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The map label for this gene is kdpD [H]

Identifier: 169630332

GI number: 169630332

Start: 3287419

End: 3289926

Strand: Reverse

Name: kdpD [H]

Synonym: MAB_3251c

Alternate gene names: 169630332

Gene position: 3289926-3287419 (Counterclockwise)

Preceding gene: 169630333

Following gene: 169630331

Centisome position: 64.93

GC content: 66.03

Gene sequence:

>2508_bases
GTGCCTGACGGTCTTCGCGCACGCGGGACGTTGCGGATCTACCTGGGGGCCGCGCCCGGTGTAGGCAAGACCTTCGCCAT
GCTCAACGAGGCGCATCGCCGGGCCGGGCGCGGAACCGATGTGGTGGCCGCGGTGGTAGAGACCCACGGTCGTAGTAAGA
CCGCCGAACTGCTCGATGGGCTGGAGCTCATTCCACCCAAGGAGATGGTCCACCGCGGAACAGCGATGTATGAGCTGGAC
GTGGACGCCGTGCTGGAGCGCAGGCCGGCCCTGGTGCTCATCGATGAGATGGCACACACCAATGTGCCGGGCAGCCGAAA
CCCCAAGCGTTGGCAGGACATCGACGAGATCCTGGATGCGGGGATCGACGTGCTGACCACCATCAACGTGCAGCACCTGG
AAAGCCTGAATGACGTCGTCGAACAGATCACCGGGATCGTGCAGCGCGAAACCGTGCCTGACGCAGTGGTGCGCCGGGCC
GAACAGGTCGAGCTTGTCGACATCACGCCGGAGGCGTTGCGGCGCAGAATGGTTCACGGCAATGTCTATGCGCCCGAGAA
GGTGGGCTCGGCGCTGAGTAACTACTTCCGGACCGGCAATCTCACCGCCCTGCGCGAGTTGGCGTTGTTGTGGCTCGCCG
ACCAGGTGGACGCGGCGCTGGCCAAATACCGCTCCGACAACAGAATCACCAAGACCTGGGAGGCGCGTGAGCGTGTGGTG
GTCGCGGTCACCGGCGGGCCCGAATCAGAGACGCTGGTGCGCCGGGCTAGTCGTATTGCGGCCAAGTCGAGTGCCGAACT
TCTCGTTGTCCACGTGGTGCGTGGTGACGGCCTGGTGGGGGCCTCCACGGCGGTCATGACGCGGGTGCGTCGGCTGGCCA
ACGACATTGGAGCCTCCGTGCAGGCGGTCACCGGTGACGATGTGCCGCAGACCCTCTTGGACTTCGCGCGCGGCGTCAAC
GCGACTCAGCTGGTACTCGGCACCTCACGGCGTTCGCGGTGGGCACGGATCCTCGACGAGGGGGTGGCAGCCGCCGTCAT
CCGGGACTCCGGCGCCATCGACGTCCACATGGTGACGCACGGGCACACCTCCGGACGGCTGCGCAGCTGGTCGGTGCCGC
AGGACGGACGTAAGCGGCTCATCATCAACTGGCTGGCCGCGATTCTGGTGCCACCCGCCACCGCGTTATTCATCCATTTC
TTTGACACCGCCTTCGGGGTGGGCAGCAAGAGTGCCCTGTTTCTCATTGCGGTACTAGGTGTTTCACTGCTCGGCGGCGT
CTCGACTGCGCTGGTCTCCGCGGTAATTTCCGGGCTGCTGCTCAATTTCTTGTTTGTTGCGCCGAGGTACAGCTTCACGA
TCGGCGAGACCGATAATGCACTGACCATTTTGATGATGATGGTGACCGCGGTCGCCGTCGCGGCGCTGGTGGATGCGGCC
GCCACGCGGGCGCGACAGGCCCGGCGTGCCTCCCGCGAGGCAGAACTGTTGGCGCTCTTCGCCGGCGGGGTCCTGGTGAA
TTCGGATCTGTCGGCACTGCTGGAACGCGTGCGGACCACCTACAACCAGACCGCGGTGAGCCTGCTGTGCGCGGAGGGAC
CGGCCGTGGCCAGCGTGGGGGAGGACCCACCCACGCGGGAGTCGGAGGCAGATTCGGTATTCCGGGTGGACGATGGCGCG
TATGCGTTGGCGCTCAACGGGCCACCGGTGCCGTCGAGTGATGCCCGGGTGTTGCAGGTGGTCGCGGGAACCGCAGTCGG
TCTGGTGCGTTCCGCACGCCTGGCCGAGGAGGCGTCGCAGGCCTCCGCTCTTGCCGAGGCGGACAGACTGCGCCGGGCGC
TGCTCTCGGCAGTCAGCCACGACCTGCGCACGCCACTGGCTGCCGTCAAGGCAGCGGTGTCGAGTCTGCGTAGTCCCGAT
ATCGAGTTCTCGCCGGAGGACACCGCCGAATTGCTTGCCACCGTGGAGGAATCGGCCGATCAGCTCACGGCGTTGGTGGG
CAATCTGCTGGACTCATCGCGGCTGGCCGCGGGCGTCGTCAAGCCCCGGGCGGTGCCGGTGTACGTGGACGAGATCGCGC
AGCGCGCCCTGTTGGGAGCCACCGAGAACGATCGCAAGCGGGTGCACCTGGACTTGGGCGGTGCGGTGGTACGGGCAGAT
CCGGGTCTGCTGGAACGTGTGTTGGCCAACCTTGTCGACAATGCGCTGCGATACTCACAGGGCGAGGTGCGGGTCAGCCA
CGAGGAGGTGGATGACCGCACGTTGGTGATCGTCGCCGATCACGGTAAGGGGTTGGAGGCGTCCAAGCGCGGCGCGGCCT
TCGATGCTTTCCAGCGGCTCGGCGATCGCGACAACACCGTCGGTGTGGGGCTTGGTCTTTCGGTGGTGAAGGGTTTTGTG
GAAGCGATGGAGGGCACGGTGAATGCGACCGACACGGCTGGCGGCGGACTGACCATGATCGTGGATCTACCCAGCGCTGG
TTCCGCTCCTACCGGGGCGATCCGATGA

Upstream 100 bases:

>100_bases
TCCCGGCAATGGGGCATTCTGGGAGAGCCGCGTGTCAACGTCCCCACACTGAACGTGGCACTGGGTCTGACCGGCCCACC
CTGCCGATGAAGGAGAGACG

Downstream 100 bases:

>100_bases
CCCGGGTGCTGGTGGTGGACGACGAGCCGCAGATTCTGCGCGCCATGCGCATAAACCTGTCGGCACGCGGATATGAGGTA
GTGACAGCCTCCTCCGGCGC

Product: sensor protein KdpD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 835; Mature: 834

Protein sequence:

>835_residues
MPDGLRARGTLRIYLGAAPGVGKTFAMLNEAHRRAGRGTDVVAAVVETHGRSKTAELLDGLELIPPKEMVHRGTAMYELD
VDAVLERRPALVLIDEMAHTNVPGSRNPKRWQDIDEILDAGIDVLTTINVQHLESLNDVVEQITGIVQRETVPDAVVRRA
EQVELVDITPEALRRRMVHGNVYAPEKVGSALSNYFRTGNLTALRELALLWLADQVDAALAKYRSDNRITKTWEARERVV
VAVTGGPESETLVRRASRIAAKSSAELLVVHVVRGDGLVGASTAVMTRVRRLANDIGASVQAVTGDDVPQTLLDFARGVN
ATQLVLGTSRRSRWARILDEGVAAAVIRDSGAIDVHMVTHGHTSGRLRSWSVPQDGRKRLIINWLAAILVPPATALFIHF
FDTAFGVGSKSALFLIAVLGVSLLGGVSTALVSAVISGLLLNFLFVAPRYSFTIGETDNALTILMMMVTAVAVAALVDAA
ATRARQARRASREAELLALFAGGVLVNSDLSALLERVRTTYNQTAVSLLCAEGPAVASVGEDPPTRESEADSVFRVDDGA
YALALNGPPVPSSDARVLQVVAGTAVGLVRSARLAEEASQASALAEADRLRRALLSAVSHDLRTPLAAVKAAVSSLRSPD
IEFSPEDTAELLATVEESADQLTALVGNLLDSSRLAAGVVKPRAVPVYVDEIAQRALLGATENDRKRVHLDLGGAVVRAD
PGLLERVLANLVDNALRYSQGEVRVSHEEVDDRTLVIVADHGKGLEASKRGAAFDAFQRLGDRDNTVGVGLGLSVVKGFV
EAMEGTVNATDTAGGGLTMIVDLPSAGSAPTGAIR

Sequences:

>Translated_835_residues
MPDGLRARGTLRIYLGAAPGVGKTFAMLNEAHRRAGRGTDVVAAVVETHGRSKTAELLDGLELIPPKEMVHRGTAMYELD
VDAVLERRPALVLIDEMAHTNVPGSRNPKRWQDIDEILDAGIDVLTTINVQHLESLNDVVEQITGIVQRETVPDAVVRRA
EQVELVDITPEALRRRMVHGNVYAPEKVGSALSNYFRTGNLTALRELALLWLADQVDAALAKYRSDNRITKTWEARERVV
VAVTGGPESETLVRRASRIAAKSSAELLVVHVVRGDGLVGASTAVMTRVRRLANDIGASVQAVTGDDVPQTLLDFARGVN
ATQLVLGTSRRSRWARILDEGVAAAVIRDSGAIDVHMVTHGHTSGRLRSWSVPQDGRKRLIINWLAAILVPPATALFIHF
FDTAFGVGSKSALFLIAVLGVSLLGGVSTALVSAVISGLLLNFLFVAPRYSFTIGETDNALTILMMMVTAVAVAALVDAA
ATRARQARRASREAELLALFAGGVLVNSDLSALLERVRTTYNQTAVSLLCAEGPAVASVGEDPPTRESEADSVFRVDDGA
YALALNGPPVPSSDARVLQVVAGTAVGLVRSARLAEEASQASALAEADRLRRALLSAVSHDLRTPLAAVKAAVSSLRSPD
IEFSPEDTAELLATVEESADQLTALVGNLLDSSRLAAGVVKPRAVPVYVDEIAQRALLGATENDRKRVHLDLGGAVVRAD
PGLLERVLANLVDNALRYSQGEVRVSHEEVDDRTLVIVADHGKGLEASKRGAAFDAFQRLGDRDNTVGVGLGLSVVKGFV
EAMEGTVNATDTAGGGLTMIVDLPSAGSAPTGAIR
>Mature_834_residues
PDGLRARGTLRIYLGAAPGVGKTFAMLNEAHRRAGRGTDVVAAVVETHGRSKTAELLDGLELIPPKEMVHRGTAMYELDV
DAVLERRPALVLIDEMAHTNVPGSRNPKRWQDIDEILDAGIDVLTTINVQHLESLNDVVEQITGIVQRETVPDAVVRRAE
QVELVDITPEALRRRMVHGNVYAPEKVGSALSNYFRTGNLTALRELALLWLADQVDAALAKYRSDNRITKTWEARERVVV
AVTGGPESETLVRRASRIAAKSSAELLVVHVVRGDGLVGASTAVMTRVRRLANDIGASVQAVTGDDVPQTLLDFARGVNA
TQLVLGTSRRSRWARILDEGVAAAVIRDSGAIDVHMVTHGHTSGRLRSWSVPQDGRKRLIINWLAAILVPPATALFIHFF
DTAFGVGSKSALFLIAVLGVSLLGGVSTALVSAVISGLLLNFLFVAPRYSFTIGETDNALTILMMMVTAVAVAALVDAAA
TRARQARRASREAELLALFAGGVLVNSDLSALLERVRTTYNQTAVSLLCAEGPAVASVGEDPPTRESEADSVFRVDDGAY
ALALNGPPVPSSDARVLQVVAGTAVGLVRSARLAEEASQASALAEADRLRRALLSAVSHDLRTPLAAVKAAVSSLRSPDI
EFSPEDTAELLATVEESADQLTALVGNLLDSSRLAAGVVKPRAVPVYVDEIAQRALLGATENDRKRVHLDLGGAVVRADP
GLLERVLANLVDNALRYSQGEVRVSHEEVDDRTLVIVADHGKGLEASKRGAAFDAFQRLGDRDNTVGVGLGLSVVKGFVE
AMEGTVNATDTAGGGLTMIVDLPSAGSAPTGAIR

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=869, Percent_Identity=32.1058688147296, Blast_Score=373, Evalue=1e-104,
Organism=Escherichia coli, GI1788393, Length=244, Percent_Identity=29.9180327868852, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=30.0448430493274, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=27.0916334661355, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1787894, Length=228, Percent_Identity=30.7017543859649, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1789808, Length=221, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788713, Length=289, Percent_Identity=23.8754325259516, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1787374, Length=225, Percent_Identity=28, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI87081816, Length=253, Percent_Identity=30.4347826086957, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=28.2700421940928, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788549, Length=230, Percent_Identity=27.3913043478261, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87082128, Length=239, Percent_Identity=26.3598326359833, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1790551, Length=218, Percent_Identity=31.1926605504587, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI48994928, Length=258, Percent_Identity=26.3565891472868, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR014729
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 88681; Mature: 88550

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDGLRARGTLRIYLGAAPGVGKTFAMLNEAHRRAGRGTDVVAAVVETHGRSKTAELLDG
CCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCC
LELIPPKEMVHRGTAMYELDVDAVLERRPALVLIDEMAHTNVPGSRNPKRWQDIDEILDA
CCCCCCHHHHHCCCEEEEECHHHHHHCCCCEEEEEHHHHCCCCCCCCCHHHHHHHHHHHC
GIDVLTTINVQHLESLNDVVEQITGIVQRETVPDAVVRRAEQVELVDITPEALRRRMVHG
CCHHEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCEEEEECCHHHHHHHHHCC
NVYAPEKVGSALSNYFRTGNLTALRELALLWLADQVDAALAKYRSDNRITKTWEARERVV
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHCCCCEE
VAVTGGPESETLVRRASRIAAKSSAELLVVHVVRGDGLVGASTAVMTRVRRLANDIGASV
EEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCE
QAVTGDDVPQTLLDFARGVNATQLVLGTSRRSRWARILDEGVAAAVIRDSGAIDVHMVTH
EEECCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCHHEEEEECCCCEEEEEEEC
GHTSGRLRSWSVPQDGRKRLIINWLAAILVPPATALFIHFFDTAFGVGSKSALFLIAVLG
CCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VSLLGGVSTALVSAVISGLLLNFLFVAPRYSFTIGETDNALTILMMMVTAVAVAALVDAA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ATRARQARRASREAELLALFAGGVLVNSDLSALLERVRTTYNQTAVSLLCAEGPAVASVG
HHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCC
EDPPTRESEADSVFRVDDGAYALALNGPPVPSSDARVLQVVAGTAVGLVRSARLAEEASQ
CCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ASALAEADRLRRALLSAVSHDLRTPLAAVKAAVSSLRSPDIEFSPEDTAELLATVEESAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
QLTALVGNLLDSSRLAAGVVKPRAVPVYVDEIAQRALLGATENDRKRVHLDLGGAVVRAD
HHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCCCCCCEEEEEEECCEEEECC
PGLLERVLANLVDNALRYSQGEVRVSHEEVDDRTLVIVADHGKGLEASKRGAAFDAFQRL
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHC
GDRDNTVGVGLGLSVVKGFVEAMEGTVNATDTAGGGLTMIVDLPSAGSAPTGAIR
CCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
PDGLRARGTLRIYLGAAPGVGKTFAMLNEAHRRAGRGTDVVAAVVETHGRSKTAELLDG
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCC
LELIPPKEMVHRGTAMYELDVDAVLERRPALVLIDEMAHTNVPGSRNPKRWQDIDEILDA
CCCCCCHHHHHCCCEEEEECHHHHHHCCCCEEEEEHHHHCCCCCCCCCHHHHHHHHHHHC
GIDVLTTINVQHLESLNDVVEQITGIVQRETVPDAVVRRAEQVELVDITPEALRRRMVHG
CCHHEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCEEEEECCHHHHHHHHHCC
NVYAPEKVGSALSNYFRTGNLTALRELALLWLADQVDAALAKYRSDNRITKTWEARERVV
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHCCCCEE
VAVTGGPESETLVRRASRIAAKSSAELLVVHVVRGDGLVGASTAVMTRVRRLANDIGASV
EEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCE
QAVTGDDVPQTLLDFARGVNATQLVLGTSRRSRWARILDEGVAAAVIRDSGAIDVHMVTH
EEECCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCHHEEEEECCCCEEEEEEEC
GHTSGRLRSWSVPQDGRKRLIINWLAAILVPPATALFIHFFDTAFGVGSKSALFLIAVLG
CCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VSLLGGVSTALVSAVISGLLLNFLFVAPRYSFTIGETDNALTILMMMVTAVAVAALVDAA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
ATRARQARRASREAELLALFAGGVLVNSDLSALLERVRTTYNQTAVSLLCAEGPAVASVG
HHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCC
EDPPTRESEADSVFRVDDGAYALALNGPPVPSSDARVLQVVAGTAVGLVRSARLAEEASQ
CCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ASALAEADRLRRALLSAVSHDLRTPLAAVKAAVSSLRSPDIEFSPEDTAELLATVEESAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
QLTALVGNLLDSSRLAAGVVKPRAVPVYVDEIAQRALLGATENDRKRVHLDLGGAVVRAD
HHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHCCCCCCCEEEEEEECCEEEECC
PGLLERVLANLVDNALRYSQGEVRVSHEEVDDRTLVIVADHGKGLEASKRGAAFDAFQRL
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHC
GDRDNTVGVGLGLSVVKGFVEAMEGTVNATDTAGGGLTMIVDLPSAGSAPTGAIR
CCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]