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The map label for this gene is guaB [H]

Identifier: 169630800

GI number: 169630800

Start: 3777265

End: 3778788

Strand: Reverse

Name: guaB [H]

Synonym: MAB_3721c

Alternate gene names: 169630800

Gene position: 3778788-3777265 (Counterclockwise)

Preceding gene: 169630802

Following gene: 169630799

Centisome position: 74.57

GC content: 67.06

Gene sequence:

>1524_bases
ATGACCATTGCGGCAGGGTCCGTCCACACCGGCGGCGACGACCCGCACAAGGTCGCGATGCTCGGGTTGACGTTTGACGA
CGTGCTGTTGCTGCCGGCGGCATCGGATGTGCTTCCGGCGGGTGCGGACACCTCGTCGCAACTGACCAAGCGGATCAGAC
TGAACGTTCCGCTGGTCAGTTCGGCGATGGACACGGTGACCGAGGCGCGGATGGCCATCGCGATGGCTCGCGCCGGGGGC
ATGGGTGTGCTGCACCGCAATCTCTCGGTGGAAGACCAGGCGGGCCAGGTGGAGACCGTGAAGCGGTCGGAGGCCGGGAT
GGTGACCAACCCGGTGACCTGCTCGCCCGCGAACACCCTCGCCGAGGTGGACGCGCTGTGCGCGCGGTTCCGTATTTCGG
GCCTGCCGGTGGTGGACGCGCAGGGCGCACTCGTGGGGATCATCACCAACCGCGATATGCGGTTCGAGGCCGACCTGTCC
AAGCCCGTCGCCGAGGTGATGACCAAGGCTCCGTTGATCACCGCTCGTGAAGGTGTCACCGCGGACGCGGCGCTGGGCCT
GTTGCGGCGCAACAAGATCGAGAAGCTGCCCATCGTCGATGGCGAGGGCCGGCTCACCGGACTGATCACCGTCAAGGACT
TCGCGAAGACCGAGCAGCACCCCAACGCCACCAAGGACAGCGACGGGCGCCTGCTGGTCGGTGCGGCGGTCGGCGTGGGT
GAAGATGCCTGGACGCGTGCCATGTCGCTGGTGGACGCGGGTGTCGACGTGCTGATCGTGGATACCGCCCATGCGCATAA
CCGCAAGGTGCTCGACATGGTGGGCAAGCTCAAGGCCGAGGTCGGCGAGCGCGTCGACGTGGTCGGTGGAAATGTGGCGA
CCCGATCGGCGGCGGCCGCGCTGGTCGAGGCGGGCGCCGACGCGGTGAAGGTCGGTGTGGGCCCCGGCTCCATCTGCACC
ACGCGTGTGGTTGCTGGTGTGGGTGCACCGCAGATCACCGCGATCCTGGAGGCGGCGACGGTGTGTCATCCGGCCGGTGT
TCCCGTGATCGCCGACGGCGGCATGCAGTATTCGGGCGATATCGCCAAGGCGCTCGCGGCGGGTGCGTCCACCACGATGC
TGGGGTCGCTGCTGGCCGGTACGGCCGAGTCGCCCGGTGAGCTGATCTTTGTCAACGGCAAGCAGTTCAAGAGCTACCGC
GGCATGGGGTCCATGGGTGCCATGCAGGGCCGTGGTGCGACCAAGTCCTATTCGAAGGACCGCTACTTCCAGGACGACGT
GCTGTCCGAGGACAAGCTGGTGCCGGAGGGCATCGAGGGCCGGGTTCCCTTCCGTGGTCCGTTGTCGACCGTCATGCATC
AGCTGACGGGCGGTCTGCGCGCGGCCATGGGGTACACCGGGGCGTCGAGCATCGAGGAACTGCAGCGCGCTCAGTTCGTA
CAGATCACCGCGGCGGGGCTCAAGGAGAGCCATCCGCATGACATCACCATGACGGCCGAAGCGCCGAACTACTACGTGCG
TTAA

Upstream 100 bases:

>100_bases
CGGAGTCTCAGCGAGCCGATAGGATGGATGCACTCCTTCCTCGTTGCGCGCCCGTTGCGCACCGGGATGTATCCGACGGC
TATCTGGCATGGAGGCGTGA

Downstream 100 bases:

>100_bases
CTGTCGGCACGGCAAAGGAAGTCAACATGCGTGACCTGGTCGAAATCGGCATGGGCAGAACCGCCCGTCGCACCTATGAA
CTCGATGATGTGAACATCGT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MTIAAGSVHTGGDDPHKVAMLGLTFDDVLLLPAASDVLPAGADTSSQLTKRIRLNVPLVSSAMDTVTEARMAIAMARAGG
MGVLHRNLSVEDQAGQVETVKRSEAGMVTNPVTCSPANTLAEVDALCARFRISGLPVVDAQGALVGIITNRDMRFEADLS
KPVAEVMTKAPLITAREGVTADAALGLLRRNKIEKLPIVDGEGRLTGLITVKDFAKTEQHPNATKDSDGRLLVGAAVGVG
EDAWTRAMSLVDAGVDVLIVDTAHAHNRKVLDMVGKLKAEVGERVDVVGGNVATRSAAAALVEAGADAVKVGVGPGSICT
TRVVAGVGAPQITAILEAATVCHPAGVPVIADGGMQYSGDIAKALAAGASTTMLGSLLAGTAESPGELIFVNGKQFKSYR
GMGSMGAMQGRGATKSYSKDRYFQDDVLSEDKLVPEGIEGRVPFRGPLSTVMHQLTGGLRAAMGYTGASSIEELQRAQFV
QITAAGLKESHPHDITMTAEAPNYYVR

Sequences:

>Translated_507_residues
MTIAAGSVHTGGDDPHKVAMLGLTFDDVLLLPAASDVLPAGADTSSQLTKRIRLNVPLVSSAMDTVTEARMAIAMARAGG
MGVLHRNLSVEDQAGQVETVKRSEAGMVTNPVTCSPANTLAEVDALCARFRISGLPVVDAQGALVGIITNRDMRFEADLS
KPVAEVMTKAPLITAREGVTADAALGLLRRNKIEKLPIVDGEGRLTGLITVKDFAKTEQHPNATKDSDGRLLVGAAVGVG
EDAWTRAMSLVDAGVDVLIVDTAHAHNRKVLDMVGKLKAEVGERVDVVGGNVATRSAAAALVEAGADAVKVGVGPGSICT
TRVVAGVGAPQITAILEAATVCHPAGVPVIADGGMQYSGDIAKALAAGASTTMLGSLLAGTAESPGELIFVNGKQFKSYR
GMGSMGAMQGRGATKSYSKDRYFQDDVLSEDKLVPEGIEGRVPFRGPLSTVMHQLTGGLRAAMGYTGASSIEELQRAQFV
QITAAGLKESHPHDITMTAEAPNYYVR
>Mature_506_residues
TIAAGSVHTGGDDPHKVAMLGLTFDDVLLLPAASDVLPAGADTSSQLTKRIRLNVPLVSSAMDTVTEARMAIAMARAGGM
GVLHRNLSVEDQAGQVETVKRSEAGMVTNPVTCSPANTLAEVDALCARFRISGLPVVDAQGALVGIITNRDMRFEADLSK
PVAEVMTKAPLITAREGVTADAALGLLRRNKIEKLPIVDGEGRLTGLITVKDFAKTEQHPNATKDSDGRLLVGAAVGVGE
DAWTRAMSLVDAGVDVLIVDTAHAHNRKVLDMVGKLKAEVGERVDVVGGNVATRSAAAALVEAGADAVKVGVGPGSICTT
RVVAGVGAPQITAILEAATVCHPAGVPVIADGGMQYSGDIAKALAAGASTTMLGSLLAGTAESPGELIFVNGKQFKSYRG
MGSMGAMQGRGATKSYSKDRYFQDDVLSEDKLVPEGIEGRVPFRGPLSTVMHQLTGGLRAAMGYTGASSIEELQRAQFVQ
ITAAGLKESHPHDITMTAEAPNYYVR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=465, Percent_Identity=41.7204301075269, Blast_Score=329, Evalue=4e-90,
Organism=Homo sapiens, GI66933016, Length=461, Percent_Identity=42.0824295010846, Blast_Score=328, Evalue=7e-90,
Organism=Homo sapiens, GI34328928, Length=465, Percent_Identity=41.7204301075269, Blast_Score=328, Evalue=8e-90,
Organism=Homo sapiens, GI156616279, Length=465, Percent_Identity=41.7204301075269, Blast_Score=328, Evalue=8e-90,
Organism=Homo sapiens, GI34328930, Length=465, Percent_Identity=41.7204301075269, Blast_Score=328, Evalue=1e-89,
Organism=Homo sapiens, GI217035152, Length=460, Percent_Identity=41.5217391304348, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI217035148, Length=465, Percent_Identity=41.0752688172043, Blast_Score=318, Evalue=1e-86,
Organism=Homo sapiens, GI217035150, Length=465, Percent_Identity=39.3548387096774, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI50541956, Length=276, Percent_Identity=33.3333333333333, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI50541954, Length=276, Percent_Identity=33.3333333333333, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI50541952, Length=276, Percent_Identity=33.3333333333333, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI50541948, Length=276, Percent_Identity=33.3333333333333, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI156104880, Length=269, Percent_Identity=33.8289962825279, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1788855, Length=490, Percent_Identity=55.1020408163265, Blast_Score=480, Evalue=1e-137,
Organism=Escherichia coli, GI1786293, Length=240, Percent_Identity=35.4166666666667, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=480, Percent_Identity=34.7916666666667, Blast_Score=254, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI71994389, Length=433, Percent_Identity=36.4896073903002, Blast_Score=248, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI17560440, Length=266, Percent_Identity=35.3383458646617, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323585, Length=459, Percent_Identity=41.3943355119826, Blast_Score=339, Evalue=5e-94,
Organism=Saccharomyces cerevisiae, GI6322012, Length=484, Percent_Identity=39.0495867768595, Blast_Score=328, Evalue=9e-91,
Organism=Saccharomyces cerevisiae, GI6323464, Length=484, Percent_Identity=40.0826446280992, Blast_Score=326, Evalue=6e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=339, Percent_Identity=38.3480825958702, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=115, Percent_Identity=42.6086956521739, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=41.0309278350515, Blast_Score=334, Evalue=7e-92,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=41.0309278350515, Blast_Score=334, Evalue=7e-92,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=39.8190045248869, Blast_Score=298, Evalue=6e-81,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52585; Mature: 52454

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAAGSVHTGGDDPHKVAMLGLTFDDVLLLPAASDVLPAGADTSSQLTKRIRLNVPLVS
CEEECCCCCCCCCCCCEEEEEEECHHHEEEECCCCCCCCCCCCCHHHHHHHHEECCCHHH
SAMDTVTEARMAIAMARAGGMGVLHRNLSVEDQAGQVETVKRSEAGMVTNPVTCSPANTL
HHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHCCCCCEECCCCCCCHHHH
AEVDALCARFRISGLPVVDAQGALVGIITNRDMRFEADLSKPVAEVMTKAPLITAREGVT
HHHHHHHHHHHCCCCCEEECCCCEEEEEECCCEEEECCHHHHHHHHHHCCCCEEECCCCC
ADAALGLLRRNKIEKLPIVDGEGRLTGLITVKDFAKTEQHPNATKDSDGRLLVGAAVGVG
HHHHHHHHHHCCCCCCCEECCCCCEEEEEEEHHHHHCCCCCCCCCCCCCCEEEEEECCCC
EDAWTRAMSLVDAGVDVLIVDTAHAHNRKVLDMVGKLKAEVGERVDVVGGNVATRSAAAA
CHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHH
LVEAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAATVCHPAGVPVIADGGMQYSGD
HHHCCCCEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEECCCCEECCH
IAKALAAGASTTMLGSLLAGTAESPGELIFVNGKQFKSYRGMGSMGAMQGRGATKSYSKD
HHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECHHHHHHCCCCCCCCCCCCCCCCCCCCC
RYFQDDVLSEDKLVPEGIEGRVPFRGPLSTVMHQLTGGLRAAMGYTGASSIEELQRAQFV
CCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHEE
QITAAGLKESHPHDITMTAEAPNYYVR
EEEECCCCCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
TIAAGSVHTGGDDPHKVAMLGLTFDDVLLLPAASDVLPAGADTSSQLTKRIRLNVPLVS
EEECCCCCCCCCCCCEEEEEEECHHHEEEECCCCCCCCCCCCCHHHHHHHHEECCCHHH
SAMDTVTEARMAIAMARAGGMGVLHRNLSVEDQAGQVETVKRSEAGMVTNPVTCSPANTL
HHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHCCCCCEECCCCCCCHHHH
AEVDALCARFRISGLPVVDAQGALVGIITNRDMRFEADLSKPVAEVMTKAPLITAREGVT
HHHHHHHHHHHCCCCCEEECCCCEEEEEECCCEEEECCHHHHHHHHHHCCCCEEECCCCC
ADAALGLLRRNKIEKLPIVDGEGRLTGLITVKDFAKTEQHPNATKDSDGRLLVGAAVGVG
HHHHHHHHHHCCCCCCCEECCCCCEEEEEEEHHHHHCCCCCCCCCCCCCCEEEEEECCCC
EDAWTRAMSLVDAGVDVLIVDTAHAHNRKVLDMVGKLKAEVGERVDVVGGNVATRSAAAA
CHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHH
LVEAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAATVCHPAGVPVIADGGMQYSGD
HHHCCCCEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEECCCCEECCH
IAKALAAGASTTMLGSLLAGTAESPGELIFVNGKQFKSYRGMGSMGAMQGRGATKSYSKD
HHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECHHHHHHCCCCCCCCCCCCCCCCCCCCC
RYFQDDVLSEDKLVPEGIEGRVPFRGPLSTVMHQLTGGLRAAMGYTGASSIEELQRAQFV
CCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHEE
QITAAGLKESHPHDITMTAEAPNYYVR
EEEECCCCCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]