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The map label for this gene is copR [H]

Identifier: 170024423

GI number: 170024423

Start: 2429976

End: 2430668

Strand: Direct

Name: copR [H]

Synonym: YPK_2192

Alternate gene names: 170024423

Gene position: 2429976-2430668 (Clockwise)

Preceding gene: 170024419

Following gene: 170024424

Centisome position: 51.82

GC content: 52.09

Gene sequence:

>693_bases
ATGCGGCTATTGTTGGTAGAAGATGAGGAGAAGACATCTTCGTATATCAATCGCGCCCTCAGCGAGTTGGGCTTTACCGT
CGATGTAGCGGCCACCGGGATCGACGGATTATATCTGGCTCTTGAGTATGATTACGATACGATTGTGCTCGATGTCATGT
TGCCCGGCATGGATGGTTACAGCGTTCTCGAAGGCCTACGCGCCAGCAAACAAACTCCGGTTCTGATGTTATCCGCCCGT
GGCTCGGTTGATGAACGAGTTAAGGGCCTGCGTCACGGTGCCGACGATTATTTGCCTAAGCCTTTTTCGCTGATTGAACT
GGTTGCGCGTATCCAGGCCTTGTTGAGGCGGCGTCCCAGTGATGGTGTAGATGTCAGCCAATTGCACATTAATGATCTAC
ATCTCGACCTGCTGGCAAGGCGTGTCACGCGAGCCGGTGAACGTCTTGAACTCACCGCCAAAGAGTTCGCCCTGTTAAGC
CTGTTAGCCAGACATCAGGGGGAAATTCTGTCAAAAATGATGATTGCAGAGCAGGTCTGGGACATGAATTTTGACAGCGA
TGCTAATGTCGTTGAGGTGGCGATAAAACGCCTGCGGGCGAAAATAGATACGCCCTACCCGGTCAAACTGCTGCATACAG
TGCGAGGCATGGGGTATGTCCTTGAAACTCGCCCCGATCGCCAGACTAAATAG

Upstream 100 bases:

>100_bases
CAAAAATGTCAGGAAAATGTCAGCCTGGTGTTGGTCATGAACAGCTAAGATAGGTGAAATGCGATTTTTGTTGCCCTGAC
GGGTAAAGGGAGAGACGAAC

Downstream 100 bases:

>100_bases
AGAGAGTGATCATGATTAAGCGTTCTATCTCTGGGCGGCTGGCGCTAATGTTTGCCTTGGCCTCCATACTGATAGTTTCG
GCTCTCGGTATTGTACTGCG

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MRLLLVEDEEKTSSYINRALSELGFTVDVAATGIDGLYLALEYDYDTIVLDVMLPGMDGYSVLEGLRASKQTPVLMLSAR
GSVDERVKGLRHGADDYLPKPFSLIELVARIQALLRRRPSDGVDVSQLHINDLHLDLLARRVTRAGERLELTAKEFALLS
LLARHQGEILSKMMIAEQVWDMNFDSDANVVEVAIKRLRAKIDTPYPVKLLHTVRGMGYVLETRPDRQTK

Sequences:

>Translated_230_residues
MRLLLVEDEEKTSSYINRALSELGFTVDVAATGIDGLYLALEYDYDTIVLDVMLPGMDGYSVLEGLRASKQTPVLMLSAR
GSVDERVKGLRHGADDYLPKPFSLIELVARIQALLRRRPSDGVDVSQLHINDLHLDLLARRVTRAGERLELTAKEFALLS
LLARHQGEILSKMMIAEQVWDMNFDSDANVVEVAIKRLRAKIDTPYPVKLLHTVRGMGYVLETRPDRQTK
>Mature_230_residues
MRLLLVEDEEKTSSYINRALSELGFTVDVAATGIDGLYLALEYDYDTIVLDVMLPGMDGYSVLEGLRASKQTPVLMLSAR
GSVDERVKGLRHGADDYLPKPFSLIELVARIQALLRRRPSDGVDVSQLHINDLHLDLLARRVTRAGERLELTAKEFALLS
LLARHQGEILSKMMIAEQVWDMNFDSDANVVEVAIKRLRAKIDTPYPVKLLHTVRGMGYVLETRPDRQTK

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=53.2751091703057, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=52.0547945205479, Blast_Score=237, Evalue=5e-64,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=43.2432432432432, Blast_Score=163, Evalue=8e-42,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=37.4449339207048, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.920704845815, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.8854625550661, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=37.3873873873874, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=34.4036697247706, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=35.2941176470588, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=32.034632034632, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=30.1801801801802, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=28, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=30.0429184549356, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=34.4827586206897, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=38.6138613861386, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=30.6306306306306, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25875; Mature: 25875

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLLVEDEEKTSSYINRALSELGFTVDVAATGIDGLYLALEYDYDTIVLDVMLPGMDGY
CEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEEECCCEEEEEEEECCCCHH
SVLEGLRASKQTPVLMLSARGSVDERVKGLRHGADDYLPKPFSLIELVARIQALLRRRPS
HHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
DGVDVSQLHINDLHLDLLARRVTRAGERLELTAKEFALLSLLARHQGEILSKMMIAEQVW
CCCCHHEEEHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DMNFDSDANVVEVAIKRLRAKIDTPYPVKLLHTVRGMGYVLETRPDRQTK
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCCCC
>Mature Secondary Structure
MRLLLVEDEEKTSSYINRALSELGFTVDVAATGIDGLYLALEYDYDTIVLDVMLPGMDGY
CEEEEECCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEEECCCEEEEEEEECCCCHH
SVLEGLRASKQTPVLMLSARGSVDERVKGLRHGADDYLPKPFSLIELVARIQALLRRRPS
HHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
DGVDVSQLHINDLHLDLLARRVTRAGERLELTAKEFALLSLLARHQGEILSKMMIAEQVW
CCCCHHEEEHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DMNFDSDANVVEVAIKRLRAKIDTPYPVKLLHTVRGMGYVLETRPDRQTK
CCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]