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The map label for this gene is purE [H]

Identifier: 169630698

GI number: 169630698

Start: 3668167

End: 3668667

Strand: Reverse

Name: purE [H]

Synonym: MAB_3619c

Alternate gene names: 169630698

Gene position: 3668667-3668167 (Counterclockwise)

Preceding gene: 169630699

Following gene: 169630697

Centisome position: 72.4

GC content: 67.66

Gene sequence:

>501_bases
GTGAGCGCACGGGTCGGCCTGATCATGGGTAGCGACAGCGACTGGTCGGTGATGTCGGATGCCGCGAACGCCTTGGCGGA
GTTCGAGATTCCATTCGAGGTCGGTGTTGTCTCTGCGCACCGCACGCCGGGGCGCATGTTGCAGTACGCACAGTCGGCCG
CCGGCCGGGGCATCGAGGTCATCATCGCCGGTGCCGGTGGTGCGGCACATCTGCCCGGAATGGTGGCCTCCGCCACACCG
TTGCCGGTGATCGGTGTCCCGGTGCCGCTGGCGCGGCTGGACGGCCTCGATTCGTTGCTTTCGATCGTGCAGATGCCCGC
GGGCGTGCCGGTCGCGACGGTGTCTATCGGCGGCGCCCGCAACGCCGGGTTGCTTGCCGCGCGAATCCTCGGCGTGGCCG
ATACCGCGCTGCGGGACAAGGTCGTTGCCTTCCAGGCGAGCATGGAAGCCACCGTTCTGGAGAAAGACGAGGCTCTGCGG
CGCAGACTGTTGGAGGACTAG

Upstream 100 bases:

>100_bases
AGATCCGGGATATGTGGCAGAGGTGCGTGAGCGCGCGGAGCGTGCCGCGCACTGGTTGTCGCACGCGGTATGGACCGATG
GATGGGAAGGACACTAGAAC

Downstream 100 bases:

>100_bases
ATTTGACCGTGACGTACAGTTAATGCCGACTAACTTTGATCGACTCTGGAGGCTGTGATGGCTGGGAACCCGTCGTTTGA
CCTGTTCAAGTTGGGCGAGG

Product: phosphoribosylaminoimidazole carboxylase PurE

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MSARVGLIMGSDSDWSVMSDAANALAEFEIPFEVGVVSAHRTPGRMLQYAQSAAGRGIEVIIAGAGGAAHLPGMVASATP
LPVIGVPVPLARLDGLDSLLSIVQMPAGVPVATVSIGGARNAGLLAARILGVADTALRDKVVAFQASMEATVLEKDEALR
RRLLED

Sequences:

>Translated_166_residues
MSARVGLIMGSDSDWSVMSDAANALAEFEIPFEVGVVSAHRTPGRMLQYAQSAAGRGIEVIIAGAGGAAHLPGMVASATP
LPVIGVPVPLARLDGLDSLLSIVQMPAGVPVATVSIGGARNAGLLAARILGVADTALRDKVVAFQASMEATVLEKDEALR
RRLLED
>Mature_165_residues
SARVGLIMGSDSDWSVMSDAANALAEFEIPFEVGVVSAHRTPGRMLQYAQSAAGRGIEVIIAGAGGAAHLPGMVASATPL
PVIGVPVPLARLDGLDSLLSIVQMPAGVPVATVSIGGARNAGLLAARILGVADTALRDKVVAFQASMEATVLEKDEALRR
RLLED

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=112, Percent_Identity=58.0357142857143, Blast_Score=132, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324702, Length=155, Percent_Identity=62.5806451612903, Blast_Score=179, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17010; Mature: 16879

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARVGLIMGSDSDWSVMSDAANALAEFEIPFEVGVVSAHRTPGRMLQYAQSAAGRGIEV
CCCEEEEEEECCCCCHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHHHCCCCEEE
IIAGAGGAAHLPGMVASATPLPVIGVPVPLARLDGLDSLLSIVQMPAGVPVATVSIGGAR
EEECCCCCCCCCCCCCCCCCCCEECCCCCHHHHCCHHHHHHHHHCCCCCCEEEEEECCCC
NAGLLAARILGVADTALRDKVVAFQASMEATVLEKDEALRRRLLED
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SARVGLIMGSDSDWSVMSDAANALAEFEIPFEVGVVSAHRTPGRMLQYAQSAAGRGIEV
CCEEEEEEECCCCCHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHHHCCCCEEE
IIAGAGGAAHLPGMVASATPLPVIGVPVPLARLDGLDSLLSIVQMPAGVPVATVSIGGAR
EEECCCCCCCCCCCCCCCCCCCEECCCCCHHHHCCHHHHHHHHHCCCCCCEEEEEECCCC
NAGLLAARILGVADTALRDKVVAFQASMEATVLEKDEALRRRLLED
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7489918; 11234002 [H]