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The map label for this gene is upp

Identifier: 169630741

GI number: 169630741

Start: 3715809

End: 3716450

Strand: Reverse

Name: upp

Synonym: MAB_3662c

Alternate gene names: 169630741

Gene position: 3716450-3715809 (Counterclockwise)

Preceding gene: 169630749

Following gene: 169630738

Centisome position: 73.34

GC content: 66.82

Gene sequence:

>642_bases
ATGCATGTGCACGTAGTTGAGCATCCGCTTGCCGCGGCCCGGTTGACCACCCTTCGCGATGCCCGCAGCGACAACGCGGC
TTTCCGGACTGCGCTGCGAGATCTGACCCTGATGCTCGTCTACGAGGCCACCGGTTCGGTGCCGGTGGAGTCGTCGACGG
TGCGCACGCCGGTGGCGGAGACAACGGGCTACCGATTGGCCAATCCGCCGTTGCTGGTGCCGGTTCTGCGGGCGGGACTG
GGCATGGTCGATCAGGCGCACGCCCTCATCCCCGAGGCGCGTGTGGGATTCGTGGGGATGGCGCGCGATGAGGACACCTG
GCAACCCACTCCGTATCTGGAATCGCTTCCGGCGGACCTCTCGGCGCAGCCGGTGTTCGTGCTGGACCCGATGCTCGCTA
CCGGCGGATCGATGGTCTACACACTCGAGCTATTGCACGCGCGCGGTGCCGCCGACATCACCATGCTCTGTGTGGTCGCG
GCTCCGCAGGGTGTGACGGCGATCCAAGAGTGCGCTGAGCGTTTCGGCCCGTCGACGTCCGTGCGGCTGTTCACTGCCAC
GATCGACGAGGGTCTCAACGACGCCGCCTACATCGTGCCCGGGTTGGGCGATGCCGGTGATCGCCAGTTCGGGCCCCGAT
AG

Upstream 100 bases:

>100_bases
CTGGGAACGATACTGAGATATCCGCCCACTGAGCGTTCGCGGTGATGCCCGTCACACCCGCGGTGATGGGGATCGATGCT
TGCTGCTTTAGGGTCGGTCC

Downstream 100 bases:

>100_bases
CTCGGGCCGCGTCAGATGTTCCGGGCGTAAGCCTCCAGCTCGGAGACCACCACCCCGGCCCAGATCCGCGCCACGGTGGG
GTCGGTGATCACGGGTTCGC

Product: Uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MHVHVVEHPLAAARLTTLRDARSDNAAFRTALRDLTLMLVYEATGSVPVESSTVRTPVAETTGYRLANPPLLVPVLRAGL
GMVDQAHALIPEARVGFVGMARDEDTWQPTPYLESLPADLSAQPVFVLDPMLATGGSMVYTLELLHARGAADITMLCVVA
APQGVTAIQECAERFGPSTSVRLFTATIDEGLNDAAYIVPGLGDAGDRQFGPR

Sequences:

>Translated_213_residues
MHVHVVEHPLAAARLTTLRDARSDNAAFRTALRDLTLMLVYEATGSVPVESSTVRTPVAETTGYRLANPPLLVPVLRAGL
GMVDQAHALIPEARVGFVGMARDEDTWQPTPYLESLPADLSAQPVFVLDPMLATGGSMVYTLELLHARGAADITMLCVVA
APQGVTAIQECAERFGPSTSVRLFTATIDEGLNDAAYIVPGLGDAGDRQFGPR
>Mature_213_residues
MHVHVVEHPLAAARLTTLRDARSDNAAFRTALRDLTLMLVYEATGSVPVESSTVRTPVAETTGYRLANPPLLVPVLRAGL
GMVDQAHALIPEARVGFVGMARDEDTWQPTPYLESLPADLSAQPVFVLDPMLATGGSMVYTLELLHARGAADITMLCVVA
APQGVTAIQECAERFGPSTSVRLFTATIDEGLNDAAYIVPGLGDAGDRQFGPR

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=200, Percent_Identity=27.5, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI57863312, Length=200, Percent_Identity=27.5, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI87082118, Length=218, Percent_Identity=37.6146788990826, Blast_Score=163, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17539892, Length=210, Percent_Identity=23.3333333333333, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539894, Length=210, Percent_Identity=24.2857142857143, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321920, Length=199, Percent_Identity=32.6633165829146, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45550449, Length=197, Percent_Identity=25.8883248730964, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573516, Length=197, Percent_Identity=25.8883248730964, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573514, Length=197, Percent_Identity=25.8883248730964, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573512, Length=197, Percent_Identity=25.8883248730964, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_MYCA9 (B1MFZ1)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001704390.1
- ProteinModelPortal:   B1MFZ1
- SMR:   B1MFZ1
- EnsemblBacteria:   EBMYCT00000004127
- GeneID:   5966160
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_3662c
- GeneTree:   EBGT00050000016428
- HOGENOM:   HBG326432
- OMA:   VYVLDPM
- BioCyc:   MABS561007:MAB_3662C-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22692; Mature: 22692

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: BINDING 77-77 BINDING 102-102 BINDING 198-198 BINDING 204-204

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVHVVEHPLAAARLTTLRDARSDNAAFRTALRDLTLMLVYEATGSVPVESSTVRTPVAE
CEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCHH
TTGYRLANPPLLVPVLRAGLGMVDQAHALIPEARVGFVGMARDEDTWQPTPYLESLPADL
CCCCEECCCCCHHHHHHCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHCCCCC
SAQPVFVLDPMLATGGSMVYTLELLHARGAADITMLCVVAAPQGVTAIQECAERFGPSTS
CCCCEEEECCHHHCCCCEEEEEEEHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCC
VRLFTATIDEGLNDAAYIVPGLGDAGDRQFGPR
EEEEEEEHHCCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MHVHVVEHPLAAARLTTLRDARSDNAAFRTALRDLTLMLVYEATGSVPVESSTVRTPVAE
CEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCHH
TTGYRLANPPLLVPVLRAGLGMVDQAHALIPEARVGFVGMARDEDTWQPTPYLESLPADL
CCCCEECCCCCHHHHHHCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHCCCCC
SAQPVFVLDPMLATGGSMVYTLELLHARGAADITMLCVVAAPQGVTAIQECAERFGPSTS
CCCCEEEECCHHHCCCCEEEEEEEHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCC
VRLFTATIDEGLNDAAYIVPGLGDAGDRQFGPR
EEEEEEEHHCCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA