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The map label for this gene is purA

Identifier: 170077504

GI number: 170077504

Start: 910910

End: 912241

Strand: Direct

Name: purA

Synonym: SYNPCC7002_A0882

Alternate gene names: 170077504

Gene position: 910910-912241 (Clockwise)

Preceding gene: 170077500

Following gene: 170077505

Centisome position: 30.28

GC content: 52.48

Gene sequence:

>1332_bases
TTGGCTAACGTAGTTGTCATTGGTGCCCAATGGGGTGACGAAGGAAAAGGAAAGATCACGGATTTACTGAGCAAATCCGC
CGATGTTGTCGTGCGCTCCCAAGGGGGCGTGAATGCAGGACACACCGTCGTTGTGCAGGGACAAACTTTTAAGCTTCATC
TAATCCCTTCCGGCATTTTATATCCAGATACCGAATGTATCATCGGCTCAGGGACGGTCATTGACCCGAAAGTCCTCCTC
GAAGAAATTGATCAGCTCCACCGTCTGAATGTTTCGACGGAAAATCTGTTTATTTCCCAAACCGCCCACGTGACGATGCC
CTACCACCGTTTAATCGATGGGGCCTCTGAAGAAATGCGCGGCGATCGCAAAATTGGCACCACCGGACGGGGAATCGGCC
CGACCTATGCCGATAAGTCCGAACGGACGGGGGTACGAGTTCTAGACCTCATGGATCTTGATAACTCCCAAGACAAATTC
GTTTGGGCGATCAAATACAAAAACGTCATTCTCGAAAAACTCTACGATCTGCCTCCCCTAGATCCCCAGGAAGTCATCGA
AGAATATCGTGCCTATGCCGATGCGCTACGTCCCCACGTCGTAGACAGTTCCCTGAAGGTTTTTGAAGGCGTCAACGCGA
AGAAAAATATCCTCTTTGAAGGCGCCCAGGGCACACTCCTCGATATTGACCACGGAACCTATCCTTACGTCACCTCCTCT
AACCCCATTGCTGGGGGGGCTTGTGTTGGTGCTGGCATTGGCCCCACCATCATTGACCGCGTGATTGGCGTCGCTAAAGC
CTACACCACACGGGTCGGCGAAGGGCCGTTCCCTACAGAACTCGACGACGAGATCGGTGAACTCCTTGGCCATGTGGGTG
CAGAATTTGGGACAACCACGGGGCGGCGGCGGCGCTGCGGCTGGTTTGATGCCGTTATTGGACGTTACGCGGCACGGATT
AATGGCCTAGATTGTCTAGCGATTACTAAATTAGATGTGCTCGATTCCCTCGATGAGATCAAGGTCTGTGTGGCCTACGA
AATCGACGGGGAAGCTTGTGAACACTTCCCGAGTAATGCTAATCTGTTTGCTCGTTGCCAGCCGATTTACAAGACAATGC
CCGGCTGGAAACAGCCCACGAGTGATTGTCGTTCCCTCGATGAGTTGCCCAAGGAAGCGCTTGCCTACTTGAAATTCCTA
GCAGAACTAATGGACGTGCCGATCGCCATTGTTTCTCTAGGGGCAGGTCGAGAACAAACCATCATCGTCGAAGACCCAAT
CCATGGTCCCAAACGGGCTTTGTTGGATCGTAACGGTGAACCCATCGGCTAA

Upstream 100 bases:

>100_bases
TTTTCCATGACTTCCCTTAGAAAACTTTTTTAAAAAGCTTGACACAAGATCGCCAAAGTCACAATAATTGAAGTTTGTGT
GAATTAGAGTAGACAAACCC

Downstream 100 bases:

>100_bases
GCCTGCTATTTTTTAACTTTTTATTTTCTAACGCTATTTATTTAGGTTATTTCCCATGTCTTTAACGATTGAATGTCAAG
CTCGCCCTGAAGGGGTTAAC

Product: adenylosuccinate synthetase

Products: NA

Alternate protein names: AMPSase; AdSS; IMP--aspartate ligase

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MANVVVIGAQWGDEGKGKITDLLSKSADVVVRSQGGVNAGHTVVVQGQTFKLHLIPSGILYPDTECIIGSGTVIDPKVLL
EEIDQLHRLNVSTENLFISQTAHVTMPYHRLIDGASEEMRGDRKIGTTGRGIGPTYADKSERTGVRVLDLMDLDNSQDKF
VWAIKYKNVILEKLYDLPPLDPQEVIEEYRAYADALRPHVVDSSLKVFEGVNAKKNILFEGAQGTLLDIDHGTYPYVTSS
NPIAGGACVGAGIGPTIIDRVIGVAKAYTTRVGEGPFPTELDDEIGELLGHVGAEFGTTTGRRRRCGWFDAVIGRYAARI
NGLDCLAITKLDVLDSLDEIKVCVAYEIDGEACEHFPSNANLFARCQPIYKTMPGWKQPTSDCRSLDELPKEALAYLKFL
AELMDVPIAIVSLGAGREQTIIVEDPIHGPKRALLDRNGEPIG

Sequences:

>Translated_443_residues
MANVVVIGAQWGDEGKGKITDLLSKSADVVVRSQGGVNAGHTVVVQGQTFKLHLIPSGILYPDTECIIGSGTVIDPKVLL
EEIDQLHRLNVSTENLFISQTAHVTMPYHRLIDGASEEMRGDRKIGTTGRGIGPTYADKSERTGVRVLDLMDLDNSQDKF
VWAIKYKNVILEKLYDLPPLDPQEVIEEYRAYADALRPHVVDSSLKVFEGVNAKKNILFEGAQGTLLDIDHGTYPYVTSS
NPIAGGACVGAGIGPTIIDRVIGVAKAYTTRVGEGPFPTELDDEIGELLGHVGAEFGTTTGRRRRCGWFDAVIGRYAARI
NGLDCLAITKLDVLDSLDEIKVCVAYEIDGEACEHFPSNANLFARCQPIYKTMPGWKQPTSDCRSLDELPKEALAYLKFL
AELMDVPIAIVSLGAGREQTIIVEDPIHGPKRALLDRNGEPIG
>Mature_442_residues
ANVVVIGAQWGDEGKGKITDLLSKSADVVVRSQGGVNAGHTVVVQGQTFKLHLIPSGILYPDTECIIGSGTVIDPKVLLE
EIDQLHRLNVSTENLFISQTAHVTMPYHRLIDGASEEMRGDRKIGTTGRGIGPTYADKSERTGVRVLDLMDLDNSQDKFV
WAIKYKNVILEKLYDLPPLDPQEVIEEYRAYADALRPHVVDSSLKVFEGVNAKKNILFEGAQGTLLDIDHGTYPYVTSSN
PIAGGACVGAGIGPTIIDRVIGVAKAYTTRVGEGPFPTELDDEIGELLGHVGAEFGTTTGRRRRCGWFDAVIGRYAARIN
GLDCLAITKLDVLDSLDEIKVCVAYEIDGEACEHFPSNANLFARCQPIYKTMPGWKQPTSDCRSLDELPKEALAYLKFLA
ELMDVPIAIVSLGAGREQTIIVEDPIHGPKRALLDRNGEPIG

Specific function: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP

COG id: COG0104

COG function: function code F; Adenylosuccinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylosuccinate synthetase family

Homologues:

Organism=Homo sapiens, GI34577063, Length=427, Percent_Identity=45.4332552693208, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI22748717, Length=426, Percent_Identity=45.0704225352113, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI40316944, Length=397, Percent_Identity=43.3249370277078, Blast_Score=312, Evalue=3e-85,
Organism=Escherichia coli, GI1790620, Length=427, Percent_Identity=49.8829039812646, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI25146553, Length=426, Percent_Identity=43.1924882629108, Blast_Score=344, Evalue=6e-95,
Organism=Caenorhabditis elegans, GI25146555, Length=426, Percent_Identity=43.1924882629108, Blast_Score=344, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6324109, Length=431, Percent_Identity=44.5475638051044, Blast_Score=362, Evalue=1e-101,
Organism=Drosophila melanogaster, GI21356033, Length=425, Percent_Identity=43.5294117647059, Blast_Score=359, Evalue=2e-99,

Paralogues:

None

Copy number: 940 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): PURA_SYNP2 (B1XIL5)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001734142.1
- ProteinModelPortal:   B1XIL5
- SMR:   B1XIL5
- GeneID:   6056299
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A0882
- HOGENOM:   HBG658237
- OMA:   YVLGIIK
- ProtClustDB:   PRK01117
- GO:   GO:0005737
- HAMAP:   MF_00011
- InterPro:   IPR018220
- InterPro:   IPR001114
- PANTHER:   PTHR11846
- SMART:   SM00788
- TIGRFAMs:   TIGR00184

Pfam domain/function: PF00709 Adenylsucc_synt

EC number: =6.3.4.4

Molecular weight: Translated: 48225; Mature: 48093

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01266 ADENYLOSUCCIN_SYN_1; PS00513 ADENYLOSUCCIN_SYN_2

Important sites: ACT_SITE 13-13 ACT_SITE 41-41 BINDING 128-128 BINDING 142-142 BINDING 223-223 BINDING 238-238 BINDING 302-302 BINDING 304-304

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANVVVIGAQWGDEGKGKITDLLSKSADVVVRSQGGVNAGHTVVVQGQTFKLHLIPSGIL
CCCEEEEEECCCCCCCCHHHHHHCCCCCEEEECCCCCCCCCEEEEECCEEEEEEECCCCC
YPDTECIIGSGTVIDPKVLLEEIDQLHRLNVSTENLFISQTAHVTMPYHRLIDGASEEMR
CCCCCEEECCCCEECHHHHHHHHHHHHHCCCCCCEEEEECCEEEEECHHHHHCCCHHHHC
GDRKIGTTGRGIGPTYADKSERTGVRVLDLMDLDNSQDKFVWAIKYKNVILEKLYDLPPL
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEHHHHHHHHHHCCCCC
DPQEVIEEYRAYADALRPHVVDSSLKVFEGVNAKKNILFEGAQGTLLDIDHGTYPYVTSS
CHHHHHHHHHHHHHHHCCHHHCCHHHHHHCCCCCCCEEEECCCCCEEECCCCCCCEEECC
NPIAGGACVGAGIGPTIIDRVIGVAKAYTTRVGEGPFPTELDDEIGELLGHVGAEFGTTT
CCCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCHHCCCCC
GRRRRCGWFDAVIGRYAARINGLDCLAITKLDVLDSLDEIKVCVAYEIDGEACEHFPSNA
CCCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHHHCCHHHEEEEEEEEECCHHHHCCCCCC
NLFARCQPIYKTMPGWKQPTSDCRSLDELPKEALAYLKFLAELMDVPIAIVSLGAGREQT
CEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCE
IIVEDPIHGPKRALLDRNGEPIG
EEEECCCCCCHHHHHCCCCCCCC
>Mature Secondary Structure 
ANVVVIGAQWGDEGKGKITDLLSKSADVVVRSQGGVNAGHTVVVQGQTFKLHLIPSGIL
CCEEEEEECCCCCCCCHHHHHHCCCCCEEEECCCCCCCCCEEEEECCEEEEEEECCCCC
YPDTECIIGSGTVIDPKVLLEEIDQLHRLNVSTENLFISQTAHVTMPYHRLIDGASEEMR
CCCCCEEECCCCEECHHHHHHHHHHHHHCCCCCCEEEEECCEEEEECHHHHHCCCHHHHC
GDRKIGTTGRGIGPTYADKSERTGVRVLDLMDLDNSQDKFVWAIKYKNVILEKLYDLPPL
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEHHHHHHHHHHCCCCC
DPQEVIEEYRAYADALRPHVVDSSLKVFEGVNAKKNILFEGAQGTLLDIDHGTYPYVTSS
CHHHHHHHHHHHHHHHCCHHHCCHHHHHHCCCCCCCEEEECCCCCEEECCCCCCCEEECC
NPIAGGACVGAGIGPTIIDRVIGVAKAYTTRVGEGPFPTELDDEIGELLGHVGAEFGTTT
CCCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCHHCCCCC
GRRRRCGWFDAVIGRYAARINGLDCLAITKLDVLDSLDEIKVCVAYEIDGEACEHFPSNA
CCCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHHHCCHHHEEEEEEEEECCHHHHCCCCCC
NLFARCQPIYKTMPGWKQPTSDCRSLDELPKEALAYLKFLAELMDVPIAIVSLGAGREQT
CEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCE
IIVEDPIHGPKRALLDRNGEPIG
EEEECCCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA