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The map label for this gene is rocD [H]

Identifier: 169630920

GI number: 169630920

Start: 3886643

End: 3887887

Strand: Direct

Name: rocD [H]

Synonym: MAB_3841

Alternate gene names: 169630920

Gene position: 3886643-3887887 (Clockwise)

Preceding gene: 169630919

Following gene: 169630921

Centisome position: 76.7

GC content: 64.34

Gene sequence:

>1245_bases
GTGACCGTCACGGAGGCCCCCGGCATGTCGCCCGATTCATACAAGAGCGCTGAGTACATCGAGTTGGCCGAGCAATACGG
CGCGCACAACTATGCGCCACTACCGGTCGTCGCCCACCGGGCCGAGGGCGCGTGGATCGAGGATGTGGACGGTAAGCGAT
ACCTGGACTGTCTGGCCGCCTACTCGGCCGTGAACTTCGGCCACGGGAATCCCGAAATCCTCGCGACCTCGCACGCCCAG
CTCGACACGGTGACACTGGTGAGCCGGGCGTTTCATTCGGATCGCCTCGGTAGGTTCTGCCGCGACCTCGCCCGGCTCTG
CGGCAAGGGCATGGTGCTGCCGATGAACACCGGGGCCGAGGCCGTCGAGAGCGGTATCAAGGTGGCCCGTAAATGGGGCA
CCGACGTCAAGGGCGTGCCGGTGGATCAGGCCAATATCGTGGTGGCACACAATAACTTCCACGGTCGAACCATCAGCATC
GTGAGCTTCTCCTCCGATGAGACCGCGCGCGGCGGATTCGGACCGTTCACTCCCGGATTCCGCATCGTGCCATTCGGCGA
TGCCGCCGCCCTGGAGCGGGCGATCGACGGCAACACCGTCGCCGTCCTGCTGGAGCCCGTTCAGGGCGAGGCCGGCATCG
TCATCCCGCCGGACGACTACCTGCCCGCCGTCCGCGCACTGTGCACCGAGAACAATGTTCTGTTCATCGCCGACGAAATC
CAGGCGGGTCTCGCCCGCACCGGACGAATGTTTGCCTGCGACCACTGGAACGTTGTTCCCGACGTCTATCTGTTGGGCAA
GGCACTCGGTGGTGGCGTGGTTCCCGTCTCGGCGGTAGTAGCCGATGCCGATGTGCTCGGCGTGCTGCATCCCGGCGAGC
ACGGCTCCACCTTCGGTGGAAATCCTTTGGGCGCAGCCATCGGATCTACCGTTGTGGCAATCCTTGAACGCGGCGAATTC
CAGCGCCGGGCTTCCGTTCTGGGGCGGCACCTACGCACCCGCCTAGATGCTCTGATCGGCCACGGCGTCACCGAGGTACG
CTCGCTAGGGCTGTGGGCAGGAGTCGACATAGACCCGAATCTGGCAACGGGAAGACAAATCGGTCTGCGCATGGCAGAGT
TTGGCGTCTTAGTGAAGGACACGCACGGTGCGACGCTCCGGTTCGCGCCACCCCTTGTCATCACCGAGGGCGAAATCGAT
TGGGCGGTAGACCAGTTCGCTGATGCGCTGGCCAGCTTCCGGTAG

Upstream 100 bases:

>100_bases
AACAGCTCCGCGACTCCGGGTTCGAACCGATCGGCATCGATCTTTCCGAACTCCTCAAGGGTGGCGGATCGGTCAAATGC
TGCACACTGGAGCTGCACTC

Downstream 100 bases:

>100_bases
CTTTCGCCCCGCCACAGGAGGCAACATGGCACCTTCGTCACCCAGCCTTGCCCAGCAACTGCTGCGGCGCCGTCCGACCT
CGGGTGCTCCCACCGCCCAC

Product: ornithine aminotransferase RocD1

Products: NA

Alternate protein names: OAT; Ornithine--oxo-acid aminotransferase [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MTVTEAPGMSPDSYKSAEYIELAEQYGAHNYAPLPVVAHRAEGAWIEDVDGKRYLDCLAAYSAVNFGHGNPEILATSHAQ
LDTVTLVSRAFHSDRLGRFCRDLARLCGKGMVLPMNTGAEAVESGIKVARKWGTDVKGVPVDQANIVVAHNNFHGRTISI
VSFSSDETARGGFGPFTPGFRIVPFGDAAALERAIDGNTVAVLLEPVQGEAGIVIPPDDYLPAVRALCTENNVLFIADEI
QAGLARTGRMFACDHWNVVPDVYLLGKALGGGVVPVSAVVADADVLGVLHPGEHGSTFGGNPLGAAIGSTVVAILERGEF
QRRASVLGRHLRTRLDALIGHGVTEVRSLGLWAGVDIDPNLATGRQIGLRMAEFGVLVKDTHGATLRFAPPLVITEGEID
WAVDQFADALASFR

Sequences:

>Translated_414_residues
MTVTEAPGMSPDSYKSAEYIELAEQYGAHNYAPLPVVAHRAEGAWIEDVDGKRYLDCLAAYSAVNFGHGNPEILATSHAQ
LDTVTLVSRAFHSDRLGRFCRDLARLCGKGMVLPMNTGAEAVESGIKVARKWGTDVKGVPVDQANIVVAHNNFHGRTISI
VSFSSDETARGGFGPFTPGFRIVPFGDAAALERAIDGNTVAVLLEPVQGEAGIVIPPDDYLPAVRALCTENNVLFIADEI
QAGLARTGRMFACDHWNVVPDVYLLGKALGGGVVPVSAVVADADVLGVLHPGEHGSTFGGNPLGAAIGSTVVAILERGEF
QRRASVLGRHLRTRLDALIGHGVTEVRSLGLWAGVDIDPNLATGRQIGLRMAEFGVLVKDTHGATLRFAPPLVITEGEID
WAVDQFADALASFR
>Mature_413_residues
TVTEAPGMSPDSYKSAEYIELAEQYGAHNYAPLPVVAHRAEGAWIEDVDGKRYLDCLAAYSAVNFGHGNPEILATSHAQL
DTVTLVSRAFHSDRLGRFCRDLARLCGKGMVLPMNTGAEAVESGIKVARKWGTDVKGVPVDQANIVVAHNNFHGRTISIV
SFSSDETARGGFGPFTPGFRIVPFGDAAALERAIDGNTVAVLLEPVQGEAGIVIPPDDYLPAVRALCTENNVLFIADEIQ
AGLARTGRMFACDHWNVVPDVYLLGKALGGGVVPVSAVVADADVLGVLHPGEHGSTFGGNPLGAAIGSTVVAILERGEFQ
RRASVLGRHLRTRLDALIGHGVTEVRSLGLWAGVDIDPNLATGRQIGLRMAEFGVLVKDTHGATLRFAPPLVITEGEIDW
AVDQFADALASFR

Specific function: Catalyzes the interconversion of ornithine to glutamate semialdehyde [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=400, Percent_Identity=48.5, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI284507298, Length=301, Percent_Identity=50.1661129568106, Blast_Score=281, Evalue=6e-76,
Organism=Homo sapiens, GI13994255, Length=462, Percent_Identity=24.6753246753247, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI37574042, Length=424, Percent_Identity=25.9433962264151, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI226442705, Length=424, Percent_Identity=25.7075471698113, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI24119277, Length=405, Percent_Identity=27.1604938271605, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI226442709, Length=389, Percent_Identity=25.4498714652956, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1789759, Length=387, Percent_Identity=33.5917312661499, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI145693181, Length=382, Percent_Identity=34.0314136125654, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI1788044, Length=389, Percent_Identity=34.4473007712082, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1787560, Length=404, Percent_Identity=31.9306930693069, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1789016, Length=412, Percent_Identity=25.9708737864078, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1786991, Length=398, Percent_Identity=28.894472361809, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1786349, Length=289, Percent_Identity=28.3737024221453, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=402, Percent_Identity=44.2786069651741, Blast_Score=359, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI25144274, Length=273, Percent_Identity=42.8571428571429, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI71981843, Length=175, Percent_Identity=46.8571428571429, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=24.367816091954, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71992977, Length=420, Percent_Identity=25.2380952380952, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17541228, Length=431, Percent_Identity=22.5058004640371, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=421, Percent_Identity=44.4180522565321, Blast_Score=349, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6324432, Length=388, Percent_Identity=28.3505154639175, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324386, Length=411, Percent_Identity=25.0608272506083, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357415, Length=381, Percent_Identity=48.2939632545932, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI28574759, Length=468, Percent_Identity=26.9230769230769, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI161085790, Length=466, Percent_Identity=25.9656652360515, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21356575, Length=424, Percent_Identity=25.2358490566038, Blast_Score=118, Evalue=7e-27,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.13 [H]

Molecular weight: Translated: 43962; Mature: 43831

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTEAPGMSPDSYKSAEYIELAEQYGAHNYAPLPVVAHRAEGAWIEDVDGKRYLDCLAA
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCEEECCCCHHHHHHHHH
YSAVNFGHGNPEILATSHAQLDTVTLVSRAFHSDRLGRFCRDLARLCGKGMVLPMNTGAE
HHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
AVESGIKVARKWGTDVKGVPVDQANIVVAHNNFHGRTISIVSFSSDETARGGFGPFTPGF
HHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCC
RIVPFGDAAALERAIDGNTVAVLLEPVQGEAGIVIPPDDYLPAVRALCTENNVLFIADEI
EEEECCCHHHHHHHCCCCEEEEEEEECCCCCCEEECCCCHHHHHHHHHCCCCEEEEEHHH
QAGLARTGRMFACDHWNVVPDVYLLGKALGGGVVPVSAVVADADVLGVLHPGEHGSTFGG
HHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHCCCCEEEEECCCCCCCCCCC
NPLGAAIGSTVVAILERGEFQRRASVLGRHLRTRLDALIGHGVTEVRSLGLWAGVDIDPN
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEEECCCCCCC
LATGRQIGLRMAEFGVLVKDTHGATLRFAPPLVITEGEIDWAVDQFADALASFR
CCCCHHHHHHHHHCCEEEEECCCCEEEECCCEEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVTEAPGMSPDSYKSAEYIELAEQYGAHNYAPLPVVAHRAEGAWIEDVDGKRYLDCLAA
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCEEECCCCHHHHHHHHH
YSAVNFGHGNPEILATSHAQLDTVTLVSRAFHSDRLGRFCRDLARLCGKGMVLPMNTGAE
HHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
AVESGIKVARKWGTDVKGVPVDQANIVVAHNNFHGRTISIVSFSSDETARGGFGPFTPGF
HHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCC
RIVPFGDAAALERAIDGNTVAVLLEPVQGEAGIVIPPDDYLPAVRALCTENNVLFIADEI
EEEECCCHHHHHHHCCCCEEEEEEEECCCCCCEEECCCCHHHHHHHHHCCCCEEEEEHHH
QAGLARTGRMFACDHWNVVPDVYLLGKALGGGVVPVSAVVADADVLGVLHPGEHGSTFGG
HHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHCCCCEEEEECCCCCCCCCCC
NPLGAAIGSTVVAILERGEFQRRASVLGRHLRTRLDALIGHGVTEVRSLGLWAGVDIDPN
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCEEECCCCCCC
LATGRQIGLRMAEFGVLVKDTHGATLRFAPPLVITEGEIDWAVDQFADALASFR
CCCCHHHHHHHHHCCEEEEECCCCEEEECCCEEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA