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The map label for this gene is lat [H]

Identifier: 169630725

GI number: 169630725

Start: 3694910

End: 3696277

Strand: Reverse

Name: lat [H]

Synonym: MAB_3646c

Alternate gene names: 169630725

Gene position: 3696277-3694910 (Counterclockwise)

Preceding gene: 169630726

Following gene: 169630719

Centisome position: 72.95

GC content: 63.16

Gene sequence:

>1368_bases
ATGACCGCACTGATCTTTCCTGGGTTCCAGGCCGGCCCGACGCACGGTGACCAGGCAACGCGCCCCGATCCGGTGACACC
GGACCGAGTGCACGACGTGCTGCGCCGCAGCATTCTGGCCGACGGGATGGACCTCGTGCTCGATCTGGAGCGTTCCCATG
GGGCGCACCTGGTGGATGCTCGCGACGGAACCGACTATCTCGACATGTTCACCTTCTTCGCCTCATCAGCGCTGGGCATG
AACCATCCGATGCTGGCCGAGGACGATGAGTTCCGTGCCGAACTGGCCACGGCTGCCATCAACAAGCCGAGCAATTCCGA
CATCTACACCGTCGAGATGGCTCGTTTTGTCGACACATTCGCGCGGGTTCTGGGTGATCCTGCCCTTCCGCATCTGTTCT
TCGTCGACGGCGGCGCGCTGGCCGTCGAGAACGCGCTGAAGGTGGCATTCGACTGGAAGAGTCGTTGGAACGAGGCGCAC
GGAATTGATGCGTCGTTGGGCACCAAGGTATTACACCTACGCGAGGCATTTCATGGCCGCAGCGGATACACCATGTCGCT
GACCAACACCGACCCCAACAAGGTTGCACGATTCCCTAAGTTCGACTGGCCGCGGATCGATGCGCCCTATCTGCGACCGG
GCGCCGATATCGAGGCCCTGGAAGCCTCGGCATTAGCGCAAGCGCGGCGCGCCTTCGCCGAAAACCCGCACGACATAGCT
TGTTTCATCGCCGAACCGATTCAGGGCGAGGGCGGCGATCACCACTTCCGTCCGGAGTTCTTCCACGCCATGCGTGCGCT
GTGTCACGAGAATGATGCCCTGTTCATCTTCGACGAGGTGCAGACCGGGTGCGGGCTCACCGGGACGGCCTGGGCATTCC
AGCAACTGGGTGTGATCCCCGACGTCGTGGCCTTCGGGAAGAAGACCCAGGTATGTGGCGTGATGGCGGGTGGACGCGTC
GACGAGGTTGACGACAACGTCTTTGCCGTCAGCTCTCGTATCAACTCCACGTGGGGCGGCAACCTGGTCGACATGGTGCG
GTCCCGTCGCATCTTGGAAGTGGTTGAGGCGCAGCGCCTTTTCGCGAACGCGATGCGGATGGGTGAGTATCTACTCGAAC
GTCTGCAGACGCTGGCGGTGCGCCATGACGCGGTCGGCGACGTCCGCGGCCGGGGCCTGATGTGTGCGTTCAGTCTTCCG
ACTGCCGAAGAGCGCGATCATCTGGTGCAGCGCCTCTGGGCCGATGAGCGCGTCATTTTGCTGCCCAGCGGCGAGAACAG
CGTTCGGTTCCGGCCGCCGCTGATTGTCAGCGCCGAGGAGATCGACGCCGCGGTGGCCGCGGTATCACGCGTGTTGGCGC
TGCGATGA

Upstream 100 bases:

>100_bases
ACCATCATCTTACAAACTTTTTACGATGGCCGCCAGCTTGTGCCGTAAAAATTCTTGTTGATATGTAGAGAAGTCGTAAA
TACTGCGTTAGTGTGGCTCT

Downstream 100 bases:

>100_bases
GCGCATTGCGCGAAGAGCACAAGGTCAGTCACCAGGCGTAAGGCGAGTGCTCACGCGCCGTGCGCAGCGCGGCGCCCCAC
CATGCCAATTCGTCGAGCAT

Product: L-lysine aminotransferase

Products: NA

Alternate protein names: L-lysine aminotransferase; Lysine 6-aminotransferase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MTALIFPGFQAGPTHGDQATRPDPVTPDRVHDVLRRSILADGMDLVLDLERSHGAHLVDARDGTDYLDMFTFFASSALGM
NHPMLAEDDEFRAELATAAINKPSNSDIYTVEMARFVDTFARVLGDPALPHLFFVDGGALAVENALKVAFDWKSRWNEAH
GIDASLGTKVLHLREAFHGRSGYTMSLTNTDPNKVARFPKFDWPRIDAPYLRPGADIEALEASALAQARRAFAENPHDIA
CFIAEPIQGEGGDHHFRPEFFHAMRALCHENDALFIFDEVQTGCGLTGTAWAFQQLGVIPDVVAFGKKTQVCGVMAGGRV
DEVDDNVFAVSSRINSTWGGNLVDMVRSRRILEVVEAQRLFANAMRMGEYLLERLQTLAVRHDAVGDVRGRGLMCAFSLP
TAEERDHLVQRLWADERVILLPSGENSVRFRPPLIVSAEEIDAAVAAVSRVLALR

Sequences:

>Translated_455_residues
MTALIFPGFQAGPTHGDQATRPDPVTPDRVHDVLRRSILADGMDLVLDLERSHGAHLVDARDGTDYLDMFTFFASSALGM
NHPMLAEDDEFRAELATAAINKPSNSDIYTVEMARFVDTFARVLGDPALPHLFFVDGGALAVENALKVAFDWKSRWNEAH
GIDASLGTKVLHLREAFHGRSGYTMSLTNTDPNKVARFPKFDWPRIDAPYLRPGADIEALEASALAQARRAFAENPHDIA
CFIAEPIQGEGGDHHFRPEFFHAMRALCHENDALFIFDEVQTGCGLTGTAWAFQQLGVIPDVVAFGKKTQVCGVMAGGRV
DEVDDNVFAVSSRINSTWGGNLVDMVRSRRILEVVEAQRLFANAMRMGEYLLERLQTLAVRHDAVGDVRGRGLMCAFSLP
TAEERDHLVQRLWADERVILLPSGENSVRFRPPLIVSAEEIDAAVAAVSRVLALR
>Mature_454_residues
TALIFPGFQAGPTHGDQATRPDPVTPDRVHDVLRRSILADGMDLVLDLERSHGAHLVDARDGTDYLDMFTFFASSALGMN
HPMLAEDDEFRAELATAAINKPSNSDIYTVEMARFVDTFARVLGDPALPHLFFVDGGALAVENALKVAFDWKSRWNEAHG
IDASLGTKVLHLREAFHGRSGYTMSLTNTDPNKVARFPKFDWPRIDAPYLRPGADIEALEASALAQARRAFAENPHDIAC
FIAEPIQGEGGDHHFRPEFFHAMRALCHENDALFIFDEVQTGCGLTGTAWAFQQLGVIPDVVAFGKKTQVCGVMAGGRVD
EVDDNVFAVSSRINSTWGGNLVDMVRSRRILEVVEAQRLFANAMRMGEYLLERLQTLAVRHDAVGDVRGRGLMCAFSLPT
AEERDHLVQRLWADERVILLPSGENSVRFRPPLIVSAEEIDAAVAAVSRVLALR

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI188536080, Length=444, Percent_Identity=28.3783783783784, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI38679950, Length=444, Percent_Identity=28.3783783783784, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI38679946, Length=444, Percent_Identity=28.3783783783784, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4557809, Length=412, Percent_Identity=27.4271844660194, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI37574042, Length=440, Percent_Identity=25.4545454545455, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI226442709, Length=354, Percent_Identity=27.1186440677966, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI226442705, Length=354, Percent_Identity=27.1186440677966, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI13994255, Length=438, Percent_Identity=26.7123287671233, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI284507298, Length=321, Percent_Identity=29.9065420560748, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI24119277, Length=429, Percent_Identity=24.4755244755245, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1789016, Length=405, Percent_Identity=31.1111111111111, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1788044, Length=402, Percent_Identity=30.8457711442786, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1789759, Length=417, Percent_Identity=26.6187050359712, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI145693181, Length=430, Percent_Identity=28.1395348837209, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1787560, Length=405, Percent_Identity=26.9135802469136, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786991, Length=440, Percent_Identity=24.3181818181818, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786349, Length=436, Percent_Identity=27.2935779816514, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17541228, Length=438, Percent_Identity=29.9086757990868, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25144271, Length=427, Percent_Identity=26.6978922716628, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=289, Percent_Identity=30.1038062283737, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI32564660, Length=430, Percent_Identity=24.8837209302326, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71992977, Length=407, Percent_Identity=25.5528255528256, Blast_Score=92, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6321456, Length=435, Percent_Identity=28.0459770114943, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323470, Length=416, Percent_Identity=26.4423076923077, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6324432, Length=417, Percent_Identity=24.7002398081535, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324386, Length=256, Percent_Identity=28.515625, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281366494, Length=443, Percent_Identity=29.1196388261851, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24667139, Length=443, Percent_Identity=29.1196388261851, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24667143, Length=443, Percent_Identity=29.1196388261851, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI21356575, Length=420, Percent_Identity=26.9047619047619, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI161085790, Length=442, Percent_Identity=27.1493212669683, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21357415, Length=412, Percent_Identity=26.6990291262136, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574759, Length=428, Percent_Identity=27.1028037383178, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR017657
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.36 [H]

Molecular weight: Translated: 50188; Mature: 50057

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALIFPGFQAGPTHGDQATRPDPVTPDRVHDVLRRSILADGMDLVLDLERSHGAHLVDA
CCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEC
RDGTDYLDMFTFFASSALGMNHPMLAEDDEFRAELATAAINKPSNSDIYTVEMARFVDTF
CCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHH
ARVLGDPALPHLFFVDGGALAVENALKVAFDWKSRWNEAHGIDASLGTKVLHLREAFHGR
HHHHCCCCCCEEEEECCCHHHHHHHHHEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
SGYTMSLTNTDPNKVARFPKFDWPRIDAPYLRPGADIEALEASALAQARRAFAENPHDIA
CCCEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEE
CFIAEPIQGEGGDHHFRPEFFHAMRALCHENDALFIFDEVQTGCGLTGTAWAFQQLGVIP
EEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCH
DVVAFGKKTQVCGVMAGGRVDEVDDNVFAVSSRINSTWGGNLVDMVRSRRILEVVEAQRL
HHHHCCCCCCEEEEECCCCCCCCCCCEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
FANAMRMGEYLLERLQTLAVRHDAVGDVRGRGLMCAFSLPTAEERDHLVQRLWADERVIL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEE
LPSGENSVRFRPPLIVSAEEIDAAVAAVSRVLALR
EECCCCCEEECCCEEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TALIFPGFQAGPTHGDQATRPDPVTPDRVHDVLRRSILADGMDLVLDLERSHGAHLVDA
CEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEC
RDGTDYLDMFTFFASSALGMNHPMLAEDDEFRAELATAAINKPSNSDIYTVEMARFVDTF
CCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHH
ARVLGDPALPHLFFVDGGALAVENALKVAFDWKSRWNEAHGIDASLGTKVLHLREAFHGR
HHHHCCCCCCEEEEECCCHHHHHHHHHEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
SGYTMSLTNTDPNKVARFPKFDWPRIDAPYLRPGADIEALEASALAQARRAFAENPHDIA
CCCEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEE
CFIAEPIQGEGGDHHFRPEFFHAMRALCHENDALFIFDEVQTGCGLTGTAWAFQQLGVIP
EEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCH
DVVAFGKKTQVCGVMAGGRVDEVDDNVFAVSSRINSTWGGNLVDMVRSRRILEVVEAQRL
HHHHCCCCCCEEEEECCCCCCCCCCCEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
FANAMRMGEYLLERLQTLAVRHDAVGDVRGRGLMCAFSLPTAEERDHLVQRLWADERVIL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEE
LPSGENSVRFRPPLIVSAEEIDAAVAAVSRVLALR
EECCCCCEEECCCEEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]