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The map label for this gene is ndhD-III [H]

Identifier: 170076805

GI number: 170076805

Start: 181266

End: 182762

Strand: Direct

Name: ndhD-III [H]

Synonym: SYNPCC7002_A0173

Alternate gene names: 170076805

Gene position: 181266-182762 (Clockwise)

Preceding gene: 170076804

Following gene: 170076806

Centisome position: 6.03

GC content: 49.3

Gene sequence:

>1497_bases
ATGCTGAGTTTCTTACTGTTTTTACCGCTCGTCGGCATTGGGGCGATCGCCCTTTTCCCCAGGCCCCTGACCCGGATTGT
GGCAACGGTGTTTACGGTTGTCACCCTGGCGATCAGTAGTGGCTTATTGATTAACCTCAACCTCCAAGATGCTGGTATGC
AATATACCGAATTCCATAATTGGTTAAGCATCCTGGGTCTCAACTATAACCTCGGTGTGGATGGTTTATCTTTGCCGCTG
ATTGTCCTAAATAGTTTGCTGACATTGGTCGCGATCTATAGCATTGGTGAAAGCAACCACCGTCCGAAGCTTTATTACTC
CCTCATTTTGTTGATTAATAGTGGGATTACAGGGGCCTTGATTGCCAATAATCTGTTGCTCTTTTTCCTCTTTTATGAAA
TTGAGTTGATTCCTTTTTATTTACTGATTGCCATTTGGGGCGGCGAAAAAAAAGGATATGCCTCGACTAAATTTTTGATT
TACACTGCCATTTCTGGACTCTGTGTATTGGCGGCATTTTTAGGGATTGTGTGGCTCAGTCAATCGAGTAATTTTGACTT
TGAGAATTTAACCCTAGAAAACCTAGAGTTCAACACTAAGGTAATCCTGCTCACGATTTTGTTGATTGGCTTTGGGATTA
AAATTCCCCTCGTGCCTTTACACACCTGGCTGCCCGACGCCTATGTAGAAGCAAATCCAGCGGTAACAGTTCTGTTGGGC
GGTGTTTTCGCGAAATTGGGCACCTATGGCTTGGTGCGCTTCGGTTTGCAACTGTTCCCGGATGTGTGGTCTACGGTTTC
CCCCGCCCTCGCAGTCATTGGTACCGTGAGCGTGATGTATGGTTCCCTGGCGGCGATCGCCCAACGGGATCTCAAGCGGA
TGGTGGCCTACAGTTCCATCGGTCACATGGGTTATATCTTGGTTTCGACGGCAGCCGGAACAGAGTTAAGTTTGCTTGGT
GCCGTGGCCCAAATGATTAGCCACAGTTTAATTCTGGCGCTGTTGTTCCACCTCGTCGGCATTATCGAACGCAAAGTCGG
CACGCGGGATTTGGATGTGTTGAATGGTTTGATGAATCCGGTACGGGGTTTGCCCCTCACCAGTAGCCTGTTGATTTTGG
CAGGGATGGCCAGTGCCGGGATTCCCGGTTTGGTCGGTTTCGTCGCGGAATTCCTCGTGTTCCAAGGTAGCTTTAGCCGC
TTCCCGATTCCGACGCTGTTTTGCATCATCGCTTCTGGTTTAACGGCGGTTTACTTCGTGATTTTGCTCAACCGCACCTG
TTTCGGTCGCCTCGACAGTCACACCGCCTATTACCCCAAAGTTTTTGCCAGTGAAAAAATTCCGGCGATCGCCTTGACGG
TCATTATCCTTTTCCTTGGTTTACAACCCGCCTGGCTCACCCGCTGGATCGAACCGACCACCAGCCAATTCATTGCCGCC
ATTCCCACGGTTCAGACCATTGCCTTGACTCCCGCTGAATTGTCGAAAGCACCCTAG

Upstream 100 bases:

>100_bases
ATTGCCGCTTTATCGTATCCCTTGCTGAAGCATTGGCAATTTTAAAGGGGGATGAGTTAACGATTTTCGCTGAAATATTT
ATGACCTTCTCCGAAAGATT

Downstream 100 bases:

>100_bases
TCAATCAGACGTTCTCGCTTGACCGATTCGCCCAGCATTTTCCTCAGGAACAAAGCACTATGATCACCACGAAAATTCCC
CCTTCAACCCATCCCCATGC

Product: NAD(P)H-quinone oxidoreductase subunit M

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4; NDH-1, chain 4 [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MLSFLLFLPLVGIGAIALFPRPLTRIVATVFTVVTLAISSGLLINLNLQDAGMQYTEFHNWLSILGLNYNLGVDGLSLPL
IVLNSLLTLVAIYSIGESNHRPKLYYSLILLINSGITGALIANNLLLFFLFYEIELIPFYLLIAIWGGEKKGYASTKFLI
YTAISGLCVLAAFLGIVWLSQSSNFDFENLTLENLEFNTKVILLTILLIGFGIKIPLVPLHTWLPDAYVEANPAVTVLLG
GVFAKLGTYGLVRFGLQLFPDVWSTVSPALAVIGTVSVMYGSLAAIAQRDLKRMVAYSSIGHMGYILVSTAAGTELSLLG
AVAQMISHSLILALLFHLVGIIERKVGTRDLDVLNGLMNPVRGLPLTSSLLILAGMASAGIPGLVGFVAEFLVFQGSFSR
FPIPTLFCIIASGLTAVYFVILLNRTCFGRLDSHTAYYPKVFASEKIPAIALTVIILFLGLQPAWLTRWIEPTTSQFIAA
IPTVQTIALTPAELSKAP

Sequences:

>Translated_498_residues
MLSFLLFLPLVGIGAIALFPRPLTRIVATVFTVVTLAISSGLLINLNLQDAGMQYTEFHNWLSILGLNYNLGVDGLSLPL
IVLNSLLTLVAIYSIGESNHRPKLYYSLILLINSGITGALIANNLLLFFLFYEIELIPFYLLIAIWGGEKKGYASTKFLI
YTAISGLCVLAAFLGIVWLSQSSNFDFENLTLENLEFNTKVILLTILLIGFGIKIPLVPLHTWLPDAYVEANPAVTVLLG
GVFAKLGTYGLVRFGLQLFPDVWSTVSPALAVIGTVSVMYGSLAAIAQRDLKRMVAYSSIGHMGYILVSTAAGTELSLLG
AVAQMISHSLILALLFHLVGIIERKVGTRDLDVLNGLMNPVRGLPLTSSLLILAGMASAGIPGLVGFVAEFLVFQGSFSR
FPIPTLFCIIASGLTAVYFVILLNRTCFGRLDSHTAYYPKVFASEKIPAIALTVIILFLGLQPAWLTRWIEPTTSQFIAA
IPTVQTIALTPAELSKAP
>Mature_498_residues
MLSFLLFLPLVGIGAIALFPRPLTRIVATVFTVVTLAISSGLLINLNLQDAGMQYTEFHNWLSILGLNYNLGVDGLSLPL
IVLNSLLTLVAIYSIGESNHRPKLYYSLILLINSGITGALIANNLLLFFLFYEIELIPFYLLIAIWGGEKKGYASTKFLI
YTAISGLCVLAAFLGIVWLSQSSNFDFENLTLENLEFNTKVILLTILLIGFGIKIPLVPLHTWLPDAYVEANPAVTVLLG
GVFAKLGTYGLVRFGLQLFPDVWSTVSPALAVIGTVSVMYGSLAAIAQRDLKRMVAYSSIGHMGYILVSTAAGTELSLLG
AVAQMISHSLILALLFHLVGIIERKVGTRDLDVLNGLMNPVRGLPLTSSLLILAGMASAGIPGLVGFVAEFLVFQGSFSR
FPIPTLFCIIASGLTAVYFVILLNRTCFGRLDSHTAYYPKVFASEKIPAIALTVIILFLGLQPAWLTRWIEPTTSQFIAA
IPTVQTIALTPAELSKAP

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=370, Percent_Identity=31.0810810810811, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI251831117, Length=385, Percent_Identity=24.9350649350649, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788613, Length=471, Percent_Identity=34.1825902335456, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1788831, Length=350, Percent_Identity=30, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1788827, Length=404, Percent_Identity=26.2376237623762, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788829, Length=347, Percent_Identity=27.6657060518732, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI145693160, Length=336, Percent_Identity=30.3571428571429, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI2367154, Length=335, Percent_Identity=26.2686567164179, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788614, Length=486, Percent_Identity=25.1028806584362, Blast_Score=82, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: 1.6.5.3

Molecular weight: Translated: 53901; Mature: 53901

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSFLLFLPLVGIGAIALFPRPLTRIVATVFTVVTLAISSGLLINLNLQDAGMQYTEFHN
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHCCCHHHHHHH
WLSILGLNYNLGVDGLSLPLIVLNSLLTLVAIYSIGESNHRPKLYYSLILLINSGITGAL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHH
IANNLLLFFLFYEIELIPFYLLIAIWGGEKKGYASTKFLIYTAISGLCVLAAFLGIVWLS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEC
QSSNFDFENLTLENLEFNTKVILLTILLIGFGIKIPLVPLHTWLPDAYVEANPAVTVLLG
CCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCEEEHHHHCCCCCCCCCCHHHHHHH
GVFAKLGTYGLVRFGLQLFPDVWSTVSPALAVIGTVSVMYGSLAAIAQRDLKRMVAYSSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GHMGYILVSTAAGTELSLLGAVAQMISHSLILALLFHLVGIIERKVGTRDLDVLNGLMNP
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VRGLPLTSSLLILAGMASAGIPGLVGFVAEFLVFQGSFSRFPIPTLFCIIASGLTAVYFV
HCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ILLNRTCFGRLDSHTAYYPKVFASEKIPAIALTVIILFLGLQPAWLTRWIEPTTSQFIAA
HHHCCHHHCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHH
IPTVQTIALTPAELSKAP
CCCHHEEEECHHHHCCCC
>Mature Secondary Structure
MLSFLLFLPLVGIGAIALFPRPLTRIVATVFTVVTLAISSGLLINLNLQDAGMQYTEFHN
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHCCCHHHHHHH
WLSILGLNYNLGVDGLSLPLIVLNSLLTLVAIYSIGESNHRPKLYYSLILLINSGITGAL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHH
IANNLLLFFLFYEIELIPFYLLIAIWGGEKKGYASTKFLIYTAISGLCVLAAFLGIVWLS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEC
QSSNFDFENLTLENLEFNTKVILLTILLIGFGIKIPLVPLHTWLPDAYVEANPAVTVLLG
CCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCEEEHHHHCCCCCCCCCCHHHHHHH
GVFAKLGTYGLVRFGLQLFPDVWSTVSPALAVIGTVSVMYGSLAAIAQRDLKRMVAYSSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GHMGYILVSTAAGTELSLLGAVAQMISHSLILALLFHLVGIIERKVGTRDLDVLNGLMNP
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VRGLPLTSSLLILAGMASAGIPGLVGFVAEFLVFQGSFSRFPIPTLFCIIASGLTAVYFV
HCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ILLNRTCFGRLDSHTAYYPKVFASEKIPAIALTVIILFLGLQPAWLTRWIEPTTSQFIAA
HHHCCHHHCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHH
IPTVQTIALTPAELSKAP
CCCHHEEEECHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA