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The map label for this gene is thyA [H]

Identifier: 169630173

GI number: 169630173

Start: 3134847

End: 3135647

Strand: Reverse

Name: thyA [H]

Synonym: MAB_3091c

Alternate gene names: 169630173

Gene position: 3135647-3134847 (Counterclockwise)

Preceding gene: 169630174

Following gene: 169630172

Centisome position: 61.88

GC content: 62.3

Gene sequence:

>801_bases
GTGTCTCTTCCCACTCCCTACGAGGATCTATTGCGTCTCGTGCTCGAAGAGGGCACGCCGAAGGCGGATCGCACCGGCAC
CGGCACCCGCAGTGTCTTCGGACACCAGCTGCGTTATCGCCTGGAGGACGGCTTCCCGCTGATCACCACCAAGAAGGTCC
ACCTGAAGTCGGTGATCTATGAGCTGCTGTGGTTCTTGCGCGGTGAATCCAATGTCCGCTGGCTCCAGGAGCGCGGGGTC
ACCATCTGGGACGAGTGGGCGTCGGAGGCCGGCGAACTGGGCCCCGTGTACGGCGTGCAGTGGCGCGCCTGGCCCACCCC
GTCTGGTGAGCACATCGACCAGATCAGCGCCGCACTGGATCTGCTGCGTACCAATCCGGATTCGCGCCGGAACATCGTTT
CGGCATGGAATGTCGGCGAAATCCCGCAGATGGCGCTGCCGCCCTGCCACGCCTTCTTCCAGTTCTATGTGGCCGACGGC
AAGCTGAGTTGCCAGCTGTATCAACGCAGCGCCGATCTATTCCTCGGGGTCCCGTTCAACATCGCCAGCTACGCACTGCT
CACCCACATGATGGCGGCACAGGCGGGCCTGGGAGTCGGAGACTTTGTGTGGACCGGTGGGGACTGCCATATCTATGACA
ACCATGTGGAGCAGGTCACCGAACAGCTCAGCCGCGACCCCTACCCCTATCCCACGCTTGTTCTGGCGCAGCGTGATTCG
ATATTCGACTACCGATACGAGGACATCACCGTCGAGAACTACCAGCATCACGCCGCCATCAAGGCGCCGGTCGCGGTATG
A

Upstream 100 bases:

>100_bases
GAGTGGAGGCGCTCGCAGAACCGTAGAACGCAGGGCGCGGGGGCGCGCTGTGGGCGTCGGGGACCTCGGGATCGTCATGG
CCGCGACGTAAACTAGCTGC

Downstream 100 bases:

>100_bases
CGGGAACCATCGGGCTGATCTGGGCGCAAACCCGAGCCGGCGTCATCGGCGCGGACGGTGCCATTCCCTGGCGGCTACCC
GAAGACCAGGCACGTTTCAA

Product: thymidylate synthase (ThyA)

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSLPTPYEDLLRLVLEEGTPKADRTGTGTRSVFGHQLRYRLEDGFPLITTKKVHLKSVIYELLWFLRGESNVRWLQERGV
TIWDEWASEAGELGPVYGVQWRAWPTPSGEHIDQISAALDLLRTNPDSRRNIVSAWNVGEIPQMALPPCHAFFQFYVADG
KLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLGVGDFVWTGGDCHIYDNHVEQVTEQLSRDPYPYPTLVLAQRDS
IFDYRYEDITVENYQHHAAIKAPVAV

Sequences:

>Translated_266_residues
MSLPTPYEDLLRLVLEEGTPKADRTGTGTRSVFGHQLRYRLEDGFPLITTKKVHLKSVIYELLWFLRGESNVRWLQERGV
TIWDEWASEAGELGPVYGVQWRAWPTPSGEHIDQISAALDLLRTNPDSRRNIVSAWNVGEIPQMALPPCHAFFQFYVADG
KLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLGVGDFVWTGGDCHIYDNHVEQVTEQLSRDPYPYPTLVLAQRDS
IFDYRYEDITVENYQHHAAIKAPVAV
>Mature_265_residues
SLPTPYEDLLRLVLEEGTPKADRTGTGTRSVFGHQLRYRLEDGFPLITTKKVHLKSVIYELLWFLRGESNVRWLQERGVT
IWDEWASEAGELGPVYGVQWRAWPTPSGEHIDQISAALDLLRTNPDSRRNIVSAWNVGEIPQMALPPCHAFFQFYVADGK
LSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLGVGDFVWTGGDCHIYDNHVEQVTEQLSRDPYPYPTLVLAQRDSI
FDYRYEDITVENYQHHAAIKAPVAV

Specific function: Provides the sole de novo source of dTMP for DNA biosynthesis [H]

COG id: COG0207

COG function: function code F; Thymidylate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate synthase family. Bacterial- type thyA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507751, Length=274, Percent_Identity=51.0948905109489, Blast_Score=273, Evalue=9e-74,
Organism=Escherichia coli, GI1789191, Length=261, Percent_Identity=67.4329501915709, Blast_Score=388, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71993377, Length=276, Percent_Identity=46.3768115942029, Blast_Score=246, Evalue=9e-66,
Organism=Saccharomyces cerevisiae, GI6324648, Length=231, Percent_Identity=42.4242424242424, Blast_Score=179, Evalue=5e-46,
Organism=Drosophila melanogaster, GI17137556, Length=283, Percent_Identity=49.469964664311, Blast_Score=273, Evalue=9e-74,

Paralogues:

None

Copy number: 391 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000398
- InterPro:   IPR020940 [H]

Pfam domain/function: PF00303 Thymidylat_synt [H]

EC number: =2.1.1.45 [H]

Molecular weight: Translated: 30184; Mature: 30053

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00091 THYMIDYLATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPTPYEDLLRLVLEEGTPKADRTGTGTRSVFGHQLRYRLEDGFPLITTKKVHLKSVIY
CCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHH
ELLWFLRGESNVRWLQERGVTIWDEWASEAGELGPVYGVQWRAWPTPSGEHIDQISAALD
HHHHHHCCCCCCHHHHHCCCEEEHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHH
LLRTNPDSRRNIVSAWNVGEIPQMALPPCHAFFQFYVADGKLSCQLYQRSADLFLGVPFN
HHHCCCCHHHHHEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCEEEECCHH
IASYALLTHMMAAQAGLGVGDFVWTGGDCHIYDNHVEQVTEQLSRDPYPYPTLVLAQRDS
HHHHHHHHHHHHHHCCCCCCCEEEECCCEEEECHHHHHHHHHHHCCCCCCCEEEEEECCC
IFDYRYEDITVENYQHHAAIKAPVAV
CCEEECCCEEECCCCCCCEECCCCCC
>Mature Secondary Structure 
SLPTPYEDLLRLVLEEGTPKADRTGTGTRSVFGHQLRYRLEDGFPLITTKKVHLKSVIY
CCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHH
ELLWFLRGESNVRWLQERGVTIWDEWASEAGELGPVYGVQWRAWPTPSGEHIDQISAALD
HHHHHHCCCCCCHHHHHCCCEEEHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHH
LLRTNPDSRRNIVSAWNVGEIPQMALPPCHAFFQFYVADGKLSCQLYQRSADLFLGVPFN
HHHCCCCHHHHHEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCEEEECCHH
IASYALLTHMMAAQAGLGVGDFVWTGGDCHIYDNHVEQVTEQLSRDPYPYPTLVLAQRDS
HHHHHHHHHHHHHHCCCCCCCEEEECCCEEEECHHHHHHHHHHHCCCCCCCEEEEEECCC
IFDYRYEDITVENYQHHAAIKAPVAV
CCEEECCCEEECCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA