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The map label for this gene is thiD [H]

Identifier: 170076661

GI number: 170076661

Start: 22367

End: 23170

Strand: Direct

Name: thiD [H]

Synonym: SYNPCC7002_A0025

Alternate gene names: 170076661

Gene position: 22367-23170 (Clockwise)

Preceding gene: 170076660

Following gene: 170076663

Centisome position: 0.74

GC content: 55.1

Gene sequence:

>804_bases
ATGGCAATTACTCCGGCGATCGCCTTAACCATTGCCGGCTCCGATAGTGGCGGTGGGGCAGGCATCCAAGCCGATCTCAA
AACCTTTGCCTTCCACGGTGTCCATGGCACCAGTGCGATCACCTGTGTCACGGCCCAAAATACCATTGGCGTCACCGATG
TGGTGGCCCTGGATTCGGCCATGGTAACTGCGCAAATTGAGGCAGTGGTCAAGGATATTGGCGTCCAGGCAGTGAAAACA
GGGATGCTCCTGAACGAAAAGATCATGGCGGCGGTTTTGATGGCTGCAGCAATCGGTAGGCTCCCCAACTGGGTTTTGGA
TCCGGTGATGGTTTCCCGCACGGGGGTACAGCTCATCGACGACGGGGCGATCACCTTTTTGCAAAAGCAATTAATCCCCC
TCGCCCAGATCCTCACGCCAAACCGTTACGAGGCGGAGATTCTCAGTGGCCTAGAAATTACCGATCTCGCCACCATGGAA
CAGGCAGCCCAAAAAATTCATCAGCTTGGTTGTGGGGCAGTGCTTGTTAAAGGGGGAGCGATGACCGGGGCATTACAAGG
GGTGGATGTGTGGTTCGATGGTGAACGGCTTGAAATTTTAAAAACGGAATGTATCCAGACCCCCCACACCCACGGCACTG
GTTGTACCCTTTCGGCGGCGATCGCCGCTCGCTTAGCCCTGGGAGATCCTCCATTCCAAGCCGTTAACAAGGCAAAGACC
TACGTCACAGAAGCCCTAAAACATAGCCTAGCCATTGGTCAGGGGACGGGGCCAGTGGGCCATTTTTATCCGATTTTGCC
CTAG

Upstream 100 bases:

>100_bases
GCACCACCCCAGGCCCAACAGCCCCCCGCCCCCCGGAATGGTTTCCCGGATATTCCTGACTTTTTGATGCGTCGTTCTAA
TCGTTCTAAGCAGTAGGTCG

Downstream 100 bases:

>100_bases
ACTGCGGCGATCTCTGCTTGTAGTCGATATAGCAGGGTTTGGCGATCGCACTGGGCAAGAATTTCTTTGATCGTCGTACT
TGCCCCCAGGTTTCCCCAAC

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MAITPAIALTIAGSDSGGGAGIQADLKTFAFHGVHGTSAITCVTAQNTIGVTDVVALDSAMVTAQIEAVVKDIGVQAVKT
GMLLNEKIMAAVLMAAAIGRLPNWVLDPVMVSRTGVQLIDDGAITFLQKQLIPLAQILTPNRYEAEILSGLEITDLATME
QAAQKIHQLGCGAVLVKGGAMTGALQGVDVWFDGERLEILKTECIQTPHTHGTGCTLSAAIAARLALGDPPFQAVNKAKT
YVTEALKHSLAIGQGTGPVGHFYPILP

Sequences:

>Translated_267_residues
MAITPAIALTIAGSDSGGGAGIQADLKTFAFHGVHGTSAITCVTAQNTIGVTDVVALDSAMVTAQIEAVVKDIGVQAVKT
GMLLNEKIMAAVLMAAAIGRLPNWVLDPVMVSRTGVQLIDDGAITFLQKQLIPLAQILTPNRYEAEILSGLEITDLATME
QAAQKIHQLGCGAVLVKGGAMTGALQGVDVWFDGERLEILKTECIQTPHTHGTGCTLSAAIAARLALGDPPFQAVNKAKT
YVTEALKHSLAIGQGTGPVGHFYPILP
>Mature_266_residues
AITPAIALTIAGSDSGGGAGIQADLKTFAFHGVHGTSAITCVTAQNTIGVTDVVALDSAMVTAQIEAVVKDIGVQAVKTG
MLLNEKIMAAVLMAAAIGRLPNWVLDPVMVSRTGVQLIDDGAITFLQKQLIPLAQILTPNRYEAEILSGLEITDLATMEQ
AAQKIHQLGCGAVLVKGGAMTGALQGVDVWFDGERLEILKTECIQTPHTHGTGCTLSAAIAARLALGDPPFQAVNKAKTY
VTEALKHSLAIGQGTGPVGHFYPILP

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=259, Percent_Identity=39.7683397683398, Blast_Score=164, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6325378, Length=271, Percent_Identity=30.2583025830258, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324517, Length=276, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6324997, Length=276, Percent_Identity=32.9710144927536, Blast_Score=99, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 27686; Mature: 27554

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITPAIALTIAGSDSGGGAGIQADLKTFAFHGVHGTSAITCVTAQNTIGVTDVVALDSA
CCCCCEEEEEEECCCCCCCCCCHHHHHHHEEECCCCCCEEEEEEECCCCCHHHHHHHHHH
MVTAQIEAVVKDIGVQAVKTGMLLNEKIMAAVLMAAAIGRLPNWVLDPVMVSRTGVQLID
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCHHHHHCCCCEEEC
DGAITFLQKQLIPLAQILTPNRYEAEILSGLEITDLATMEQAAQKIHQLGCGAVLVKGGA
CHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCC
MTGALQGVDVWFDGERLEILKTECIQTPHTHGTGCTLSAAIAARLALGDPPFQAVNKAKT
CCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHH
YVTEALKHSLAIGQGTGPVGHFYPILP
HHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AITPAIALTIAGSDSGGGAGIQADLKTFAFHGVHGTSAITCVTAQNTIGVTDVVALDSA
CCCCEEEEEEECCCCCCCCCCHHHHHHHEEECCCCCCEEEEEEECCCCCHHHHHHHHHH
MVTAQIEAVVKDIGVQAVKTGMLLNEKIMAAVLMAAAIGRLPNWVLDPVMVSRTGVQLID
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCHHHHHCCCCEEEC
DGAITFLQKQLIPLAQILTPNRYEAEILSGLEITDLATMEQAAQKIHQLGCGAVLVKGGA
CHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCC
MTGALQGVDVWFDGERLEILKTECIQTPHTHGTGCTLSAAIAARLALGDPPFQAVNKAKT
CCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHH
YVTEALKHSLAIGQGTGPVGHFYPILP
HHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA