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The map label for this gene is ispH [H]

Identifier: 170025800

GI number: 170025800

Start: 3951173

End: 3952126

Strand: Reverse

Name: ispH [H]

Synonym: YPK_3585

Alternate gene names: 170025800

Gene position: 3952126-3951173 (Counterclockwise)

Preceding gene: 170025801

Following gene: 170025799

Centisome position: 84.28

GC content: 49.48

Gene sequence:

>954_bases
ATGCAGATATTGCTGGCTAATCCACGTGGCTTTTGTGCTGGCGTTGACCGGGCTATCAGTATTGTTGAACGTGCGATAGA
AATGTATGGCGCGCCAATTTATGTACGCCATGAGGTGGTACATAACCGCTATGTGGTTGAGAGCCTGTGCGAGCGCGGTG
CTATCTTCATCGAGGAAATTTCAGAGGTGCCAGATGGCTCCATTCTGATTTTCTCGGCCCATGGTGTGTCACAGGCTGTT
CGGGCAGAGGCCCGTTCGCGTAATTTGACGATGCTGTTTGATGCGACCTGTCCATTGGTTACCAAAGTCCATATGGAAGT
CGCCCGTGCGAGCCGTAAGGGTAAAGAAGCTATTTTGATCGGCCATGCCGGTCATCCAGAAGTGGAAGGGACCATGGGGC
AATACAGCAACCCTAACGGGGGGATGTATTTGGTTGAATCGCCTGATGACGTTTGGCAGTTGAACGTCAAGGATGAGAAT
AATCTGTGTTTTATGACGCAGACCACCTTATCGGTCGATGATACCTCCGCTGTGATCGATGCGTTGAACACGCGCTTCCC
AAAGATAGTCGGCCCACGCAAAGATGATATTTGCTATGCCACAACCAATCGGCAAGAGGCAGTACGTAATCTGGCAAATG
ATGCTGATATCGTATTGGTCGTGGGGTCGAAAAATTCCTCTAACTCTAACCGATTGGCCGAACTGGTACAGCGAATGGGT
AAGCCCGCTTATCTGATTGACTCTGCGGCAGATATTCAGGAATTTTGGTTACAGGGCGCCCAGTGTATTGGTGTTACCGC
GGGTGCATCTGCCCCCGATATTTTGGTGCAGCAAGTGATTGCACGCTTAAAAGATCTTGGTGCTGGTGAATCGATTGAAC
TCAGCGGTCGCGAAGAAAATATTGTTTTTGAAGTACCGAAAGAACTGCGTGTTGAGGTTAAACAGATCGACTGA

Upstream 100 bases:

>100_bases
GAAGAGTCTATTACTGTTGATTTTAATCACCCGTTGGCTGGGCACTCTGTCAGTTTTGAACTTGAAATACTGGAGATTGA
CCCCCAACAGGAGGTTGTCT

Downstream 100 bases:

>100_bases
TTCAGGTGTTTCTTTGTCGATCAGGTAGGTGTTTACTCGATATGTATTTACTGACGAAAGCAGCCCTTTGCGGCTGCTTT
GAGGTTATTGACAAAGTGCC

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MQILLANPRGFCAGVDRAISIVERAIEMYGAPIYVRHEVVHNRYVVESLCERGAIFIEEISEVPDGSILIFSAHGVSQAV
RAEARSRNLTMLFDATCPLVTKVHMEVARASRKGKEAILIGHAGHPEVEGTMGQYSNPNGGMYLVESPDDVWQLNVKDEN
NLCFMTQTTLSVDDTSAVIDALNTRFPKIVGPRKDDICYATTNRQEAVRNLANDADIVLVVGSKNSSNSNRLAELVQRMG
KPAYLIDSAADIQEFWLQGAQCIGVTAGASAPDILVQQVIARLKDLGAGESIELSGREENIVFEVPKELRVEVKQID

Sequences:

>Translated_317_residues
MQILLANPRGFCAGVDRAISIVERAIEMYGAPIYVRHEVVHNRYVVESLCERGAIFIEEISEVPDGSILIFSAHGVSQAV
RAEARSRNLTMLFDATCPLVTKVHMEVARASRKGKEAILIGHAGHPEVEGTMGQYSNPNGGMYLVESPDDVWQLNVKDEN
NLCFMTQTTLSVDDTSAVIDALNTRFPKIVGPRKDDICYATTNRQEAVRNLANDADIVLVVGSKNSSNSNRLAELVQRMG
KPAYLIDSAADIQEFWLQGAQCIGVTAGASAPDILVQQVIARLKDLGAGESIELSGREENIVFEVPKELRVEVKQID
>Mature_317_residues
MQILLANPRGFCAGVDRAISIVERAIEMYGAPIYVRHEVVHNRYVVESLCERGAIFIEEISEVPDGSILIFSAHGVSQAV
RAEARSRNLTMLFDATCPLVTKVHMEVARASRKGKEAILIGHAGHPEVEGTMGQYSNPNGGMYLVESPDDVWQLNVKDEN
NLCFMTQTTLSVDDTSAVIDALNTRFPKIVGPRKDDICYATTNRQEAVRNLANDADIVLVVGSKNSSNSNRLAELVQRMG
KPAYLIDSAADIQEFWLQGAQCIGVTAGASAPDILVQQVIARLKDLGAGESIELSGREENIVFEVPKELRVEVKQID

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=317, Percent_Identity=82.3343848580442, Blast_Score=543, Evalue=1e-156,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 34709; Mature: 34709

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQILLANPRGFCAGVDRAISIVERAIEMYGAPIYVRHEVVHNRYVVESLCERGAIFIEEI
CEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCEEEHHH
SEVPDGSILIFSAHGVSQAVRAEARSRNLTMLFDATCPLVTKVHMEVARASRKGKEAILI
HHCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEE
GHAGHPEVEGTMGQYSNPNGGMYLVESPDDVWQLNVKDENNLCFMTQTTLSVDDTSAVID
ECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCEEEEEEEEECCCHHHHHHH
ALNTRFPKIVGPRKDDICYATTNRQEAVRNLANDADIVLVVGSKNSSNSNRLAELVQRMG
HHHCCCCHHCCCCCCCEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHC
KPAYLIDSAADIQEFWLQGAQCIGVTAGASAPDILVQQVIARLKDLGAGESIELSGREEN
CCEEEECCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCC
IVFEVPKELRVEVKQID
EEEECCHHHHHEEECCC
>Mature Secondary Structure
MQILLANPRGFCAGVDRAISIVERAIEMYGAPIYVRHEVVHNRYVVESLCERGAIFIEEI
CEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCEEEHHH
SEVPDGSILIFSAHGVSQAVRAEARSRNLTMLFDATCPLVTKVHMEVARASRKGKEAILI
HHCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEE
GHAGHPEVEGTMGQYSNPNGGMYLVESPDDVWQLNVKDENNLCFMTQTTLSVDDTSAVID
ECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCEEEEEEEEECCCHHHHHHH
ALNTRFPKIVGPRKDDICYATTNRQEAVRNLANDADIVLVVGSKNSSNSNRLAELVQRMG
HHHCCCCHHCCCCCCCEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHC
KPAYLIDSAADIQEFWLQGAQCIGVTAGASAPDILVQQVIARLKDLGAGESIELSGREEN
CCEEEECCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCC
IVFEVPKELRVEVKQID
EEEECCHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA