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The map label for this gene is nhaA2 [H]

Identifier: 169630074

GI number: 169630074

Start: 3052070

End: 3053395

Strand: Reverse

Name: nhaA2 [H]

Synonym: MAB_2991c

Alternate gene names: 169630074

Gene position: 3053395-3052070 (Counterclockwise)

Preceding gene: 169630075

Following gene: 169630073

Centisome position: 60.26

GC content: 67.5

Gene sequence:

>1326_bases
ATGCGATTGAGCCAGCGCGTCTTCACCCGCGGATCATGGGCGGAGTCGTCGCGTGTCGCTGAGATCCTTCGCAAGGAGAC
CGTCGGTGGTGTCCTGTTGGTGGTGGCGGCAGTGGCCGCGCTGTTGTGGGCCAATTCGCCGTGGAGCTCGTGGTATTACC
GGCTGGGTGCCATCACCGTCGGGCCGGAGCAGTTGCACCTGCATCTGACCCTGGCCGGCTGGGCCACCGACGGGCTGCTG
GCGATCTTCTTCTTCGTGGTGGGAGTGGAACTCAAACGCGAATTCGTCGCCGGGGATCTGCGCGACCCCGGTCGCGCCGC
GCTGCCGATCGTCGCGGCCGTGGGCGGCATGCTGGTCCCCGCCGCCATCTATCTGGCGGTCAACGCCTCCGGAGGTGGCG
CGGCGATGCGCGGCTGGGCGATTCCCACGGCCACCGACATCGCCTTCGCACTCGCTGTGCTCGCGGTGATTTCTACGCAC
CTGCCCACGGCGCTGCGTACCTTTTTGCTCACCCTGGCGGTGGTGGACGATCTGCTGGCGGTCATCGTGATCGCGGTCTT
CTATACCGATGAGCTGCATTGGGGGCCGTTGGGACTGGCGCTGGTACCGCTGGGGTTGTTCGCGCTGGCGGTGCAGCGTC
GGCGTCGGGAGTGGTGGTTGCTGGTGCCGCTGGCGGTGGCCACCTGGGCACTGGTGCACGCCTCCGGTGTGCACGCGACG
GTGGCGGGGGTGCTGCTGGGCTTCACGGTCCCGGTGTTGAGGCGCGACGGCCGCACCGATGCGCACGGTATGGCCGAGCA
ATTCGAGCACCGGCTGCGGCCGTTGTCGGCAGGTGTCGCGGTACCGGTCTTCGCGTTCTTCGCCGCTGGCGTCACGCTGG
GCGGTTTCGCTGGGCTCGGGCAGGCCCTGCTGGATCCGGTGGCGCTCGGCGTGGTCCTGGGGTTGTTGGTGGGCAAACCG
GTGGGAGTCTTCCTCACCACCTACCTGTTGGCGCGGTTTACCCGCGCCAGCCTCGACGATGACCTGAGTTGGCTGGATAT
TGCCGGAGTGGCGCTGCTCGCCGGAATCGGTTTCACGGTGTCCCTGCTCATCGGCGAACTGGCGTTCGGAGCCGCCGAGT
CGGCGACATCCGGCGTGGGCGCGGAGACCGCGTCGCATGTCAAGGTCGGGGTGCTCGCCGGATCGTTGACCTCGGCGGCG
GTGGCATCGGTCGTGCTGCGGTTGCGTAACCGGGTGTATCAGCGCATCGAGGCCAAGGAGACTCTTGACGCCGATCACGA
CGGGGTACCCGATGTTTTTGGCTCTGCTCCAGGCGACCGGATCTAA

Upstream 100 bases:

>100_bases
GACAGCGACCGGTGTAAAGATCTTATAAAGTAGCTCTCAGGTGTGCCGGGAAGTCTGGTCGGCGGTACTGAACCCTGCCT
GAAAGAACGGACACCGACTC

Downstream 100 bases:

>100_bases
ATCGCTGCGTAGACTGGCCAGATGCTTGACGACATCAGGGGGCCGGGTGACCTGCAGGGTCTCTCGAAGCGAGAACTGGA
CTTGCTCGCTGACGAGATCC

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 2 [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MRLSQRVFTRGSWAESSRVAEILRKETVGGVLLVVAAVAALLWANSPWSSWYYRLGAITVGPEQLHLHLTLAGWATDGLL
AIFFFVVGVELKREFVAGDLRDPGRAALPIVAAVGGMLVPAAIYLAVNASGGGAAMRGWAIPTATDIAFALAVLAVISTH
LPTALRTFLLTLAVVDDLLAVIVIAVFYTDELHWGPLGLALVPLGLFALAVQRRRREWWLLVPLAVATWALVHASGVHAT
VAGVLLGFTVPVLRRDGRTDAHGMAEQFEHRLRPLSAGVAVPVFAFFAAGVTLGGFAGLGQALLDPVALGVVLGLLVGKP
VGVFLTTYLLARFTRASLDDDLSWLDIAGVALLAGIGFTVSLLIGELAFGAAESATSGVGAETASHVKVGVLAGSLTSAA
VASVVLRLRNRVYQRIEAKETLDADHDGVPDVFGSAPGDRI

Sequences:

>Translated_441_residues
MRLSQRVFTRGSWAESSRVAEILRKETVGGVLLVVAAVAALLWANSPWSSWYYRLGAITVGPEQLHLHLTLAGWATDGLL
AIFFFVVGVELKREFVAGDLRDPGRAALPIVAAVGGMLVPAAIYLAVNASGGGAAMRGWAIPTATDIAFALAVLAVISTH
LPTALRTFLLTLAVVDDLLAVIVIAVFYTDELHWGPLGLALVPLGLFALAVQRRRREWWLLVPLAVATWALVHASGVHAT
VAGVLLGFTVPVLRRDGRTDAHGMAEQFEHRLRPLSAGVAVPVFAFFAAGVTLGGFAGLGQALLDPVALGVVLGLLVGKP
VGVFLTTYLLARFTRASLDDDLSWLDIAGVALLAGIGFTVSLLIGELAFGAAESATSGVGAETASHVKVGVLAGSLTSAA
VASVVLRLRNRVYQRIEAKETLDADHDGVPDVFGSAPGDRI
>Mature_441_residues
MRLSQRVFTRGSWAESSRVAEILRKETVGGVLLVVAAVAALLWANSPWSSWYYRLGAITVGPEQLHLHLTLAGWATDGLL
AIFFFVVGVELKREFVAGDLRDPGRAALPIVAAVGGMLVPAAIYLAVNASGGGAAMRGWAIPTATDIAFALAVLAVISTH
LPTALRTFLLTLAVVDDLLAVIVIAVFYTDELHWGPLGLALVPLGLFALAVQRRRREWWLLVPLAVATWALVHASGVHAT
VAGVLLGFTVPVLRRDGRTDAHGMAEQFEHRLRPLSAGVAVPVFAFFAAGVTLGGFAGLGQALLDPVALGVVLGLLVGKP
VGVFLTTYLLARFTRASLDDDLSWLDIAGVALLAGIGFTVSLLIGELAFGAAESATSGVGAETASHVKVGVLAGSLTSAA
VASVVLRLRNRVYQRIEAKETLDADHDGVPDVFGSAPGDRI

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=367, Percent_Identity=40.5994550408719, Blast_Score=235, Evalue=4e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 46246; Mature: 46246

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSQRVFTRGSWAESSRVAEILRKETVGGVLLVVAAVAALLWANSPWSSWYYRLGAITV
CCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCEEEE
GPEQLHLHLTLAGWATDGLLAIFFFVVGVELKREFVAGDLRDPGRAALPIVAAVGGMLVP
CCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
AAIYLAVNASGGGAAMRGWAIPTATDIAFALAVLAVISTHLPTALRTFLLTLAVVDDLLA
HHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
VIVIAVFYTDELHWGPLGLALVPLGLFALAVQRRRREWWLLVPLAVATWALVHASGVHAT
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCHHHH
VAGVLLGFTVPVLRRDGRTDAHGMAEQFEHRLRPLSAGVAVPVFAFFAAGVTLGGFAGLG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QALLDPVALGVVLGLLVGKPVGVFLTTYLLARFTRASLDDDLSWLDIAGVALLAGIGFTV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SLLIGELAFGAAESATSGVGAETASHVKVGVLAGSLTSAAVASVVLRLRNRVYQRIEAKE
HHHHHHHHHCCHHHCCCCCCCCCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLDADHDGVPDVFGSAPGDRI
HCCCCCCCCCHHHCCCCCCCC
>Mature Secondary Structure
MRLSQRVFTRGSWAESSRVAEILRKETVGGVLLVVAAVAALLWANSPWSSWYYRLGAITV
CCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCEEEE
GPEQLHLHLTLAGWATDGLLAIFFFVVGVELKREFVAGDLRDPGRAALPIVAAVGGMLVP
CCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
AAIYLAVNASGGGAAMRGWAIPTATDIAFALAVLAVISTHLPTALRTFLLTLAVVDDLLA
HHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
VIVIAVFYTDELHWGPLGLALVPLGLFALAVQRRRREWWLLVPLAVATWALVHASGVHAT
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCHHHH
VAGVLLGFTVPVLRRDGRTDAHGMAEQFEHRLRPLSAGVAVPVFAFFAAGVTLGGFAGLG
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QALLDPVALGVVLGLLVGKPVGVFLTTYLLARFTRASLDDDLSWLDIAGVALLAGIGFTV
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SLLIGELAFGAAESATSGVGAETASHVKVGVLAGSLTSAAVASVVLRLRNRVYQRIEAKE
HHHHHHHHHCCHHHCCCCCCCCCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLDADHDGVPDVFGSAPGDRI
HCCCCCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA