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The map label for this gene is gltX

Identifier: 170078008

GI number: 170078008

Start: 1459385

End: 1460830

Strand: Direct

Name: gltX

Synonym: SYNPCC7002_A1394

Alternate gene names: 170078008

Gene position: 1459385-1460830 (Clockwise)

Preceding gene: 170078007

Following gene: 170078010

Centisome position: 48.52

GC content: 50.41

Gene sequence:

>1446_bases
GTGACTGTTCGCGTTCGTATTGCCCCAAGTCCCACCGGAAATCTCCACATCGGGACAGCTAGAACTGCTGTCTTTAATTG
GCTTTTTGCCCATCACCATGGCGGTACCTTTGTCCTCCGGGTTGAAGATACCGATTTGGAACGGTCTAAGCCCGAATACA
CCGAAAACATTAAAACGGGTCTCCAATGGCTCGGTTTGCACTGGGATGAAGGCCCTTTTTTCCAAACCCAACGGCTGGAT
CAATACAAAGCAGCAATCCAAACCCTTTTAGATCAAGGTCTTGCCTATCGTTGTTACTGTACCCCCGCAGAACTTGAGGC
GATGCGGGAACAACAAAAAGCGAATAATCAAGCGCCCCGCTATGACAATCGTCACCGCAACTTAACGGAGGCGCAGCGAG
CTGAATTTGAAGCCCAAGGTCGTAAACCCGTGATTCGCTTCAAAATTGACGATGCCCAGCAAATCGTTTGGCAAGATCTG
ATCCGAGGCACCATGACTTGGAAAGGTAGTGATCTCGGTGGTGACATGGTGATTGCCCGCACCCCTGAAGGGGATGAGTC
TTTTGGTCAGCCTCTATATAATCTTGCGGTGGTGGTTGATGATATTGATATGCAAATCTCCCACGTGATTCGAGGGGAAG
ACCACATCGCTAATACCGCTAAACAAATTCTTTTATATGAAGCCCTCGGCGCGGCAGTACCTCAGTTTGCCCACACACCC
TTAATCCTCAATCAAGAGGGACGTAAATTGTCGAAACGGGATGGGGTGACATCTATTGATGATTTTCGCCAAATGGGATT
TCTCCCCCAGGCGATCGCCAACTATATGAGTCTTTTGGGCTGGACGCCGACCGACTCAACCCAAGAAATTTTTACCCTCG
AAGAAGCTGCGAAGGAATTTTCCCTAGAGCGGGTCAATAAAGCTGGCGCAAAATTTGACTGGGACAAGCTCGATTGGATT
AATGCCCAGTACCTCCACCAAATGCCGATCCCCGCCCTGACTGATCTGCTTATCCCTTATTTACAAGCAGCAGGTTACGG
AGATTATCTAGGCGATCGCCCCTGGCTAGAGTCCCTCGTCGCCCTCGTTGCGCCCAGCCTCACCCGCTTGGCCGATGTTA
CCCAAGAAACCCGACTTCTTTTTGGTGACAGCATCACCTTAGACGAAAAAGCCACGGCCCAACTCCAAACCGAAGGCGTT
AAAGTGATTCTCCAGGAAATCCTCCAAAACATCCAAGCCAGTACTAATTTCACCCCCGATGAGGCAAAAGCACTCATTAA
CCAAGCCACCAAAGCCCATGGCGTCAAAAAAGGTGTCGTCATGAAATCCATGCGTGCCGGGCTGATGGGCGAACTCCAAG
GCCCCGATCTCATGCAATCCTGGGTACTCCTCCACCAAAAAGGTTGGGATATCGAAAGACTCAATCAGGCGATCGCCTCG
ATCTAG

Upstream 100 bases:

>100_bases
GGGGCGGTGTTTTTATATGCCCCTTCAAATTCCTAAAGGACAATGGGAAAATAGCCACCACAAAGATTAAATTAAACCAC
TACAACAAAGGATTAACCCC

Downstream 100 bases:

>100_bases
CTCGCCATCGTAGGGATTTGGTTTTCAAATCCAAGAAGACCTCTGGTACTCATCAGTGAAATGAGGAAGGAGGTTTTTTT
TAAATCCTCACCTAATCGAG

Product: glutamyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamate--tRNA ligase; GluRS

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MTVRVRIAPSPTGNLHIGTARTAVFNWLFAHHHGGTFVLRVEDTDLERSKPEYTENIKTGLQWLGLHWDEGPFFQTQRLD
QYKAAIQTLLDQGLAYRCYCTPAELEAMREQQKANNQAPRYDNRHRNLTEAQRAEFEAQGRKPVIRFKIDDAQQIVWQDL
IRGTMTWKGSDLGGDMVIARTPEGDESFGQPLYNLAVVVDDIDMQISHVIRGEDHIANTAKQILLYEALGAAVPQFAHTP
LILNQEGRKLSKRDGVTSIDDFRQMGFLPQAIANYMSLLGWTPTDSTQEIFTLEEAAKEFSLERVNKAGAKFDWDKLDWI
NAQYLHQMPIPALTDLLIPYLQAAGYGDYLGDRPWLESLVALVAPSLTRLADVTQETRLLFGDSITLDEKATAQLQTEGV
KVILQEILQNIQASTNFTPDEAKALINQATKAHGVKKGVVMKSMRAGLMGELQGPDLMQSWVLLHQKGWDIERLNQAIAS
I

Sequences:

>Translated_481_residues
MTVRVRIAPSPTGNLHIGTARTAVFNWLFAHHHGGTFVLRVEDTDLERSKPEYTENIKTGLQWLGLHWDEGPFFQTQRLD
QYKAAIQTLLDQGLAYRCYCTPAELEAMREQQKANNQAPRYDNRHRNLTEAQRAEFEAQGRKPVIRFKIDDAQQIVWQDL
IRGTMTWKGSDLGGDMVIARTPEGDESFGQPLYNLAVVVDDIDMQISHVIRGEDHIANTAKQILLYEALGAAVPQFAHTP
LILNQEGRKLSKRDGVTSIDDFRQMGFLPQAIANYMSLLGWTPTDSTQEIFTLEEAAKEFSLERVNKAGAKFDWDKLDWI
NAQYLHQMPIPALTDLLIPYLQAAGYGDYLGDRPWLESLVALVAPSLTRLADVTQETRLLFGDSITLDEKATAQLQTEGV
KVILQEILQNIQASTNFTPDEAKALINQATKAHGVKKGVVMKSMRAGLMGELQGPDLMQSWVLLHQKGWDIERLNQAIAS
I
>Mature_480_residues
TVRVRIAPSPTGNLHIGTARTAVFNWLFAHHHGGTFVLRVEDTDLERSKPEYTENIKTGLQWLGLHWDEGPFFQTQRLDQ
YKAAIQTLLDQGLAYRCYCTPAELEAMREQQKANNQAPRYDNRHRNLTEAQRAEFEAQGRKPVIRFKIDDAQQIVWQDLI
RGTMTWKGSDLGGDMVIARTPEGDESFGQPLYNLAVVVDDIDMQISHVIRGEDHIANTAKQILLYEALGAAVPQFAHTPL
ILNQEGRKLSKRDGVTSIDDFRQMGFLPQAIANYMSLLGWTPTDSTQEIFTLEEAAKEFSLERVNKAGAKFDWDKLDWIN
AQYLHQMPIPALTDLLIPYLQAAGYGDYLGDRPWLESLVALVAPSLTRLADVTQETRLLFGDSITLDEKATAQLQTEGVK
VILQEILQNIQASTNFTPDEAKALINQATKAHGVKKGVVMKSMRAGLMGELQGPDLMQSWVLLHQKGWDIERLNQAIASI

Specific function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI134288884, Length=503, Percent_Identity=36.182902584493, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI4826960, Length=318, Percent_Identity=24.8427672955975, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1788743, Length=483, Percent_Identity=40.5797101449275, Blast_Score=353, Evalue=2e-98,
Organism=Escherichia coli, GI226510925, Length=255, Percent_Identity=34.9019607843137, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1786895, Length=343, Percent_Identity=26.530612244898, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71993394, Length=467, Percent_Identity=30.8351177730193, Blast_Score=214, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6324540, Length=468, Percent_Identity=31.8376068376068, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6324742, Length=127, Percent_Identity=34.6456692913386, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321192, Length=152, Percent_Identity=30.2631578947368, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24665321, Length=499, Percent_Identity=34.8697394789579, Blast_Score=258, Evalue=5e-69,

Paralogues:

None

Copy number: 1,800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYE_SYNP2 (P31970)

Other databases:

- EMBL:   CP000951
- EMBL:   M99379
- RefSeq:   YP_001734646.1
- ProteinModelPortal:   P31970
- SMR:   P31970
- GeneID:   6055293
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A1394
- HOGENOM:   HBG628189
- OMA:   NELIRES
- ProtClustDB:   PRK01406
- GO:   GO:0005737
- HAMAP:   MF_00022_B
- InterPro:   IPR008925
- InterPro:   IPR020751
- InterPro:   IPR001412
- InterPro:   IPR004527
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR014729
- Gene3D:   G3DSA:1.10.1160.10
- Gene3D:   G3DSA:3.40.50.620
- Gene3D:   G3DSA:1.10.10.350
- PRINTS:   PR00987
- TIGRFAMs:   TIGR00464

Pfam domain/function: PF00749 tRNA-synt_1c; SSF48163 tRNA-synt_bind

EC number: =6.1.1.17

Molecular weight: Translated: 54135; Mature: 54004

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 252-252

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRVRIAPSPTGNLHIGTARTAVFNWLFAHHHGGTFVLRVEDTDLERSKPEYTENIKTG
CEEEEEECCCCCCCEEECHHHHHHHHHHHHEECCCEEEEEEECCCCCCCCCHHHHHHHHH
LQWLGLHWDEGPFFQTQRLDQYKAAIQTLLDQGLAYRCYCTPAELEAMREQQKANNQAPR
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCCCC
YDNRHRNLTEAQRAEFEAQGRKPVIRFKIDDAQQIVWQDLIRGTMTWKGSDLGGDMVIAR
CCCCCCCHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHCCEECCCCCCCCEEEEE
TPEGDESFGQPLYNLAVVVDDIDMQISHVIRGEDHIANTAKQILLYEALGAAVPQFAHTP
CCCCCHHHCCHHHHHEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LILNQEGRKLSKRDGVTSIDDFRQMGFLPQAIANYMSLLGWTPTDSTQEIFTLEEAAKEF
EEECCCCCHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
SLERVNKAGAKFDWDKLDWINAQYLHQMPIPALTDLLIPYLQAAGYGDYLGDRPWLESLV
HHHHHHHCCCCCCCCHHCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
ALVAPSLTRLADVTQETRLLFGDSITLDEKATAQLQTEGVKVILQEILQNIQASTNFTPD
HHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
EAKALINQATKAHGVKKGVVMKSMRAGLMGELQGPDLMQSWVLLHQKGWDIERLNQAIAS
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHC
I
C
>Mature Secondary Structure 
TVRVRIAPSPTGNLHIGTARTAVFNWLFAHHHGGTFVLRVEDTDLERSKPEYTENIKTG
EEEEEECCCCCCCEEECHHHHHHHHHHHHEECCCEEEEEEECCCCCCCCCHHHHHHHHH
LQWLGLHWDEGPFFQTQRLDQYKAAIQTLLDQGLAYRCYCTPAELEAMREQQKANNQAPR
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCCCC
YDNRHRNLTEAQRAEFEAQGRKPVIRFKIDDAQQIVWQDLIRGTMTWKGSDLGGDMVIAR
CCCCCCCHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHCCEECCCCCCCCEEEEE
TPEGDESFGQPLYNLAVVVDDIDMQISHVIRGEDHIANTAKQILLYEALGAAVPQFAHTP
CCCCCHHHCCHHHHHEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LILNQEGRKLSKRDGVTSIDDFRQMGFLPQAIANYMSLLGWTPTDSTQEIFTLEEAAKEF
EEECCCCCHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
SLERVNKAGAKFDWDKLDWINAQYLHQMPIPALTDLLIPYLQAAGYGDYLGDRPWLESLV
HHHHHHHCCCCCCCCHHCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
ALVAPSLTRLADVTQETRLLFGDSITLDEKATAQLQTEGVKVILQEILQNIQASTNFTPD
HHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
EAKALINQATKAHGVKKGVVMKSMRAGLMGELQGPDLMQSWVLLHQKGWDIERLNQAIAS
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHC
I
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8412664