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The map label for this gene is uraA [H]

Identifier: 170023595

GI number: 170023595

Start: 1493850

End: 1495136

Strand: Direct

Name: uraA [H]

Synonym: YPK_1353

Alternate gene names: 170023595

Gene position: 1493850-1495136 (Clockwise)

Preceding gene: 170023594

Following gene: 170023596

Centisome position: 31.86

GC content: 50.12

Gene sequence:

>1287_bases
ATGAGCCGTCGCACCATTGGTGTTAGCGAACGACCACCGCTGCTTCAAACAATTCCCCTGAGTTTTCAACATTTATTCGC
TATGTTTGGTGCCACAGTTTTAGTTCCTATTCTGTTTAAAATTAACCCGGCGACCGTGCTGTTGTTCAATGGTATTGGTA
CGTTGCTCTATTTATTTATCTGTAAGGGCAAAATTCCGGCGTATTTGGGGTCCAGTTTTGCTTTTATCTCACCGGTATTG
CTGTTGTTGCCGCTGGGGTATGAAGTCGCGTTAGGCGGTTTTATCATGTGTGGCCTGCTGTTCTGTCTGGTGGCGCTAAT
TGTAAAAAAAGCGGGGACCGGGTGGCTGGATGTCATCTTCCCTCCGGCAGCTATGGGGGCGATTGTCGCGGTTATCGGCT
TGGAGTTGGCCGGGGTTGCTGCGGGTATGGCGGGGCTACTGCCTGCTGAGGGCGTAACGGCAGATTCAACGACCATCACC
ATTTCACTGGTGACCTTAGGGGTAACCATTCTGGGTTCGGTGCTGTTCCGCGGCTTCTTCGCGATTATCCCTATTTTGAT
TGGGGTGTTGGTGGGCTATACCTTATCATTCGTTATGGGCGTGGTTGATCTAACACCAATTCGTGATGCTCATTGGTTCG
CGTTGCCCACTTTCTATACTCCACGTTTTGAGTGGTTTGCCATTTTAACTATTCTGCCTGCGGCGTTAGTGGTGATTGCC
GAACATGTTGGGCATTTAGTGGTAACGGCCAATATCGTGAAAAAAGATCTGATCCGCGATCCGGGCCTGCACCGCTCCAT
GTTTGCCAACGGCATTTCTACGGTGATTTCGGGTTTCTTCGGTTCCACACCCAATACCACTTACGGTGAGAATATCGGTG
TTATGGCGATCACCAAGGTTTACAGTACTTGGGTGATTGGCGGTGCCGCTATTCTGGCGATTATGCTGTCCTGTGTGGGT
AAACTGGCGGCGGCGATCCAAGCCGTACCGGTACCGGTCATGGGCGGTGTTTCTCTGCTGTTGTATGGTGTCATTGGTGC
GTCGGGTATTCGTGTCCTGATCGAGTCAAAAGTTGACTATAACAAAGCACAAAACCTGATTTTAACCTCGGTTATTCTGA
TTATCGGAGTGAGCGGGGCGAAAGTGAACATCGGCGCAACCGAATTGAAAGGCATGGCGTTAGCGACCGTGGTTGGGATC
GGTCTGAGCCTGTTGTTCAAAGTGATCAGCTTGATTCGCACGGAAGAAGAAATTATTGATGTGCAGGACGAAAAGCCCAC
GCATTGA

Upstream 100 bases:

>100_bases
TTTTTTTTGATTTTTTATATAGCGCTAAACAAGACAACACTAAACAAGACAACACTAAACAAGACAACACTGTATAACCC
TGATTAAGAGGATCGAAATA

Downstream 100 bases:

>100_bases
TTGAAGTTGATACTGGTCGGGGCTGATATTGAACGCTGCAGATATTGATCGGTTATTGATACGGATCTGCATGGGTATGA
GCTCTGTTGTATCAATAATA

Product: uracil transporter

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSRRTIGVSERPPLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVL
LLLPLGYEVALGGFIMCGLLFCLVALIVKKAGTGWLDVIFPPAAMGAIVAVIGLELAGVAAGMAGLLPAEGVTADSTTIT
ISLVTLGVTILGSVLFRGFFAIIPILIGVLVGYTLSFVMGVVDLTPIRDAHWFALPTFYTPRFEWFAILTILPAALVVIA
EHVGHLVVTANIVKKDLIRDPGLHRSMFANGISTVISGFFGSTPNTTYGENIGVMAITKVYSTWVIGGAAILAIMLSCVG
KLAAAIQAVPVPVMGGVSLLLYGVIGASGIRVLIESKVDYNKAQNLILTSVILIIGVSGAKVNIGATELKGMALATVVGI
GLSLLFKVISLIRTEEEIIDVQDEKPTH

Sequences:

>Translated_428_residues
MSRRTIGVSERPPLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVL
LLLPLGYEVALGGFIMCGLLFCLVALIVKKAGTGWLDVIFPPAAMGAIVAVIGLELAGVAAGMAGLLPAEGVTADSTTIT
ISLVTLGVTILGSVLFRGFFAIIPILIGVLVGYTLSFVMGVVDLTPIRDAHWFALPTFYTPRFEWFAILTILPAALVVIA
EHVGHLVVTANIVKKDLIRDPGLHRSMFANGISTVISGFFGSTPNTTYGENIGVMAITKVYSTWVIGGAAILAIMLSCVG
KLAAAIQAVPVPVMGGVSLLLYGVIGASGIRVLIESKVDYNKAQNLILTSVILIIGVSGAKVNIGATELKGMALATVVGI
GLSLLFKVISLIRTEEEIIDVQDEKPTH
>Mature_427_residues
SRRTIGVSERPPLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVLL
LLPLGYEVALGGFIMCGLLFCLVALIVKKAGTGWLDVIFPPAAMGAIVAVIGLELAGVAAGMAGLLPAEGVTADSTTITI
SLVTLGVTILGSVLFRGFFAIIPILIGVLVGYTLSFVMGVVDLTPIRDAHWFALPTFYTPRFEWFAILTILPAALVVIAE
HVGHLVVTANIVKKDLIRDPGLHRSMFANGISTVISGFFGSTPNTTYGENIGVMAITKVYSTWVIGGAAILAIMLSCVGK
LAAAIQAVPVPVMGGVSLLLYGVIGASGIRVLIESKVDYNKAQNLILTSVILIIGVSGAKVNIGATELKGMALATVVGIG
LSLLFKVISLIRTEEEIIDVQDEKPTH

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=224, Percent_Identity=28.125, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI40316845, Length=224, Percent_Identity=28.125, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI44680145, Length=234, Percent_Identity=26.9230769230769, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI44680143, Length=234, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1788843, Length=428, Percent_Identity=88.5514018691589, Blast_Score=753, Evalue=0.0,
Organism=Escherichia coli, GI87081818, Length=434, Percent_Identity=36.6359447004608, Blast_Score=257, Evalue=8e-70,
Organism=Escherichia coli, GI87082181, Length=391, Percent_Identity=27.1099744245524, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790087, Length=407, Percent_Identity=25.0614250614251, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI87082178, Length=367, Percent_Identity=24.7956403269755, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17541904, Length=223, Percent_Identity=25.5605381165919, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17542262, Length=223, Percent_Identity=24.6636771300448, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17558856, Length=179, Percent_Identity=27.3743016759777, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356175, Length=430, Percent_Identity=24.6511627906977, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45060; Mature: 44929

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRTIGVSERPPLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGIGTLLYLFI
CCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEHHHHHHHHHHH
CKGKIPAYLGSSFAFISPVLLLLPLGYEVALGGFIMCGLLFCLVALIVKKAGTGWLDVIF
HCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
PPAAMGAIVAVIGLELAGVAAGMAGLLPAEGVTADSTTITISLVTLGVTILGSVLFRGFF
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
AIIPILIGVLVGYTLSFVMGVVDLTPIRDAHWFALPTFYTPRFEWFAILTILPAALVVIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHH
EHVGHLVVTANIVKKDLIRDPGLHRSMFANGISTVISGFFGSTPNTTYGENIGVMAITKV
HHHCHHEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
YSTWVIGGAAILAIMLSCVGKLAAAIQAVPVPVMGGVSLLLYGVIGASGIRVLIESKVDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCH
NKAQNLILTSVILIIGVSGAKVNIGATELKGMALATVVGIGLSLLFKVISLIRTEEEIID
HHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHC
VQDEKPTH
CCCCCCCC
>Mature Secondary Structure 
SRRTIGVSERPPLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGIGTLLYLFI
CCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEHHHHHHHHHHH
CKGKIPAYLGSSFAFISPVLLLLPLGYEVALGGFIMCGLLFCLVALIVKKAGTGWLDVIF
HCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
PPAAMGAIVAVIGLELAGVAAGMAGLLPAEGVTADSTTITISLVTLGVTILGSVLFRGFF
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
AIIPILIGVLVGYTLSFVMGVVDLTPIRDAHWFALPTFYTPRFEWFAILTILPAALVVIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHH
EHVGHLVVTANIVKKDLIRDPGLHRSMFANGISTVISGFFGSTPNTTYGENIGVMAITKV
HHHCHHEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
YSTWVIGGAAILAIMLSCVGKLAAAIQAVPVPVMGGVSLLLYGVIGASGIRVLIESKVDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCH
NKAQNLILTSVILIIGVSGAKVNIGATELKGMALATVVGIGLSLLFKVISLIRTEEEIID
HHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHC
VQDEKPTH
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]