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The map label for this gene is prfC [H]

Identifier: 170078308

GI number: 170078308

Start: 1784463

End: 1786079

Strand: Direct

Name: prfC [H]

Synonym: SYNPCC7002_A1701

Alternate gene names: 170078308

Gene position: 1784463-1786079 (Clockwise)

Preceding gene: 170078307

Following gene: 170078309

Centisome position: 59.32

GC content: 49.41

Gene sequence:

>1617_bases
ATGGCGACAGAATTGCACACAGAGCTAGAAGAAGCCGTCCGATTGCGACGGAATTTTGCGATCATCTCCCACCCCGACGC
GGGTAAAACCACCCTCACCGAAAAACTCTTGTTATACGGAGGTGCCATTCACGAAGCCGGAGCCGTCAAAGCCCGTCGCG
AACAGCGCAAAGTTACCTCTGACTGGATGGAGATGGAGCAACAACGGGGGATTTCCATTACCTCGACGGTGCTGCAATTT
TTGTATAACGGTTACCAAATTAATCTGCTCGATACCCCTGGTCACCAAGACTTTAGTGAAGATACTTACCGTACCCTCGC
AGCGGCGGATAATGCGGTAATGCTGGTGGATGCGGCCAAGGGTCTGGAGACCCAAACTCGGAAATTATTTGAAGTCTGCA
AACTGCGATCGCTGCCCATTTTTACCTTTATCAACAAATTAGACCGTCCGGGGCGGGAACCCCTCGAACTCCTCGATGAA
ATTGAACAGGAATTGGGTCTGCAAACCTATGCGGTAAATTGGCCGATTGGCATGGGAGACAGATTCCAGGGAGTTTATGA
CCGTCGCCTCAAGAAAGTGCATTTATTTGAACGGACAGCCCACGGCACCAAGGCCGCCACGGAAACCGTTTATAAAATTG
ACGATCCGGCCCTCGAAGGTATTTTAGATGCAGATCTTTACGAACAACTCCAGGAAGAATTAGAAATTCTCGAAGAAATT
GGTGCCGACTTTGACCTAGAAGCGATCCATGCGGGCAAGCAAACTCCCATTTTCTTTGGCAGTGCAATGACCAATTTTGG
GGTGCAACTCTTCCTCAGTGCGTTCCTGGAATATGCCCTGAAGCCGGAGCCACGGGCCTCTAGCCTTGGTGATTTAGAAC
CCACCTATCCCGAATTTACTGGGTTTGTCTTTAAACTCCAGGCGAATATGGACCCCAAACACCGCGATCGCGTTGCCTTT
GTGCGGGTCTGTACCGGGAAATTTGAAAAGGATATGACCGTCAGCCATGCCCGCACCGGAAAAACAGTGCGTCTATCCCG
TCCCCAAAAGCTCTTTGCCCAGGGCCGTGAATCCCTCGAAGAAGCCTATGCGGGCGATGTAATCGGTTTAAATAATCCGG
GGGTGTTTGCCATTGGCGATACGATCTACTGCGGCAAAAAATTGGAATATGAAGGTATTCCCTGCTTTTCACCGGAACTA
TTTGCCTATCTAAAAAATCCCAACCCCTCGAAGTTTAAACAATTCCAAAAAGGAGTCAAAGAACTCCAGGAGGAAGGGGC
CGTACAAATTATGTATTCCGCCGATGAATTTAAACGGGAACCCATTTTAGCTGCCGTTGGACAACTGCAATTTGAGGTGG
TGCAACATCGTCTCAAAAGCGAATATGGCGTGGATAGTAGACTTGAACCGATCCCCTACAGTGTGGCGCGCTGGGTGACG
AACGGTTGGGAAGCCCTGGAAAAGGCGGGCAAAATTTTTAACACGATGATCGTTAAAGACCTTTGGGAACGGCCCGTGAT
TCTCTTTAAAAATGAGTGGAATCTCCACCAAATCCAAGGGGATCATCCCCATCTCAAACTGTCGGCGATCGCCCCCATTG
GTTCTTCTGTTAAATGA

Upstream 100 bases:

>100_bases
TTCTCGCCGGGAAAAGCCTAGAGGACTTTCTGGGGGAGATTGAAGCAGTACAATTGTAGACGCACCATTCATCCAGAAGC
ACAAACCCCAGACCAGATTT

Downstream 100 bases:

>100_bases
TGTTTCGCTTGGTAAAAGCCCATGGCAATTCAACTGAAAAAAGGCAACCGCATTTCCCTCAAAAAAGAAGCCCCTGGCCT
CAAGAAAGTGATGCTTGGCC

Product: peptide chain release factor 3

Products: NA

Alternate protein names: RF-3 [H]

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MATELHTELEEAVRLRRNFAIISHPDAGKTTLTEKLLLYGGAIHEAGAVKARREQRKVTSDWMEMEQQRGISITSTVLQF
LYNGYQINLLDTPGHQDFSEDTYRTLAAADNAVMLVDAAKGLETQTRKLFEVCKLRSLPIFTFINKLDRPGREPLELLDE
IEQELGLQTYAVNWPIGMGDRFQGVYDRRLKKVHLFERTAHGTKAATETVYKIDDPALEGILDADLYEQLQEELEILEEI
GADFDLEAIHAGKQTPIFFGSAMTNFGVQLFLSAFLEYALKPEPRASSLGDLEPTYPEFTGFVFKLQANMDPKHRDRVAF
VRVCTGKFEKDMTVSHARTGKTVRLSRPQKLFAQGRESLEEAYAGDVIGLNNPGVFAIGDTIYCGKKLEYEGIPCFSPEL
FAYLKNPNPSKFKQFQKGVKELQEEGAVQIMYSADEFKREPILAAVGQLQFEVVQHRLKSEYGVDSRLEPIPYSVARWVT
NGWEALEKAGKIFNTMIVKDLWERPVILFKNEWNLHQIQGDHPHLKLSAIAPIGSSVK

Sequences:

>Translated_538_residues
MATELHTELEEAVRLRRNFAIISHPDAGKTTLTEKLLLYGGAIHEAGAVKARREQRKVTSDWMEMEQQRGISITSTVLQF
LYNGYQINLLDTPGHQDFSEDTYRTLAAADNAVMLVDAAKGLETQTRKLFEVCKLRSLPIFTFINKLDRPGREPLELLDE
IEQELGLQTYAVNWPIGMGDRFQGVYDRRLKKVHLFERTAHGTKAATETVYKIDDPALEGILDADLYEQLQEELEILEEI
GADFDLEAIHAGKQTPIFFGSAMTNFGVQLFLSAFLEYALKPEPRASSLGDLEPTYPEFTGFVFKLQANMDPKHRDRVAF
VRVCTGKFEKDMTVSHARTGKTVRLSRPQKLFAQGRESLEEAYAGDVIGLNNPGVFAIGDTIYCGKKLEYEGIPCFSPEL
FAYLKNPNPSKFKQFQKGVKELQEEGAVQIMYSADEFKREPILAAVGQLQFEVVQHRLKSEYGVDSRLEPIPYSVARWVT
NGWEALEKAGKIFNTMIVKDLWERPVILFKNEWNLHQIQGDHPHLKLSAIAPIGSSVK
>Mature_537_residues
ATELHTELEEAVRLRRNFAIISHPDAGKTTLTEKLLLYGGAIHEAGAVKARREQRKVTSDWMEMEQQRGISITSTVLQFL
YNGYQINLLDTPGHQDFSEDTYRTLAAADNAVMLVDAAKGLETQTRKLFEVCKLRSLPIFTFINKLDRPGREPLELLDEI
EQELGLQTYAVNWPIGMGDRFQGVYDRRLKKVHLFERTAHGTKAATETVYKIDDPALEGILDADLYEQLQEELEILEEIG
ADFDLEAIHAGKQTPIFFGSAMTNFGVQLFLSAFLEYALKPEPRASSLGDLEPTYPEFTGFVFKLQANMDPKHRDRVAFV
RVCTGKFEKDMTVSHARTGKTVRLSRPQKLFAQGRESLEEAYAGDVIGLNNPGVFAIGDTIYCGKKLEYEGIPCFSPELF
AYLKNPNPSKFKQFQKGVKELQEEGAVQIMYSADEFKREPILAAVGQLQFEVVQHRLKSEYGVDSRLEPIPYSVARWVTN
GWEALEKAGKIFNTMIVKDLWERPVILFKNEWNLHQIQGDHPHLKLSAIAPIGSSVK

Specific function: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-

COG id: COG4108

COG function: function code J; Peptide chain release factor RF-3

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. PrfC subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=482, Percent_Identity=31.7427385892116, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI19923640, Length=555, Percent_Identity=26.4864864864865, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI25306287, Length=527, Percent_Identity=26.7552182163188, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI25306283, Length=403, Percent_Identity=29.2803970223325, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI157426893, Length=151, Percent_Identity=33.7748344370861, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI4503483, Length=149, Percent_Identity=32.2147651006711, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI94966754, Length=137, Percent_Identity=35.036496350365, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI310132016, Length=116, Percent_Identity=37.0689655172414, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI310110807, Length=116, Percent_Identity=37.0689655172414, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI310123363, Length=116, Percent_Identity=37.0689655172414, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI217272892, Length=147, Percent_Identity=29.2517006802721, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI217272894, Length=147, Percent_Identity=29.2517006802721, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1790835, Length=469, Percent_Identity=50.319829424307, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1789738, Length=498, Percent_Identity=27.9116465863454, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788922, Length=183, Percent_Identity=33.879781420765, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI48994988, Length=145, Percent_Identity=37.2413793103448, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17533571, Length=478, Percent_Identity=28.4518828451883, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17556745, Length=160, Percent_Identity=36.25, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17557151, Length=135, Percent_Identity=37.037037037037, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17506493, Length=161, Percent_Identity=30.4347826086957, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71988819, Length=133, Percent_Identity=33.8345864661654, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71988811, Length=150, Percent_Identity=32.6666666666667, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323098, Length=477, Percent_Identity=27.8825995807128, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322359, Length=510, Percent_Identity=27.0588235294118, Blast_Score=130, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6323320, Length=138, Percent_Identity=35.5072463768116, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324707, Length=180, Percent_Identity=33.8888888888889, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320593, Length=180, Percent_Identity=33.8888888888889, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24582462, Length=477, Percent_Identity=30.398322851153, Blast_Score=188, Evalue=7e-48,
Organism=Drosophila melanogaster, GI221458488, Length=505, Percent_Identity=25.5445544554455, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI78706572, Length=155, Percent_Identity=38.0645161290323, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585711, Length=153, Percent_Identity=31.3725490196078, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24585713, Length=153, Percent_Identity=31.3725490196078, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24585709, Length=153, Percent_Identity=31.3725490196078, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21357743, Length=151, Percent_Identity=32.4503311258278, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574573, Length=142, Percent_Identity=35.2112676056338, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR004548
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 60898; Mature: 60767

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATELHTELEEAVRLRRNFAIISHPDAGKTTLTEKLLLYGGAIHEAGAVKARREQRKVTS
CCCHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
DWMEMEQQRGISITSTVLQFLYNGYQINLLDTPGHQDFSEDTYRTLAAADNAVMLVDAAK
HHHHHHHHCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCC
GLETQTRKLFEVCKLRSLPIFTFINKLDRPGREPLELLDEIEQELGLQTYAVNWPIGMGD
CCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCC
RFQGVYDRRLKKVHLFERTAHGTKAATETVYKIDDPALEGILDADLYEQLQEELEILEEI
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
GADFDLEAIHAGKQTPIFFGSAMTNFGVQLFLSAFLEYALKPEPRASSLGDLEPTYPEFT
CCCCCCHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GFVFKLQANMDPKHRDRVAFVRVCTGKFEKDMTVSHARTGKTVRLSRPQKLFAQGRESLE
CEEEEEECCCCCCHHHHEEEEEECCCCCCCCCCHHHHCCCCEEEECCCHHHHHHHHHHHH
EAYAGDVIGLNNPGVFAIGDTIYCGKKLEYEGIPCFSPELFAYLKNPNPSKFKQFQKGVK
HHHCCCEEECCCCCEEEECCEEEECCEECCCCCCCCCHHHHHEECCCCHHHHHHHHHHHH
ELQEEGAVQIMYSADEFKREPILAAVGQLQFEVVQHRLKSEYGVDSRLEPIPYSVARWVT
HHHHCCCEEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
NGWEALEKAGKIFNTMIVKDLWERPVILFKNEWNLHQIQGDHPHLKLSAIAPIGSSVK
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
ATELHTELEEAVRLRRNFAIISHPDAGKTTLTEKLLLYGGAIHEAGAVKARREQRKVTS
CCHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
DWMEMEQQRGISITSTVLQFLYNGYQINLLDTPGHQDFSEDTYRTLAAADNAVMLVDAAK
HHHHHHHHCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCC
GLETQTRKLFEVCKLRSLPIFTFINKLDRPGREPLELLDEIEQELGLQTYAVNWPIGMGD
CCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCC
RFQGVYDRRLKKVHLFERTAHGTKAATETVYKIDDPALEGILDADLYEQLQEELEILEEI
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
GADFDLEAIHAGKQTPIFFGSAMTNFGVQLFLSAFLEYALKPEPRASSLGDLEPTYPEFT
CCCCCCHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GFVFKLQANMDPKHRDRVAFVRVCTGKFEKDMTVSHARTGKTVRLSRPQKLFAQGRESLE
CEEEEEECCCCCCHHHHEEEEEECCCCCCCCCCHHHHCCCCEEEECCCHHHHHHHHHHHH
EAYAGDVIGLNNPGVFAIGDTIYCGKKLEYEGIPCFSPELFAYLKNPNPSKFKQFQKGVK
HHHCCCEEECCCCCEEEECCEEEECCEECCCCCCCCCHHHHHEECCCCHHHHHHHHHHHH
ELQEEGAVQIMYSADEFKREPILAAVGQLQFEVVQHRLKSEYGVDSRLEPIPYSVARWVT
HHHHCCCEEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
NGWEALEKAGKIFNTMIVKDLWERPVILFKNEWNLHQIQGDHPHLKLSAIAPIGSSVK
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA