Click here to switch to the map view.

The map label for this gene is bccA [H]

Identifier: 169630722

GI number: 169630722

Start: 3692033

End: 3693829

Strand: Direct

Name: bccA [H]

Synonym: MAB_3643

Alternate gene names: 169630722

Gene position: 3692033-3693829 (Clockwise)

Preceding gene: 169630721

Following gene: 169630723

Centisome position: 72.86

GC content: 69.06

Gene sequence:

>1797_bases
GTGCCCAATCACGCCAGCTCGAAGATCAGCAAGGTACTCGTCGCCAACCGCGGCGAGATTGCGGTTCGGGTGATCCGCGC
GGCGAAGGACGCTGGACTGGGCAGCGTCGCGATCTACGCCGAACCCGATGCTGATGCCCCCCACGTCCACCTCGCCGACG
AGGCCTTCGGCATCGGCGGTAACACCGCCGCCGAGTCCTACCTGGACTTCGGCAAGATCCTGGAGGCCGCCGAGAAGTCC
GGTGCCAACGCTATCCACCCCGGCTACGGCTTCCTGTCAGAGAACGCAGACTTTGCCCAGGCCGTCATCGATGCCGGGCT
GATCTGGATCGGGCCCAGCCCGCAGTCCATCCGCGACCTCGGCGACAAGGTCACCGCCCGCCACATCGCGGCACGTGCGC
AGGCCCCGCTGGTCCCCGGCACCCCCGATCCCGTGAAGGACGCTGACGAGGTCGTCGCCTTCGCCAAGGAGCATGGTCTC
CCCATCGCCATCAAGGCCGCCTTCGGCGGTGGTGGCCGCGGCATGAAGGTGGCCCGCACCCTCGAAGAGGTACCCGAGCT
GTTTGAGTCGGCCACCCGCGAGGCCGTCGCCGCGTTCGGTCGCGGCGAGTGCTTCGTGGAGCGCTACTTGGACAAGCCGC
GCCACGTCGAGGCCCAGGTCATCGCCGACCAGCACGGCAATGTCGTGGTCGCCGGCACCCGCGACTGCTCGCTGCAGCGC
CGCTTCCAGAAGCTGGTCGAAGAGGCGCCGGCGCCGTTCCTGACCGACGCCCAGCGCAAGGAGATCCACGAGTCCGCCAA
GCGCATCTGCAAGGAGGCCGGGTACTACGGTGCCGGCACCGTGGAATACCTGGTGGGCCAGGACGGCCTGATCTCCTTCC
TCGAGGTCAACACCCGTCTGCAGGTGGAACACCCCGTCACCGAGGAGACCGCGGGCGTCGATCTGGTGCTCGAGCAGTTC
AAGATCGCCAACGGCGAGGCGCTGCAGTTCACCGAAGACCCCGAGCCGCGTGGCCACTCGATCGAGTTCCGCATCAACGG
CGAGGACGCCGGCCGCAACTTCCTGCCGGCCCCCGGCCCGGTCAAGGTGTATGACACCCCGACCGGTCCCGGCGTGCGCC
TGGATTCGGGCGTTCAGGCCGGATCCGTGATCGGCGGCCAGTTCGACTCCATGCTGGCCAAGCTGATCGTGACCGGCCGC
GACCGCAACGAGGCCCTCGCCCGCTCGCGGCGCGCACTGGCCGAGTTCAACGTCGAGGGCCTGGCCACCGTCATCCCGTT
CCACCGCGCCGTGGTGTCCGACCCTGCCTTCATCGGCGACGAGGACGGCTTCACCGTCCACACCCGCTGGATCGAGACCG
AGTGGAACAACACCATCGAGCCGTTCACCGCTGGCGGTGAGGCAGCCGACGAGGACGAGGCCCTGCCCCGCCAGAAGCTG
GTCGTCGAGGTCGGCGGCCGCCGTCTCGAGGTGTCGCTGCCCGGTGACATCTCGCTCGGCGGAGGAGGCGGCGCCGCGAA
CGGTGTGGTGCGCAAGAAGCCCAAGGCCCGCAAGCGTGGCGGCCACGGCGGTGGCGCTGCCACCGGCGACTCGGTCACCG
CGCCGATGCAGGGCACCGTGGTCAAGGTCGCGGTTGAGGAGGGCCAGGAGGTCGAGGCCGGCGAGCTGATCGTGGTGCTG
GAGGCCATGAAGATGGAGAACCCCGTCACCGCGCACAAGGCCGGTACCGTCACCGGGCTGAGTGTCGAGGCCGGGGCCGC
CATCACCCAGGGCACGGTCATCGCCGAAATCAAGTAG

Upstream 100 bases:

>100_bases
ACCCCATCCCCGATGTGTGTTTGACGCCACGGATGCATAAACTCACTGCCGAGACTTTAAGAAATCGATAAAGAACAGCA
CTAACGATCCAGGAGGCCCG

Downstream 100 bases:

>100_bases
GACCTTGTCGTCGAGCGTGAAGCTACGGCGGGATTCTCATCGAATTGCCGCCGCAGCTTCACGCTCGACGCATTTCTAGC
CTTATGGAACCCATCGAGAT

Product: bifunctional protein acetyl-/propionyl-CoA carboxylase (alpha chain) AccA3

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MPNHASSKISKVLVANRGEIAVRVIRAAKDAGLGSVAIYAEPDADAPHVHLADEAFGIGGNTAAESYLDFGKILEAAEKS
GANAIHPGYGFLSENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKDADEVVAFAKEHGL
PIAIKAAFGGGGRGMKVARTLEEVPELFESATREAVAAFGRGECFVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQR
RFQKLVEEAPAPFLTDAQRKEIHESAKRICKEAGYYGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGVDLVLEQF
KIANGEALQFTEDPEPRGHSIEFRINGEDAGRNFLPAPGPVKVYDTPTGPGVRLDSGVQAGSVIGGQFDSMLAKLIVTGR
DRNEALARSRRALAEFNVEGLATVIPFHRAVVSDPAFIGDEDGFTVHTRWIETEWNNTIEPFTAGGEAADEDEALPRQKL
VVEVGGRRLEVSLPGDISLGGGGGAANGVVRKKPKARKRGGHGGGAATGDSVTAPMQGTVVKVAVEEGQEVEAGELIVVL
EAMKMENPVTAHKAGTVTGLSVEAGAAITQGTVIAEIK

Sequences:

>Translated_598_residues
MPNHASSKISKVLVANRGEIAVRVIRAAKDAGLGSVAIYAEPDADAPHVHLADEAFGIGGNTAAESYLDFGKILEAAEKS
GANAIHPGYGFLSENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKDADEVVAFAKEHGL
PIAIKAAFGGGGRGMKVARTLEEVPELFESATREAVAAFGRGECFVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQR
RFQKLVEEAPAPFLTDAQRKEIHESAKRICKEAGYYGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGVDLVLEQF
KIANGEALQFTEDPEPRGHSIEFRINGEDAGRNFLPAPGPVKVYDTPTGPGVRLDSGVQAGSVIGGQFDSMLAKLIVTGR
DRNEALARSRRALAEFNVEGLATVIPFHRAVVSDPAFIGDEDGFTVHTRWIETEWNNTIEPFTAGGEAADEDEALPRQKL
VVEVGGRRLEVSLPGDISLGGGGGAANGVVRKKPKARKRGGHGGGAATGDSVTAPMQGTVVKVAVEEGQEVEAGELIVVL
EAMKMENPVTAHKAGTVTGLSVEAGAAITQGTVIAEIK
>Mature_597_residues
PNHASSKISKVLVANRGEIAVRVIRAAKDAGLGSVAIYAEPDADAPHVHLADEAFGIGGNTAAESYLDFGKILEAAEKSG
ANAIHPGYGFLSENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKDADEVVAFAKEHGLP
IAIKAAFGGGGRGMKVARTLEEVPELFESATREAVAAFGRGECFVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRR
FQKLVEEAPAPFLTDAQRKEIHESAKRICKEAGYYGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGVDLVLEQFK
IANGEALQFTEDPEPRGHSIEFRINGEDAGRNFLPAPGPVKVYDTPTGPGVRLDSGVQAGSVIGGQFDSMLAKLIVTGRD
RNEALARSRRALAEFNVEGLATVIPFHRAVVSDPAFIGDEDGFTVHTRWIETEWNNTIEPFTAGGEAADEDEALPRQKLV
VEVGGRRLEVSLPGDISLGGGGGAANGVVRKKPKARKRGGHGGGAATGDSVTAPMQGTVVKVAVEEGQEVEAGELIVVLE
AMKMENPVTAHKAGTVTGLSVEAGAAITQGTVIAEIK

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=674, Percent_Identity=36.4985163204748, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI116805327, Length=445, Percent_Identity=44.9438202247191, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI295821183, Length=646, Percent_Identity=37.3065015479876, Blast_Score=378, Evalue=1e-104,
Organism=Homo sapiens, GI106049528, Length=450, Percent_Identity=46, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI106049295, Length=450, Percent_Identity=46, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI106049292, Length=450, Percent_Identity=46, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI189095269, Length=665, Percent_Identity=35.6390977443609, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI38679960, Length=472, Percent_Identity=31.9915254237288, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI38679977, Length=472, Percent_Identity=31.9915254237288, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI38679967, Length=472, Percent_Identity=31.9915254237288, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI38679974, Length=472, Percent_Identity=31.9915254237288, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI38679971, Length=472, Percent_Identity=31.9915254237288, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI134142062, Length=506, Percent_Identity=30.2371541501976, Blast_Score=209, Evalue=8e-54,
Organism=Escherichia coli, GI1789654, Length=431, Percent_Identity=46.6357308584687, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17562816, Length=437, Percent_Identity=48.2837528604119, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71987519, Length=431, Percent_Identity=45.0116009280742, Blast_Score=347, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI17567343, Length=438, Percent_Identity=41.0958904109589, Blast_Score=345, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI133931226, Length=459, Percent_Identity=29.8474945533769, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71997163, Length=513, Percent_Identity=28.4600389863548, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71997168, Length=513, Percent_Identity=28.4600389863548, Blast_Score=188, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6319695, Length=437, Percent_Identity=47.1395881006865, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6321376, Length=437, Percent_Identity=46.9107551487414, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319685, Length=428, Percent_Identity=41.8224299065421, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6323863, Length=443, Percent_Identity=29.5711060948081, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6324343, Length=513, Percent_Identity=29.4346978557505, Blast_Score=193, Evalue=7e-50,
Organism=Drosophila melanogaster, GI281363050, Length=436, Percent_Identity=47.2477064220183, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=436, Percent_Identity=47.2477064220183, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=436, Percent_Identity=47.2477064220183, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=436, Percent_Identity=47.2477064220183, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=436, Percent_Identity=47.2477064220183, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652212, Length=436, Percent_Identity=47.2477064220183, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652210, Length=436, Percent_Identity=47.2477064220183, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652214, Length=436, Percent_Identity=47.2477064220183, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19921944, Length=436, Percent_Identity=47.2477064220183, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652216, Length=436, Percent_Identity=47.2477064220183, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651757, Length=457, Percent_Identity=42.4507658643326, Blast_Score=360, Evalue=2e-99,
Organism=Drosophila melanogaster, GI24651759, Length=418, Percent_Identity=41.6267942583732, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24586458, Length=500, Percent_Identity=29.2, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI161076407, Length=500, Percent_Identity=29.2, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24586460, Length=500, Percent_Identity=29.2, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI161076409, Length=500, Percent_Identity=29.2, Blast_Score=200, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 63113; Mature: 62982

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNHASSKISKVLVANRGEIAVRVIRAAKDAGLGSVAIYAEPDADAPHVHLADEAFGIGG
CCCCHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCEEEEEECCCCCCCEEEECCHHCCCCC
NTAAESYLDFGKILEAAEKSGANAIHPGYGFLSENADFAQAVIDAGLIWIGPSPQSIRDL
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCHHHHHH
GDKVTARHIAARAQAPLVPGTPDPVKDADEVVAFAKEHGLPIAIKAAFGGGGRGMKVART
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHH
LEEVPELFESATREAVAAFGRGECFVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQR
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHHH
RFQKLVEEAPAPFLTDAQRKEIHESAKRICKEAGYYGAGTVEYLVGQDGLISFLEVNTRL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCEE
QVEHPVTEETAGVDLVLEQFKIANGEALQFTEDPEPRGHSIEFRINGEDAGRNFLPAPGP
EECCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCC
VKVYDTPTGPGVRLDSGVQAGSVIGGQFDSMLAKLIVTGRDRNEALARSRRALAEFNVEG
EEEEECCCCCCEEECCCCCCCCEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCH
LATVIPFHRAVVSDPAFIGDEDGFTVHTRWIETEWNNTIEPFTAGGEAADEDEALPRQKL
HHHHHHHHHHHHCCCCEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHCCCHHHE
VVEVGGRRLEVSLPGDISLGGGGGAANGVVRKKPKARKRGGHGGGAATGDSVTAPMQGTV
EEEECCCEEEEECCCCEEECCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCEECCCCCCE
VKVAVEEGQEVEAGELIVVLEAMKMENPVTAHKAGTVTGLSVEAGAAITQGTVIAEIK
EEEEECCCCCCCCCCEEEEEEHHHCCCCCCCCCCCCEEEEEEECCCEEECCEEEEEEC
>Mature Secondary Structure 
PNHASSKISKVLVANRGEIAVRVIRAAKDAGLGSVAIYAEPDADAPHVHLADEAFGIGG
CCCHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCEEEEEECCCCCCCEEEECCHHCCCCC
NTAAESYLDFGKILEAAEKSGANAIHPGYGFLSENADFAQAVIDAGLIWIGPSPQSIRDL
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCHHHHHH
GDKVTARHIAARAQAPLVPGTPDPVKDADEVVAFAKEHGLPIAIKAAFGGGGRGMKVART
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHH
LEEVPELFESATREAVAAFGRGECFVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQR
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHHH
RFQKLVEEAPAPFLTDAQRKEIHESAKRICKEAGYYGAGTVEYLVGQDGLISFLEVNTRL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCEE
QVEHPVTEETAGVDLVLEQFKIANGEALQFTEDPEPRGHSIEFRINGEDAGRNFLPAPGP
EECCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCC
VKVYDTPTGPGVRLDSGVQAGSVIGGQFDSMLAKLIVTGRDRNEALARSRRALAEFNVEG
EEEEECCCCCCEEECCCCCCCCEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCH
LATVIPFHRAVVSDPAFIGDEDGFTVHTRWIETEWNNTIEPFTAGGEAADEDEALPRQKL
HHHHHHHHHHHHCCCCEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHCCCHHHE
VVEVGGRRLEVSLPGDISLGGGGGAANGVVRKKPKARKRGGHGGGAATGDSVTAPMQGTV
EEEECCCEEEEECCCCEEECCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCEECCCCCCE
VKVAVEEGQEVEAGELIVVLEAMKMENPVTAHKAGTVTGLSVEAGAAITQGTVIAEIK
EEEEECCCCCCCCCCEEEEEEHHHCCCCCCCCCCCCEEEEEEECCCEEECCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7909542; 11234002 [H]