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The map label for this gene is fhuB [H]

Identifier: 170025675

GI number: 170025675

Start: 3799266

End: 3801263

Strand: Reverse

Name: fhuB [H]

Synonym: YPK_3460

Alternate gene names: 170025675

Gene position: 3801263-3799266 (Counterclockwise)

Preceding gene: 170025676

Following gene: 170025673

Centisome position: 81.06

GC content: 54.75

Gene sequence:

>1998_bases
ATGAGCGCCATAAGTTTACGCCAGGGTTGGCGGCTCCCTGCGGGTCTACTTGGCCTACTGGTGGTTATTGCCGTTTCCCT
GACATTTTATAACCTCAGTCAATTACTGCCTTCCTCTCTCTGGTCTGAAGCCCTATGGCGACCTGATCGAGACGATGTAC
GCCAGATGCTATTTCATTACAGCCAATTACCTCGCCTAGCGGTGGCATTACTCACCGGAGCGGGGCTGGGGCTGGTAGGG
GTTTTATTTCAACAAGTTCTGCGTAATCCCCTGGCTGAACCGGCCACTCTGGGGGTTGCTGCGGGTGCCCAGTTAGGGCT
AACGATAGCCACACTGTGGATGTTACCCGGTGGTGAGTTAACCCGGCAACTGGCGGCAATGGCCGGTGGTATGACGGTTG
GGGCACTGGTCTTTGGCGTAGCCTGGGGGAAGCGCCTGTCACCGGTGACATTGATTTTGGCCGGTCTGGTGTTGGGGCTT
TACTGTAGCGCGGTGAGTAACCTACTGGCACTGTTCAATTATGACCAGTTACAGGGGTTGTTTTTGTGGAGCAGTGGCGC
ACTGAATCAGCAGGATTGGAGTACGGTACAGTTTCTGTTACCGCGCTTACTGATTAGCGGCATATTGGCGGCCTTCTTGA
TTCGTCCGTTGACCCTCTTGGGGTTAGATGATGGTGTCGCCCGCAATCTGGGGTTAGGGCTGTCACTGGCCCGCCTGAGT
GCGCTGGGATTAGCCATTATATTCAGCGCCATGTTGGTTAATGCGGTGGGTGTGATTGGTTTTATCGGGCTGTTTGCACC
ATTGTTGGCGAAAATTTTGGGGGCACGGCGCTTATCACAACGTCTGATACTGGCCCCTATTGTAGGGGCATTGCTGCTCT
GGGTGACGGACCAGGGCATCATCTGGCTGACACAAGTCTGGCGAGAGATCCCAACCGGTGCCGCTACGGCGCTGATTGGT
GCGCCATTGTTATTGTGGTTGTTGCCTCGCTTACACAGTACGACTGCGCCAAACATGGATTTGGGTGACTCGGTTCCGGT
AGAGCGGCAGCGTTTAGGATTATGGATCAGTGCGGGTTTGCTGCTGCTGTTGGGGGGATTGATCGTAGCGCTGATGTTTG
GCCGTGATAGCCAAGGTTGGCGCTGGATCGTCGGTGATGAATTACAGGCGCTGTTACATTGGCGCTGGCCACGGGTATTG
GCGGCACTGGCTGCCGGTATGATGCTGGCGGTTGCGGGAACATTAATTCAAAAGTTGACTGGTAACCCGATGGCCAGCCC
GGAAGTGTTGGGTATCAGCTCTGGTGCAGCTTTCGGCGTGGTCATTATGTTGTTTATCGTCCCTGGTAATGCACTGGAAT
GGTTGTTGCCTGCGGGGAGCCTAGGGGCTGCCATCACGCTATTGCTGATCATGGTTGTTGCTGGGCGAGGCGGGTTTTCT
CCGGGCAGGATGCTATTGGCAGGGATTGCATTGAGTACCGCTTTTACCACGGTGATCACCATGTTGCTGGCCAGTGGCGA
CCCACGGATGCGCGGGTTGCTGGCATGGATTTCTGGCTCAACTTATTCTGTTGAGGGCTCACAAGCGTTGACGACAGGCT
TAATTGCCGTGGTGTTGATAGCACTAGCCCCTTTGTGCCGCCGTTGGTTAATGATTTTGCCATTAGGCAGTGTGACCGCC
AGAGCATTAGGGATGGCTCTGGCCCCCAGCCGGTTAGCGATTTTATTATTGGCAGCCACATTGACGGCGGCGGCGACCCT
GACCGTCGGGCCGTTGAGTTTTGTGGGATTGATGGCTCCGCATATGGCCCGGATGCTGGGTTTCCGTCGTGCTATTCCGC
AACTGATTATTGCGGCTATTTTGGGCGGATTATTGATGATATTAGCTGATTGGTGTGGGCGGATGCTGTTGTTCCCAAAT
CAGATCCCCGCAGGCCTATTAGCGACATTTATCGGGGCGCCCTATTTTGTTTATTTGCTGCGCAAACAGGGGCGGTAA

Upstream 100 bases:

>100_bases
AAAACCAATTACGTCTCTTGCCACCGGTTTGGTTCTACGGCGCGACACTGTCAGCTATGCGTTTCGTTCGTTTACTGGAA
CAGGCGTGGGGGAAAGCACC

Downstream 100 bases:

>100_bases
TTTTATCAGGCGAATGCCCTGCTAATTTGACGCCGCCGCGTGACTATTCTGCCTATCCTCACCGTTTCAGATCGCGTCAT
TGAGGGTTGTCAGCAGTCTG

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MSAISLRQGWRLPAGLLGLLVVIAVSLTFYNLSQLLPSSLWSEALWRPDRDDVRQMLFHYSQLPRLAVALLTGAGLGLVG
VLFQQVLRNPLAEPATLGVAAGAQLGLTIATLWMLPGGELTRQLAAMAGGMTVGALVFGVAWGKRLSPVTLILAGLVLGL
YCSAVSNLLALFNYDQLQGLFLWSSGALNQQDWSTVQFLLPRLLISGILAAFLIRPLTLLGLDDGVARNLGLGLSLARLS
ALGLAIIFSAMLVNAVGVIGFIGLFAPLLAKILGARRLSQRLILAPIVGALLLWVTDQGIIWLTQVWREIPTGAATALIG
APLLLWLLPRLHSTTAPNMDLGDSVPVERQRLGLWISAGLLLLLGGLIVALMFGRDSQGWRWIVGDELQALLHWRWPRVL
AALAAGMMLAVAGTLIQKLTGNPMASPEVLGISSGAAFGVVIMLFIVPGNALEWLLPAGSLGAAITLLLIMVVAGRGGFS
PGRMLLAGIALSTAFTTVITMLLASGDPRMRGLLAWISGSTYSVEGSQALTTGLIAVVLIALAPLCRRWLMILPLGSVTA
RALGMALAPSRLAILLLAATLTAAATLTVGPLSFVGLMAPHMARMLGFRRAIPQLIIAAILGGLLMILADWCGRMLLFPN
QIPAGLLATFIGAPYFVYLLRKQGR

Sequences:

>Translated_665_residues
MSAISLRQGWRLPAGLLGLLVVIAVSLTFYNLSQLLPSSLWSEALWRPDRDDVRQMLFHYSQLPRLAVALLTGAGLGLVG
VLFQQVLRNPLAEPATLGVAAGAQLGLTIATLWMLPGGELTRQLAAMAGGMTVGALVFGVAWGKRLSPVTLILAGLVLGL
YCSAVSNLLALFNYDQLQGLFLWSSGALNQQDWSTVQFLLPRLLISGILAAFLIRPLTLLGLDDGVARNLGLGLSLARLS
ALGLAIIFSAMLVNAVGVIGFIGLFAPLLAKILGARRLSQRLILAPIVGALLLWVTDQGIIWLTQVWREIPTGAATALIG
APLLLWLLPRLHSTTAPNMDLGDSVPVERQRLGLWISAGLLLLLGGLIVALMFGRDSQGWRWIVGDELQALLHWRWPRVL
AALAAGMMLAVAGTLIQKLTGNPMASPEVLGISSGAAFGVVIMLFIVPGNALEWLLPAGSLGAAITLLLIMVVAGRGGFS
PGRMLLAGIALSTAFTTVITMLLASGDPRMRGLLAWISGSTYSVEGSQALTTGLIAVVLIALAPLCRRWLMILPLGSVTA
RALGMALAPSRLAILLLAATLTAAATLTVGPLSFVGLMAPHMARMLGFRRAIPQLIIAAILGGLLMILADWCGRMLLFPN
QIPAGLLATFIGAPYFVYLLRKQGR
>Mature_664_residues
SAISLRQGWRLPAGLLGLLVVIAVSLTFYNLSQLLPSSLWSEALWRPDRDDVRQMLFHYSQLPRLAVALLTGAGLGLVGV
LFQQVLRNPLAEPATLGVAAGAQLGLTIATLWMLPGGELTRQLAAMAGGMTVGALVFGVAWGKRLSPVTLILAGLVLGLY
CSAVSNLLALFNYDQLQGLFLWSSGALNQQDWSTVQFLLPRLLISGILAAFLIRPLTLLGLDDGVARNLGLGLSLARLSA
LGLAIIFSAMLVNAVGVIGFIGLFAPLLAKILGARRLSQRLILAPIVGALLLWVTDQGIIWLTQVWREIPTGAATALIGA
PLLLWLLPRLHSTTAPNMDLGDSVPVERQRLGLWISAGLLLLLGGLIVALMFGRDSQGWRWIVGDELQALLHWRWPRVLA
ALAAGMMLAVAGTLIQKLTGNPMASPEVLGISSGAAFGVVIMLFIVPGNALEWLLPAGSLGAAITLLLIMVVAGRGGFSP
GRMLLAGIALSTAFTTVITMLLASGDPRMRGLLAWISGSTYSVEGSQALTTGLIAVVLIALAPLCRRWLMILPLGSVTAR
ALGMALAPSRLAILLLAATLTAAATLTVGPLSFVGLMAPHMARMLGFRRAIPQLIIAAILGGLLMILADWCGRMLLFPNQ
IPAGLLATFIGAPYFVYLLRKQGR

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=645, Percent_Identity=68.3720930232558, Blast_Score=778, Evalue=0.0,
Organism=Escherichia coli, GI1790741, Length=282, Percent_Identity=37.5886524822695, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI1790740, Length=309, Percent_Identity=33.0097087378641, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786805, Length=288, Percent_Identity=34.375, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1786804, Length=322, Percent_Identity=32.2981366459627, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788004, Length=273, Percent_Identity=31.1355311355311, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 70356; Mature: 70225

Theoretical pI: Translated: 11.65; Mature: 11.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAISLRQGWRLPAGLLGLLVVIAVSLTFYNLSQLLPSSLWSEALWRPDRDDVRQMLFHY
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SQLPRLAVALLTGAGLGLVGVLFQQVLRNPLAEPATLGVAAGAQLGLTIATLWMLPGGEL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHCCCHHH
TRQLAAMAGGMTVGALVFGVAWGKRLSPVTLILAGLVLGLYCSAVSNLLALFNYDQLQGL
HHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCEE
FLWSSGALNQQDWSTVQFLLPRLLISGILAAFLIRPLTLLGLDDGVARNLGLGLSLARLS
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHH
ALGLAIIFSAMLVNAVGVIGFIGLFAPLLAKILGARRLSQRLILAPIVGALLLWVTDQGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
IWLTQVWREIPTGAATALIGAPLLLWLLPRLHSTTAPNMDLGDSVPVERQRLGLWISAGL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LLLLGGLIVALMFGRDSQGWRWIVGDELQALLHWRWPRVLAALAAGMMLAVAGTLIQKLT
HHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNPMASPEVLGISSGAAFGVVIMLFIVPGNALEWLLPAGSLGAAITLLLIMVVAGRGGFS
CCCCCCCCEEECCCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
PGRMLLAGIALSTAFTTVITMLLASGDPRMRGLLAWISGSTYSVEGSQALTTGLIAVVLI
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHH
ALAPLCRRWLMILPLGSVTARALGMALAPSRLAILLLAATLTAAATLTVGPLSFVGLMAP
HHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HMARMLGFRRAIPQLIIAAILGGLLMILADWCGRMLLFPNQIPAGLLATFIGAPYFVYLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHH
RKQGR
HHCCC
>Mature Secondary Structure 
SAISLRQGWRLPAGLLGLLVVIAVSLTFYNLSQLLPSSLWSEALWRPDRDDVRQMLFHY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SQLPRLAVALLTGAGLGLVGVLFQQVLRNPLAEPATLGVAAGAQLGLTIATLWMLPGGEL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHCCCHHH
TRQLAAMAGGMTVGALVFGVAWGKRLSPVTLILAGLVLGLYCSAVSNLLALFNYDQLQGL
HHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCEE
FLWSSGALNQQDWSTVQFLLPRLLISGILAAFLIRPLTLLGLDDGVARNLGLGLSLARLS
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHH
ALGLAIIFSAMLVNAVGVIGFIGLFAPLLAKILGARRLSQRLILAPIVGALLLWVTDQGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
IWLTQVWREIPTGAATALIGAPLLLWLLPRLHSTTAPNMDLGDSVPVERQRLGLWISAGL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LLLLGGLIVALMFGRDSQGWRWIVGDELQALLHWRWPRVLAALAAGMMLAVAGTLIQKLT
HHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNPMASPEVLGISSGAAFGVVIMLFIVPGNALEWLLPAGSLGAAITLLLIMVVAGRGGFS
CCCCCCCCEEECCCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
PGRMLLAGIALSTAFTTVITMLLASGDPRMRGLLAWISGSTYSVEGSQALTTGLIAVVLI
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHH
ALAPLCRRWLMILPLGSVTARALGMALAPSRLAILLLAATLTAAATLTVGPLSFVGLMAP
HHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HMARMLGFRRAIPQLIIAAILGGLLMILADWCGRMLLFPNQIPAGLLATFIGAPYFVYLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHH
RKQGR
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]