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The map label for this gene is cysC [H]

Identifier: 170025649

GI number: 170025649

Start: 3766318

End: 3767022

Strand: Reverse

Name: cysC [H]

Synonym: YPK_3434

Alternate gene names: 170025649

Gene position: 3767022-3766318 (Counterclockwise)

Preceding gene: 170025650

Following gene: 170025648

Centisome position: 80.33

GC content: 50.92

Gene sequence:

>705_bases
ATGCCTTGGTTCGCCGTCATTTCCCACATTGGGGTGCGCGTGATCTGCTGGGGGGGAAATAGCGTGCCAGCCCATCAGTT
AGATGACCATAACCAAGAAACGCGGTCAGACGATGAGAATATCGTCTGGCACCCCCATGCGATCACCCGACAGGATCGCG
AACAACAGCACGGTCATCAGGGCGTAGTTCTTTGGTTTACCGGCCTGTCGGGTTCCGGGAAATCCACTCTGGCCGGTGCG
CTGGAACAAGCGTTGTTCGCTCGCGGTGTCAGTACTTACTTACTGGATGGTGATAACGTGCGCCATGGCCTCTGCCGCGA
TTTGGGCTTTTCTGACGCTGATCGTCGTGAAAATATCCGGCGGGTTGGCGAGGTGGCTAAACTGATGGTTGATGCCGGTC
TGGTGGTCTTGACGGCGTTTATTTCCCCTCATCGGGCTGAACGGAAAATGGTACAAGATATGCTGGCATCGGGTCAGTTT
ATTGAGGTATTTGTCGATACGCCGTTAGCAATTTGTGAGGCCCGTGACCCGAAAGGCTTATACAAAAAAGCCCGTGCCGG
AGAGCTTAAAAATTTTACAGGGATCGATTCAGTTTATGAATCGCCTGCGTCTCCTGATATCCATTTGCAGGGTGAACAAT
TAGTAACAAATTTGATTGAACAATTGTTAGACGTACTGCGTGGTAGAGCTATTATCAAATCCTAA

Upstream 100 bases:

>100_bases
CGGCTGAGTAATGTCACTGTCGGTGCGGGGTTGGTCCGTGAAGCGCTGGCGTCGGTTTATCAGGAGAATCATGACTTCAG
TACCTTTGAGCTGGAATTAA

Downstream 100 bases:

>100_bases
ACGTATCCCCTTCGCACTTGACGCTACAGGGTCGTTCGCTGCAGGTATTCACTCGAATCACTGACGTTGTCAGCTAGCCG
TGATTTATTTGCAGCCTACC

Product: adenylylsulfate kinase

Products: NA

Alternate protein names: APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenosine-5'-phosphosulfate kinase [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MPWFAVISHIGVRVICWGGNSVPAHQLDDHNQETRSDDENIVWHPHAITRQDREQQHGHQGVVLWFTGLSGSGKSTLAGA
LEQALFARGVSTYLLDGDNVRHGLCRDLGFSDADRRENIRRVGEVAKLMVDAGLVVLTAFISPHRAERKMVQDMLASGQF
IEVFVDTPLAICEARDPKGLYKKARAGELKNFTGIDSVYESPASPDIHLQGEQLVTNLIEQLLDVLRGRAIIKS

Sequences:

>Translated_234_residues
MPWFAVISHIGVRVICWGGNSVPAHQLDDHNQETRSDDENIVWHPHAITRQDREQQHGHQGVVLWFTGLSGSGKSTLAGA
LEQALFARGVSTYLLDGDNVRHGLCRDLGFSDADRRENIRRVGEVAKLMVDAGLVVLTAFISPHRAERKMVQDMLASGQF
IEVFVDTPLAICEARDPKGLYKKARAGELKNFTGIDSVYESPASPDIHLQGEQLVTNLIEQLLDVLRGRAIIKS
>Mature_233_residues
PWFAVISHIGVRVICWGGNSVPAHQLDDHNQETRSDDENIVWHPHAITRQDREQQHGHQGVVLWFTGLSGSGKSTLAGAL
EQALFARGVSTYLLDGDNVRHGLCRDLGFSDADRRENIRRVGEVAKLMVDAGLVVLTAFISPHRAERKMVQDMLASGQFI
EVFVDTPLAICEARDPKGLYKKARAGELKNFTGIDSVYESPASPDIHLQGEQLVTNLIEQLLDVLRGRAIIKS

Specific function: Catalyzes the synthesis of activated sulfate [H]

COG id: COG0529

COG function: function code P; Adenylylsulfate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the APS kinase family [H]

Homologues:

Organism=Homo sapiens, GI34447231, Length=213, Percent_Identity=46.9483568075117, Blast_Score=198, Evalue=3e-51,
Organism=Homo sapiens, GI62912492, Length=213, Percent_Identity=46.9483568075117, Blast_Score=198, Evalue=4e-51,
Organism=Homo sapiens, GI46094058, Length=200, Percent_Identity=49, Blast_Score=198, Evalue=4e-51,
Organism=Escherichia coli, GI1789107, Length=197, Percent_Identity=80.2030456852792, Blast_Score=330, Evalue=4e-92,
Organism=Caenorhabditis elegans, GI17542422, Length=200, Percent_Identity=49, Blast_Score=194, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6322852, Length=176, Percent_Identity=52.2727272727273, Blast_Score=199, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24667032, Length=174, Percent_Identity=50, Blast_Score=177, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24667028, Length=174, Percent_Identity=50, Blast_Score=177, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24667036, Length=174, Percent_Identity=50, Blast_Score=177, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24667040, Length=174, Percent_Identity=50, Blast_Score=177, Evalue=5e-45,
Organism=Drosophila melanogaster, GI116007838, Length=174, Percent_Identity=50, Blast_Score=177, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24667044, Length=174, Percent_Identity=50, Blast_Score=177, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002891 [H]

Pfam domain/function: PF01583 APS_kinase [H]

EC number: =2.7.1.25 [H]

Molecular weight: Translated: 25912; Mature: 25781

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWFAVISHIGVRVICWGGNSVPAHQLDDHNQETRSDDENIVWHPHAITRQDREQQHGHQ
CCHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHCCCCCCEEECCCHHHHHHHHHHCCCC
GVVLWFTGLSGSGKSTLAGALEQALFARGVSTYLLDGDNVRHGLCRDLGFSDADRRENIR
CEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHEEECCCCCHHHHHHHCCCCCCHHHHHHH
RVGEVAKLMVDAGLVVLTAFISPHRAERKMVQDMLASGQFIEVFVDTPLAICEARDPKGL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCHHH
YKKARAGELKNFTGIDSVYESPASPDIHLQGEQLVTNLIEQLLDVLRGRAIIKS
HHHHHCCCCCCCCCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure 
PWFAVISHIGVRVICWGGNSVPAHQLDDHNQETRSDDENIVWHPHAITRQDREQQHGHQ
CHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHCCCCCCEEECCCHHHHHHHHHHCCCC
GVVLWFTGLSGSGKSTLAGALEQALFARGVSTYLLDGDNVRHGLCRDLGFSDADRRENIR
CEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHEEECCCCCHHHHHHHCCCCCCHHHHHHH
RVGEVAKLMVDAGLVVLTAFISPHRAERKMVQDMLASGQFIEVFVDTPLAICEARDPKGL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCHHH
YKKARAGELKNFTGIDSVYESPASPDIHLQGEQLVTNLIEQLLDVLRGRAIIKS
HHHHHCCCCCCCCCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]