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The map label for this gene is iclR [H]

Identifier: 169630376

GI number: 169630376

Start: 3334203

End: 3334904

Strand: Direct

Name: iclR [H]

Synonym: MAB_3295

Alternate gene names: 169630376

Gene position: 3334203-3334904 (Clockwise)

Preceding gene: 169630372

Following gene: 169630377

Centisome position: 65.8

GC content: 68.8

Gene sequence:

>702_bases
GTGAGACAGCATAGCGGCATCGGCGTCCTCGACAAAGCGGTGCAGGTCCTGACCGCCATAGGCGACTCGCCCTGCGGGCT
CGCGGAATTGTGCGAACGCACGGGTCTCCCCCGCGCCACCGCACACCGGCTTGCGGCAGGGCTGGAGGTGCACCGACTCT
TATCCCGCGACGGTGACGGGCAGTGGCAGCTCGGCGCGGGGCTTACCGAACTCGCAGCGCATGTCAACGATCCACTCCTG
AGTGCCAGCGCCCAGGTGCTCCCCAAGCTGCGCGAAATCACGGGCGAGAGCGTGCAGCTGTACCGACGAGAAGGCACCGT
GCGCATATGTGTGGCGGCTCTCGAACCGCCGGCGGGGCTTCGTGACACCGTGCCGGTCGGCTCGCGGCTGCCGATGTCGG
CCGGATCGGGCGCCAAAGTATTACTTGCCCACAGTGATCCAGGCACGCAGGCGGCAGTGCTGCCCGGCGCGACGTTCACC
GAGCGCGCTCTTGCCGATGTGCGCAAGCGCGGTTGGGCGCAGAGCGCGGCCGAGCGCGAGGCCGGGGTCGCCAGCGTTTC
GGCACCTGTTCGCGATCGGCACGGCAATGTCATTGCGGCAATATCGGTTTCCGGCCCCATCGACCGGATGGGCCGACGGC
CCGGGGCACGCTGGGCCGCCGATCTCGTTGCCGCCTCCGAGGCGATAACGGCCCGGCTTTAA

Upstream 100 bases:

>100_bases
GTCCCAGACCTTCTCTGCCAGGGTCCTGGGCTGTTGGACACTAGTCATCATTGGCTCCGTGCTGATTGCGTCTCAATATT
TGGAACGTTAGTATCGTTAC

Downstream 100 bases:

>100_bases
GCTCCGAATATGGGAAGCAACCAGCGCTCGCAGATCGTCATGTCCGACGAAGAGATCACCGAGTTCATCAACAACTCACG
CACCACCACCATGGCCACCG

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MRQHSGIGVLDKAVQVLTAIGDSPCGLAELCERTGLPRATAHRLAAGLEVHRLLSRDGDGQWQLGAGLTELAAHVNDPLL
SASAQVLPKLREITGESVQLYRREGTVRICVAALEPPAGLRDTVPVGSRLPMSAGSGAKVLLAHSDPGTQAAVLPGATFT
ERALADVRKRGWAQSAAEREAGVASVSAPVRDRHGNVIAAISVSGPIDRMGRRPGARWAADLVAASEAITARL

Sequences:

>Translated_233_residues
MRQHSGIGVLDKAVQVLTAIGDSPCGLAELCERTGLPRATAHRLAAGLEVHRLLSRDGDGQWQLGAGLTELAAHVNDPLL
SASAQVLPKLREITGESVQLYRREGTVRICVAALEPPAGLRDTVPVGSRLPMSAGSGAKVLLAHSDPGTQAAVLPGATFT
ERALADVRKRGWAQSAAEREAGVASVSAPVRDRHGNVIAAISVSGPIDRMGRRPGARWAADLVAASEAITARL
>Mature_233_residues
MRQHSGIGVLDKAVQVLTAIGDSPCGLAELCERTGLPRATAHRLAAGLEVHRLLSRDGDGQWQLGAGLTELAAHVNDPLL
SASAQVLPKLREITGESVQLYRREGTVRICVAALEPPAGLRDTVPVGSRLPMSAGSGAKVLLAHSDPGTQAAVLPGATFT
ERALADVRKRGWAQSAAEREAGVASVSAPVRDRHGNVIAAISVSGPIDRMGRRPGARWAADLVAASEAITARL

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=249, Percent_Identity=25.3012048192771, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082359, Length=241, Percent_Identity=26.9709543568465, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1786715, Length=225, Percent_Identity=26.2222222222222, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789999, Length=245, Percent_Identity=26.9387755102041, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786468, Length=222, Percent_Identity=25.6756756756757, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788581, Length=221, Percent_Identity=26.2443438914027, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 24255; Mature: 24255

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQHSGIGVLDKAVQVLTAIGDSPCGLAELCERTGLPRATAHRLAAGLEVHRLLSRDGDG
CCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
QWQLGAGLTELAAHVNDPLLSASAQVLPKLREITGESVQLYRREGTVRICVAALEPPAGL
CEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHEEHHHCCCEEEEEEECCCCCCC
RDTVPVGSRLPMSAGSGAKVLLAHSDPGTQAAVLPGATFTERALADVRKRGWAQSAAERE
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
AGVASVSAPVRDRHGNVIAAISVSGPIDRMGRRPGARWAADLVAASEAITARL
CCCHHCCCCCHHCCCCEEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRQHSGIGVLDKAVQVLTAIGDSPCGLAELCERTGLPRATAHRLAAGLEVHRLLSRDGDG
CCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
QWQLGAGLTELAAHVNDPLLSASAQVLPKLREITGESVQLYRREGTVRICVAALEPPAGL
CEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHEEHHHCCCEEEEEEECCCCCCC
RDTVPVGSRLPMSAGSGAKVLLAHSDPGTQAAVLPGATFTERALADVRKRGWAQSAAERE
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
AGVASVSAPVRDRHGNVIAAISVSGPIDRMGRRPGARWAADLVAASEAITARL
CCCHHCCCCCHHCCCCEEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]