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The map label for this gene is fhuD [H]

Identifier: 170025676

GI number: 170025676

Start: 3801260

End: 3802312

Strand: Reverse

Name: fhuD [H]

Synonym: YPK_3461

Alternate gene names: 170025676

Gene position: 3802312-3801260 (Counterclockwise)

Preceding gene: 170025677

Following gene: 170025675

Centisome position: 81.08

GC content: 50.24

Gene sequence:

>1053_bases
ATGAAGACACATTTACCCATGGATCTCTCTTCTTCATCGGCTTCGAATTATTTATCGGGTCCAGATTGCTCATCGGATCC
AGATTGTTCAGTAAGGCCAGCTTGTTCATCGGGGCCCGATTATTATCGGCGTCGGCTACTGATGGCATTAACGTTATCGC
CATTACTGCTCTCATTGCCCAGTCTGGTAGCGGCGGCACCGAAGAGCGATCAGCCATTACTCAATATAGACAGAGTGATT
GATATCCAAAGAGATATCGATACTAAAAGGGTCGTCGCACTGGAGTGGCTACCTGTCGAATTGCTACTGGCATTGGGGGT
TACACCGTTTGGTGTCGCTGATATTCATAACTATCGCCTATGGGTTGGGGAGCCTGCTCTGCCGGCGGATGTGATTAATG
TCGGTCAGCGCACTGAACCCAATTTGGAATTACTGCAACAAATGGCTCCATCGCTGATCCTGCTGTCGCAGGGTTATGGC
CCTTCGCCGGAGAAACTTGCGCCTATCGCGCCCACGATGAGTTTTGCGTTTAATGAACAGGGCAGTTCACCGCTGGCTGT
AGGCAAAAACTCATTACAGACATTGGGGCAGCGTTTGGGATTGGAGACGGCTGCGCAACAGCATCTTGCTGATTTTGACC
ATTTTATGCTGGCAGCCCGTGCGCGTTTATCTGGCGACACGCAGACTCCGTTATTAATGTTCTCTCTGTTGGATCCCCGC
CATGCGTTGATTATCGGTAACGGCAGCCTGTTTCAGGATGTATTGAGCACCTTGAATATTGAGAATGCCTGGCAAGGGGA
GACCAATTTTTGGGGCAGCGCGGTGGTGGGTATTGAACGTTTAGCGACGATAAAAACGGCACGTGCAGTGTGTTTCGGCC
ATGGAAATAATGAGATGTTACAGCAGGTTGCACGTACCCCATTATGGCAATCGCTGTCTTTTGTACGAGAAAACCAATTA
CGTCTCTTGCCACCGGTTTGGTTCTACGGCGCGACACTGTCAGCTATGCGTTTCGTTCGTTTACTGGAACAGGCGTGGGG
GAAAGCACCATGA

Upstream 100 bases:

>100_bases
ATAGCCTGATGCAGAGTGCGGTGTTAGAACAAATTTATGGTATCCCAATGGGTATTTTACCGCACCCGGCTGGCGGTGCG
CCGGTAAGTTTTGTTTATTA

Downstream 100 bases:

>100_bases
GCGCCATAAGTTTACGCCAGGGTTGGCGGCTCCCTGCGGGTCTACTTGGCCTACTGGTGGTTATTGCCGTTTCCCTGACA
TTTTATAACCTCAGTCAATT

Product: iron-hydroxamate transporter substrate-binding subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein D; Ferrichrome-binding periplasmic protein; Iron(III)-hydroxamate-binding protein fhuD [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKTHLPMDLSSSSASNYLSGPDCSSDPDCSVRPACSSGPDYYRRRLLMALTLSPLLLSLPSLVAAAPKSDQPLLNIDRVI
DIQRDIDTKRVVALEWLPVELLLALGVTPFGVADIHNYRLWVGEPALPADVINVGQRTEPNLELLQQMAPSLILLSQGYG
PSPEKLAPIAPTMSFAFNEQGSSPLAVGKNSLQTLGQRLGLETAAQQHLADFDHFMLAARARLSGDTQTPLLMFSLLDPR
HALIIGNGSLFQDVLSTLNIENAWQGETNFWGSAVVGIERLATIKTARAVCFGHGNNEMLQQVARTPLWQSLSFVRENQL
RLLPPVWFYGATLSAMRFVRLLEQAWGKAP

Sequences:

>Translated_350_residues
MKTHLPMDLSSSSASNYLSGPDCSSDPDCSVRPACSSGPDYYRRRLLMALTLSPLLLSLPSLVAAAPKSDQPLLNIDRVI
DIQRDIDTKRVVALEWLPVELLLALGVTPFGVADIHNYRLWVGEPALPADVINVGQRTEPNLELLQQMAPSLILLSQGYG
PSPEKLAPIAPTMSFAFNEQGSSPLAVGKNSLQTLGQRLGLETAAQQHLADFDHFMLAARARLSGDTQTPLLMFSLLDPR
HALIIGNGSLFQDVLSTLNIENAWQGETNFWGSAVVGIERLATIKTARAVCFGHGNNEMLQQVARTPLWQSLSFVRENQL
RLLPPVWFYGATLSAMRFVRLLEQAWGKAP
>Mature_350_residues
MKTHLPMDLSSSSASNYLSGPDCSSDPDCSVRPACSSGPDYYRRRLLMALTLSPLLLSLPSLVAAAPKSDQPLLNIDRVI
DIQRDIDTKRVVALEWLPVELLLALGVTPFGVADIHNYRLWVGEPALPADVINVGQRTEPNLELLQQMAPSLILLSQGYG
PSPEKLAPIAPTMSFAFNEQGSSPLAVGKNSLQTLGQRLGLETAAQQHLADFDHFMLAARARLSGDTQTPLLMFSLLDPR
HALIIGNGSLFQDVLSTLNIENAWQGETNFWGSAVVGIERLATIKTARAVCFGHGNNEMLQQVARTPLWQSLSFVRENQL
RLLPPVWFYGATLSAMRFVRLLEQAWGKAP

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrich

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786346, Length=305, Percent_Identity=51.4754098360656, Blast_Score=305, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008091
- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 38334; Mature: 38334

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50983 FE_B12_PBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTHLPMDLSSSSASNYLSGPDCSSDPDCSVRPACSSGPDYYRRRLLMALTLSPLLLSLP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SLVAAAPKSDQPLLNIDRVIDIQRDIDTKRVVALEWLPVELLLALGVTPFGVADIHNYRL
HHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHCCCCCCHHHCCCEEE
WVGEPALPADVINVGQRTEPNLELLQQMAPSLILLSQGYGPSPEKLAPIAPTMSFAFNEQ
EECCCCCCHHHHHCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCC
GSSPLAVGKNSLQTLGQRLGLETAAQQHLADFDHFMLAARARLSGDTQTPLLMFSLLDPR
CCCCHHHCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCCC
HALIIGNGSLFQDVLSTLNIENAWQGETNFWGSAVVGIERLATIKTARAVCFGHGNNEML
EEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCHHHH
QQVARTPLWQSLSFVRENQLRLLPPVWFYGATLSAMRFVRLLEQAWGKAP
HHHHHCCHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKTHLPMDLSSSSASNYLSGPDCSSDPDCSVRPACSSGPDYYRRRLLMALTLSPLLLSLP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SLVAAAPKSDQPLLNIDRVIDIQRDIDTKRVVALEWLPVELLLALGVTPFGVADIHNYRL
HHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHCCCCCCHHHCCCEEE
WVGEPALPADVINVGQRTEPNLELLQQMAPSLILLSQGYGPSPEKLAPIAPTMSFAFNEQ
EECCCCCCHHHHHCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCC
GSSPLAVGKNSLQTLGQRLGLETAAQQHLADFDHFMLAARARLSGDTQTPLLMFSLLDPR
CCCCHHHCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCCC
HALIIGNGSLFQDVLSTLNIENAWQGETNFWGSAVVGIERLATIKTARAVCFGHGNNEML
EEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCHHHH
QQVARTPLWQSLSFVRENQLRLLPPVWFYGATLSAMRFVRLLEQAWGKAP
HHHHHCCHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3301821; 2823072; 8202364; 9278503; 7651325; 10742172 [H]