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The map label for this gene is deoA [H]

Identifier: 169630750

GI number: 169630750

Start: 3724075

End: 3725364

Strand: Reverse

Name: deoA [H]

Synonym: MAB_3671c

Alternate gene names: 169630750

Gene position: 3725364-3724075 (Counterclockwise)

Preceding gene: 169630751

Following gene: 169630749

Centisome position: 73.52

GC content: 67.83

Gene sequence:

>1290_bases
ATGGCAAATACATATGCCTTCGATATGCCGTCGATCATCGCCACCAAGCGGGACGGCGCGGAGCTGAGCCCGGCCGCCAT
CGATTGGCTGATTGGCCAGTACACCAGCGGCGACATCGGTGAGGAACAGGTCGCGGCTCTGCTGATGGCGATTTATCTGC
GCGGCATGAACGGCGCCGAGACGGCGGCGTGGACAGCGGCGATCCTGGCGTCCGGCGAGCGGCTGGACCTGTCCGGGTTG
TCCCGGCCGACCGTCGACAAGCACTCCACCGGCGGAGTGGGCGACAAGATCAGCTTGCCGCTGGTCGCGGTGGTCGCGGC
CTGCGGAGCGGCAGTTCCACAGCTTTCCGGGCGTGGCCTCGGACACACCGGCGGCACCCTCGACAAGCTCGAATCCGTTG
CGGGTATCCGTGTCGATCTCTCCAATGACCAGATACGTCAGCAGCTTTCCGACGTGGGAGCGGTGATCTGCGCGGCCGGG
GCGTCATTGGCGCCCGCCGACCGAAAGCTCTACGCGCTGCGGGATATCACCGGCACCGTCGAGTCGATTCCGCTCATCGC
CGGGTCGATCATGGGTAAGAAGCTGGCGGAAGGTACCGCCGCGCTGGTTCTGGACGTCAAGGTCGGCGCGGGCGCGTTCA
TGAAATCCGAACAGCGCGCTCGTGAATTGGCCTCGGCGATGGTCGATCTGGGTACCGCGCACGGGGTGGCCACCAGCGCC
CTGCTGACCGCGATGGACACCCCATTGGGAGCCACCGCGGGAAACGCGGTCGAGGTGCAGGAATCGCTCGACGTGCTGGC
TGGGGGAGGGCCCGAGGATGTTGTCGCGCTCACCGTGACGCTGGCCCGCGAGATGCTTGCGGCGGCCGGGATCGACGGCA
AGGATCCGGCCGCGACGCTGACCGACGGCACCGCCATGGACGTGTTCCGCACGATGATCCACGCGCAGGGCGGTGACCTC
GCCGTGCCACTACCGCTGGGGCAGTGTCAGGAGACCGTGCTGGCCCCGGTCGGTGGTGTCATGCGCCGTATCGACGCGAT
GCCTGTCGGGATCGCGGCCTGGCGCCTAGGTGCCGGACGCAGCCGCCCGGGGGAGGCGGTGCAGCACGGTGCCGGGGTGC
GCATTCACCGTCGGCCGGGGGAGGCGGTGGTAGCCGGAGAACCACTGTTCACGCTGTATACCGACACCCAGGAGCGATTG
CCCGCCGCGCTCGACGCGCTGGAAGGTGGGTGGGAGATCGGTGCGGCACCGACCGCTACCCCCCTCATCATCGATAGACT
TCCGGTGTGA

Upstream 100 bases:

>100_bases
GTCCGGACCTGCTGATCGACCATGCTGATGGTCCGCGACGCCTGGCGCAGCTGCTACCGGATGCCTTCGGGCCCGACGAC
TTGGACCGGGGGCGCATCTG

Downstream 100 bases:

>100_bases
CGGCCGAACTTGATTTGGTGTCAATCACCCAGGCTCCCAAAGCGCTACTGCATGATCATCTGGACGGGGGTTTGCGACCA
GGCACCGTCCTGGACCTAGC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MANTYAFDMPSIIATKRDGAELSPAAIDWLIGQYTSGDIGEEQVAALLMAIYLRGMNGAETAAWTAAILASGERLDLSGL
SRPTVDKHSTGGVGDKISLPLVAVVAACGAAVPQLSGRGLGHTGGTLDKLESVAGIRVDLSNDQIRQQLSDVGAVICAAG
ASLAPADRKLYALRDITGTVESIPLIAGSIMGKKLAEGTAALVLDVKVGAGAFMKSEQRARELASAMVDLGTAHGVATSA
LLTAMDTPLGATAGNAVEVQESLDVLAGGGPEDVVALTVTLAREMLAAAGIDGKDPAATLTDGTAMDVFRTMIHAQGGDL
AVPLPLGQCQETVLAPVGGVMRRIDAMPVGIAAWRLGAGRSRPGEAVQHGAGVRIHRRPGEAVVAGEPLFTLYTDTQERL
PAALDALEGGWEIGAAPTATPLIIDRLPV

Sequences:

>Translated_429_residues
MANTYAFDMPSIIATKRDGAELSPAAIDWLIGQYTSGDIGEEQVAALLMAIYLRGMNGAETAAWTAAILASGERLDLSGL
SRPTVDKHSTGGVGDKISLPLVAVVAACGAAVPQLSGRGLGHTGGTLDKLESVAGIRVDLSNDQIRQQLSDVGAVICAAG
ASLAPADRKLYALRDITGTVESIPLIAGSIMGKKLAEGTAALVLDVKVGAGAFMKSEQRARELASAMVDLGTAHGVATSA
LLTAMDTPLGATAGNAVEVQESLDVLAGGGPEDVVALTVTLAREMLAAAGIDGKDPAATLTDGTAMDVFRTMIHAQGGDL
AVPLPLGQCQETVLAPVGGVMRRIDAMPVGIAAWRLGAGRSRPGEAVQHGAGVRIHRRPGEAVVAGEPLFTLYTDTQERL
PAALDALEGGWEIGAAPTATPLIIDRLPV
>Mature_428_residues
ANTYAFDMPSIIATKRDGAELSPAAIDWLIGQYTSGDIGEEQVAALLMAIYLRGMNGAETAAWTAAILASGERLDLSGLS
RPTVDKHSTGGVGDKISLPLVAVVAACGAAVPQLSGRGLGHTGGTLDKLESVAGIRVDLSNDQIRQQLSDVGAVICAAGA
SLAPADRKLYALRDITGTVESIPLIAGSIMGKKLAEGTAALVLDVKVGAGAFMKSEQRARELASAMVDLGTAHGVATSAL
LTAMDTPLGATAGNAVEVQESLDVLAGGGPEDVVALTVTLAREMLAAAGIDGKDPAATLTDGTAMDVFRTMIHAQGGDLA
VPLPLGQCQETVLAPVGGVMRRIDAMPVGIAAWRLGAGRSRPGEAVQHGAGVRIHRRPGEAVVAGEPLFTLYTDTQERLP
AALDALEGGWEIGAAPTATPLIIDRLPV

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=409, Percent_Identity=42.7872860635697, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI4503445, Length=409, Percent_Identity=42.7872860635697, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI166158922, Length=409, Percent_Identity=42.7872860635697, Blast_Score=281, Evalue=1e-75,
Organism=Escherichia coli, GI1790842, Length=439, Percent_Identity=40.7744874715262, Blast_Score=271, Evalue=8e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 43768; Mature: 43636

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANTYAFDMPSIIATKRDGAELSPAAIDWLIGQYTSGDIGEEQVAALLMAIYLRGMNGAE
CCCCEECCCCHHHEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCH
TAAWTAAILASGERLDLSGLSRPTVDKHSTGGVGDKISLPLVAVVAACGAAVPQLSGRGL
HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
GHTGGTLDKLESVAGIRVDLSNDQIRQQLSDVGAVICAAGASLAPADRKLYALRDITGTV
CCCCCHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHCHH
ESIPLIAGSIMGKKLAEGTAALVLDVKVGAGAFMKSEQRARELASAMVDLGTAHGVATSA
HHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTAMDTPLGATAGNAVEVQESLDVLAGGGPEDVVALTVTLAREMLAAAGIDGKDPAATL
HHHHHCCCCCCCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
TDGTAMDVFRTMIHAQGGDLAVPLPLGQCQETVLAPVGGVMRRIDAMPVGIAAWRLGAGR
CCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCC
SRPGEAVQHGAGVRIHRRPGEAVVAGEPLFTLYTDTQERLPAALDALEGGWEIGAAPTAT
CCCCHHHHCCCCEEEEECCCCEEEECCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCC
PLIIDRLPV
CEEEECCCC
>Mature Secondary Structure 
ANTYAFDMPSIIATKRDGAELSPAAIDWLIGQYTSGDIGEEQVAALLMAIYLRGMNGAE
CCCEECCCCHHHEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCH
TAAWTAAILASGERLDLSGLSRPTVDKHSTGGVGDKISLPLVAVVAACGAAVPQLSGRGL
HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
GHTGGTLDKLESVAGIRVDLSNDQIRQQLSDVGAVICAAGASLAPADRKLYALRDITGTV
CCCCCHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHCHH
ESIPLIAGSIMGKKLAEGTAALVLDVKVGAGAFMKSEQRARELASAMVDLGTAHGVATSA
HHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTAMDTPLGATAGNAVEVQESLDVLAGGGPEDVVALTVTLAREMLAAAGIDGKDPAATL
HHHHHCCCCCCCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
TDGTAMDVFRTMIHAQGGDLAVPLPLGQCQETVLAPVGGVMRRIDAMPVGIAAWRLGAGR
CCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCC
SRPGEAVQHGAGVRIHRRPGEAVVAGEPLFTLYTDTQERLPAALDALEGGWEIGAAPTAT
CCCCHHHHCCCCEEEEECCCCEEEECCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCC
PLIIDRLPV
CEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]