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The map label for this gene is lpxC [H]

Identifier: 170025727

GI number: 170025727

Start: 3857320

End: 3858243

Strand: Reverse

Name: lpxC [H]

Synonym: YPK_3512

Alternate gene names: 170025727

Gene position: 3858243-3857320 (Counterclockwise)

Preceding gene: 170025728

Following gene: 170025725

Centisome position: 82.28

GC content: 46.0

Gene sequence:

>924_bases
ATGATGATCAAACAAAGGACTTTAAAACGTATTGTTCAGGCGACGGGTGTCGGTTTGCACACCGGTAAAAAAGTCACGCT
GACAATGCGACCCGCGCCGGCTAATACCGGGGTCATCTATCGTCGCACTGACTTGAATCCACCGGTTGATTTTCCGGCAG
ATGCAAAATCCGTGCGTGATACCATGCTCTGTACTTGCCTGGTCAATGAGCATGACGTGCGTATTTCTACTGTTGAACAT
CTCAACGCTGCTTTGGCAGGGTTAGGGATTGATAACATTATTATTGAAGTTAACGCCCCCGAAGTACCAATCATGGATGG
CAGCGCCAGTCCATTCGTGTACTTGTTGCTGGATGCCGGTATTGAAGAGTTAAACTCAGCGAAGAAATTCCTGCGTTTGA
AAGAGACAGTACGGGTTGAAGATGGTGATAAATGGGCTGAATTGTCTCCATTCAATGGATTCCGTTTGGACTTTACCATT
GATTTTAATCACCCGGCGATTGACTCAAGTACACAGCGTTATTGCTTAGATTTCTCGGCCGATTCTTTCGTCCGCCAAAT
CAGCCGTGCGCGTACTTTTGGTTTCATGCGTGATATCGAATATCTGCAGTCCCGCGGTTTGTGCCTGGGCGGTAGTTTCG
ATTGTGCCATCGTGGTAGATGATTACCGCGTATTAAATGAAGATGGCCTACGCTTTGAAGATGAGTTTGTTCGTCACAAA
ATGTTGGACGCTATTGGCGACCTGTTTATGTGCGGCCATAATATTATTGGCGCATTTACGGCGTACAAATCTGGTCATGC
CTTAAATAACAAGCTGTTGCAGGCTGTTTTAGCGAAGCAAGAAGCTTGGGAATTTGTGACGTTCCAAGATGAAGCTGAAA
TGCCTTTGGCATTCAAAGCACCGTCTACAGTATTAGCTTACTAA

Upstream 100 bases:

>100_bases
TTAATTTCCGAATATTTGGAATCTCCGCTCTTTGTGCTAAACTGTCCCACCGATCTTGTTATAAGCTTGGTCGGTAGGAT
GGATAACATTGCGAGATAAA

Downstream 100 bases:

>100_bases
ATATACTTGTACCCAAAGTAATTGGGAGTTGAAGTAATTGAAGTTGAAGTAATTGAAGTTGAAGTAATTGAAGTTGAAGT
AATTGAAGTTGAAGTAATTG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MMIKQRTLKRIVQATGVGLHTGKKVTLTMRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEH
LNAALAGLGIDNIIIEVNAPEVPIMDGSASPFVYLLLDAGIEELNSAKKFLRLKETVRVEDGDKWAELSPFNGFRLDFTI
DFNHPAIDSSTQRYCLDFSADSFVRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHK
MLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDEAEMPLAFKAPSTVLAY

Sequences:

>Translated_307_residues
MMIKQRTLKRIVQATGVGLHTGKKVTLTMRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEH
LNAALAGLGIDNIIIEVNAPEVPIMDGSASPFVYLLLDAGIEELNSAKKFLRLKETVRVEDGDKWAELSPFNGFRLDFTI
DFNHPAIDSSTQRYCLDFSADSFVRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHK
MLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDEAEMPLAFKAPSTVLAY
>Mature_307_residues
MMIKQRTLKRIVQATGVGLHTGKKVTLTMRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEH
LNAALAGLGIDNIIIEVNAPEVPIMDGSASPFVYLLLDAGIEELNSAKKFLRLKETVRVEDGDKWAELSPFNGFRLDFTI
DFNHPAIDSSTQRYCLDFSADSFVRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHK
MLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDEAEMPLAFKAPSTVLAY

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=305, Percent_Identity=92.7868852459016, Blast_Score=600, Evalue=1e-173,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 34307; Mature: 34307

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIKQRTLKRIVQATGVGLHTGKKVTLTMRPAPANTGVIYRRTDLNPPVDFPADAKSVRD
CCCHHHHHHHHHHHCCCCEECCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHH
TMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIIIEVNAPEVPIMDGSASPFVYLLLDAG
HEEEEEEECCCCEEEEHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCEEEEEEHHC
IEELNSAKKFLRLKETVRVEDGDKWAELSPFNGFRLDFTIDFNHPAIDSSTQRYCLDFSA
HHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCH
DSFVRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHK
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEECEEEECCCCCCCHHHHHHHH
MLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDEAEMPLAFKA
HHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCEEEEC
PSTVLAY
CCCEECC
>Mature Secondary Structure
MMIKQRTLKRIVQATGVGLHTGKKVTLTMRPAPANTGVIYRRTDLNPPVDFPADAKSVRD
CCCHHHHHHHHHHHCCCCEECCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHH
TMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIIIEVNAPEVPIMDGSASPFVYLLLDAG
HEEEEEEECCCCEEEEHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCEEEEEEHHC
IEELNSAKKFLRLKETVRVEDGDKWAELSPFNGFRLDFTIDFNHPAIDSSTQRYCLDFSA
HHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCH
DSFVRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHK
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEECEEEECCCCCCCHHHHHHHH
MLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEFVTFQDEAEMPLAFKA
HHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEECCCCCCCEEEEC
PSTVLAY
CCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA