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The map label for this gene is pyc [H]

Identifier: 169630348

GI number: 169630348

Start: 3303766

End: 3307149

Strand: Reverse

Name: pyc [H]

Synonym: MAB_3267c

Alternate gene names: 169630348

Gene position: 3307149-3303766 (Counterclockwise)

Preceding gene: 169630349

Following gene: 169630347

Centisome position: 65.27

GC content: 65.43

Gene sequence:

>3384_bases
ATGTTCTCGAAGGTTCTTGTCGCCAACCGCGGTGAGATCGCGATCCGTGCATTTCGTGCCGCCTACGAACTAGGTGCCGA
AACCGTCGCTGTCTACCCCTATGAAGATCGCAACTCGGGTCATCGGCTGAAGGCCGATGAGGCCTATCAGATTGGTGAGA
AGGGCCATCCGGTCCGCGCCTATCTGTCGGTTTCCGAGGTCGTCAACGCTGCCAGGAATGCCGGCGCCGATGCGATCTAC
CCCGGCTACGGCTTCCTGTCCGAGAATCCCGACCTCGCGGCGGCCTGCGCAGAGGCCGGCATCACGTTTGTCGGGCCGCC
CGCCGATGTTTTGGAGTTGACGGGTAACAAGGCCCGTGCCATCGCTGCTGCGCGTGAGGCGGGACTGCCGGTGTTGGCAT
CCTCGGAGCCTTCGGCATCGGTTGAGGAGCTGCTGGCGGCCGCCGAGTCCATGGAATTTCCGGTGTTCGTCAAGGCCGTT
GCCGGTGGTGGCGGGCGCGGTATGCGGCGGGTCGCCGAGCGTGATCAGCTGCGCGAGGCGATCGAGGCAGCCAGCCGCGA
GGCAGAGTCCGCGTTCGGAGACCCGACGGTTTTCCTGGAGCAAGCTGTCATCAACCCGCGGCATATCGAGGTGCAGATCC
TGGCGGACACCGCGGGAAACGTCATTCACCTCTACGAGCGCGACTGTAGCGTGCAGCGGCGCCATCAGAAGGTCATCGAG
CTCGCTCCCGCGCCCAACCTGCCGCCTGAACTGCGTGAGAAGATCTGTTCGGACGCTGTCGCTTTCGCCCGTCACATCGG
GTACAGCTGCGCCGGCACCGTTGAGTTCCTGCTCGACGAGCGCGGTCACCACGTCTTCATTGAGATGAATCCCCGAATTC
AGGTGGAGCACACGGTGACCGAGGAGATCACCGATGTGGACCTGGTGGCGAGTCAGCTGCGGATCGCCTCCGGAGAAACC
CTCGATGACCTTGGTCTGCACCAGGATTCCATCACGCCGCGCGGTGCGGCCCTGCAATGCCGGATTACCACCGAGGATCC
TGCCAATGGCTTCCGGCCCGACACCGGTCGAATCACCGCCTACCGCAGCCCCGGTGGCGCGGGCATCCGCCTCGACGGTG
GCACCACCCTCGGCGCCGAGGTGGGTGCGCATTTCGATTCGATGCTGGTGAAGCTGACGTGTCGCGGGCGGGACTTCCAG
ACTGCGGTGGCTCGTGCCCGTCGCGCGGTCGCCGAGTTCCGCATCCGCGGTGTGGCCACCAATATCCCGTTTTTGCAAGC
AGTTCTGGACGACCCGGACTTCCGCGCCGGACACGTCACGACGTCGTTCATCGAGGAACGCCCGCAGCTGCTGACGGCGC
GATCCTCCGCGGATCGCGGCACCAAGATCCTGAACTATCTGGCCGACGTCACCGTCAACAAGCCGCACGGCGCCAAGCCT
TCGACGGTGTACCCGCACGATAAGCTGCCGCCCATCGATTTATCGGTACCGCCTCCGGACGGCTCGCGTCAGCGTCTGTT
GGCGTTGGGGCCCGAGGGTTTCGCGAAGGCGCTGCGTGAGCAGAAGGCCGTGGGCCTGACCGACACTACGTTCCGAGATG
CTCATCAGTCGCTGCTGGCCACCCGAGTGCGCACCACCGGTCTGCTTGCCGTCGCGCCGTACGTGGCACGGTTGACACCG
GAGTTGCTCTCGATCGAAGCCTGGGGGGGAGCGACATACGATGTGGCTCTTCGCTTTCTGAAGGAAGACCCGTGGGAGCG
GCTCGCCGACCTGCGTGAGGCGGTCCCGAACATCTGTCTGCAGATGCTGCTACGCGGCCGCAACACGGTGGGGTACACGC
CGTATCCCGAGACGGTGACCAAGGCGTTCATTCGCGAGGCCAGTGCCACCGGGGTGGACATCTACCGAATCTTTGACGCA
CTCAACAACATCGAGGCCATGCGGCCCGCGATCGATGCGGTGCGCGAGGTCGGTACCTCGGTGGCCGAGGTGGCCATGTG
TTACACCGGCGACCTGTCCAACCCCGGTGAAAACCTGTACACGCTGGACTACTACCTCAAGCTCGCCGAGCAGATCGTCG
ATGCGGGCGCGCATGTGCTGGCGATCAAGGACATGGCGGGCCTGCTGCGCCCGCCCGCGGCGGCGACCTTGGTGACGGCG
CTGCGCTCTCGGTTCGACCTGCCCGTGCACGTCCACACACATGACACCGCGGGTGGACAACTGGCCACGTACCTGGCGGC
CTGGCAGGCGGGTGCCGATGCGGTGGACGGTGCCGCGGCACCCATGGCCGGGACCACCAGCCAGCCCTCCCTGTCGGCGA
TTGTCGCAGCGGCCGCACACAGCGAGTACGACACCGGAGTGTCCCTGACCTCGGTATGCGATCTGGAACCGTACTGGGAG
GCATTGCGAAAGGTCTACGCCCCCTTCGAGTCCGGGCTTCCCTCACCGACCGGCCGTGTGTACACGCACGAGATTCCGGG
CGGGCAGCTGTCGAACCTGCGTCAGCAGGCCATCGCGCTGGGACTGGGCGACCAGTTCGAAGAGATCGAGGCACGCTATG
CCGCAGCTGACCGGATGCTCGGCCGATTGGTCAAGGTGACACCGTCGTCCAAGGTGGTGGGCGATCTGGCGCTGGCACTC
GTGGGCACCGGCGTGAGCGCCGACGAATTCGCTTCTGACCCAGGTCGTTTCGATATCCCCGAATCCGTCATCGGATTCCT
GCGCGGCGAACTCGGCGATCCCCCCGGCGGTTGGCCCGAGCCGTTCCGTACCCGGGCACTACAAGGCCGTGGGCCGGCGC
GCGCCGAGGTGGCGCTCACGGCCGATGACGAGTCCCAGCTCGACGGTGATAGCGCGACGCGGCGTGCGGCGCTAAACCGT
CTGTTGTTCCCCGGGCCCACCAAGGAATTTCTGGCACACCGTGAGCAGTATGGCGACACCTCGCGGCTTTCGGCCAACCA
GTTCTTCTACGGCCTGCGATACGGCGAGGAGCACCGGGTCAAACTGGAGAAGGGTGTCGAGCTGCTCATCGGGCTCGAAG
CGATATCCGACGCAGACGAGCATGGAATGCGCACCGTGATGTGCATCCTGAACGGGCAGCTGCGCCCGGTGCAGGTACGC
GACAGAAGCATCGAGAGCGCGGTGGCCAGTGCGGAGAAGGCCGACCGGGCGAACGCCGATCATGTCCCAGCGCCCTTCGC
GGGTGTGGTGACGCTCAACGTGGTCTCGGGCCAAGAGGTTTCAGCAGGGGAGACCATCGGCACCATTGAGGCCATGAAGA
TGGAGGCCTCGATCACCGCGCCCAAGGCGGGTACCGTCGCGCGGGTGGCGCTGACCGAGACTGCTCAGGTCGAGGGCGGA
GATCTGCTGGTGGTGATCAGCTGA

Upstream 100 bases:

>100_bases
CTCGAACGATTCTGGGATTACTGGATCACACTCGTCTGAACCGAATTGTGAAATTGAGCGGACGCGCGTTCGCTCAATCC
TCACGGTACGGTCAGTGACT

Downstream 100 bases:

>100_bases
CCCGGATTATCGCCGGTGTCGCGGGCGGGCGCCGGATCGCGGTGCCGCCAAAGGGAACCCGGCCCACCACGGATCGGGTG
CGAGAAGCGTTGTTCAGCAT

Product: pyruvate carboxylase

Products: NA

Alternate protein names: Pyruvic carboxylase; PYC [H]

Number of amino acids: Translated: 1127; Mature: 1127

Protein sequence:

>1127_residues
MFSKVLVANRGEIAIRAFRAAYELGAETVAVYPYEDRNSGHRLKADEAYQIGEKGHPVRAYLSVSEVVNAARNAGADAIY
PGYGFLSENPDLAAACAEAGITFVGPPADVLELTGNKARAIAAAREAGLPVLASSEPSASVEELLAAAESMEFPVFVKAV
AGGGGRGMRRVAERDQLREAIEAASREAESAFGDPTVFLEQAVINPRHIEVQILADTAGNVIHLYERDCSVQRRHQKVIE
LAPAPNLPPELREKICSDAVAFARHIGYSCAGTVEFLLDERGHHVFIEMNPRIQVEHTVTEEITDVDLVASQLRIASGET
LDDLGLHQDSITPRGAALQCRITTEDPANGFRPDTGRITAYRSPGGAGIRLDGGTTLGAEVGAHFDSMLVKLTCRGRDFQ
TAVARARRAVAEFRIRGVATNIPFLQAVLDDPDFRAGHVTTSFIEERPQLLTARSSADRGTKILNYLADVTVNKPHGAKP
STVYPHDKLPPIDLSVPPPDGSRQRLLALGPEGFAKALREQKAVGLTDTTFRDAHQSLLATRVRTTGLLAVAPYVARLTP
ELLSIEAWGGATYDVALRFLKEDPWERLADLREAVPNICLQMLLRGRNTVGYTPYPETVTKAFIREASATGVDIYRIFDA
LNNIEAMRPAIDAVREVGTSVAEVAMCYTGDLSNPGENLYTLDYYLKLAEQIVDAGAHVLAIKDMAGLLRPPAAATLVTA
LRSRFDLPVHVHTHDTAGGQLATYLAAWQAGADAVDGAAAPMAGTTSQPSLSAIVAAAAHSEYDTGVSLTSVCDLEPYWE
ALRKVYAPFESGLPSPTGRVYTHEIPGGQLSNLRQQAIALGLGDQFEEIEARYAAADRMLGRLVKVTPSSKVVGDLALAL
VGTGVSADEFASDPGRFDIPESVIGFLRGELGDPPGGWPEPFRTRALQGRGPARAEVALTADDESQLDGDSATRRAALNR
LLFPGPTKEFLAHREQYGDTSRLSANQFFYGLRYGEEHRVKLEKGVELLIGLEAISDADEHGMRTVMCILNGQLRPVQVR
DRSIESAVASAEKADRANADHVPAPFAGVVTLNVVSGQEVSAGETIGTIEAMKMEASITAPKAGTVARVALTETAQVEGG
DLLVVIS

Sequences:

>Translated_1127_residues
MFSKVLVANRGEIAIRAFRAAYELGAETVAVYPYEDRNSGHRLKADEAYQIGEKGHPVRAYLSVSEVVNAARNAGADAIY
PGYGFLSENPDLAAACAEAGITFVGPPADVLELTGNKARAIAAAREAGLPVLASSEPSASVEELLAAAESMEFPVFVKAV
AGGGGRGMRRVAERDQLREAIEAASREAESAFGDPTVFLEQAVINPRHIEVQILADTAGNVIHLYERDCSVQRRHQKVIE
LAPAPNLPPELREKICSDAVAFARHIGYSCAGTVEFLLDERGHHVFIEMNPRIQVEHTVTEEITDVDLVASQLRIASGET
LDDLGLHQDSITPRGAALQCRITTEDPANGFRPDTGRITAYRSPGGAGIRLDGGTTLGAEVGAHFDSMLVKLTCRGRDFQ
TAVARARRAVAEFRIRGVATNIPFLQAVLDDPDFRAGHVTTSFIEERPQLLTARSSADRGTKILNYLADVTVNKPHGAKP
STVYPHDKLPPIDLSVPPPDGSRQRLLALGPEGFAKALREQKAVGLTDTTFRDAHQSLLATRVRTTGLLAVAPYVARLTP
ELLSIEAWGGATYDVALRFLKEDPWERLADLREAVPNICLQMLLRGRNTVGYTPYPETVTKAFIREASATGVDIYRIFDA
LNNIEAMRPAIDAVREVGTSVAEVAMCYTGDLSNPGENLYTLDYYLKLAEQIVDAGAHVLAIKDMAGLLRPPAAATLVTA
LRSRFDLPVHVHTHDTAGGQLATYLAAWQAGADAVDGAAAPMAGTTSQPSLSAIVAAAAHSEYDTGVSLTSVCDLEPYWE
ALRKVYAPFESGLPSPTGRVYTHEIPGGQLSNLRQQAIALGLGDQFEEIEARYAAADRMLGRLVKVTPSSKVVGDLALAL
VGTGVSADEFASDPGRFDIPESVIGFLRGELGDPPGGWPEPFRTRALQGRGPARAEVALTADDESQLDGDSATRRAALNR
LLFPGPTKEFLAHREQYGDTSRLSANQFFYGLRYGEEHRVKLEKGVELLIGLEAISDADEHGMRTVMCILNGQLRPVQVR
DRSIESAVASAEKADRANADHVPAPFAGVVTLNVVSGQEVSAGETIGTIEAMKMEASITAPKAGTVARVALTETAQVEGG
DLLVVIS
>Mature_1127_residues
MFSKVLVANRGEIAIRAFRAAYELGAETVAVYPYEDRNSGHRLKADEAYQIGEKGHPVRAYLSVSEVVNAARNAGADAIY
PGYGFLSENPDLAAACAEAGITFVGPPADVLELTGNKARAIAAAREAGLPVLASSEPSASVEELLAAAESMEFPVFVKAV
AGGGGRGMRRVAERDQLREAIEAASREAESAFGDPTVFLEQAVINPRHIEVQILADTAGNVIHLYERDCSVQRRHQKVIE
LAPAPNLPPELREKICSDAVAFARHIGYSCAGTVEFLLDERGHHVFIEMNPRIQVEHTVTEEITDVDLVASQLRIASGET
LDDLGLHQDSITPRGAALQCRITTEDPANGFRPDTGRITAYRSPGGAGIRLDGGTTLGAEVGAHFDSMLVKLTCRGRDFQ
TAVARARRAVAEFRIRGVATNIPFLQAVLDDPDFRAGHVTTSFIEERPQLLTARSSADRGTKILNYLADVTVNKPHGAKP
STVYPHDKLPPIDLSVPPPDGSRQRLLALGPEGFAKALREQKAVGLTDTTFRDAHQSLLATRVRTTGLLAVAPYVARLTP
ELLSIEAWGGATYDVALRFLKEDPWERLADLREAVPNICLQMLLRGRNTVGYTPYPETVTKAFIREASATGVDIYRIFDA
LNNIEAMRPAIDAVREVGTSVAEVAMCYTGDLSNPGENLYTLDYYLKLAEQIVDAGAHVLAIKDMAGLLRPPAAATLVTA
LRSRFDLPVHVHTHDTAGGQLATYLAAWQAGADAVDGAAAPMAGTTSQPSLSAIVAAAAHSEYDTGVSLTSVCDLEPYWE
ALRKVYAPFESGLPSPTGRVYTHEIPGGQLSNLRQQAIALGLGDQFEEIEARYAAADRMLGRLVKVTPSSKVVGDLALAL
VGTGVSADEFASDPGRFDIPESVIGFLRGELGDPPGGWPEPFRTRALQGRGPARAEVALTADDESQLDGDSATRRAALNR
LLFPGPTKEFLAHREQYGDTSRLSANQFFYGLRYGEEHRVKLEKGVELLIGLEAISDADEHGMRTVMCILNGQLRPVQVR
DRSIESAVASAEKADRANADHVPAPFAGVVTLNVVSGQEVSAGETIGTIEAMKMEASITAPKAGTVARVALTETAQVEGG
DLLVVIS

Specific function: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second, leading to oxaloacetate production. Fulfills an anaplerotic functi

COG id: COG1038

COG function: function code C; Pyruvate carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=1142, Percent_Identity=47.8984238178634, Blast_Score=1014, Evalue=0.0,
Organism=Homo sapiens, GI106049295, Length=1142, Percent_Identity=47.8984238178634, Blast_Score=1014, Evalue=0.0,
Organism=Homo sapiens, GI106049292, Length=1142, Percent_Identity=47.8984238178634, Blast_Score=1014, Evalue=0.0,
Organism=Homo sapiens, GI116805327, Length=497, Percent_Identity=42.0523138832998, Blast_Score=381, Evalue=1e-105,
Organism=Homo sapiens, GI189095269, Length=448, Percent_Identity=39.5089285714286, Blast_Score=312, Evalue=1e-84,
Organism=Homo sapiens, GI65506442, Length=448, Percent_Identity=39.5089285714286, Blast_Score=312, Evalue=1e-84,
Organism=Homo sapiens, GI295821183, Length=448, Percent_Identity=39.5089285714286, Blast_Score=311, Evalue=2e-84,
Organism=Homo sapiens, GI38679960, Length=567, Percent_Identity=30.8641975308642, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI38679971, Length=567, Percent_Identity=30.8641975308642, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI38679977, Length=567, Percent_Identity=30.8641975308642, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI38679967, Length=567, Percent_Identity=30.8641975308642, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI38679974, Length=567, Percent_Identity=30.8641975308642, Blast_Score=228, Evalue=3e-59,
Organism=Homo sapiens, GI134142062, Length=507, Percent_Identity=31.3609467455621, Blast_Score=222, Evalue=2e-57,
Organism=Escherichia coli, GI1789654, Length=449, Percent_Identity=44.7661469933185, Blast_Score=357, Evalue=3e-99,
Organism=Escherichia coli, GI1786216, Length=237, Percent_Identity=25.3164556962025, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562816, Length=1143, Percent_Identity=46.8941382327209, Blast_Score=1009, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71987519, Length=456, Percent_Identity=45.3947368421053, Blast_Score=359, Evalue=6e-99,
Organism=Caenorhabditis elegans, GI17567343, Length=448, Percent_Identity=40.1785714285714, Blast_Score=330, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=30.2040816326531, Blast_Score=221, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71997168, Length=437, Percent_Identity=32.2654462242563, Blast_Score=215, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=437, Percent_Identity=32.2654462242563, Blast_Score=215, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6319695, Length=1153, Percent_Identity=46.8343451864701, Blast_Score=1003, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321376, Length=1153, Percent_Identity=47.0945359930616, Blast_Score=997, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=38.6516853932584, Blast_Score=327, Evalue=7e-90,
Organism=Saccharomyces cerevisiae, GI6323863, Length=460, Percent_Identity=32.6086956521739, Blast_Score=216, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6324343, Length=527, Percent_Identity=30.7400379506641, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24652212, Length=1142, Percent_Identity=47.723292469352, Blast_Score=1028, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652210, Length=1142, Percent_Identity=47.723292469352, Blast_Score=1028, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652214, Length=1142, Percent_Identity=47.723292469352, Blast_Score=1028, Evalue=0.0,
Organism=Drosophila melanogaster, GI19921944, Length=1142, Percent_Identity=47.723292469352, Blast_Score=1028, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652216, Length=1142, Percent_Identity=47.723292469352, Blast_Score=1028, Evalue=0.0,
Organism=Drosophila melanogaster, GI281363050, Length=1156, Percent_Identity=47.318339100346, Blast_Score=1024, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652224, Length=1156, Percent_Identity=47.318339100346, Blast_Score=1024, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652222, Length=1156, Percent_Identity=47.318339100346, Blast_Score=1024, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652220, Length=1156, Percent_Identity=47.318339100346, Blast_Score=1024, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652218, Length=1156, Percent_Identity=47.318339100346, Blast_Score=1024, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651757, Length=449, Percent_Identity=42.9844097995546, Blast_Score=353, Evalue=5e-97,
Organism=Drosophila melanogaster, GI24651759, Length=410, Percent_Identity=42.1951219512195, Blast_Score=317, Evalue=4e-86,
Organism=Drosophila melanogaster, GI161076407, Length=516, Percent_Identity=31.9767441860465, Blast_Score=223, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24586460, Length=516, Percent_Identity=31.9767441860465, Blast_Score=223, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24586458, Length=516, Percent_Identity=31.9767441860465, Blast_Score=223, Evalue=4e-58,
Organism=Drosophila melanogaster, GI161076409, Length=516, Percent_Identity=31.9767441860465, Blast_Score=223, Evalue=6e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR003379
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR000891
- InterPro:   IPR005930
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 120877; Mature: 120877

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50975 ATP_GRASP ; PS00165 DEHYDRATASE_SER_THR ; PS00867 CPSASE_2 ; PS50979 BC ; PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSKVLVANRGEIAIRAFRAAYELGAETVAVYPYEDRNSGHRLKADEAYQIGEKGHPVRA
CCCCEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCHHHHCCCCCCCEEE
YLSVSEVVNAARNAGADAIYPGYGFLSENPDLAAACAEAGITFVGPPADVLELTGNKARA
EEEHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHCCCEEECCCHHHHHCCCCHHHH
IAAAREAGLPVLASSEPSASVEELLAAAESMEFPVFVKAVAGGGGRGMRRVAERDQLREA
HHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
IEAASREAESAFGDPTVFLEQAVINPRHIEVQILADTAGNVIHLYERDCSVQRRHQKVIE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHE
LAPAPNLPPELREKICSDAVAFARHIGYSCAGTVEFLLDERGHHVFIEMNPRIQVEHTVT
ECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCEEEEEEHH
EEITDVDLVASQLRIASGETLDDLGLHQDSITPRGAALQCRITTEDPANGFRPDTGRITA
HHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEE
YRSPGGAGIRLDGGTTLGAEVGAHFDSMLVKLTCRGRDFQTAVARARRAVAEFRIRGVAT
EECCCCCEEEECCCCEEHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHEEC
NIPFLQAVLDDPDFRAGHVTTSFIEERPQLLTARSSADRGTKILNYLADVTVNKPHGAKP
CCHHHHHHHCCCCCCCCCCCHHHHHCCHHHEEECCCCCHHHHHHHHHHHCEECCCCCCCC
STVYPHDKLPPIDLSVPPPDGSRQRLLALGPEGFAKALREQKAVGLTDTTFRDAHQSLLA
CCCCCCCCCCCCCEECCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
TRVRTTGLLAVAPYVARLTPELLSIEAWGGATYDVALRFLKEDPWERLADLREAVPNICL
HHHHHCCHHHHHHHHHHCCHHHEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
QMLLRGRNTVGYTPYPETVTKAFIREASATGVDIYRIFDALNNIEAMRPAIDAVREVGTS
HHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
VAEVAMCYTGDLSNPGENLYTLDYYLKLAEQIVDAGAHVLAIKDMAGLLRPPAAATLVTA
HHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCHHHHHHHH
LRSRFDLPVHVHTHDTAGGQLATYLAAWQAGADAVDGAAAPMAGTTSQPSLSAIVAAAAH
HHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
SEYDTGVSLTSVCDLEPYWEALRKVYAPFESGLPSPTGRVYTHEIPGGQLSNLRQQAIAL
CCCCCCCCHHHEECCCHHHHHHHHHHCHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHH
GLGDQFEEIEARYAAADRMLGRLVKVTPSSKVVGDLALALVGTGVSADEFASDPGRFDIP
CCCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCH
ESVIGFLRGELGDPPGGWPEPFRTRALQGRGPARAEVALTADDESQLDGDSATRRAALNR
HHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
LLFPGPTKEFLAHREQYGDTSRLSANQFFYGLRYGEEHRVKLEKGVELLIGLEAISDADE
CCCCCCCHHHHHHHHHCCCCCCCCHHHEEEEEECCCCHHEEHHCCCEEEEEHHHHCCCHH
HGMRTVMCILNGQLRPVQVRDRSIESAVASAEKADRANADHVPAPFAGVVTLNVVSGQEV
HCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCC
SAGETIGTIEAMKMEASITAPKAGTVARVALTETAQVEGGDLLVVIS
CCCCCCCHHHHEEEECEECCCCCCCEEEEEEEEECEECCCCEEEEEC
>Mature Secondary Structure
MFSKVLVANRGEIAIRAFRAAYELGAETVAVYPYEDRNSGHRLKADEAYQIGEKGHPVRA
CCCCEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCHHHHCCCCCCCEEE
YLSVSEVVNAARNAGADAIYPGYGFLSENPDLAAACAEAGITFVGPPADVLELTGNKARA
EEEHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHCCCEEECCCHHHHHCCCCHHHH
IAAAREAGLPVLASSEPSASVEELLAAAESMEFPVFVKAVAGGGGRGMRRVAERDQLREA
HHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
IEAASREAESAFGDPTVFLEQAVINPRHIEVQILADTAGNVIHLYERDCSVQRRHQKVIE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHE
LAPAPNLPPELREKICSDAVAFARHIGYSCAGTVEFLLDERGHHVFIEMNPRIQVEHTVT
ECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCEEEEEEHH
EEITDVDLVASQLRIASGETLDDLGLHQDSITPRGAALQCRITTEDPANGFRPDTGRITA
HHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEE
YRSPGGAGIRLDGGTTLGAEVGAHFDSMLVKLTCRGRDFQTAVARARRAVAEFRIRGVAT
EECCCCCEEEECCCCEEHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHEEC
NIPFLQAVLDDPDFRAGHVTTSFIEERPQLLTARSSADRGTKILNYLADVTVNKPHGAKP
CCHHHHHHHCCCCCCCCCCCHHHHHCCHHHEEECCCCCHHHHHHHHHHHCEECCCCCCCC
STVYPHDKLPPIDLSVPPPDGSRQRLLALGPEGFAKALREQKAVGLTDTTFRDAHQSLLA
CCCCCCCCCCCCCEECCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
TRVRTTGLLAVAPYVARLTPELLSIEAWGGATYDVALRFLKEDPWERLADLREAVPNICL
HHHHHCCHHHHHHHHHHCCHHHEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
QMLLRGRNTVGYTPYPETVTKAFIREASATGVDIYRIFDALNNIEAMRPAIDAVREVGTS
HHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
VAEVAMCYTGDLSNPGENLYTLDYYLKLAEQIVDAGAHVLAIKDMAGLLRPPAAATLVTA
HHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCHHHHHHHH
LRSRFDLPVHVHTHDTAGGQLATYLAAWQAGADAVDGAAAPMAGTTSQPSLSAIVAAAAH
HHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
SEYDTGVSLTSVCDLEPYWEALRKVYAPFESGLPSPTGRVYTHEIPGGQLSNLRQQAIAL
CCCCCCCCHHHEECCCHHHHHHHHHHCHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHH
GLGDQFEEIEARYAAADRMLGRLVKVTPSSKVVGDLALALVGTGVSADEFASDPGRFDIP
CCCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCH
ESVIGFLRGELGDPPGGWPEPFRTRALQGRGPARAEVALTADDESQLDGDSATRRAALNR
HHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
LLFPGPTKEFLAHREQYGDTSRLSANQFFYGLRYGEEHRVKLEKGVELLIGLEAISDADE
CCCCCCCHHHHHHHHHCCCCCCCCHHHEEEEEECCCCHHEEHHCCCEEEEEHHHHCCCHH
HGMRTVMCILNGQLRPVQVRDRSIESAVASAEKADRANADHVPAPFAGVVTLNVVSGQEV
HCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCC
SAGETIGTIEAMKMEASITAPKAGTVARVALTETAQVEGGDLLVVIS
CCCCCCCHHHHEEEECEECCCCCCCEEEEEEEEECEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]