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The map label for this gene is map [H]

Identifier: 169630246

GI number: 169630246

Start: 3211172

End: 3211975

Strand: Reverse

Name: map [H]

Synonym: MAB_3164c

Alternate gene names: 169630246

Gene position: 3211975-3211172 (Counterclockwise)

Preceding gene: 169630247

Following gene: 169630245

Centisome position: 63.39

GC content: 62.19

Gene sequence:

>804_bases
GTGTCGATCGATCGTCCCGAGTATGTGGGCAAGTCCAAGGTCGCCGAGGCCATCGGAGAGCCGTACGTGCAGACCCCCGA
AGTCATCGAGAAGATGCGGGTCGCGGGCCGGATCGCGGCGAGGGCGCTGGCGCTTGCCGGTGAGGCGGTGGCTCCCGGTG
TCACCACCGATGAGCTGGACCGCATCGCACACGACTACATGGTGTCCCAGGGGGCATACCCGTCAACGCTGGGGTACAAG
GGATTTCCGAAGTCGTGCTGCACATCGCTGAACGAGATCATCTGCCACGGAATCCCGGACTCGACCGTGATCGAGGACGG
TGACATCGTCAACATCGACGTCACCGCCTACATCGACGGTGTACACGGCGATACCAACGCCACCTTCCTGGCCGGAGATG
TCTCCGAGGAGCATCGCCTGCTCGTCGAGCGCACCCGGGAGGCCACCATGCGGGCGATCAACGCCGTCAAGCCGGGACGG
GCGCTGAGCGTGGTCGGCAGGGTGATCGAGGCCTATGCAAAACGGTTTGGGTACAACGTGGTTCGAGCATTCACTGGTCA
TGGCGTGGGCCCGACGTTCCACAACGGCCTCATTGTGCCGCATTACGACGACCCCAATCTGGACATCGTCATCGAACCGG
GCATGACGTTCACCATTGAACCGATGATCAACCTGGGATCCCTGGAGTACGAGATCTGGGATGACACCTGGACCGTGGCG
ACCGCCGACAAGTTGTGGACCGCGCAGTTCGAGCACACCATGGTGGTCACCGAGGACGGAGTAGAGATCCTGACAGTGCC
ATGA

Upstream 100 bases:

>100_bases
CGCTGCCTTCATGACTGTTTCTGATTCTCTTCGCGCAAGCGGCTCATCGCCACGTGCCGCACTGCGCCCGGGGGAGTTGT
CTCCGGAGCGTCAGGTTCCC

Downstream 100 bases:

>100_bases
CGGGCGCCGTATCCGGCGCGCTGCTGGTCGGGGGCGTAAGCTCCGATGCCGGTAAGAGTCTGGTGGTGACGGGCCTGTGT
CGATTGTTGGCCCGCAAGGG

Product: methionine aminopeptidase (MAP)

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSIDRPEYVGKSKVAEAIGEPYVQTPEVIEKMRVAGRIAARALALAGEAVAPGVTTDELDRIAHDYMVSQGAYPSTLGYK
GFPKSCCTSLNEIICHGIPDSTVIEDGDIVNIDVTAYIDGVHGDTNATFLAGDVSEEHRLLVERTREATMRAINAVKPGR
ALSVVGRVIEAYAKRFGYNVVRAFTGHGVGPTFHNGLIVPHYDDPNLDIVIEPGMTFTIEPMINLGSLEYEIWDDTWTVA
TADKLWTAQFEHTMVVTEDGVEILTVP

Sequences:

>Translated_267_residues
MSIDRPEYVGKSKVAEAIGEPYVQTPEVIEKMRVAGRIAARALALAGEAVAPGVTTDELDRIAHDYMVSQGAYPSTLGYK
GFPKSCCTSLNEIICHGIPDSTVIEDGDIVNIDVTAYIDGVHGDTNATFLAGDVSEEHRLLVERTREATMRAINAVKPGR
ALSVVGRVIEAYAKRFGYNVVRAFTGHGVGPTFHNGLIVPHYDDPNLDIVIEPGMTFTIEPMINLGSLEYEIWDDTWTVA
TADKLWTAQFEHTMVVTEDGVEILTVP
>Mature_266_residues
SIDRPEYVGKSKVAEAIGEPYVQTPEVIEKMRVAGRIAARALALAGEAVAPGVTTDELDRIAHDYMVSQGAYPSTLGYKG
FPKSCCTSLNEIICHGIPDSTVIEDGDIVNIDVTAYIDGVHGDTNATFLAGDVSEEHRLLVERTREATMRAINAVKPGRA
LSVVGRVIEAYAKRFGYNVVRAFTGHGVGPTFHNGLIVPHYDDPNLDIVIEPGMTFTIEPMINLGSLEYEIWDDTWTVAT
ADKLWTAQFEHTMVVTEDGVEILTVP

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=270, Percent_Identity=45.1851851851852, Blast_Score=241, Evalue=5e-64,
Organism=Homo sapiens, GI40385867, Length=263, Percent_Identity=43.3460076045627, Blast_Score=225, Evalue=2e-59,
Organism=Escherichia coli, GI1786364, Length=246, Percent_Identity=50, Blast_Score=247, Evalue=7e-67,
Organism=Escherichia coli, GI1788728, Length=214, Percent_Identity=28.5046728971963, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=244, Percent_Identity=48.7704918032787, Blast_Score=239, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6323273, Length=238, Percent_Identity=48.7394957983193, Blast_Score=233, Evalue=3e-62,
Organism=Drosophila melanogaster, GI21355531, Length=270, Percent_Identity=48.5185185185185, Blast_Score=261, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24583427, Length=264, Percent_Identity=42.4242424242424, Blast_Score=224, Evalue=5e-59,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29093; Mature: 28962

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDRPEYVGKSKVAEAIGEPYVQTPEVIEKMRVAGRIAARALALAGEAVAPGVTTDELD
CCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
RIAHDYMVSQGAYPSTLGYKGFPKSCCTSLNEIICHGIPDSTVIEDGDIVNIDVTAYIDG
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCEEEEEEEEEEEC
VHGDTNATFLAGDVSEEHRLLVERTREATMRAINAVKPGRALSVVGRVIEAYAKRFGYNV
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHH
VRAFTGHGVGPTFHNGLIVPHYDDPNLDIVIEPGMTFTIEPMINLGSLEYEIWDDTWTVA
HHHHHCCCCCCCCCCCEEEECCCCCCEEEEECCCCEEEECCCCCCCCEEEEEECCEEEEE
TADKLWTAQFEHTMVVTEDGVEILTVP
EHHHHEEEECCEEEEEEECCEEEEECC
>Mature Secondary Structure 
SIDRPEYVGKSKVAEAIGEPYVQTPEVIEKMRVAGRIAARALALAGEAVAPGVTTDELD
CCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
RIAHDYMVSQGAYPSTLGYKGFPKSCCTSLNEIICHGIPDSTVIEDGDIVNIDVTAYIDG
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCEEEEEEEEEEEC
VHGDTNATFLAGDVSEEHRLLVERTREATMRAINAVKPGRALSVVGRVIEAYAKRFGYNV
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHH
VRAFTGHGVGPTFHNGLIVPHYDDPNLDIVIEPGMTFTIEPMINLGSLEYEIWDDTWTVA
HHHHHCCCCCCCCCCCEEEECCCCCCEEEEECCCCEEEECCCCCCCCEEEEEECCEEEEE
TADKLWTAQFEHTMVVTEDGVEILTVP
EHHHHEEEECCEEEEEEECCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]