTIFGLQTNGR
HHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEEEEECCEEEEEECCCC
TESILMSLPPLVRWEYSYSPEPGTPEAELYERFLKPQDWANWQG
CHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]