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The map label for this gene is hemE [H]

Identifier: 169630069

GI number: 169630069

Start: 3046421

End: 3047590

Strand: Reverse

Name: hemE [H]

Synonym: MAB_2986c

Alternate gene names: 169630069

Gene position: 3047590-3046421 (Counterclockwise)

Preceding gene: 169630073

Following gene: 169630068

Centisome position: 60.14

GC content: 67.69

Gene sequence:

>1170_bases
ATGGACGGTAGCGCGCCGGGCCGACATGCTCCCGCAGGCGCGCCGTGCGAAGCCGTCATGGCAGCATGGGCTGTGATGAC
CGGATTGAACGAAGATAGCGCCACGGCGGCGCAAACCACTTCGAAAACGCGGCGTGACCTGCCTCTTTCGCCCTATTTGG
TGGCTGCCGCGGGCGGGGTGCCCAGCCACCCGCCGGTGTGGTTCATGCGGCAAGCCGGACGTTCGCTGCCGGAGTACCGG
GCGGTGCGAGCCGATCACGCCATGCTGGACGCTTGTTTTAACCCCGAACTGGTTTGCGAGATCACACTGCAGCCGATCCG
TCGGCACCGTGTGGATGCCGCCATTCTCTTCTCGGACATCGTGGTGCCACTCAAGGCCGCCGGAATCGACCTGGACATCG
TTCCGGATGTCGGGCCCGTGATCGCCAACCCGGTGCGCACCACCGCGGATGTGGCGGCGCTGCCGCGGCTGGAGCCCGGA
CAGGTCGAGGCCGTCAGCGCCGCGGTGCGGCTACTGGTCGGCGAGCTCGGCGCCACCCCGCTGATCGGCTTCGCCGGTGC
GCCCTTCACATTGGCTTCCTACCTCGTGGAGGGCGGCCCGAGCCGTCACCATCAGCGCACCAAGGCCCTGCTGCTGGGCG
ATCCGCAGACCTGGCATGCGTTGATGACGGCGTTGACCGACATCACCATCGCGTTTCTGCGGGCGCAGCTCGACGCGGGA
GTGGACGCGCTGCAGTTGTTCGACTCGTGGGCGGGCGCACTGTCCCTGGCCGATTACCGCGCTGCGGTGTTGCCGCACAG
CACAAGGATTTTCCAGGAGTTCGCGGGAGTCGGTGTGCCGATGACGCACTTCGGGGTGGGCACCGCCGAGCTGCTGGGGG
CGATGGGGGAGGCCGGCGCCACGGTGGTGGGGGTGGACTGGCGCACCCCGCTGAATGTCGCGGCGAGCCGAGTTGGTTCC
GGAAAAGCCTTGCAGGGCAACCTCGATCCTGCCGTGCTGTTGGCGGGATGGCCGGTAGTGGAGAGTGAAGTTCGCCGTAT
CGTCGCCGAGGGACGCCAGGCGGTGGCTGACGGCGCCGCCGGGCATATCTTCAATCTGGGGCATGGCGTGCTGCCGGATA
CCGATCCGGCGGTACTGACCGATGCGGCGGCGCTGGTGCATTCGTTGTGA

Upstream 100 bases:

>100_bases
GGGACGAATAGTGCCCAGCTCGATTTCCGGACGCGCGGTCACGGAGTTCATCGCGTCGACCGCCGCGCGGAACGGGGCTG
GTTCGGCAGACGTCACAGCA

Downstream 100 bases:

>100_bases
TGTGTGAGCTGGCCAAGTGACGCCGCAGCCGTCGGGTTCTCCCTCCATTGCCATTGTGGGGGGCGGTATTTCGGGCCTGA
CGGCGGCATATCGGCTCCGC

Product: uroporphyrinogen decarboxylase (HemE)

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MDGSAPGRHAPAGAPCEAVMAAWAVMTGLNEDSATAAQTTSKTRRDLPLSPYLVAAAGGVPSHPPVWFMRQAGRSLPEYR
AVRADHAMLDACFNPELVCEITLQPIRRHRVDAAILFSDIVVPLKAAGIDLDIVPDVGPVIANPVRTTADVAALPRLEPG
QVEAVSAAVRLLVGELGATPLIGFAGAPFTLASYLVEGGPSRHHQRTKALLLGDPQTWHALMTALTDITIAFLRAQLDAG
VDALQLFDSWAGALSLADYRAAVLPHSTRIFQEFAGVGVPMTHFGVGTAELLGAMGEAGATVVGVDWRTPLNVAASRVGS
GKALQGNLDPAVLLAGWPVVESEVRRIVAEGRQAVADGAAGHIFNLGHGVLPDTDPAVLTDAAALVHSL

Sequences:

>Translated_389_residues
MDGSAPGRHAPAGAPCEAVMAAWAVMTGLNEDSATAAQTTSKTRRDLPLSPYLVAAAGGVPSHPPVWFMRQAGRSLPEYR
AVRADHAMLDACFNPELVCEITLQPIRRHRVDAAILFSDIVVPLKAAGIDLDIVPDVGPVIANPVRTTADVAALPRLEPG
QVEAVSAAVRLLVGELGATPLIGFAGAPFTLASYLVEGGPSRHHQRTKALLLGDPQTWHALMTALTDITIAFLRAQLDAG
VDALQLFDSWAGALSLADYRAAVLPHSTRIFQEFAGVGVPMTHFGVGTAELLGAMGEAGATVVGVDWRTPLNVAASRVGS
GKALQGNLDPAVLLAGWPVVESEVRRIVAEGRQAVADGAAGHIFNLGHGVLPDTDPAVLTDAAALVHSL
>Mature_389_residues
MDGSAPGRHAPAGAPCEAVMAAWAVMTGLNEDSATAAQTTSKTRRDLPLSPYLVAAAGGVPSHPPVWFMRQAGRSLPEYR
AVRADHAMLDACFNPELVCEITLQPIRRHRVDAAILFSDIVVPLKAAGIDLDIVPDVGPVIANPVRTTADVAALPRLEPG
QVEAVSAAVRLLVGELGATPLIGFAGAPFTLASYLVEGGPSRHHQRTKALLLGDPQTWHALMTALTDITIAFLRAQLDAG
VDALQLFDSWAGALSLADYRAAVLPHSTRIFQEFAGVGVPMTHFGVGTAELLGAMGEAGATVVGVDWRTPLNVAASRVGS
GKALQGNLDPAVLLAGWPVVESEVRRIVAEGRQAVADGAAGHIFNLGHGVLPDTDPAVLTDAAALVHSL

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=342, Percent_Identity=40.6432748538012, Blast_Score=216, Evalue=4e-56,
Organism=Escherichia coli, GI2367337, Length=319, Percent_Identity=44.2006269592476, Blast_Score=241, Evalue=8e-65,
Organism=Saccharomyces cerevisiae, GI6320252, Length=355, Percent_Identity=33.5211267605634, Blast_Score=202, Evalue=5e-53,
Organism=Drosophila melanogaster, GI19921920, Length=334, Percent_Identity=38.0239520958084, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI221330099, Length=334, Percent_Identity=38.0239520958084, Blast_Score=203, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 40496; Mature: 40496

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGSAPGRHAPAGAPCEAVMAAWAVMTGLNEDSATAAQTTSKTRRDLPLSPYLVAAAGGV
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCC
PSHPPVWFMRQAGRSLPEYRAVRADHAMLDACFNPELVCEITLQPIRRHRVDAAILFSDI
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHH
VVPLKAAGIDLDIVPDVGPVIANPVRTTADVAALPRLEPGQVEAVSAAVRLLVGELGATP
HHHHHHCCCCEEECCCCCHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
LIGFAGAPFTLASYLVEGGPSRHHQRTKALLLGDPQTWHALMTALTDITIAFLRAQLDAG
EEECCCCHHHHHHHHHHCCCCHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
VDALQLFDSWAGALSLADYRAAVLPHSTRIFQEFAGVGVPMTHFGVGTAELLGAMGEAGA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHCCCCHHHHHHHHCCCCC
TVVGVDWRTPLNVAASRVGSGKALQGNLDPAVLLAGWPVVESEVRRIVAEGRQAVADGAA
EEEEECCCCCHHHHHHHCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCC
GHIFNLGHGVLPDTDPAVLTDAAALVHSL
CCEEECCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MDGSAPGRHAPAGAPCEAVMAAWAVMTGLNEDSATAAQTTSKTRRDLPLSPYLVAAAGGV
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCC
PSHPPVWFMRQAGRSLPEYRAVRADHAMLDACFNPELVCEITLQPIRRHRVDAAILFSDI
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHH
VVPLKAAGIDLDIVPDVGPVIANPVRTTADVAALPRLEPGQVEAVSAAVRLLVGELGATP
HHHHHHCCCCEEECCCCCHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
LIGFAGAPFTLASYLVEGGPSRHHQRTKALLLGDPQTWHALMTALTDITIAFLRAQLDAG
EEECCCCHHHHHHHHHHCCCCHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
VDALQLFDSWAGALSLADYRAAVLPHSTRIFQEFAGVGVPMTHFGVGTAELLGAMGEAGA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHCCCCHHHHHHHHCCCCC
TVVGVDWRTPLNVAASRVGSGKALQGNLDPAVLLAGWPVVESEVRRIVAEGRQAVADGAA
EEEEECCCCCHHHHHHHCCCCCEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCC
GHIFNLGHGVLPDTDPAVLTDAAALVHSL
CCEEECCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA