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The map label for this gene is ahcY [H]

Identifier: 169630675

GI number: 169630675

Start: 3645148

End: 3646608

Strand: Reverse

Name: ahcY [H]

Synonym: MAB_3595c

Alternate gene names: 169630675

Gene position: 3646608-3645148 (Counterclockwise)

Preceding gene: 169630676

Following gene: 169630674

Centisome position: 71.97

GC content: 63.93

Gene sequence:

>1461_bases
ATGACCGAGCTGGTAGCCGACGTACGCAACGGCATTGAATACAAGGTGGCCGATCTTTCCGAGGCCGAGTTCGGCCGTAA
GGAGATCCGTCTCGCCGAGCACGAGATGCCGGGCCTGATGGCGCTGCGCCGGGAATATGCGGAGGTGTTGCCGCTCAAGG
GCGCTCGCATTTCCGGCTCGCTGCATATGACGATTCAGACCGCCGTGCTGATCGAGACCCTGGTGGCGCTCGGAGCTGAG
GTTCGGTGGGCGTCGTGCAATATTTTCTCCACCCAGGACCACGCCGCCGCCGCGGTGGTCGTCGGCCCCAACGGCACCCC
GGAGGAGCCTCAGGGCACCCCGGTCTTCGCCTGGAAGGGCGAGACGCTCGAGGAGTACTGGTGGGCGGCCGAGCAGATGC
TCACCTGGCCGAACGAGCCAGCCAACATGATCCTGGACGATGGTGGCGACGCCACCATGCTGGTGCTGCGCGGTGCGCAG
TTCGAGCAGGCCGGCGTGGTGCCGCCCGCGGACGATAACGACTCGGCCGAGTACAAGGTGTTCCTGAACCTGTTGCGCGA
GCGGTTCGAGACCGACAAGGACAAGTGGACCAAGATCGCCGAATCGGTTCAGGGCGTCACCGAGGAGACCACCACGGGCG
TGCTGCGCCTGTACCAGTTCGCCGCCGCCGGCGAACTGGCGTTCCCGGCCATCAACGTCAACGACTCGGTGACCAAGAGC
AAGTTCGACAACAAGTACGGCACCCGGCACTCGCTGGTCGACGGCATCAACCGGGGCACCGACGTGCTCATCGGCGGCAA
GAAGGTACTGATCTGTGGCTACGGCGACGTAGGCAAGGGTTGCGCCGAGTCCCTCGCCGGTCAGGGCGCCCGCGTCCAGG
TCACCGAGATCGACCCGATCAACGCGCTGCAGGCACTCATGGACGGATTCGACGTGGTGACCGTCGAGCAGGCCATCGGC
GATGCCGACATCGTGGTGACCGCAACCGGTAACTTCGACATCATCCTGCTGGAGCACATGAAGGCCATGAAGGACCAGGC
GATCCTGGGCAACATCGGCCACTTCGACAACGAAATCGACATGGCTGCCCTCGAGAAGTCGGGCGCCGTTCGCCTCAACA
TCAAGCCTCAGGTCGATCTGTGGACCTTCGGCGACAGCGGCAAGTCGATCATCGTGCTGTCCGAGGGGCGTCTGCTCAAC
CTCGGTAACGCCACCGGCCACCCGTCGTTCGTGATGAGCAACAGCTTCTCCAACCAGGTGATCGCCCAGATCGAGCTGTG
GACCAAGAACGACGAGTACGACAACGAGGTCTACCGGCTGGCCAAGCACCTCGACGAGAAGGTTGCGCGCATCCACGTCG
AGGCTCTCGGCGGCACGCTGACCAAGCTCACCAAGGACCAGGCCGAGTACATCGGTGTCGACGTGGAGGGTCCCTACAAG
CCGGAGCACTACCGCTACTGA

Upstream 100 bases:

>100_bases
TACCTGATCTAACTATCCGTCGCTCTCACGCGCTAACCTGGTGACGGACCCGTGTGTGTCAGCTGAATTGACATGCTTCA
GAGACTTGATTGAGGTGGCG

Downstream 100 bases:

>100_bases
TCGCCGCCAATCCACGTAGAGGCCCCTTGCACTTCGGTGCCGGGGGCCTTTGCGTAGGCTGACCAGCCGTGGGCCAGCTG
ATTGCGATCGAGGGCGTGGA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTELVADVRNGIEYKVADLSEAEFGRKEIRLAEHEMPGLMALRREYAEVLPLKGARISGSLHMTIQTAVLIETLVALGAE
VRWASCNIFSTQDHAAAAVVVGPNGTPEEPQGTPVFAWKGETLEEYWWAAEQMLTWPNEPANMILDDGGDATMLVLRGAQ
FEQAGVVPPADDNDSAEYKVFLNLLRERFETDKDKWTKIAESVQGVTEETTTGVLRLYQFAAAGELAFPAINVNDSVTKS
KFDNKYGTRHSLVDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARVQVTEIDPINALQALMDGFDVVTVEQAIG
DADIVVTATGNFDIILLEHMKAMKDQAILGNIGHFDNEIDMAALEKSGAVRLNIKPQVDLWTFGDSGKSIIVLSEGRLLN
LGNATGHPSFVMSNSFSNQVIAQIELWTKNDEYDNEVYRLAKHLDEKVARIHVEALGGTLTKLTKDQAEYIGVDVEGPYK
PEHYRY

Sequences:

>Translated_486_residues
MTELVADVRNGIEYKVADLSEAEFGRKEIRLAEHEMPGLMALRREYAEVLPLKGARISGSLHMTIQTAVLIETLVALGAE
VRWASCNIFSTQDHAAAAVVVGPNGTPEEPQGTPVFAWKGETLEEYWWAAEQMLTWPNEPANMILDDGGDATMLVLRGAQ
FEQAGVVPPADDNDSAEYKVFLNLLRERFETDKDKWTKIAESVQGVTEETTTGVLRLYQFAAAGELAFPAINVNDSVTKS
KFDNKYGTRHSLVDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARVQVTEIDPINALQALMDGFDVVTVEQAIG
DADIVVTATGNFDIILLEHMKAMKDQAILGNIGHFDNEIDMAALEKSGAVRLNIKPQVDLWTFGDSGKSIIVLSEGRLLN
LGNATGHPSFVMSNSFSNQVIAQIELWTKNDEYDNEVYRLAKHLDEKVARIHVEALGGTLTKLTKDQAEYIGVDVEGPYK
PEHYRY
>Mature_485_residues
TELVADVRNGIEYKVADLSEAEFGRKEIRLAEHEMPGLMALRREYAEVLPLKGARISGSLHMTIQTAVLIETLVALGAEV
RWASCNIFSTQDHAAAAVVVGPNGTPEEPQGTPVFAWKGETLEEYWWAAEQMLTWPNEPANMILDDGGDATMLVLRGAQF
EQAGVVPPADDNDSAEYKVFLNLLRERFETDKDKWTKIAESVQGVTEETTTGVLRLYQFAAAGELAFPAINVNDSVTKSK
FDNKYGTRHSLVDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARVQVTEIDPINALQALMDGFDVVTVEQAIGD
ADIVVTATGNFDIILLEHMKAMKDQAILGNIGHFDNEIDMAALEKSGAVRLNIKPQVDLWTFGDSGKSIIVLSEGRLLNL
GNATGHPSFVMSNSFSNQVIAQIELWTKNDEYDNEVYRLAKHLDEKVARIHVEALGGTLTKLTKDQAEYIGVDVEGPYKP
EHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=475, Percent_Identity=54.5263157894737, Blast_Score=497, Evalue=1e-140,
Organism=Homo sapiens, GI239937451, Length=451, Percent_Identity=54.7671840354767, Blast_Score=474, Evalue=1e-134,
Organism=Homo sapiens, GI195539337, Length=475, Percent_Identity=44.421052631579, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI24308043, Length=475, Percent_Identity=44.421052631579, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI298286489, Length=475, Percent_Identity=44.421052631579, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI195539349, Length=475, Percent_Identity=44.421052631579, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI21361647, Length=474, Percent_Identity=44.0928270042194, Blast_Score=397, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17506425, Length=477, Percent_Identity=55.3459119496855, Blast_Score=498, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6320882, Length=489, Percent_Identity=54.8057259713701, Blast_Score=481, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24642172, Length=474, Percent_Identity=56.7510548523207, Blast_Score=510, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24656245, Length=466, Percent_Identity=46.3519313304721, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI45553387, Length=476, Percent_Identity=44.5378151260504, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI45553385, Length=475, Percent_Identity=44.421052631579, Blast_Score=391, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 53218; Mature: 53087

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELVADVRNGIEYKVADLSEAEFGRKEIRLAEHEMPGLMALRREYAEVLPLKGARISGS
CCHHHHHHHCCCEEEEECCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEECCE
LHMTIQTAVLIETLVALGAEVRWASCNIFSTQDHAAAAVVVGPNGTPEEPQGTPVFAWKG
EEEEEHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEEECC
ETLEEYWWAAEQMLTWPNEPANMILDDGGDATMLVLRGAQFEQAGVVPPADDNDSAEYKV
CCHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEECCCHHHCCCCCCCCCCCCHHHHH
FLNLLRERFETDKDKWTKIAESVQGVTEETTTGVLRLYQFAAAGELAFPAINVNDSVTKS
HHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEECEEECCCCCHHHH
KFDNKYGTRHSLVDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARVQVTEIDPI
HCCCCCCCHHHHHHHCCCCCEEEECCCEEEEEECCCCCHHHHHHHCCCCCEEEEEECCCH
NALQALMDGFDVVTVEQAIGDADIVVTATGNFDIILLEHMKAMKDQAILGNIGHFDNEID
HHHHHHHCCCCEEEEHHHCCCCEEEEEECCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCH
MAALEKSGAVRLNIKPQVDLWTFGDSGKSIIVLSEGRLLNLGNATGHPSFVMSNSFSNQV
HHHHCCCCEEEEEECCCEEEEEECCCCCEEEEEECCCEEECCCCCCCCCEEEECCCCCCE
IAQIELWTKNDEYDNEVYRLAKHLDEKVARIHVEALGGTLTKLTKDQAEYIGVDVEGPYK
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHCCHHEEEEECCCCCC
PEHYRY
CCCCCC
>Mature Secondary Structure 
TELVADVRNGIEYKVADLSEAEFGRKEIRLAEHEMPGLMALRREYAEVLPLKGARISGS
CHHHHHHHCCCEEEEECCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEECCE
LHMTIQTAVLIETLVALGAEVRWASCNIFSTQDHAAAAVVVGPNGTPEEPQGTPVFAWKG
EEEEEHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEEECC
ETLEEYWWAAEQMLTWPNEPANMILDDGGDATMLVLRGAQFEQAGVVPPADDNDSAEYKV
CCHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEECCCHHHCCCCCCCCCCCCHHHHH
FLNLLRERFETDKDKWTKIAESVQGVTEETTTGVLRLYQFAAAGELAFPAINVNDSVTKS
HHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEECEEECCCCCHHHH
KFDNKYGTRHSLVDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARVQVTEIDPI
HCCCCCCCHHHHHHHCCCCCEEEECCCEEEEEECCCCCHHHHHHHCCCCCEEEEEECCCH
NALQALMDGFDVVTVEQAIGDADIVVTATGNFDIILLEHMKAMKDQAILGNIGHFDNEID
HHHHHHHCCCCEEEEHHHCCCCEEEEEECCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCH
MAALEKSGAVRLNIKPQVDLWTFGDSGKSIIVLSEGRLLNLGNATGHPSFVMSNSFSNQV
HHHHCCCCEEEEEECCCEEEEEECCCCCEEEEEECCCEEECCCCCCCCCEEEECCCCCCE
IAQIELWTKNDEYDNEVYRLAKHLDEKVARIHVEALGGTLTKLTKDQAEYIGVDVEGPYK
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHCCHHEEEEECCCCCC
PEHYRY
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA