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The map label for this gene is ndhF-III [H]

Identifier: 170076804

GI number: 170076804

Start: 179360

End: 181210

Strand: Direct

Name: ndhF-III [H]

Synonym: SYNPCC7002_A0172

Alternate gene names: 170076804

Gene position: 179360-181210 (Clockwise)

Preceding gene: 170076803

Following gene: 170076805

Centisome position: 5.96

GC content: 49.76

Gene sequence:

>1851_bases
ATGAATACTTTTTTCAGTCAGAGTGTCTGGCTTGTTCCCTGCTATCCTTTGCTGGGCATGGGTCTATCGGCGCTATGGAT
GCCGAGCATCACCCGAAAAACAGGGCCACGGCCTGCGGGCTACGTCAATATGTTGCTTACTTTTATGGCCCTAGTCCATA
GTTGTCTTGCCTTCATCGAGCGATGGGAACAGCCCGCCCTAAAACCATCGTTAACTTGGCTCCAGGCGGCGGACTTGACC
CTCAGCATCGACCTCGATATTTCCAGCATTACTATCGGGGCGCTGATTCTGATTGCCGGGATTAATTTACTCGCCCAACT
CTATGCTGTGGCCTACTTAGAAATGGATTGGGGCTGGGCGAGATTTTTCGCGACCATGAGCTTATTTGAAGCGGGGATGT
GTGCCTTGGTGCTCTGTAATTCCCTTTTCTTTAGCTATGTGGTACTCGAAATTTTGACCCTCGGTACTTATCTGTTAATT
GGCTATTGGTTTAACCAGTCCCTGGTGGTCACGGGGGCGCGGGATGCGTTTTTAACAAAACGGGTCGGCGATCTGTTCTT
GCTGATGGGGGTTGTGGCTCTGTTGCCCCTTGCTGGTACTTGGAATTTTGATGGTCTGGCTGAATGGGCAGCAACGGCAG
AACTCGATCCGACTTTGGCAACGCTGCTTTGCTTGGCCTTAATTGCGGGGCCGTTGGGGAAATGCGCCCAATTTCCTTTA
CACCTCTGGCTTGATGAGGCGATGGAAAGTCCTGTCCCGGCAACGGTGGTGCGGAATAGTCTCGTGGTTGGTACTGGAGC
CTGGGTGCTGATTAAGTTGCAGCCGATTTTTGCCCTCTCGGATTTTGCTTCTACCTTTATGATTGCGATTGGGGCAACAA
CGGCCTTGGGGGCGGCCATGGTGGCGATCGCCCAGATTGATATCAAACGTTCTTTGTCCTATTCCGTCAGTGCCTACATG
GGCATGGTCTTTATGGCGGTGGGTTCCCAACAGGATCAAACGACATTGGTCTTGCTGCTCACCTATGGCGTGGCGATGGC
AATTCTCGTGATGGCGATCGGTGGCGTTGTTTTAGTCAATATCAGCCAAGATTTAACCCAATATGGCGGCCTCTGGTCAC
GGCGACCGATTACGGGGATTTGCTACCTCGTCGGTGCTGCTTCCCTCGTTGCCCTACCGCCGTTTGGGGGATTCTGGAGC
CTGGCCCAACTGACGACAAATTTTTGGAAAACAAGTCCGATTCTGGCCGTGATTTTGATTACGGTCAATGCCTTGACTTC
CTTTAGTATCATGCGAGAATTTGGCCTGATTTTTGGCGGTAAGCCGAAGCAGATGACCGTGCGATCGCCAGAAGGATTAT
GGGCTTTGGTTCTGCCGATGGTGATTCTTGCGGGTTTCGCCCTCCACAGTCCTTTTATTCTGGCGAAACTGAATTTTCTA
CCGGATTGGCACCAGTTGAATCTGCCCCTAGCTGCAGTTTTGATTATTTCGACCATGGTCGGTGGCGGTACCGCGATGTA
TCTTTATCTCAATGAAAAAATCAGTAAACCGATTCATATTTTTTCAGATCCGGTGCGGGAATTTTTCGCCAAGGATTTGT
ACACAGCGGAGTTGTATAAAAACACAGTTATTTTTGCCGTTGCCTTGATTTCCAAAATCATTGACTGGTTAGACCGCTAT
TTTGTCGATGGGGTGATCAACTTTCTCGGTTTAGCAACCCTTTTCGGTGGCCAAAGTTTGAAATATAACAACTCTGGTCA
AAGCCAATCCTATGCCCTCTCGATTGTGGCCGGTATTCTCCTCTTTATTGCCGCTTTATCGTATCCCTTGCTGAAGCATT
GGCAATTTTAA

Upstream 100 bases:

>100_bases
GTGCCTTTGGTAGGTCGAAGTTGGTAATTGCCCAACCAGTAAAAAAGATGGGTCATCAGCCCGCTTTTTCCTAAGCAAAT
TATTTCAGCGTCATCGTCAT

Downstream 100 bases:

>100_bases
AGGGGGATGAGTTAACGATTTTCGCTGAAATATTTATGACCTTCTCCGAAAGATTATGCTGAGTTTCTTACTGTTTTTAC
CGCTCGTCGGCATTGGGGCG

Product: NAD(P)H-quinone oxidoreductase subunit F

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 5; NDH-1, chain 5 [H]

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MNTFFSQSVWLVPCYPLLGMGLSALWMPSITRKTGPRPAGYVNMLLTFMALVHSCLAFIERWEQPALKPSLTWLQAADLT
LSIDLDISSITIGALILIAGINLLAQLYAVAYLEMDWGWARFFATMSLFEAGMCALVLCNSLFFSYVVLEILTLGTYLLI
GYWFNQSLVVTGARDAFLTKRVGDLFLLMGVVALLPLAGTWNFDGLAEWAATAELDPTLATLLCLALIAGPLGKCAQFPL
HLWLDEAMESPVPATVVRNSLVVGTGAWVLIKLQPIFALSDFASTFMIAIGATTALGAAMVAIAQIDIKRSLSYSVSAYM
GMVFMAVGSQQDQTTLVLLLTYGVAMAILVMAIGGVVLVNISQDLTQYGGLWSRRPITGICYLVGAASLVALPPFGGFWS
LAQLTTNFWKTSPILAVILITVNALTSFSIMREFGLIFGGKPKQMTVRSPEGLWALVLPMVILAGFALHSPFILAKLNFL
PDWHQLNLPLAAVLIISTMVGGGTAMYLYLNEKISKPIHIFSDPVREFFAKDLYTAELYKNTVIFAVALISKIIDWLDRY
FVDGVINFLGLATLFGGQSLKYNNSGQSQSYALSIVAGILLFIAALSYPLLKHWQF

Sequences:

>Translated_616_residues
MNTFFSQSVWLVPCYPLLGMGLSALWMPSITRKTGPRPAGYVNMLLTFMALVHSCLAFIERWEQPALKPSLTWLQAADLT
LSIDLDISSITIGALILIAGINLLAQLYAVAYLEMDWGWARFFATMSLFEAGMCALVLCNSLFFSYVVLEILTLGTYLLI
GYWFNQSLVVTGARDAFLTKRVGDLFLLMGVVALLPLAGTWNFDGLAEWAATAELDPTLATLLCLALIAGPLGKCAQFPL
HLWLDEAMESPVPATVVRNSLVVGTGAWVLIKLQPIFALSDFASTFMIAIGATTALGAAMVAIAQIDIKRSLSYSVSAYM
GMVFMAVGSQQDQTTLVLLLTYGVAMAILVMAIGGVVLVNISQDLTQYGGLWSRRPITGICYLVGAASLVALPPFGGFWS
LAQLTTNFWKTSPILAVILITVNALTSFSIMREFGLIFGGKPKQMTVRSPEGLWALVLPMVILAGFALHSPFILAKLNFL
PDWHQLNLPLAAVLIISTMVGGGTAMYLYLNEKISKPIHIFSDPVREFFAKDLYTAELYKNTVIFAVALISKIIDWLDRY
FVDGVINFLGLATLFGGQSLKYNNSGQSQSYALSIVAGILLFIAALSYPLLKHWQF
>Mature_616_residues
MNTFFSQSVWLVPCYPLLGMGLSALWMPSITRKTGPRPAGYVNMLLTFMALVHSCLAFIERWEQPALKPSLTWLQAADLT
LSIDLDISSITIGALILIAGINLLAQLYAVAYLEMDWGWARFFATMSLFEAGMCALVLCNSLFFSYVVLEILTLGTYLLI
GYWFNQSLVVTGARDAFLTKRVGDLFLLMGVVALLPLAGTWNFDGLAEWAATAELDPTLATLLCLALIAGPLGKCAQFPL
HLWLDEAMESPVPATVVRNSLVVGTGAWVLIKLQPIFALSDFASTFMIAIGATTALGAAMVAIAQIDIKRSLSYSVSAYM
GMVFMAVGSQQDQTTLVLLLTYGVAMAILVMAIGGVVLVNISQDLTQYGGLWSRRPITGICYLVGAASLVALPPFGGFWS
LAQLTTNFWKTSPILAVILITVNALTSFSIMREFGLIFGGKPKQMTVRSPEGLWALVLPMVILAGFALHSPFILAKLNFL
PDWHQLNLPLAAVLIISTMVGGGTAMYLYLNEKISKPIHIFSDPVREFFAKDLYTAELYKNTVIFAVALISKIIDWLDRY
FVDGVINFLGLATLFGGQSLKYNNSGQSQSYALSIVAGILLFIAALSYPLLKHWQF

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=407, Percent_Identity=28.009828009828, Blast_Score=139, Evalue=1e-32,
Organism=Escherichia coli, GI1788614, Length=457, Percent_Identity=29.9781181619256, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1788827, Length=438, Percent_Identity=23.7442922374429, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788831, Length=387, Percent_Identity=26.8733850129199, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788829, Length=426, Percent_Identity=23.943661971831, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1788613, Length=353, Percent_Identity=24.6458923512748, Blast_Score=76, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: 1.6.5.3

Molecular weight: Translated: 67203; Mature: 67203

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTFFSQSVWLVPCYPLLGMGLSALWMPSITRKTGPRPAGYVNMLLTFMALVHSCLAFIE
CCCCCCCCEEEEECHHHHHCCHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RWEQPALKPSLTWLQAADLTLSIDLDISSITIGALILIAGINLLAQLYAVAYLEMDWGWA
HHCCCCCCCCHHHEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
RFFATMSLFEAGMCALVLCNSLFFSYVVLEILTLGTYLLIGYWFNQSLVVTGARDAFLTK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHH
RVGDLFLLMGVVALLPLAGTWNFDGLAEWAATAELDPTLATLLCLALIAGPLGKCAQFPL
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHCHH
HLWLDEAMESPVPATVVRNSLVVGTGAWVLIKLQPIFALSDFASTFMIAIGATTALGAAM
HHHHHHHHCCCCCHHHHHCCEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
VAIAQIDIKRSLSYSVSAYMGMVFMAVGSQQDQTTLVLLLTYGVAMAILVMAIGGVVLVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEE
ISQDLTQYGGLWSRRPITGICYLVGAASLVALPPFGGFWSLAQLTTNFWKTSPILAVILI
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCHHHHHHHH
TVNALTSFSIMREFGLIFGGKPKQMTVRSPEGLWALVLPMVILAGFALHSPFILAKLNFL
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCHHEEEECCC
PDWHQLNLPLAAVLIISTMVGGGTAMYLYLNEKISKPIHIFSDPVREFFAKDLYTAELYK
CCHHHCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NTVIFAVALISKIIDWLDRYFVDGVINFLGLATLFGGQSLKYNNSGQSQSYALSIVAGIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHH
LFIAALSYPLLKHWQF
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTFFSQSVWLVPCYPLLGMGLSALWMPSITRKTGPRPAGYVNMLLTFMALVHSCLAFIE
CCCCCCCCEEEEECHHHHHCCHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RWEQPALKPSLTWLQAADLTLSIDLDISSITIGALILIAGINLLAQLYAVAYLEMDWGWA
HHCCCCCCCCHHHEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
RFFATMSLFEAGMCALVLCNSLFFSYVVLEILTLGTYLLIGYWFNQSLVVTGARDAFLTK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHH
RVGDLFLLMGVVALLPLAGTWNFDGLAEWAATAELDPTLATLLCLALIAGPLGKCAQFPL
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHCHH
HLWLDEAMESPVPATVVRNSLVVGTGAWVLIKLQPIFALSDFASTFMIAIGATTALGAAM
HHHHHHHHCCCCCHHHHHCCEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
VAIAQIDIKRSLSYSVSAYMGMVFMAVGSQQDQTTLVLLLTYGVAMAILVMAIGGVVLVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEE
ISQDLTQYGGLWSRRPITGICYLVGAASLVALPPFGGFWSLAQLTTNFWKTSPILAVILI
CHHHHHHHCCCCCCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCHHHHHHHH
TVNALTSFSIMREFGLIFGGKPKQMTVRSPEGLWALVLPMVILAGFALHSPFILAKLNFL
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCHHEEEECCC
PDWHQLNLPLAAVLIISTMVGGGTAMYLYLNEKISKPIHIFSDPVREFFAKDLYTAELYK
CCHHHCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NTVIFAVALISKIIDWLDRYFVDGVINFLGLATLFGGQSLKYNNSGQSQSYALSIVAGIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHH
LFIAALSYPLLKHWQF
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8501038; 1554697 [H]