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The map label for this gene is caiD [C]

Identifier: 169630936

GI number: 169630936

Start: 3902780

End: 3903556

Strand: Reverse

Name: caiD [C]

Synonym: MAB_3857c

Alternate gene names: 169630936

Gene position: 3903556-3902780 (Counterclockwise)

Preceding gene: 169630937

Following gene: 169630935

Centisome position: 77.04

GC content: 68.98

Gene sequence:

>777_bases
ATGAGTGAAGAGATGCAGCCGGCGGTCCGGGTGGAGAAGGCGGGCCCGGTGACAACGGTCATTCTCAATCGGCCGCATGC
GCGCAACGCCGTCGACGGGCCGACCGCGGCGGCGCTGCTCGCGGCGTTCACCGAGTTCGACGCGGATCCCGAGGCGTCGG
TGGCGGTGCTGTGGGGTGACAACGGAACCTTCTGTGCTGGAGCTGATCTCAAGGCGATGGGGACCGACCGCGGTAACGAA
CTGCACCCGCATGGCCCAGGTCCGATGGGCCCTTCGCGGTTGCGGCTGTCCAAACCGGTGATCGCGGCGATATCGGGGCA
CGCCGTCGCCGGCGGGATCGAGCTCGCGTTGTGGTGCGACCTTCGGGTGGTCGAGGAGGACGCCGTGCTGGGTGTGTTCT
GCCGGCGTTGGGGCGTTCCGCTCATCGACGGTGGCACGATCAGGCTGCCGCGGCTGATCGGGCACTCGCGTGCGATGGAT
CTCATCCTGACCGGGCGTCCCGTCCACGCGAATGAGGCGCTGGACATCGGGCTCGTCAACCGCGTGGTCGCGCGTGGTCA
GGCGCGTGAGGCTGCCGAGACACTGGCTGCCGAGATCGCTGCCTTCCCGCAACAGTGCGTGCGTGCCGACCGTGATTCGG
CCATCGCGCAGTGGGGGATGGCCGAGGAAGCGGCACTGGACAACGAGTTTGGCAGCATCGAGCGCGTCGCAACGGAGGCG
CTGGAGGGTGCGGGTCGGTTCGCCGCGGGTGAGGGCCGGCATGGAGCCGGGGTCTGA

Upstream 100 bases:

>100_bases
CGGCTGATTGGCCTGCTGACGAAATGCGTGCCCGTTACCGGGAATTCAAGGATGAGCTAGTGACCCTGCGGGATACCGCC
GAGATGGAAGAAGCCTCGCT

Downstream 100 bases:

>100_bases
CACACCCGGCTCCAGGCACCGACACACTTCGCACATATCGGTGACGCGCAAGACGCGGACGTACTGTGGACACCGTGACT
GTGCGGATGCTCCCGGTTTC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MSEEMQPAVRVEKAGPVTTVILNRPHARNAVDGPTAAALLAAFTEFDADPEASVAVLWGDNGTFCAGADLKAMGTDRGNE
LHPHGPGPMGPSRLRLSKPVIAAISGHAVAGGIELALWCDLRVVEEDAVLGVFCRRWGVPLIDGGTIRLPRLIGHSRAMD
LILTGRPVHANEALDIGLVNRVVARGQAREAAETLAAEIAAFPQQCVRADRDSAIAQWGMAEEAALDNEFGSIERVATEA
LEGAGRFAAGEGRHGAGV

Sequences:

>Translated_258_residues
MSEEMQPAVRVEKAGPVTTVILNRPHARNAVDGPTAAALLAAFTEFDADPEASVAVLWGDNGTFCAGADLKAMGTDRGNE
LHPHGPGPMGPSRLRLSKPVIAAISGHAVAGGIELALWCDLRVVEEDAVLGVFCRRWGVPLIDGGTIRLPRLIGHSRAMD
LILTGRPVHANEALDIGLVNRVVARGQAREAAETLAAEIAAFPQQCVRADRDSAIAQWGMAEEAALDNEFGSIERVATEA
LEGAGRFAAGEGRHGAGV
>Mature_257_residues
SEEMQPAVRVEKAGPVTTVILNRPHARNAVDGPTAAALLAAFTEFDADPEASVAVLWGDNGTFCAGADLKAMGTDRGNEL
HPHGPGPMGPSRLRLSKPVIAAISGHAVAGGIELALWCDLRVVEEDAVLGVFCRRWGVPLIDGGTIRLPRLIGHSRAMDL
ILTGRPVHANEALDIGLVNRVVARGQAREAAETLAAEIAAFPQQCVRADRDSAIAQWGMAEEAALDNEFGSIERVATEAL
EGAGRFAAGEGRHGAGV

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=208, Percent_Identity=33.1730769230769, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI70995211, Length=193, Percent_Identity=33.160621761658, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI68989263, Length=136, Percent_Identity=38.9705882352941, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI20127408, Length=178, Percent_Identity=30.8988764044944, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4502327, Length=193, Percent_Identity=32.6424870466321, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI31542718, Length=231, Percent_Identity=24.6753246753247, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI213417737, Length=217, Percent_Identity=26.2672811059908, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI157694516, Length=217, Percent_Identity=26.2672811059908, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI221142681, Length=198, Percent_Identity=33.8383838383838, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787659, Length=243, Percent_Identity=34.156378600823, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788597, Length=184, Percent_Identity=30.4347826086957, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788682, Length=142, Percent_Identity=41.5492957746479, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790281, Length=201, Percent_Identity=27.363184079602, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787660, Length=205, Percent_Identity=32.1951219512195, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560910, Length=242, Percent_Identity=47.1074380165289, Blast_Score=214, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17540714, Length=170, Percent_Identity=34.7058823529412, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17554946, Length=205, Percent_Identity=35.1219512195122, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25145438, Length=220, Percent_Identity=32.2727272727273, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17534483, Length=190, Percent_Identity=34.7368421052632, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17558304, Length=182, Percent_Identity=31.8681318681319, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17508951, Length=246, Percent_Identity=32.9268292682927, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25144276, Length=246, Percent_Identity=32.9268292682927, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508953, Length=214, Percent_Identity=34.5794392523364, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17540306, Length=202, Percent_Identity=28.2178217821782, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21357171, Length=212, Percent_Identity=50.4716981132076, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24650670, Length=261, Percent_Identity=44.8275862068966, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24653139, Length=188, Percent_Identity=35.1063829787234, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI20129971, Length=188, Percent_Identity=36.1702127659575, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24653477, Length=188, Percent_Identity=36.1702127659575, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24583077, Length=179, Percent_Identity=32.9608938547486, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583079, Length=179, Percent_Identity=32.9608938547486, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921000, Length=179, Percent_Identity=32.9608938547486, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 27029; Mature: 26898

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEMQPAVRVEKAGPVTTVILNRPHARNAVDGPTAAALLAAFTEFDADPEASVAVLWGD
CCCCCCCHHEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECC
NGTFCAGADLKAMGTDRGNELHPHGPGPMGPSRLRLSKPVIAAISGHAVAGGIELALWCD
CCCEEECCCCEECCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCEEECCEEEEEEEE
LRVVEEDAVLGVFCRRWGVPLIDGGTIRLPRLIGHSRAMDLILTGRPVHANEALDIGLVN
EEEECCCHHHHHHHHHCCCCEECCCCEEEHHHHCCCHHEEEEEECCCCCCCCCHHHHHHH
RVVARGQAREAAETLAAEIAAFPQQCVRADRDSAIAQWGMAEEAALDNEFGSIERVATEA
HHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHCCCCHHHHHHHHHH
LEGAGRFAAGEGRHGAGV
HHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SEEMQPAVRVEKAGPVTTVILNRPHARNAVDGPTAAALLAAFTEFDADPEASVAVLWGD
CCCCCCHHEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECC
NGTFCAGADLKAMGTDRGNELHPHGPGPMGPSRLRLSKPVIAAISGHAVAGGIELALWCD
CCCEEECCCCEECCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCEEECCEEEEEEEE
LRVVEEDAVLGVFCRRWGVPLIDGGTIRLPRLIGHSRAMDLILTGRPVHANEALDIGLVN
EEEECCCHHHHHHHHHCCCCEECCCCEEEHHHHCCCHHEEEEEECCCCCCCCCHHHHHHH
RVVARGQAREAAETLAAEIAAFPQQCVRADRDSAIAQWGMAEEAALDNEFGSIERVATEA
HHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHCCCCHHHHHHHHHH
LEGAGRFAAGEGRHGAGV
HHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA