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The map label for this gene is guaB [C]

Identifier: 169630799

GI number: 169630799

Start: 3776102

End: 3777238

Strand: Reverse

Name: guaB [C]

Synonym: MAB_3720c

Alternate gene names: 169630799

Gene position: 3777238-3776102 (Counterclockwise)

Preceding gene: 169630800

Following gene: 169630798

Centisome position: 74.54

GC content: 66.75

Gene sequence:

>1137_bases
ATGCGTGACCTGGTCGAAATCGGCATGGGCAGAACCGCCCGTCGCACCTATGAACTCGATGATGTGAACATCGTCCCGTC
GCGCCGCACGCGTTCCTCGCAGGACGTGTCGACGGCGTGGCAGCTCGATGCCTACCGTTTCGAGATTCCTGTGGTGGCGC
ATCCGACCGATGCGCTGGTTTCGCCGCGCTTTGCCATCGAACTGGGTAAGGCCGGCGGGCTCGGCGTCATCAACGGCGAG
GGACTGTGGGGCCGGCACGCCGATGTCGAGGCCCGTATCGCCGAGGTGGTCGAGGTCGCGCAGAAGGAGCCGGAGCCCTC
CGCCGCTATTCGCCTGTTGCAGCAATTGCATTCGGCCCCAATCGATCCCGATCTATTGGCTGCGGCCATCGCCGAGGTGC
GCGGGGCCGGGGTGACCACCGCGGTGCGGGTGAGTCCGCAGAACGCGCAGCTACTCACCCCGCATCTGATTGCCGCGGGC
ATCGACCTGCTGGTCATTCACGGCACCATCGTGTCGGCCGAGCGGGTGGCCCGCGACGGCGAGCCGCTGAACCTGAAAAC
CTTTATTTCCGAACTGGATATCCCCGTTGTTGCCGGTGGCGTGATCGATCACCGCACGGCCCTGCACCTGATGCGAACCG
GAGCCGCGGGCGTCATCGTCGGGTATGGGCAGACCGCGGGCGCGACCACCAGCAGTGAGGTGCTGGGCGTCAGCGTCGCC
ATGGCGACCGCCATTGCCGATGCCGCTGCTGCCCGCCGCGAGTACCTCGATGAGACCGGCGGCCGGTACGTGCACGTGTT
GGCCGACGGTGACATCCACACCTCTGGAGACCTGGCCAAGTCGATCGCCTGTGGCGCCGATGCCGTCGTACTGGGGACCC
CGCTGGCCGCGGCGCAGGAAGCCGCCGGTGACGGATGGTTCTGGCCGAACGCGGCCGCGCATCCATCCCTGCCGCGCGGC
GCGCTGCTGCAGGTGGCGGTGGGGGAGCGGCCGCCATTGAGCGAGGTACTCGCGGGGCCCTCCGACGATCCGTTTGGCAC
CTTGAATCTTGTTGGTGGGCTCCGCCGTTCGATGGCCAAGTCCGGATATTGCGATCTCAAGGAGTTCCAGAAGGTCGGAC
TGACCGTCAACTCTTAG

Upstream 100 bases:

>100_bases
CGGCGGGGCTCAAGGAGAGCCATCCGCATGACATCACCATGACGGCCGAAGCGCCGAACTACTACGTGCGTTAACTGTCG
GCACGGCAAAGGAAGTCAAC

Downstream 100 bases:

>100_bases
ACATGTGTCTATTTAGGGTGACCTAATTTACAATACCCCCCTGGTTGTATTTCATACTGGTCGGTAACGTGACCACGCGG
AGGTAGGCCAACGATGTCAT

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MRDLVEIGMGRTARRTYELDDVNIVPSRRTRSSQDVSTAWQLDAYRFEIPVVAHPTDALVSPRFAIELGKAGGLGVINGE
GLWGRHADVEARIAEVVEVAQKEPEPSAAIRLLQQLHSAPIDPDLLAAAIAEVRGAGVTTAVRVSPQNAQLLTPHLIAAG
IDLLVIHGTIVSAERVARDGEPLNLKTFISELDIPVVAGGVIDHRTALHLMRTGAAGVIVGYGQTAGATTSSEVLGVSVA
MATAIADAAAARREYLDETGGRYVHVLADGDIHTSGDLAKSIACGADAVVLGTPLAAAQEAAGDGWFWPNAAAHPSLPRG
ALLQVAVGERPPLSEVLAGPSDDPFGTLNLVGGLRRSMAKSGYCDLKEFQKVGLTVNS

Sequences:

>Translated_378_residues
MRDLVEIGMGRTARRTYELDDVNIVPSRRTRSSQDVSTAWQLDAYRFEIPVVAHPTDALVSPRFAIELGKAGGLGVINGE
GLWGRHADVEARIAEVVEVAQKEPEPSAAIRLLQQLHSAPIDPDLLAAAIAEVRGAGVTTAVRVSPQNAQLLTPHLIAAG
IDLLVIHGTIVSAERVARDGEPLNLKTFISELDIPVVAGGVIDHRTALHLMRTGAAGVIVGYGQTAGATTSSEVLGVSVA
MATAIADAAAARREYLDETGGRYVHVLADGDIHTSGDLAKSIACGADAVVLGTPLAAAQEAAGDGWFWPNAAAHPSLPRG
ALLQVAVGERPPLSEVLAGPSDDPFGTLNLVGGLRRSMAKSGYCDLKEFQKVGLTVNS
>Mature_378_residues
MRDLVEIGMGRTARRTYELDDVNIVPSRRTRSSQDVSTAWQLDAYRFEIPVVAHPTDALVSPRFAIELGKAGGLGVINGE
GLWGRHADVEARIAEVVEVAQKEPEPSAAIRLLQQLHSAPIDPDLLAAAIAEVRGAGVTTAVRVSPQNAQLLTPHLIAAG
IDLLVIHGTIVSAERVARDGEPLNLKTFISELDIPVVAGGVIDHRTALHLMRTGAAGVIVGYGQTAGATTSSEVLGVSVA
MATAIADAAAARREYLDETGGRYVHVLADGDIHTSGDLAKSIACGADAVVLGTPLAAAQEAAGDGWFWPNAAAHPSLPRG
ALLQVAVGERPPLSEVLAGPSDDPFGTLNLVGGLRRSMAKSGYCDLKEFQKVGLTVNS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

None

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 39501; Mature: 39501

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDLVEIGMGRTARRTYELDDVNIVPSRRTRSSQDVSTAWQLDAYRFEIPVVAHPTDALV
CCCHHHHCCCCCCCEEEECCCCEECCCCCCCCCCCCCHHEEECEEEEEEEEEECCCHHHH
SPRFAIELGKAGGLGVINGEGLWGRHADVEARIAEVVEVAQKEPEPSAAIRLLQQLHSAP
CCCEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
IDPDLLAAAIAEVRGAGVTTAVRVSPQNAQLLTPHLIAAGIDLLVIHGTIVSAERVARDG
CCHHHHHHHHHHHCCCCCEEEEEECCCCCEEECHHHHHCCCEEEEEECCHHHHHHHHCCC
EPLNLKTFISELDIPVVAGGVIDHRTALHLMRTGAAGVIVGYGQTAGATTSSEVLGVSVA
CCCCHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHH
MATAIADAAAARREYLDETGGRYVHVLADGDIHTSGDLAKSIACGADAVVLGTPLAAAQE
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEECCCHHHHHH
AAGDGWFWPNAAAHPSLPRGALLQVAVGERPPLSEVLAGPSDDPFGTLNLVGGLRRSMAK
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHH
SGYCDLKEFQKVGLTVNS
CCCCCHHHHHHCCCEECC
>Mature Secondary Structure
MRDLVEIGMGRTARRTYELDDVNIVPSRRTRSSQDVSTAWQLDAYRFEIPVVAHPTDALV
CCCHHHHCCCCCCCEEEECCCCEECCCCCCCCCCCCCHHEEECEEEEEEEEEECCCHHHH
SPRFAIELGKAGGLGVINGEGLWGRHADVEARIAEVVEVAQKEPEPSAAIRLLQQLHSAP
CCCEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
IDPDLLAAAIAEVRGAGVTTAVRVSPQNAQLLTPHLIAAGIDLLVIHGTIVSAERVARDG
CCHHHHHHHHHHHCCCCCEEEEEECCCCCEEECHHHHHCCCEEEEEECCHHHHHHHHCCC
EPLNLKTFISELDIPVVAGGVIDHRTALHLMRTGAAGVIVGYGQTAGATTSSEVLGVSVA
CCCCHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHH
MATAIADAAAARREYLDETGGRYVHVLADGDIHTSGDLAKSIACGADAVVLGTPLAAAQE
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEECCCHHHHHH
AAGDGWFWPNAAAHPSLPRGALLQVAVGERPPLSEVLAGPSDDPFGTLNLVGGLRRSMAK
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHH
SGYCDLKEFQKVGLTVNS
CCCCCHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA