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The map label for this gene is purK [H]

Identifier: 169630699

GI number: 169630699

Start: 3668671

End: 3669876

Strand: Reverse

Name: purK [H]

Synonym: MAB_3620c

Alternate gene names: 169630699

Gene position: 3669876-3668671 (Counterclockwise)

Preceding gene: 169630700

Following gene: 169630698

Centisome position: 72.42

GC content: 67.41

Gene sequence:

>1206_bases
GTGTCCGCGACTCCCGTGGTCACCATGATCGGTGGCGGTCAGCTGGCCCGGATGACCCACCAGGCGTCGATCGCCCTGGG
TCAGACCCTGCGGGTACTCGCCCACGCCGCCGACGAGCCGGCGGCGCAGGTAACCCCCGATATCGTGCTTGGTTCGCATA
CCGAGCTGGACGATCTGCGCCGGGCGGCCAAGGATGCCACCGTCGTCACCTTTGACCACGAGCATGTTCCGACCGCGTTC
CTGGAGACCCTGCAGGGCGAGGGCGTCAACGTGCAGCCGCCGCCGTCGGCCCTCATCTACGCGCAGGACAAGACGCTCAT
GCGGCGCAAGCTGCGGGACATTGGTGCGCCGGTGCCGGGATTCGCCGACATTCGGGCTGTCTCCGATGTCGAACGATTCG
CCGCGGAGACGGGCAGCCACGTCGTGCTGAAGGCGGTGCGCGGCGGTTACGACGGCCGTGGCGTATGGATCACCGACACT
CTCGATGAGGCGCGCACAGTGGCCGCCGAACAGCTGGCCGCGGGTGTCGAGCTATTGGCCGAGGAGCGCGTCGACATGCG
CCGCGAGCTTTCGGCGATGGTGGCCCGTTCGCCCTTTGGGCAGGGTGCCGCCTGGCCGGTGGTGGAAACCGTTCAGCGCG
AAGGCATTTGCGCCGTGGTGATCGCGCCGGCTCCGCAGCTGCCCGAGGAGCTGGCGCTGCAGGCCGAGCAGCTCGCGCTG
CGGATCGCCAACGAGCTTGGCGTGACGGGGTGTCTGGCGGTGGAGCTGTTCGAGACCAACGACGGCCGGCTCTTGGTCAA
CGAATTGGCGATGCGACCGCACAACTCGGGGCATTGGAGCATGGACGGGGCGCGCACCGGACAGTTCGAGCAGCACCTGC
GTGCGGTGCTCGATTACCCGCTCGGATCCACCGAACCACTGGCTCCCGTTACCGTCATGGCGAATGTATTGGGCGCTCCG
CAGACGCCCGCGATGTCGCTCGACGAACGGATGCATCACCTGATGGGCCGCATCCCGGAGGCAAAGGTGCACCTGTACGG
CAAGGGCGAGCGCCCGGGCCGCAAGCTCGGACATGTGAATATCCAAGGCCGCGAGGATGGTTCGCTGGCAGATCCGGGAT
ATGTGGCAGAGGTGCGTGAGCGCGCGGAGCGTGCCGCGCACTGGTTGTCGCACGCGGTATGGACCGATGGATGGGAAGGA
CACTAG

Upstream 100 bases:

>100_bases
CGAGCCGGTATTTGCGGAGACATACCGTTCTCATAGGGCGCCGCGGTCCGCATGACAACATATGTCTGTGTCTGATGGTC
TTCGCGCAAGCGGCTCATCC

Downstream 100 bases:

>100_bases
AACGTGAGCGCACGGGTCGGCCTGATCATGGGTAGCGACAGCGACTGGTCGGTGATGTCGGATGCCGCGAACGCCTTGGC
GGAGTTCGAGATTCCATTCG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSATPVVTMIGGGQLARMTHQASIALGQTLRVLAHAADEPAAQVTPDIVLGSHTELDDLRRAAKDATVVTFDHEHVPTAF
LETLQGEGVNVQPPPSALIYAQDKTLMRRKLRDIGAPVPGFADIRAVSDVERFAAETGSHVVLKAVRGGYDGRGVWITDT
LDEARTVAAEQLAAGVELLAEERVDMRRELSAMVARSPFGQGAAWPVVETVQREGICAVVIAPAPQLPEELALQAEQLAL
RIANELGVTGCLAVELFETNDGRLLVNELAMRPHNSGHWSMDGARTGQFEQHLRAVLDYPLGSTEPLAPVTVMANVLGAP
QTPAMSLDERMHHLMGRIPEAKVHLYGKGERPGRKLGHVNIQGREDGSLADPGYVAEVRERAERAAHWLSHAVWTDGWEG
H

Sequences:

>Translated_401_residues
MSATPVVTMIGGGQLARMTHQASIALGQTLRVLAHAADEPAAQVTPDIVLGSHTELDDLRRAAKDATVVTFDHEHVPTAF
LETLQGEGVNVQPPPSALIYAQDKTLMRRKLRDIGAPVPGFADIRAVSDVERFAAETGSHVVLKAVRGGYDGRGVWITDT
LDEARTVAAEQLAAGVELLAEERVDMRRELSAMVARSPFGQGAAWPVVETVQREGICAVVIAPAPQLPEELALQAEQLAL
RIANELGVTGCLAVELFETNDGRLLVNELAMRPHNSGHWSMDGARTGQFEQHLRAVLDYPLGSTEPLAPVTVMANVLGAP
QTPAMSLDERMHHLMGRIPEAKVHLYGKGERPGRKLGHVNIQGREDGSLADPGYVAEVRERAERAAHWLSHAVWTDGWEG
H
>Mature_400_residues
SATPVVTMIGGGQLARMTHQASIALGQTLRVLAHAADEPAAQVTPDIVLGSHTELDDLRRAAKDATVVTFDHEHVPTAFL
ETLQGEGVNVQPPPSALIYAQDKTLMRRKLRDIGAPVPGFADIRAVSDVERFAAETGSHVVLKAVRGGYDGRGVWITDTL
DEARTVAAEQLAAGVELLAEERVDMRRELSAMVARSPFGQGAAWPVVETVQREGICAVVIAPAPQLPEELALQAEQLALR
IANELGVTGCLAVELFETNDGRLLVNELAMRPHNSGHWSMDGARTGQFEQHLRAVLDYPLGSTEPLAPVTVMANVLGAPQ
TPAMSLDERMHHLMGRIPEAKVHLYGKGERPGRKLGHVNIQGREDGSLADPGYVAEVRERAERAAHWLSHAVWTDGWEGH

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=367, Percent_Identity=29.9727520435967, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324702, Length=368, Percent_Identity=33.695652173913, Blast_Score=184, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 43316; Mature: 43185

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATPVVTMIGGGQLARMTHQASIALGQTLRVLAHAADEPAAQVTPDIVLGSHTELDDLR
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEECCCCCHHHHH
RAAKDATVVTFDHEHVPTAFLETLQGEGVNVQPPPSALIYAQDKTLMRRKLRDIGAPVPG
HHHCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCC
FADIRAVSDVERFAAETGSHVVLKAVRGGYDGRGVWITDTLDEARTVAAEQLAAGVELLA
HHHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHH
EERVDMRRELSAMVARSPFGQGAAWPVVETVQREGICAVVIAPAPQLPEELALQAEQLAL
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHH
RIANELGVTGCLAVELFETNDGRLLVNELAMRPHNSGHWSMDGARTGQFEQHLRAVLDYP
HHHHHCCCCEEEEEEEEECCCCEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
LGSTEPLAPVTVMANVLGAPQTPAMSLDERMHHLMGRIPEAKVHLYGKGERPGRKLGHVN
CCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEE
IQGREDGSLADPGYVAEVRERAERAAHWLSHAVWTDGWEGH
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SATPVVTMIGGGQLARMTHQASIALGQTLRVLAHAADEPAAQVTPDIVLGSHTELDDLR
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEECCCCCHHHHH
RAAKDATVVTFDHEHVPTAFLETLQGEGVNVQPPPSALIYAQDKTLMRRKLRDIGAPVPG
HHHCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCC
FADIRAVSDVERFAAETGSHVVLKAVRGGYDGRGVWITDTLDEARTVAAEQLAAGVELLA
HHHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHH
EERVDMRRELSAMVARSPFGQGAAWPVVETVQREGICAVVIAPAPQLPEELALQAEQLAL
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHH
RIANELGVTGCLAVELFETNDGRLLVNELAMRPHNSGHWSMDGARTGQFEQHLRAVLDYP
HHHHHCCCCEEEEEEEEECCCCEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
LGSTEPLAPVTVMANVLGAPQTPAMSLDERMHHLMGRIPEAKVHLYGKGERPGRKLGHVN
CCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEE
IQGREDGSLADPGYVAEVRERAERAAHWLSHAVWTDGWEGH
EECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]