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The map label for this gene is cyoE

Identifier: 170077777

GI number: 170077777

Start: 1191298

End: 1192251

Strand: Reverse

Name: cyoE

Synonym: SYNPCC7002_A1160

Alternate gene names: 170077777

Gene position: 1192251-1191298 (Counterclockwise)

Preceding gene: 170077778

Following gene: 170077776

Centisome position: 39.64

GC content: 49.79

Gene sequence:

>954_bases
ATGCTCGGCACCAGCCTTTCTCCGCACCATGAAAACTTTTGGGCGGTTATCAAAAGCTATTACCAACTCACCAAACCCCG
CATTATTCCCCTACTGCTGATTACCACCGCTGCTTCGATGTGGATTGCCTCCCACGGTCACATTGACCCGGTAAAGTTAC
TGATTACGTTGCTGGGGGGAACCCTCGCCGCAGCCTCTGCCCAAACCCTCAACTGTATCTATGACCAGGACATCGATTTT
TCGATGCAGCGCACCCGTAAGCGGCCCATTCCTTCCGGTCGCGTTCAACCACGCCATGCTTTAATTTTTGCGCTGATTTT
GGGGAGTTTGTCTTTTTCCCTGTTAATGGTATTTGTGAACCTGCTTAGCGCCTGTTTAGCGTTATCGGGCATTGTGTTTT
ATATGCTGGTCTATACCCACTGGCTGAAACGGCACCACGTACAAAATATTGTGATCGGTGGGGCCGCAGGCTCGATTCCG
CCCCTGGTGGGTTGGGCGGCGGTTACGGGTCAGTTGGATTGGTCGGCCTGGATTTTGTTTGCACTGATTTTCCTCTGGAC
GCCGCCCCATTTCTGGGCCTTGGCCTTGATGATCAAAGAAGATTATGCAGAAGTTGAGGTGCCGATGCTGCCCGTGGTCA
AGGGAGAGAAAATAACCGTCGATCAAATTTGGATTTACACATTAATCGTTGTGCCCTTTAGTTTGTTGCTGGTGTTCCCA
TTCCAAGCGTCTGGGCTGTTTTATGCGATCGCCGCCTTAGTGCTGGGAGCCATTTTTATCCAAAAAGCCTGGGAATTGAA
GCAAAATCCCTTTGATCAGTCCCTAGCAAAGTCAATGTTTAAATATTCGATCCTTTACATGATGTTGCTTTGTACAGCGA
TGGTGGTGGATAGTTTACCTGCGGTGCATGATGTCACTGCCCTGGTGACCACAACCTTAGCCTCCCTGACTTAA

Upstream 100 bases:

>100_bases
GTTTTCTGTCTTTGCGTTCCGCGATCGCCAGCCCCACACCAGTTAAGTCAAACCCTATCTCTCCATTCCTCTGCGTCTTT
AATTAAATTCAGGTATTTTT

Downstream 100 bases:

>100_bases
ATTAATGACGCCCCTGTTTTCGCGCCTGCTCGCCCTCGCCCACGATAACCATGCAGCCTTCTATGCCCCCGGTCACAAAG
GTGGTCAGGGGATTTTTTCT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MLGTSLSPHHENFWAVIKSYYQLTKPRIIPLLLITTAASMWIASHGHIDPVKLLITLLGGTLAAASAQTLNCIYDQDIDF
SMQRTRKRPIPSGRVQPRHALIFALILGSLSFSLLMVFVNLLSACLALSGIVFYMLVYTHWLKRHHVQNIVIGGAAGSIP
PLVGWAAVTGQLDWSAWILFALIFLWTPPHFWALALMIKEDYAEVEVPMLPVVKGEKITVDQIWIYTLIVVPFSLLLVFP
FQASGLFYAIAALVLGAIFIQKAWELKQNPFDQSLAKSMFKYSILYMMLLCTAMVVDSLPAVHDVTALVTTTLASLT

Sequences:

>Translated_317_residues
MLGTSLSPHHENFWAVIKSYYQLTKPRIIPLLLITTAASMWIASHGHIDPVKLLITLLGGTLAAASAQTLNCIYDQDIDF
SMQRTRKRPIPSGRVQPRHALIFALILGSLSFSLLMVFVNLLSACLALSGIVFYMLVYTHWLKRHHVQNIVIGGAAGSIP
PLVGWAAVTGQLDWSAWILFALIFLWTPPHFWALALMIKEDYAEVEVPMLPVVKGEKITVDQIWIYTLIVVPFSLLLVFP
FQASGLFYAIAALVLGAIFIQKAWELKQNPFDQSLAKSMFKYSILYMMLLCTAMVVDSLPAVHDVTALVTTTLASLT
>Mature_317_residues
MLGTSLSPHHENFWAVIKSYYQLTKPRIIPLLLITTAASMWIASHGHIDPVKLLITLLGGTLAAASAQTLNCIYDQDIDF
SMQRTRKRPIPSGRVQPRHALIFALILGSLSFSLLMVFVNLLSACLALSGIVFYMLVYTHWLKRHHVQNIVIGGAAGSIP
PLVGWAAVTGQLDWSAWILFALIFLWTPPHFWALALMIKEDYAEVEVPMLPVVKGEKITVDQIWIYTLIVVPFSLLLVFP
FQASGLFYAIAALVLGAIFIQKAWELKQNPFDQSLAKSMFKYSILYMMLLCTAMVVDSLPAVHDVTALVTTTLASLT

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=192, Percent_Identity=34.8958333333333, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1786631, Length=293, Percent_Identity=35.1535836177474, Blast_Score=161, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71998235, Length=231, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6325085, Length=242, Percent_Identity=31.8181818181818, Blast_Score=112, Evalue=6e-26,
Organism=Drosophila melanogaster, GI19921064, Length=272, Percent_Identity=28.3088235294118, Blast_Score=121, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_SYNP2 (B1XKB3)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001734415.1
- GeneID:   6056303
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A1160
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- ProtClustDB:   PRK04375
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 35239; Mature: 35239

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x19a1bc30)-; HASH(0x1b7a9318)-; HASH(0x1be30ca4)-; HASH(0x1c254c50)-; HASH(0x1a58a8f8)-; HASH(0x1be73064)-; HASH(0x1bf16700)-; HASH(0x19e8a170)-; HASH(0x1bcc6404)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGTSLSPHHENFWAVIKSYYQLTKPRIIPLLLITTAASMWIASHGHIDPVKLLITLLGG
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
TLAAASAQTLNCIYDQDIDFSMQRTRKRPIPSGRVQPRHALIFALILGSLSFSLLMVFVN
HHHHCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLSACLALSGIVFYMLVYTHWLKRHHVQNIVIGGAAGSIPPLVGWAAVTGQLDWSAWILF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHCCCCHHHHHHH
ALIFLWTPPHFWALALMIKEDYAEVEVPMLPVVKGEKITVDQIWIYTLIVVPFSLLLVFP
HHHHHHCCHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEHHHHHHHHHHHHHHHHHHHHC
FQASGLFYAIAALVLGAIFIQKAWELKQNPFDQSLAKSMFKYSILYMMLLCTAMVVDSLP
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AVHDVTALVTTTLASLT
HHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MLGTSLSPHHENFWAVIKSYYQLTKPRIIPLLLITTAASMWIASHGHIDPVKLLITLLGG
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
TLAAASAQTLNCIYDQDIDFSMQRTRKRPIPSGRVQPRHALIFALILGSLSFSLLMVFVN
HHHHCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LLSACLALSGIVFYMLVYTHWLKRHHVQNIVIGGAAGSIPPLVGWAAVTGQLDWSAWILF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHCCCCHHHHHHH
ALIFLWTPPHFWALALMIKEDYAEVEVPMLPVVKGEKITVDQIWIYTLIVVPFSLLLVFP
HHHHHHCCHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEHHHHHHHHHHHHHHHHHHHHC
FQASGLFYAIAALVLGAIFIQKAWELKQNPFDQSLAKSMFKYSILYMMLLCTAMVVDSLP
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AVHDVTALVTTTLASLT
HHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA