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The map label for this gene is lrp [H]

Identifier: 169630726

GI number: 169630726

Start: 3696330

End: 3696806

Strand: Reverse

Name: lrp [H]

Synonym: MAB_3647c

Alternate gene names: 169630726

Gene position: 3696806-3696330 (Counterclockwise)

Preceding gene: 169630733

Following gene: 169630725

Centisome position: 72.96

GC content: 63.52

Gene sequence:

>477_bases
GTGACTGTGGATTCCGAGAGGACGCCCGAGCGACCGCTCGACGATGTCGATCGAATTCTGGTGCGCGAGTTGGCTCGCGA
TGGCCGGGCTACTCTCGCGCATTTGGCCGCCAAGGCGGGACTGTCGATCTCGGCGGTGCAAACCCGCGTACGGAGACTGG
AAGCTCGGGGGGTGCTCGCCGGGTACGCGGCGCGGGTCAATCCGGAGTCGGTCGGCCAGCTGTTGTCGGCGTTCGTGGCA
ATCACCCCTCTCGATCCTTCTCAACCCGATGATGCTCCTGCGCGGCTTGAGCACATCGACGCCATCGAGTCGTGCTATTC
GGTGGCAGGCGAGGAGAGTTACGTCCTCCTGGTGCGGGTGCCGTCACCGCGTGCGCTCGAGGAGCTGCTGCAGCTGATCC
GCACCACCGCCAATGTTCGCACGCGAAGCACCATCATCTTACAAACTTTTTACGATGGCCGCCAGCTTGTGCCGTAA

Upstream 100 bases:

>100_bases
AGCGCTGCACCAGGGCGGTCATCGAATTCGTCCCTGAGTTGAGGCGATTGGCCTGTGCAAGTCCGTTCCTTGTTCTGCCT
GGTCGCGGTACTCTGCCCCC

Downstream 100 bases:

>100_bases
AAATTCTTGTTGATATGTAGAGAAGTCGTAAATACTGCGTTAGTGTGGCTCTATGACCGCACTGATCTTTCCTGGGTTCC
AGGCCGGCCCGACGCACGGT

Product: transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MTVDSERTPERPLDDVDRILVRELARDGRATLAHLAAKAGLSISAVQTRVRRLEARGVLAGYAARVNPESVGQLLSAFVA
ITPLDPSQPDDAPARLEHIDAIESCYSVAGEESYVLLVRVPSPRALEELLQLIRTTANVRTRSTIILQTFYDGRQLVP

Sequences:

>Translated_158_residues
MTVDSERTPERPLDDVDRILVRELARDGRATLAHLAAKAGLSISAVQTRVRRLEARGVLAGYAARVNPESVGQLLSAFVA
ITPLDPSQPDDAPARLEHIDAIESCYSVAGEESYVLLVRVPSPRALEELLQLIRTTANVRTRSTIILQTFYDGRQLVP
>Mature_157_residues
TVDSERTPERPLDDVDRILVRELARDGRATLAHLAAKAGLSISAVQTRVRRLEARGVLAGYAARVNPESVGQLLSAFVAI
TPLDPSQPDDAPARLEHIDAIESCYSVAGEESYVLLVRVPSPRALEELLQLIRTTANVRTRSTIILQTFYDGRQLVP

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=160, Percent_Identity=34.375, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790182, Length=136, Percent_Identity=26.4705882352941, Blast_Score=60, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17327; Mature: 17196

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVDSERTPERPLDDVDRILVRELARDGRATLAHLAAKAGLSISAVQTRVRRLEARGVLA
CCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GYAARVNPESVGQLLSAFVAITPLDPSQPDDAPARLEHIDAIESCYSVAGEESYVLLVRV
HHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEC
PSPRALEELLQLIRTTANVRTRSTIILQTFYDGRQLVP
CCCHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCC
>Mature Secondary Structure 
TVDSERTPERPLDDVDRILVRELARDGRATLAHLAAKAGLSISAVQTRVRRLEARGVLA
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GYAARVNPESVGQLLSAFVAITPLDPSQPDDAPARLEHIDAIESCYSVAGEESYVLLVRV
HHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEC
PSPRALEELLQLIRTTANVRTRSTIILQTFYDGRQLVP
CCCHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]