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The map label for this gene is manA [H]

Identifier: 170024223

GI number: 170024223

Start: 2207767

End: 2208846

Strand: Direct

Name: manA [H]

Synonym: YPK_1986

Alternate gene names: 170024223

Gene position: 2207767-2208846 (Clockwise)

Preceding gene: 170024221

Following gene: 170024224

Centisome position: 47.08

GC content: 48.89

Gene sequence:

>1080_bases
ATGGCTGAACTGTGGATGGGTGCGCACCCGAAAAGCAGTTCCCAGGTTATTGACGCAAATGGCCAGTGGCATTCATTACG
TGATGTGATTGATCAAGATCCAGATAACACGCTGGGGAGTGATATTTTCAAGCGCTTTGGTGAACTGCCATTCCTGTTCA
AAGTACTTTGTGCAGCTCAACCTCTATCGATTCAGGTTCACCCGAGCAAAGCGGCAGCAGAGGTCGGTTTTGCTAAAGAA
AACCAGGCAGGTATCCCACTGGATGCGGCTGAGCGCAATTATAAAGATGCGAACCATAAGCCTGAGCTGGTTTATGCCCT
CACCCCTTTTCAGGCAATGAATGGTTTTCGCACACTAGAAGATATCCAGGCGCTGTTACAACCACTAGCAGCGGCACACC
CTGATATTGCCGCGTTCTTGCGCCAACCCGATACTGAGCATTTAGCCAGTTTATTTGCCAGCTTACTCAGTATGAGCGGT
GAGACAAAAACGCGGGCACTCGGTATTCTGAAAGCGGCATTGAATAGCCAACTCGGAGAGCCTTGGGATACGATCCGCAG
CATTTCGTGTTTTTATCCCGATGACAGCGGGTTGTTCTCCCCACTACTGCTTAATGTCGTGACATTGCAACCGGGTGAGG
CCATGTTCCTTTATGCCGAAACACCGCACGCTTACCTCAATGGGGTTGCATTAGAGGTCATGGCAAACTCGGATAATGTG
TTGAGAGCCGGGCTAACGCCGAAGTTTATTGATATTCCAGAGTTAATGTCCAATCTGCAATTTATCCCTAAACCGGCTAA
TGCCCTACTCACAACACCAAAGCAACAGGGTAACGAACTGATATTCCCTATTCCTGTCGAGGACTTCGCTTTCTCACTGC
ATACCTTGGTGGCTGAACCACACGTTCTGGCACAACACAGTGCGGCAATTATTTTTTGTGTTGAAGGCTGTGCGGTGCTG
AAAAAACAAGAGCAAGAAATTACGCTGCACCCTGGTGAGTCTTGCTTCATATCGGCTAAGGAATCACCTGTAACCGTGCA
AGGGGTGGGTTCAATTGCTCGTGTTTATAACGCGGTGTGA

Upstream 100 bases:

>100_bases
AAACATGCTAAAAATGAATAACGCAGTTCAAAACTATGCTTGGGGCAGTACTGATGCCCTGACCCAGCTTTATGGCATAC
CTAACCCACAAGGAATGCCA

Downstream 100 bases:

>100_bases
ACTAACTTAATGAATTTGTTGTCAATAAATAGCTTCTCACCATAAATTGAAGGCTCTGTCGCGATTAAGTCCTTGTTACG
GTCGCGATAATATTTGTGTA

Product: mannose-6-phosphate isomerase, class I

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MAELWMGAHPKSSSQVIDANGQWHSLRDVIDQDPDNTLGSDIFKRFGELPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKE
NQAGIPLDAAERNYKDANHKPELVYALTPFQAMNGFRTLEDIQALLQPLAAAHPDIAAFLRQPDTEHLASLFASLLSMSG
ETKTRALGILKAALNSQLGEPWDTIRSISCFYPDDSGLFSPLLLNVVTLQPGEAMFLYAETPHAYLNGVALEVMANSDNV
LRAGLTPKFIDIPELMSNLQFIPKPANALLTTPKQQGNELIFPIPVEDFAFSLHTLVAEPHVLAQHSAAIIFCVEGCAVL
KKQEQEITLHPGESCFISAKESPVTVQGVGSIARVYNAV

Sequences:

>Translated_359_residues
MAELWMGAHPKSSSQVIDANGQWHSLRDVIDQDPDNTLGSDIFKRFGELPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKE
NQAGIPLDAAERNYKDANHKPELVYALTPFQAMNGFRTLEDIQALLQPLAAAHPDIAAFLRQPDTEHLASLFASLLSMSG
ETKTRALGILKAALNSQLGEPWDTIRSISCFYPDDSGLFSPLLLNVVTLQPGEAMFLYAETPHAYLNGVALEVMANSDNV
LRAGLTPKFIDIPELMSNLQFIPKPANALLTTPKQQGNELIFPIPVEDFAFSLHTLVAEPHVLAQHSAAIIFCVEGCAVL
KKQEQEITLHPGESCFISAKESPVTVQGVGSIARVYNAV
>Mature_358_residues
AELWMGAHPKSSSQVIDANGQWHSLRDVIDQDPDNTLGSDIFKRFGELPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKEN
QAGIPLDAAERNYKDANHKPELVYALTPFQAMNGFRTLEDIQALLQPLAAAHPDIAAFLRQPDTEHLASLFASLLSMSGE
TKTRALGILKAALNSQLGEPWDTIRSISCFYPDDSGLFSPLLLNVVTLQPGEAMFLYAETPHAYLNGVALEVMANSDNVL
RAGLTPKFIDIPELMSNLQFIPKPANALLTTPKQQGNELIFPIPVEDFAFSLHTLVAEPHVLAQHSAAIIFCVEGCAVLK
KQEQEITLHPGESCFISAKESPVTVQGVGSIARVYNAV

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=371, Percent_Identity=36.9272237196765, Blast_Score=194, Evalue=1e-49,
Organism=Escherichia coli, GI1787899, Length=359, Percent_Identity=71.5877437325905, Blast_Score=522, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI71997620, Length=364, Percent_Identity=32.4175824175824, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17557650, Length=299, Percent_Identity=31.438127090301, Blast_Score=124, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6320839, Length=393, Percent_Identity=32.3155216284987, Blast_Score=173, Evalue=4e-44,
Organism=Drosophila melanogaster, GI21356061, Length=357, Percent_Identity=30.2521008403361, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 39049; Mature: 38918

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00965 PMI_I_1 ; PS00966 PMI_I_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELWMGAHPKSSSQVIDANGQWHSLRDVIDQDPDNTLGSDIFKRFGELPFLFKVLCAAQ
CCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCC
PLSIQVHPSKAAAEVGFAKENQAGIPLDAAERNYKDANHKPELVYALTPFQAMNGFRTLE
CCEEEECCCHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCHHHHCCCCHHH
DIQALLQPLAAAHPDIAAFLRQPDTEHLASLFASLLSMSGETKTRALGILKAALNSQLGE
HHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
PWDTIRSISCFYPDDSGLFSPLLLNVVTLQPGEAMFLYAETPHAYLNGVALEVMANSDNV
CHHHHCCEEEECCCCCCCHHHHHHEEEEECCCCEEEEEECCCHHHHCCEEEEEEECCCCE
LRAGLTPKFIDIPELMSNLQFIPKPANALLTTPKQQGNELIFPIPVEDFAFSLHTLVAEP
EEECCCCCEECHHHHHHCCEECCCCCHHEEECCHHCCCEEEEECCHHHHHHHHHHHHCCC
HVLAQHSAAIIFCVEGCAVLKKQEQEITLHPGESCFISAKESPVTVQGVGSIARVYNAV
HHHHCCCCEEEEEECCHHHHHCCCCEEEECCCCCEEEECCCCCEEEEHHHHHHHHHHCC
>Mature Secondary Structure 
AELWMGAHPKSSSQVIDANGQWHSLRDVIDQDPDNTLGSDIFKRFGELPFLFKVLCAAQ
CCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCC
PLSIQVHPSKAAAEVGFAKENQAGIPLDAAERNYKDANHKPELVYALTPFQAMNGFRTLE
CCEEEECCCHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCHHHHCCCCHHH
DIQALLQPLAAAHPDIAAFLRQPDTEHLASLFASLLSMSGETKTRALGILKAALNSQLGE
HHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
PWDTIRSISCFYPDDSGLFSPLLLNVVTLQPGEAMFLYAETPHAYLNGVALEVMANSDNV
CHHHHCCEEEECCCCCCCHHHHHHEEEEECCCCEEEEEECCCHHHHCCEEEEEEECCCCE
LRAGLTPKFIDIPELMSNLQFIPKPANALLTTPKQQGNELIFPIPVEDFAFSLHTLVAEP
EEECCCCCEECHHHHHHCCEECCCCCHHEEECCHHCCCEEEEECCHHHHHHHHHHHHCCC
HVLAQHSAAIIFCVEGCAVLKKQEQEITLHPGESCFISAKESPVTVQGVGSIARVYNAV
HHHHCCCCEEEEEECCHHHHHCCCCEEEECCCCCEEEECCCCCEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1879695; 11677609 [H]