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The map label for this gene is macA [H]

Identifier: 170078092

GI number: 170078092

Start: 1561728

End: 1563110

Strand: Reverse

Name: macA [H]

Synonym: SYNPCC7002_A1483

Alternate gene names: 170078092

Gene position: 1563110-1561728 (Counterclockwise)

Preceding gene: 170078094

Following gene: 170078091

Centisome position: 51.96

GC content: 52.49

Gene sequence:

>1383_bases
GTGGCCACAAACGCCGTCGTATCCTCAAAAGTTTTAGACCTTCAGCTCAAACCATGGCTGTATGGTTTGGGGATCATCGC
CGTTGCTGGAATTTGTGTTGTCCTCTTCCGCCCAAAACCGATTCCGGTAGAAGTCGTGACCATTAAACCGGGGCCTTTGC
AAGTGATGGTCATTGAGGAAGGACAGACCTACCTTGAGGATCGCTACCTGGTGTCTACCTCCGTTGCAGGTTATGTGCCC
CGACTGGATCTTGAAGTCGGTGATCCGGTGAGTCAGGATCAAGTAATCGCCCAGATTGATCCCCTCGAATTTGATAATGA
TGTGTCGGCAATCTTGGCCCAAATCAACGCCCTCCAAGCCGAAAAAACAGGCGTTGCCACCCTCCGACCAAAGACAGAGA
GTTTGACCCAAGCAGAAGCCAAGATCAAGGCGGTTGAAGCGGAAATTGCAGGGGATCAGGCGATCGCCACGGAATTGAGA
ATTCGTTTCATCCAAGCGCAACAGGAACAACAACGGGGAGAATTTCTCTACCGCAATGGGGCCATCTCGAAACAAGCGCT
GGAAACATTGGCACTGAATACGAAGGCGATCGCCCAAAATTTAGAAGTGGCGCAACAAAGACTGAACCAAGCCCAGGCGA
ATCTGCAAGAGGCGATCGCCGCACGGGATGAACTGCGGGCCACCCAACAGGATCCTGATTATTTGCTCGAAGTTTATGAT
GCCCAAATTCGCAGTTTAGAGGCAGAGCTTGCCAACCGCACCGACCAAGTCCAACGCACCGCGATCAAAGCGCCCATCAG
TGGCCAAGTGCTGCGTCTCTATCAAAAAAATTACCAATATCTGGAAGCGGGACAGCCCCTGCTAGAGCTTGGAGATCTAC
AAAATTTAGCAGTGATGGTGGATGTGCTCTCCAGTGAAGCGACTCAGATTCAACCCGGAAATCCCGTCATCATCAACCAA
TGGGGTGGCGATCGCCCTTTGACGGGCCAAGTGAAACGCCTTGAACCAGCGGCTTTTACAAAAGTGTCGGCCCTCGGCGT
CGAAGAACAACGGGTGAATGTGGTGGTTAGCCTCGATGACATTCCCGCCAACCTGGGCGATCAATATCGGGTCGAAACCC
AGATCGTGGTTTGGCAAGCCGAAGATGTATTGCAGGTGCCCCTTAGCGCCCTATTTCGCTGCGATGAGCAATGGTGTGTG
TTTCTCATGGAAGCGGGACAGGCCCAAGCGGTGGCGGTGGAGATTGGCCACAAAACGGAACAAAATGCCCAAGTCAAAAG
CGGTTTAGCTGCCAATGATCAAGTGATCCTTTATCCCTCTGGAGATATTCAAACTGGGCGTCGAGTACAGCCCCAAGCAG
ACCGTGCAGCGCCGACAAACTAG

Upstream 100 bases:

>100_bases
TTAGCGAAACATTACCATACCAGGCTGAGGTAAGTGGCAATGGCTACCATGGAAGTAGGCTCCCAGACTTATAACCTGAC
TCCATCGGTTTCATTGCGTC

Downstream 100 bases:

>100_bases
GGGGGCAATAATTATGACCGACTCACCCATTGTTCTTTTTTGGATCCAACACCTTTCCAAGACCTATTACATCGGCGATG
TGGCCGTACAAGCCCTAAAA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MATNAVVSSKVLDLQLKPWLYGLGIIAVAGICVVLFRPKPIPVEVVTIKPGPLQVMVIEEGQTYLEDRYLVSTSVAGYVP
RLDLEVGDPVSQDQVIAQIDPLEFDNDVSAILAQINALQAEKTGVATLRPKTESLTQAEAKIKAVEAEIAGDQAIATELR
IRFIQAQQEQQRGEFLYRNGAISKQALETLALNTKAIAQNLEVAQQRLNQAQANLQEAIAARDELRATQQDPDYLLEVYD
AQIRSLEAELANRTDQVQRTAIKAPISGQVLRLYQKNYQYLEAGQPLLELGDLQNLAVMVDVLSSEATQIQPGNPVIINQ
WGGDRPLTGQVKRLEPAAFTKVSALGVEEQRVNVVVSLDDIPANLGDQYRVETQIVVWQAEDVLQVPLSALFRCDEQWCV
FLMEAGQAQAVAVEIGHKTEQNAQVKSGLAANDQVILYPSGDIQTGRRVQPQADRAAPTN

Sequences:

>Translated_460_residues
MATNAVVSSKVLDLQLKPWLYGLGIIAVAGICVVLFRPKPIPVEVVTIKPGPLQVMVIEEGQTYLEDRYLVSTSVAGYVP
RLDLEVGDPVSQDQVIAQIDPLEFDNDVSAILAQINALQAEKTGVATLRPKTESLTQAEAKIKAVEAEIAGDQAIATELR
IRFIQAQQEQQRGEFLYRNGAISKQALETLALNTKAIAQNLEVAQQRLNQAQANLQEAIAARDELRATQQDPDYLLEVYD
AQIRSLEAELANRTDQVQRTAIKAPISGQVLRLYQKNYQYLEAGQPLLELGDLQNLAVMVDVLSSEATQIQPGNPVIINQ
WGGDRPLTGQVKRLEPAAFTKVSALGVEEQRVNVVVSLDDIPANLGDQYRVETQIVVWQAEDVLQVPLSALFRCDEQWCV
FLMEAGQAQAVAVEIGHKTEQNAQVKSGLAANDQVILYPSGDIQTGRRVQPQADRAAPTN
>Mature_459_residues
ATNAVVSSKVLDLQLKPWLYGLGIIAVAGICVVLFRPKPIPVEVVTIKPGPLQVMVIEEGQTYLEDRYLVSTSVAGYVPR
LDLEVGDPVSQDQVIAQIDPLEFDNDVSAILAQINALQAEKTGVATLRPKTESLTQAEAKIKAVEAEIAGDQAIATELRI
RFIQAQQEQQRGEFLYRNGAISKQALETLALNTKAIAQNLEVAQQRLNQAQANLQEAIAARDELRATQQDPDYLLEVYDA
QIRSLEAELANRTDQVQRTAIKAPISGQVLRLYQKNYQYLEAGQPLLELGDLQNLAVMVDVLSSEATQIQPGNPVIINQW
GGDRPLTGQVKRLEPAAFTKVSALGVEEQRVNVVVSLDDIPANLGDQYRVETQIVVWQAEDVLQVPLSALFRCDEQWCVF
LMEAGQAQAVAVEIGHKTEQNAQVKSGLAANDQVILYPSGDIQTGRRVQPQADRAAPTN

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=428, Percent_Identity=24.0654205607477, Blast_Score=75, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 50427; Mature: 50296

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATNAVVSSKVLDLQLKPWLYGLGIIAVAGICVVLFRPKPIPVEVVTIKPGPLQVMVIEE
CCCCCEECCEEEEEEECCHHHHHHHHHHHHHHEEEECCCCCCEEEEEECCCCEEEEEECC
GQTYLEDRYLVSTSVAGYVPRLDLEVGDPVSQDQVIAQIDPLEFDNDVSAILAQINALQA
CCHHHHCCEEEEECCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
EKTGVATLRPKTESLTQAEAKIKAVEAEIAGDQAIATELRIRFIQAQQEQQRGEFLYRNG
HCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEECC
AISKQALETLALNTKAIAQNLEVAQQRLNQAQANLQEAIAARDELRATQQDPDYLLEVYD
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AQIRSLEAELANRTDQVQRTAIKAPISGQVLRLYQKNYQYLEAGQPLLELGDLQNLAVMV
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCCCCHHHHCCCCHHHHHH
DVLSSEATQIQPGNPVIINQWGGDRPLTGQVKRLEPAAFTKVSALGVEEQRVNVVVSLDD
HHHCCCCCEECCCCCEEEECCCCCCCCCCCHHHCCCHHHHHHHHCCCCCCEEEEEEEECC
IPANLGDQYRVETQIVVWQAEDVLQVPLSALFRCDEQWCVFLMEAGQAQAVAVEIGHKTE
CCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCHHHEEEEEECCCCEEEEEEECCCCC
QNAQVKSGLAANDQVILYPSGDIQTGRRVQPQADRAAPTN
CCCHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATNAVVSSKVLDLQLKPWLYGLGIIAVAGICVVLFRPKPIPVEVVTIKPGPLQVMVIEE
CCCCEECCEEEEEEECCHHHHHHHHHHHHHHEEEECCCCCCEEEEEECCCCEEEEEECC
GQTYLEDRYLVSTSVAGYVPRLDLEVGDPVSQDQVIAQIDPLEFDNDVSAILAQINALQA
CCHHHHCCEEEEECCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
EKTGVATLRPKTESLTQAEAKIKAVEAEIAGDQAIATELRIRFIQAQQEQQRGEFLYRNG
HCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEECC
AISKQALETLALNTKAIAQNLEVAQQRLNQAQANLQEAIAARDELRATQQDPDYLLEVYD
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AQIRSLEAELANRTDQVQRTAIKAPISGQVLRLYQKNYQYLEAGQPLLELGDLQNLAVMV
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCCCCHHHHCCCCHHHHHH
DVLSSEATQIQPGNPVIINQWGGDRPLTGQVKRLEPAAFTKVSALGVEEQRVNVVVSLDD
HHHCCCCCEECCCCCEEEECCCCCCCCCCCHHHCCCHHHHHHHHCCCCCCEEEEEEEECC
IPANLGDQYRVETQIVVWQAEDVLQVPLSALFRCDEQWCVFLMEAGQAQAVAVEIGHKTE
CCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCHHHEEEEEECCCCEEEEEEECCCCC
QNAQVKSGLAANDQVILYPSGDIQTGRRVQPQADRAAPTN
CCCHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]