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The map label for this gene is pyrE [H]

Identifier: 170077823

GI number: 170077823

Start: 1250621

End: 1251217

Strand: Reverse

Name: pyrE [H]

Synonym: SYNPCC7002_A1206

Alternate gene names: 170077823

Gene position: 1251217-1250621 (Counterclockwise)

Preceding gene: 170077827

Following gene: 170077822

Centisome position: 41.6

GC content: 52.43

Gene sequence:

>597_bases
ATGCCTGCCCTTTCTGACCTCCTGACCGCTGATCAAGCCACCCTCAGACAAACACTCCTCAATCAAATCGCCACAGATGC
GTATAAAGAAGGCGACTTCACCCTCTCTTCCGGACAAAAAAGCACCTACTATATCAACGGTAAATTGGTCACCCTCACCC
CAATGGGAGCGCTCCTCATCGGTCGTCTGATCCTTGCTCAGCTCGATCAAGACGTTGCCGCCGTCGCTGGTTTAACCCTA
GGGGCTGACCCGATTGTTAGCGCCGTCAGTGTTGTGTCAGCCTACGAAAATTGTCCCATTCCGGCTCTGATTATTCGCAA
AAAAGCAAAGGGCCACGGCACCCAAGCCTATATCGAAGGGCCATCCCTTACCCCAGGCGCGAAAGTGGTTGTCCTTGAAG
ATGTTGTGACCACTGGACAGTCCGCCGCCCAAGCCGTTGAGCGTCTCCGGGATGCCGGTTACCAAGTAGAAGAAATTATT
GCCCTTGTTGACCGTCAGCAGGGAGGGGCCGAATTTTACGCTAGCCAAAATCTCAAATTTTCTAGCTTGTTTACGATCAC
CGAAGTACAAGCCGCCTACCGCGCTTTAAATGCTTAG

Upstream 100 bases:

>100_bases
TTTTCATGGCATTACATCCATAAGTCAAATCTTTACCAGCATCTTTGCTCACAAAACCCAATTGGTCAAGTTTTCTCTGT
ACTGAACTTCATATACAACC

Downstream 100 bases:

>100_bases
TCCCAGACATTGAATCTAATCAAAGTCCTCACTCAATCTGGTGGGGACTTTTGGAATTAGCCCCTGCGTAATGTTTGGTA
AATGCTCCCTTGGCTAGGTT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MPALSDLLTADQATLRQTLLNQIATDAYKEGDFTLSSGQKSTYYINGKLVTLTPMGALLIGRLILAQLDQDVAAVAGLTL
GADPIVSAVSVVSAYENCPIPALIIRKKAKGHGTQAYIEGPSLTPGAKVVVLEDVVTTGQSAAQAVERLRDAGYQVEEII
ALVDRQQGGAEFYASQNLKFSSLFTITEVQAAYRALNA

Sequences:

>Translated_198_residues
MPALSDLLTADQATLRQTLLNQIATDAYKEGDFTLSSGQKSTYYINGKLVTLTPMGALLIGRLILAQLDQDVAAVAGLTL
GADPIVSAVSVVSAYENCPIPALIIRKKAKGHGTQAYIEGPSLTPGAKVVVLEDVVTTGQSAAQAVERLRDAGYQVEEII
ALVDRQQGGAEFYASQNLKFSSLFTITEVQAAYRALNA
>Mature_197_residues
PALSDLLTADQATLRQTLLNQIATDAYKEGDFTLSSGQKSTYYINGKLVTLTPMGALLIGRLILAQLDQDVAAVAGLTLG
ADPIVSAVSVVSAYENCPIPALIIRKKAKGHGTQAYIEGPSLTPGAKVVVLEDVVTTGQSAAQAVERLRDAGYQVEEIIA
LVDRQQGGAEFYASQNLKFSSLFTITEVQAAYRALNA

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=169, Percent_Identity=32.5443786982249, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17508631, Length=174, Percent_Identity=32.7586206896552, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17554964, Length=192, Percent_Identity=31.7708333333333, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17933654, Length=176, Percent_Identity=30.6818181818182, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 20958; Mature: 20827

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALSDLLTADQATLRQTLLNQIATDAYKEGDFTLSSGQKSTYYINGKLVTLTPMGALLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEECCEEEEECCHHHHHH
GRLILAQLDQDVAAVAGLTLGADPIVSAVSVVSAYENCPIPALIIRKKAKGHGTQAYIEG
HHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCCEEEEEC
PSLTPGAKVVVLEDVVTTGQSAAQAVERLRDAGYQVEEIIALVDRQQGGAEFYASQNLKF
CCCCCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHCCCCCH
SSLFTITEVQAAYRALNA
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PALSDLLTADQATLRQTLLNQIATDAYKEGDFTLSSGQKSTYYINGKLVTLTPMGALLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEECCEEEEECCHHHHHH
GRLILAQLDQDVAAVAGLTLGADPIVSAVSVVSAYENCPIPALIIRKKAKGHGTQAYIEG
HHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCCEEEEEC
PSLTPGAKVVVLEDVVTTGQSAAQAVERLRDAGYQVEEIIALVDRQQGGAEFYASQNLKF
CCCCCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHCCCCCH
SSLFTITEVQAAYRALNA
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]