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The map label for this gene is hisN [H]

Identifier: 169630566

GI number: 169630566

Start: 3526414

End: 3527205

Strand: Direct

Name: hisN [H]

Synonym: MAB_3485

Alternate gene names: 169630566

Gene position: 3526414-3527205 (Clockwise)

Preceding gene: 169630564

Following gene: 169630567

Centisome position: 69.59

GC content: 65.91

Gene sequence:

>792_bases
ATGACGCCCACCGTGTCCTTGCGTGAAGATCGTCGACTCGCACTCGAATTGGCCGACGCGGCCGACGAAATCACCACGTC
CCGGTTCGGCGCCCTTGACCTTCGGGTGGATACCAAACCGGATCTCACTCCGGTGACCGACGCCGACACCTCGGTAGAAA
CCGTCCTGCGCTCGTTGCTGCATCGATCACGTCCGGCCGATTCGGTGCTGGGCGAGGAGTACGGCGGCGAGGCCACGTTC
ACGGGCCGGCAATGGGTCATCGATCCCATCGACGGCACCAAGAACTTCGCGCGCGGCGTCCCCATCTGGGCCACCCTCAT
CGCATTGCTCCAAGACGGCGTTCCCGTCGTCGGCGTTGTCAGCGCCCCGGCACTGTCTCGCCGGTGGTGGGCAGCCGAAG
GCCTCGGCGCACATAGCCGCGTGGGATCCGAAGAGGAACGATCGATACATGTTTCCGCGGTCGATCAGCTGTCGTCGGCA
AGTCTGTCGTTCTCCAGCCTGTCCGGCTGGGCGGACCGCGGGAAGCGCGACCGGTTCATCGATCTGACCGACGAGATCTG
GCGCGTTCGCGGGTTCGGTGACTTCTTCTCCTACTGCTTGGTGGCAGAGGGGGCGGTCGATATCGCCGCAGAGCCCGAGG
TCTCGCTGTGGGATCTGGCCCCGCTGGACATCCTCGTGCGCGAAGCGGGCGGCCGGTTCACAAATCTGGCCGGCGAGCCC
GGCCCCCACGGCGGCAGTGCGGTGGCAACCAATGGGTTGCTGCACGAGGAGGTGCTCAAGGCCCTGTCCTAG

Upstream 100 bases:

>100_bases
TGTCGGCCACGCCGCATCTGCATGATGAGGAGAGCGAGCGAGCCGCCGATCAGCAGTAGCACCAAGAATTCCCACACAGT
GTCATGGTAGGACTGCACAC

Downstream 100 bases:

>100_bases
CCGACTTCTCCCGCGTTACCCGCGAGCAGACGGATCAGCGGGTGTGACATGCGCCTCGTTTCCTGAGGATCTTACCGCTT
AGTAAGATACGGTTCTTACT

Product: monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MTPTVSLREDRRLALELADAADEITTSRFGALDLRVDTKPDLTPVTDADTSVETVLRSLLHRSRPADSVLGEEYGGEATF
TGRQWVIDPIDGTKNFARGVPIWATLIALLQDGVPVVGVVSAPALSRRWWAAEGLGAHSRVGSEEERSIHVSAVDQLSSA
SLSFSSLSGWADRGKRDRFIDLTDEIWRVRGFGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLDILVREAGGRFTNLAGEP
GPHGGSAVATNGLLHEEVLKALS

Sequences:

>Translated_263_residues
MTPTVSLREDRRLALELADAADEITTSRFGALDLRVDTKPDLTPVTDADTSVETVLRSLLHRSRPADSVLGEEYGGEATF
TGRQWVIDPIDGTKNFARGVPIWATLIALLQDGVPVVGVVSAPALSRRWWAAEGLGAHSRVGSEEERSIHVSAVDQLSSA
SLSFSSLSGWADRGKRDRFIDLTDEIWRVRGFGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLDILVREAGGRFTNLAGEP
GPHGGSAVATNGLLHEEVLKALS
>Mature_262_residues
TPTVSLREDRRLALELADAADEITTSRFGALDLRVDTKPDLTPVTDADTSVETVLRSLLHRSRPADSVLGEEYGGEATFT
GRQWVIDPIDGTKNFARGVPIWATLIALLQDGVPVVGVVSAPALSRRWWAAEGLGAHSRVGSEEERSIHVSAVDQLSSAS
LSFSSLSGWADRGKRDRFIDLTDEIWRVRGFGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLDILVREAGGRFTNLAGEPG
PHGGSAVATNGLLHEEVLKALS

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1790659, Length=193, Percent_Identity=31.0880829015544, Blast_Score=68, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193202570, Length=243, Percent_Identity=31.2757201646091, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193202572, Length=239, Percent_Identity=28.8702928870293, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320493, Length=199, Percent_Identity=29.6482412060301, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21357329, Length=208, Percent_Identity=31.25, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24664922, Length=247, Percent_Identity=27.1255060728745, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24664918, Length=206, Percent_Identity=29.126213592233, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24664926, Length=204, Percent_Identity=28.4313725490196, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28305; Mature: 28174

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTVSLREDRRLALELADAADEITTSRFGALDLRVDTKPDLTPVTDADTSVETVLRSLL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
HRSRPADSVLGEEYGGEATFTGRQWVIDPIDGTKNFARGVPIWATLIALLQDGVPVVGVV
HCCCCCHHHHHHHCCCCEEECCCEEEEECCCCCHHHHCCCCHHHHHHHHHHCCCCEEEEE
SAPALSRRWWAAEGLGAHSRVGSEEERSIHVSAVDQLSSASLSFSSLSGWADRGKRDRFI
CCCHHHHHHHHHCCCCCHHHCCCCHHHEEEHHHHHHHHHCCCCHHHHHHHHHCCCCCCEE
DLTDEIWRVRGFGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLDILVREAGGRFTNLAGEP
ECHHHHHHHCCHHHHHHHHHHHCCCEEECCCCCCCEECCCHHHHHHHHCCCCEEECCCCC
GPHGGSAVATNGLLHEEVLKALS
CCCCCCHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
TPTVSLREDRRLALELADAADEITTSRFGALDLRVDTKPDLTPVTDADTSVETVLRSLL
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
HRSRPADSVLGEEYGGEATFTGRQWVIDPIDGTKNFARGVPIWATLIALLQDGVPVVGVV
HCCCCCHHHHHHHCCCCEEECCCEEEEECCCCCHHHHCCCCHHHHHHHHHHCCCCEEEEE
SAPALSRRWWAAEGLGAHSRVGSEEERSIHVSAVDQLSSASLSFSSLSGWADRGKRDRFI
CCCHHHHHHHHHCCCCCHHHCCCCHHHEEEHHHHHHHHHCCCCHHHHHHHHHCCCCCCEE
DLTDEIWRVRGFGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLDILVREAGGRFTNLAGEP
ECHHHHHHHCCHHHHHHHHHHHCCCEEECCCCCCCEECCCHHHHHHHHCCCCEEECCCCC
GPHGGSAVATNGLLHEEVLKALS
CCCCCCHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]