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The map label for this gene is sdhA [H]

Identifier: 169630754

GI number: 169630754

Start: 3726937

End: 3728703

Strand: Direct

Name: sdhA [H]

Synonym: MAB_3675

Alternate gene names: 169630754

Gene position: 3726937-3728703 (Clockwise)

Preceding gene: 169630753

Following gene: 169630755

Centisome position: 73.55

GC content: 64.69

Gene sequence:

>1767_bases
ATGGGTTCCCCCATCATTCAGGAACATCGGTACGACGTTGTCATCATCGGCGCGGGCGGTGCGGGTATGCGCGCCGCCGT
GGAGGCCGGACCCCGAGCTCGTACTGCGGTACTGACCAAGCTGTACCCGACACGTAGCCACACCGGGGCAGCCCAGGGCG
GCATGTGCGCCGCGCTGGCCAACGTCGAAGAAGACAACTGGGAATGGCACACCTTCGACACCGTCAAGGGTGGCGACTAC
CTCGCCGACCAGGATGCCGTGGAGATCATGTGCAAGGAGGCGATCGACGCCGTCCTCGATCTCGAAAAGATGGGTATGCC
GTTCAACCGGACACCCCAGGGCAGAATCGATCAGCGCCGCTTCGGTGGCCACACTCGCGATCACGGTAAGGCGCCGGTAC
GCCGGGCCTGCTACGCCGCTGACCGCACCGGGCACATGATCCTGCAGACGCTGTACCAAAACTGCGTCAAGCACGATGTC
GAGTTCTTCAACGAGTTCTACGCACTGGACATCGCACTCACCGAGACGCCGAACGGCCCGGTGGCCACCGGCGTCGTCGC
CTACGAGCTGGCGACCGGCGATATCCACGTGTTCCACGCCAAGGCAATTGTTTTCGCCACCGGCGGCTCGGGCCGTATGT
ACAAGACCACCTCCAACGCGCACACCCTGACCGGCGACGGCCTGGGCATCGTGTTCCGCAAGGGACTTCCGTTGGAGGAC
ATGGAATTCCACCAGTTCCACCCGACAGGCCTTGCCGGCCTGGGAATTCTGATCTCCGAAGCCGTCCGTGGGGAGGGTGG
CCGTCTGCTCAACGCCGACGGCGAGCGCTTCATGGAGCGCTATGCCCCCACCATCGTTGACCTCGCGCCTCGCGACATCG
TCGCGCGGTCAATGGTTCTCGAAGTGCTCGAAGGCCGCGGCGCCGGACCGAACAAGGACTACGTCTACATTGACGTGCGT
CATCTCGGTGCGGACGTGCTGGAAGCCAAGCTGCCGGACATCACCGAATTCGCGCGCACCTACCTGGGCGTCGACCCGGT
GACCGAGCTGGTTCCGGTGTACCCCACCTGCCACTACGTGATGGGCGGTATCCCGACCAACATCCACGGCCAGGTGCTAC
GCGACAACGACAACGTGGTTCCCGGCCTGTACGCGGCCGGCGAATGCGCCTGCGTGTCGGTGCACGGCGCCAACCGGCTG
GGCACCAACTCGCTGCTGGACATCAACGTGTTCGGTCGGCGGGCGGGCATCGCCGCGGCCGAGTACGCCGAGGCCCACGA
CTTCATCGATCTACCGGAGAACCCGGCGACGATGGTCACCGAATGGGTGGCGGACGTGCTGTCCGAGCACGGCGACGAGC
GGGTGGCCGACATCCGCACCGAGCTGCAGCAGTCGATGGACAACAATGCCGCGGTGTTCCGTACCGAAGACACCCTCAAG
CAGGCGCTCAACGACATCCACGCGCTGAAGGAGCGGTACAGCCGAATCACGGTGCACGACAAGGGCAAGCGCTACAACAG
CGACCTGCTTGAGGCCATCGAGCTCGGCTTCCTGCTCGAGCTCGCCGAGGTGACCGTGGTGGGCGCGCTCAACCGCAAGG
AATCGCGTGGCGGCCACGCCCGCGAGGACTACCCCAACCGCGACGACACCAACTACATGCGACACACCATGGCGTACAAG
CAGGGTGCCGAGCTGCTGTCCGACATCCGGCTGGACTACAAGCCCGTTGTCCAGACCCGGTACGAGCCGATGGAACGGAA
GTACTGA

Upstream 100 bases:

>100_bases
CTCAATTGCTTGCTGGCACTGTCGATCATCTTCACGGTTGTGCTCGGCACGTACGTCCTGCTGACCTTCAACCCGAACAT
CGGTTAGGGGCTTTTTCACT

Downstream 100 bases:

>100_bases
GATGACTGCGGTTATCGAGAAAGCCGAAGCAGGCGACCCGCCGCTGCCTCCGGTCCCCGAGGGCGCGGTCATGGTGGATC
TGAAGATCCAGCGTTTCAAC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MGSPIIQEHRYDVVIIGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGAAQGGMCAALANVEEDNWEWHTFDTVKGGDY
LADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPQGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDV
EFFNEFYALDIALTETPNGPVATGVVAYELATGDIHVFHAKAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLED
MEFHQFHPTGLAGLGILISEAVRGEGGRLLNADGERFMERYAPTIVDLAPRDIVARSMVLEVLEGRGAGPNKDYVYIDVR
HLGADVLEAKLPDITEFARTYLGVDPVTELVPVYPTCHYVMGGIPTNIHGQVLRDNDNVVPGLYAAGECACVSVHGANRL
GTNSLLDINVFGRRAGIAAAEYAEAHDFIDLPENPATMVTEWVADVLSEHGDERVADIRTELQQSMDNNAAVFRTEDTLK
QALNDIHALKERYSRITVHDKGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDTNYMRHTMAYK
QGAELLSDIRLDYKPVVQTRYEPMERKY

Sequences:

>Translated_588_residues
MGSPIIQEHRYDVVIIGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGAAQGGMCAALANVEEDNWEWHTFDTVKGGDY
LADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPQGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDV
EFFNEFYALDIALTETPNGPVATGVVAYELATGDIHVFHAKAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLED
MEFHQFHPTGLAGLGILISEAVRGEGGRLLNADGERFMERYAPTIVDLAPRDIVARSMVLEVLEGRGAGPNKDYVYIDVR
HLGADVLEAKLPDITEFARTYLGVDPVTELVPVYPTCHYVMGGIPTNIHGQVLRDNDNVVPGLYAAGECACVSVHGANRL
GTNSLLDINVFGRRAGIAAAEYAEAHDFIDLPENPATMVTEWVADVLSEHGDERVADIRTELQQSMDNNAAVFRTEDTLK
QALNDIHALKERYSRITVHDKGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDTNYMRHTMAYK
QGAELLSDIRLDYKPVVQTRYEPMERKY
>Mature_587_residues
GSPIIQEHRYDVVIIGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGAAQGGMCAALANVEEDNWEWHTFDTVKGGDYL
ADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPQGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVE
FFNEFYALDIALTETPNGPVATGVVAYELATGDIHVFHAKAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLEDM
EFHQFHPTGLAGLGILISEAVRGEGGRLLNADGERFMERYAPTIVDLAPRDIVARSMVLEVLEGRGAGPNKDYVYIDVRH
LGADVLEAKLPDITEFARTYLGVDPVTELVPVYPTCHYVMGGIPTNIHGQVLRDNDNVVPGLYAAGECACVSVHGANRLG
TNSLLDINVFGRRAGIAAAEYAEAHDFIDLPENPATMVTEWVADVLSEHGDERVADIRTELQQSMDNNAAVFRTEDTLKQ
ALNDIHALKERYSRITVHDKGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDTNYMRHTMAYKQ
GAELLSDIRLDYKPVVQTRYEPMERKY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=565, Percent_Identity=47.6106194690266, Blast_Score=507, Evalue=1e-144,
Organism=Escherichia coli, GI1786942, Length=585, Percent_Identity=48.5470085470085, Blast_Score=514, Evalue=1e-147,
Organism=Escherichia coli, GI1790597, Length=572, Percent_Identity=39.3356643356643, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1788928, Length=554, Percent_Identity=33.7545126353791, Blast_Score=238, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI17550100, Length=576, Percent_Identity=47.7430555555556, Blast_Score=523, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17505833, Length=523, Percent_Identity=49.9043977055449, Blast_Score=510, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6322701, Length=586, Percent_Identity=48.4641638225256, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6322416, Length=586, Percent_Identity=48.8054607508532, Blast_Score=523, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6320788, Length=487, Percent_Identity=28.952772073922, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17137288, Length=576, Percent_Identity=47.3958333333333, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24655642, Length=576, Percent_Identity=47.3958333333333, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24655647, Length=576, Percent_Identity=47.3958333333333, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24663005, Length=601, Percent_Identity=45.757071547421, Blast_Score=483, Evalue=1e-136,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64843; Mature: 64712

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSPIIQEHRYDVVIIGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGAAQGGMCAALA
CCCCCCCCCCCCEEEEECCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEC
NVEEDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPQGRIDQRR
CCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
FGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFNEFYALDIALTETPNGP
CCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCC
VATGVVAYELATGDIHVFHAKAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLED
EEECEEEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCEEEEECCCCCCC
MEFHQFHPTGLAGLGILISEAVRGEGGRLLNADGERFMERYAPTIVDLAPRDIVARSMVL
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHH
EVLEGRGAGPNKDYVYIDVRHLGADVLEAKLPDITEFARTYLGVDPVTELVPVYPTCHYV
HHHHCCCCCCCCCEEEEEHHHCCHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCHHHH
MGGIPTNIHGQVLRDNDNVVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRAGIAAA
HCCCCCCCCCEEEECCCCCCCCEEECCCEEEEEEECCCCCCCCCEEEEEECCCCCCCHHH
EYAEAHDFIDLPENPATMVTEWVADVLSEHGDERVADIRTELQQSMDNNAAVFRTEDTLK
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECHHHHH
QALNDIHALKERYSRITVHDKGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHA
HHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCC
REDYPNRDDTNYMRHTMAYKQGAELLSDIRLDYKPVVQTRYEPMERKY
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHCCC
>Mature Secondary Structure 
GSPIIQEHRYDVVIIGAGGAGMRAAVEAGPRARTAVLTKLYPTRSHTGAAQGGMCAALA
CCCCCCCCCCCEEEEECCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEC
NVEEDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPQGRIDQRR
CCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
FGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFNEFYALDIALTETPNGP
CCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCC
VATGVVAYELATGDIHVFHAKAIVFATGGSGRMYKTTSNAHTLTGDGLGIVFRKGLPLED
EEECEEEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCEEEEECCCCCCC
MEFHQFHPTGLAGLGILISEAVRGEGGRLLNADGERFMERYAPTIVDLAPRDIVARSMVL
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHH
EVLEGRGAGPNKDYVYIDVRHLGADVLEAKLPDITEFARTYLGVDPVTELVPVYPTCHYV
HHHHCCCCCCCCCEEEEEHHHCCHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCHHHH
MGGIPTNIHGQVLRDNDNVVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRAGIAAA
HCCCCCCCCCEEEECCCCCCCCEEECCCEEEEEEECCCCCCCCCEEEEEECCCCCCCHHH
EYAEAHDFIDLPENPATMVTEWVADVLSEHGDERVADIRTELQQSMDNNAAVFRTEDTLK
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECHHHHH
QALNDIHALKERYSRITVHDKGKRYNSDLLEAIELGFLLELAEVTVVGALNRKESRGGHA
HHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCC
REDYPNRDDTNYMRHTMAYKQGAELLSDIRLDYKPVVQTRYEPMERKY
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA